Characterization and aerodynamic evaluation of spray dried recombinant human growth hormone using protein stabilizing agents

International Journal of Pharmaceutics

Volumn 352, Issue 1-2, 2008, Pages 209-216

  Jalalipour, Monireh ^a   Gilani, Kambiz ^a   Tajerzadeh, Hosnieh ^a   Najafabadi, Abdolhossien Rouholamini ^a,b   Barghi, Mohammadali ^c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

^c UNIVERSITY OF TEHRAN   (Iran)

Author keywords

Dry powder inhaler; Fine particle fraction; Protein stabilizers; Recombinant human growth hormone; Spray drying

Indexed keywords

POLYSORBATE; RECOMBINANT GROWTH HORMONE;

AEROSOL; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG FORMULATION; HUMAN; IN VITRO STUDY; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN STABILITY; REACTOR CASCADE; SPRAY DRYING;

AEROSOLS; CHEMISTRY, PHARMACEUTICAL; CHLORIDES; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; DESICCATION; DRUG STABILITY; EXCIPIENTS; HUMAN GROWTH HORMONE; HUMANS; LACTOSE; PARTICLE SIZE; POLYSORBATES; PROTEIN DENATURATION; RECOMBINANT PROTEINS; SCATTERING, RADIATION; TECHNOLOGY, PHARMACEUTICAL; ZINC COMPOUNDS;

EID: 39549088108     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.10.053     Document Type: Article

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