In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery

Advanced Drug Delivery Reviews

Volumn 58, Issue 9-10, 2006, Pages 1030-1060

  Sakagami, Masahiro ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Absorption; Deposition; Disposition; Inhalation; Lung; Metabolism; Mucociliary clearance; Preclinical

Indexed keywords

ABSORPTION; DEPOSITION; METABOLISM; PHARMACODYNAMICS; PROTEINS; PULMONARY DISEASES;

DISPOSITION; INHALATION; LUNGS; MUCOCILIARY CLEARANCE;

DRUG PRODUCTS;

ACEPROMAZINE; ANESTHETIC AGENT; DROPERIDOL; ETHER; FENTANYL; HALOTHANE; INSULIN; ISOFLURANE; KETAMINE; LEUPRORELIN; PARATHYROID HORMONE; PENTOBARBITAL; POLYGLACTIN; URETHAN; XYLAZINE;

AEROSOL; CORRELATION ANALYSIS; DEVICE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG TRANSPORT; EPITHELIUM CELL; HUMAN; KINETICS; LUNG; LUNG CIRCULATION; MACROMOLECULE; METERED DOSE INHALER; MUCOCILIARY CLEARANCE; NEBULIZATION; NONHUMAN; PERMEABILITY; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; RODENT; TIGHT JUNCTION; TRACHEOBRONCHIAL TREE; TRANSPORT KINETICS;

ABSORPTION; ADMINISTRATION, INHALATION; ANIMALS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; HUMANS; LUNG; MODELS, ANIMAL; PHARMACEUTICAL PREPARATIONS; TISSUE DISTRIBUTION;

EID: 33750845387     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2006.07.012     Document Type: Review

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