Systemic delivery of insulin via the nasal route using a new microemulsion system: In vitro and in vivo studies

Journal of Controlled Release

Volumn 148, Issue 2, 2010, Pages 168-176

  Sintov, Amnon C ^a   Levy, Haim V ^b   Botner, Shafir ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b NanoDerma Ltd   (Israel)

Author keywords

Bioavailability; Insulin; Interspecies differences; Intranasal delivery; Microemulsion; Nasal spray

Indexed keywords

AQUEOUS PHASE; AQUEOUS SOLUTIONS; BIOAVAILABILITY; DROPLET SIZES; GLUCOSE LEVEL; IN-VITRO; INTERSPECIES DIFFERENCES; INTRANASAL; INVERSE MICRO EMULSION; LAG-TIME; MICROEMULSION SYSTEMS; NASAL ABSORPTION; NASAL SPRAY; OIL RATIO; PERMEABILITY COEFFICIENTS; PLASMA GLUCOSE LEVEL; PSEUDOTERNARY PHASE DIAGRAMS; SPRAY APPLICATION; TEM; TRANSPORT PROCESS;

BIOCHEMISTRY; DROP FORMATION; GLUCOSE; INSULIN; PHASE DIAGRAMS; SOLUTIONS; SURFACE ACTIVE AGENTS; VISCOSITY MEASUREMENT; WATER ABSORPTION;

MICROEMULSIONS;

FLUORESCEIN ISOTHIOCYANATE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG PENETRATION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; MALE; MICROEMULSION; NONHUMAN; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; VISCOSITY;

ADMINISTRATION, INTRANASAL; AEROSOLS; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD GLUCOSE; CHEMISTRY, PHARMACEUTICAL; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG COMPOUNDING; EMULSIONS; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; LIGHT; MICROSCOPY, ELECTRON, TRANSMISSION; NASAL MUCOSA; PARTICLE SIZE; PERMEABILITY; RABBITS; SCATTERING, RADIATION; SURFACE PROPERTIES; SWINE; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY;

EID: 78649318567     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.08.004     Document Type: Article

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