Chitosan-aprotinin coated liposomes for oral peptide delivery: Development, characterisation and in vivo evaluation

International Journal of Pharmaceutics

Volumn 370, Issue 1-2, 2009, Pages 26-32

  Werle, Martin ^a   Takeuchi, Hirofumi ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Calcitonin; Liposomes; Oral peptide delivery; Polymer protease inhibitor conjugate

Indexed keywords

APROTININ PLUS CHITOSAN; CALCITONIN; CALCIUM; COUMARIN; LIPOSOME; PROTEINASE INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM BLOOD LEVEL; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG COATING; DRUG DEVELOPMENT; DRUG EFFICACY; DRUG SCREENING; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; WISTAR RAT;

ADHESIVES; ADMINISTRATION, ORAL; ANIMALS; APROTININ; CALCITONIN; CALCIUM; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DRUG DELIVERY SYSTEMS; LIPOSOMES; MALE; POLYMERS; PROTEASE INHIBITORS; RATS; RATS, WISTAR;

EID: 61349145559     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.11.013     Document Type: Article

References (21)

1. Aungst B.J. Intestinal permeation enhancers. J. Pharm. Sci. 89 (2000) 429-442
2. Bai J.P.F., Chang L.L., and Guo J.H. Effects of polyacrylic polymers on the degradation of insulin and peptide drugs by chymotrypsin and trypsin. J. Pharm. Pharmacol. 48 (1996) 17-21
3. Bernkop-Schnürch A. Chitosan and its derivatives: potential excipients for peroral peptide delivery systems. Int. J. Pharm. 194 (2000) 1-13
4. Bernkop-Schnürch A., and Kast C.E. Chemically modified chitosans as enzyme inhibitors. Adv. Drug Deliv. Rev. 52 (2001) 127-137
5. Bernkop-Schnürch A., and Pasta M. Intestinal peptide and protein delivery: novel bioadhesive drug-carrier matrix shielding from enzymatic attack. J. Pharm. Sci. 87 (1998) 430-434
6. Bernkop-Schnürch A., and Scerbe-Saiko A. Synthesis and in vitro evaluation of chitosan-EDTA-protease-inhibitor conjugates which might be useful in oral delivery of peptides and proteins. Pharm. Res. 15 (1998) 263-269
7. Ge Y.C., and Morgan R.G.H. The effect of trypsin inhibitor on the pancreas and small intestine of mice. Br. J. Nutr. 70 (1993) 333
8. Luessen H.L., de Leeuw B.J., Langemeyer M.W., de Boer A.G., Verhoef J.C., and Junginger H.E. Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharm. Res. 13 (1996) 1668-1672
9. Melmed R.N., El-Aaser A.A., and Holt S.J. Hypertrophy and hyperplasia of the neonatal rat exocrine pancreas induced by orally administered soybean trypsin inhibitor. Biochim. Biophys. Acta 421 (1976) 280-288
10. Tahara K., Yamamoto H., Takeuchi H., and Kawashima Y. Development of gene delivery system using PLGA nanospheres. Yakugaku Zasshi 127 (2007) 1541-1548
11. Takeuchi H., Matsui Y., Sugihara H., Yamamoto H., and Kawashima Y. Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugs. Int. J. Pharm. 303 (2005) 160-170
12. Takeuchi H., Matsui Y., Yamamoto H., and Kawashima Y. Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats. J. Control Rel. 86 (2003) 235-242
13. Takeuchi H., Thongborisute J., Matsui Y., Sugihara H., Yamamoto H., and Kawashima Y. Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems. Adv. Drug Deliv. Rev. 57 (2005) 1583-1594
14. Takeuchi H., Yamamoto H., Niwa T., Hino T., and Kawashima Y. Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes. Pharm. Res. 13 (1996) 896-901
15. Takeuchi H., Yamamoto H., Niwa T., Hino T., and Kawashima Y. Mucoadhesion of polymer-coated liposomes to rat intestine in vitro. Chem. Pharm. Bull. 42 (1994) 1954-1956
16. Thongborisute J., Tsuruta A., Kawabata Y., and Takeuchi H. The effect of particle structure of chitosan-coated liposomes and type of chitosan on oral delivery of calcitonin. J. Drug Target 14 (2006) 147-154
17. Werle M., Loretz B., Entstrasser D., and Föger F. Design and evaluation of a chitosan-aprotinin conjugate for the peroral delivery of therapeutic peptides and proteins susceptible to enzymatic degradation. J. Drug Target 15 (2007) 327-333
18. Werle M., Schmitz T., Huang H., Wentzel A., Kolmar H., and Bernkop-Schnürch A. The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery. J. Drug Target 14 (2006) 137-146
19. Woodley J.F. Enzymatic barriers for GI peptide and protein delivery. Crit. Rev. Ther. Drug Carrier Syst. 11 (1994) 61-95
20. Yamamoto A., Taniguchi T., Rikyun K., Tsuji T., Fujita T., Murakami M., and Muranishi S. Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm. Res. 11 (1994) 1496-1500
21. Zheng F., Shi X.W., Yang G.F., Gong L.L., Yuan H.Y., Cui Y.J., Wang Y., Du Y.M., and Li Y. Chitosan nanoparticle as gene therapy vector via gastrointestinal mucosa administration: results of an in vitro and in vivo study. Life Sci. 80 (2007) 388-396