Novel oral formulation safely improving intestinal absorption of poorly absorbable drugs: Utilization of polyamines and bile acids

Journal of Controlled Release

Volumn 111, Issue 1-2, 2006, Pages 27-34

  Miyake, Masateru ^a   Minami, Takanori ^b   Hirota, Masao ^a   Toguchi, Hajime ^a   Odomi, Masaaki ^a   Ogawara, Ken Ichi ^c   Higaki, Kazutaka ^c   Kimura, Toshikiro ^c  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^b Tokushima Research Institute   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

Bile acids; Gastrointestinal absorption; Histopathology; Membrane permeability; Polyamines

Indexed keywords

ABSORPTION; AMINES; BIOLOGICAL MEMBRANES; GASTROENTEROLOGY; MECHANICAL PERMEABILITY; ORGANIC ACIDS;

BILE ACIDS; GASTROINTESTINAL ABSORPTION; HISTOPATHOLOGY; MEMBRANE PERMEABILITY; POLYAMINES;

DRUG PRODUCTS;

BILE ACID; POLYAMINE; REBAMIPIDE; SPERMIDINE; SPERMINE; TAUROCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLON; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DUODENUM; GASTROINTESTINAL TRACT; HISTOPATHOLOGY; INTESTINE ABSORPTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; STOMACH; TOXICITY TESTING;

ADJUVANTS, PHARMACEUTIC; ADMINISTRATION, ORAL; ALANINE; ANIMALS; ANTI-ULCER AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; COLON; GASTRIC MUCOSA; INTESTINAL ABSORPTION; MALE; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; SPERMIDINE; SPERMINE; TAUROCHOLIC ACID;

EID: 33344468568     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.11.010     Document Type: Article

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