Pulmonary delivery of salmon calcitonin dry powders containing absorption enhancers in rats

Pharmaceutical Research

Volumn 13, Issue 1, 1996, Pages 80-83

  Kobayashi, Shinzo ^a   Kondo, Shuji ^a   Juni, Kazuhiko ^b  

^a SANOFI   (France)

^b JOSAI UNIVERSITY   (Japan)

Author keywords

Absorption enhancer; Dry powder; Pulmonary absorption; Salmon calcitonin

Indexed keywords

BETA CYCLODEXTRIN DERIVATIVE; CITRIC ACID; OCTYL GLUCOSIDE; OLEIC ACID; PHOSPHATIDYLCHOLINE; SALCATONIN; TAUROCHOLIC ACID;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG FORMULATION; DRUG MIXTURE; FREEZE DRYING; INTRATRACHEAL DRUG ADMINISTRATION; LUNG ALVEOLUS EPITHELIUM; MALE; NONHUMAN; POWDER; PRIORITY JOURNAL; RAT;

ABSORPTION; ANIMALS; CALCITONIN; DEXTRANS; DRUG SYNERGISM; EVALUATION STUDIES; FLUORESCEIN-5-ISOTHIOCYANATE; INTUBATION, INTRATRACHEAL; LUNG; MALE; POWDERS; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; SOLUTIONS;

EID: 0029918843     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016081301369     Document Type: Article

References (14)

1. K. Okumura, S. Iwakawa, T. Yoshida, T. Seki and F. Komada. Intratracheal delivery of insulin absorption from solution and aerosol by rat lung. Int. J. Pharm. 88:63-73 (1992).
2. P. Colthorpe, S. J. Farr, G. Taylor, I. J. Smith and D. Wyatt. The pharmacokinetics of pulmonary-delivered insulin: A comparison of intratracheal and aerosol administration to the rabbit. Pharm. Res. 9:764-768 (1992).
3. S. Kobayashi, S. Kondo and K. Juni. Study on pulmonary delivery of salmon calcitonin in rats: Effects of protease inhibitors and absorption enhancers. Pharm. Res. 11:1239-1243 (1994).
4. F. Komada, S. Iwakawa, N. Yamamoto, H. Sakakibara and K. Okumura. Intratracheal delivery of peptide and protein agents: Absorption from solution and dry powder by rat lung. J. Pharm. Sci. 83:863-867 (1994).
5. R. W. Niven, F. D. Lott, A. Y. Ip and J. M. Cribbs. Pulmonary delivery of powders and solutions containing recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the rabbit. Pharm. Res. 11:1101-1109 (1994).
6. P. R. Byron and R. W. Niven. A novel dosing method for drug administration to the airways of the isolated perfused rat lung. J. Pharm. Sci. 77:693-695 (1988).
7. E. D. Crandall. Water and nonelectrolyte transport across alveolar epithelium. Am. Rev. Resp. Dis. 127:S16-S24 (1983).
8. E. R. Weibel. Oxygen demand and the size of respiratory structures in mammals, pp.289-346. In Evolution of respiratory processes a comparative approach, ed. by S.C. Wood and L. Lenfant, Marcel Dekker Inc., New York (1979).
9. E. R. Weibel. Morphometric estimation of pulmonary diffusion capacity. Resp. Physiol. 11:54-75 (1970/71).
10. V. H. Lee, A. Yamamoto, and U. B. Kompella. Mucosal penetration enhancers for facilitation of peptide and protein drug absorption. Crit. Rev. Ther. Drug Carrier Syst. 8:91-192 (1991).
11. L. Y. Wang, J. K. H. Ma, W. F. Pan, D. Toledo-Velasquez, C. J. Malanga, and Y. Rojanasakul. Alveolar permeability enhancement by oleic acid and related fatty acids: Evidence for a calcium-dependent mechanism. Pharm. Res. 11:513-517 (1994).
12. Z. Shao and A. Mitra. Nasal membrane and intracellular protein and enzyme release by bile salts and bile salt-fatty acid mixed micelles: Correlation with facilitated drug transport. Pharm. Res. 9:1184-1189 (1992).
13. 1,7)-eel calcitonin by various protease inhibitors in rats. Pharm. Res. 11:909-913 (1994).
14. J. Hochman and P. Artursson. Mechanisms of absorption enhancement and tight junction regulation. J. of Controlled Release. 29:253-267 (1994).