A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa

Journal of Controlled Release

Volumn 149, Issue 1, 2011, Pages 81-88

  Makhlof, Abdallah ^a   Werle, Martin ^a   Tozuka, Yuichi ^a   Takeuchi, Hirofumi ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Mucoadhesion; Nanoparticles; Oral peptide delivery; Permeation enhancement; Polyamines; Spermine

Indexed keywords

MUCOADHESION; ORAL PEPTIDE DELIVERY; PERMEATION ENHANCEMENT; POLYAMINES; SPERMINE;

AMINES; COAGULATION; CONFOCAL MICROSCOPY; DRUG PRODUCTS; GELATION; GLUCOSE; MONOLAYERS; NANOPARTICLES; ORGANIC ACIDS; PEPTIDES; RATS; WALLS (STRUCTURAL PARTITIONS);

PERMEATION;

CALCITONIN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; NANOPARTICLE; POLYACRYLIC ACID; SPERMINE;

ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE PERMEABILITY; CYTOTOXICITY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; INTESTINE MUCOSA; MACROMOLECULE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACRYLIC RESINS; ADHESIVENESS; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CALCITONIN; CELL SURVIVAL; DEXTRANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG COMPOUNDING; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; ILEUM; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MACROMOLECULAR SUBSTANCES; MALE; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PEPTIDES; PERMEABILITY; RATS; RATS, WISTAR; SPERMINE; SURFACE PROPERTIES;

EID: 78651228118     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.02.001     Document Type: Article

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