Characterization of insulin protection properties of complexation hydrogels in gastric and intestinal enzyme fluids

Journal of Controlled Release

Volumn 112, Issue 3, 2006, Pages 343-349

  Yamagata, Tetsuo ^a   Morishita, Mariko ^a   Kavimandan, Nikhil J ^b   Nakamura, Koji ^a   Fukuoka, Yu ^a   Takayama, Kozo ^a   Peppas, Nicholas A ^b  

^a HOSHI UNIVERSITY   (Japan)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Ca2+ deprivation; Complexation hydrogel; Enzyme inhibition; Insulin

Indexed keywords

COMPLEXATION; DEGRADATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYMES; HYDROGELS;

CA2+ DEPRIVATION; COMPLEXATION HYDROGEL; DEGRADATION RATE; PROTEASES;

INSULIN;

CALCIUM ION; INSULIN; INTESTINE ENZYME; MACROGOL; POLYMER; POLYMETHACRYLIC ACID; PROTEIN; PROTEINASE;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG FORMULATION; DRUG RELEASE; GASTROINTESTINAL ABSORPTION; HYDROGEL; INSULIN DEGRADATION; INTESTINE FLUID; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH JUICE; ANIMAL; COMPARATIVE STUDY; ENZYMOLOGY; INTESTINE SECRETION; METABOLISM; SECRETION; WISTAR RAT;

ANIMALS; GASTRIC JUICE; HYDROGELS; INSULIN; INTESTINAL SECRETIONS; RATS; RATS, WISTAR;

EID: 33746404368     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.03.005     Document Type: Article

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