Facilitated nanoscale delivery of insulin across intestinal membrane models

International Journal of Pharmaceutics

Volumn 412, Issue 1-2, 2011, Pages 123-131

  Woitiski, Camile B ^a,b   Sarmento, Bruno ^c,d   Carvalho, Rui A ^e   Neufeld, Ronald J ^b   Veiga, Francisco ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b QUEEN S UNIVERSITY   (Canada)

^c UNIVERSITY OF PORTO   (Portugal)

^d UNIVERSITY INSTITUTE OF HEALTH SCIENCES IUCS   (Portugal)

^e UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Cell culture; Insulin; Intestinal mucosa; Nanoparticles; Permeation

Indexed keywords

ALBUMIN; ALGINIC ACID; CALCIUM CHLORIDE; CHITOSAN; DEXTRAN SULFATE; FLUORESCEIN ISOTHIOCYANATE; INSULIN; POLOXAMER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CELL CULTURE; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG TRANSPORT; INTERNALIZATION; INTESTINE CELL; INTESTINE EPITHELIUM; MEMBRANE MODEL; NANOANALYSIS; NANOENCAPSULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; COCULTURE TECHNIQUES; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; ELECTRIC IMPEDANCE; ENTEROCYTES; GOBLET CELLS; HT29 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINAL MUCOSA; MITOCHONDRIA; NANOPARTICLES; POLOXAMER; RATS; RATS, WISTAR; SERUM ALBUMIN, BOVINE;

EID: 79957529691     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.04.003     Document Type: Article

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