Thiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery

Acta Biomaterialia

Volumn 6, Issue 8, 2010, Pages 3072-3080

  Sajeesh, S ^a,b   Vauthier, C ^b   Gueutin, C ^b   Ponchel, G ^b   Sharma, Chandra P ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

^b UNIV PARIS SUD   (France)

Author keywords

Hydrogel; Microparticles; Mucoadhesion; Oral insulin; Thiolation

Indexed keywords

AMINO ACIDS; CELLS; ENCAPSULATION; ENZYMES; INSULIN; MONOLAYERS; TISSUE;

CACO-2 CELLS; FUNCTIONALIZED; IN-VITRO; MICRO PARTICLES; MUCOADHESION; ORAL INSULIN; ORAL INSULIN DELIVERY; POLYMETHACRYLIC ACID; PROTEASE ENZYME; THIOLATION;

HYDROGELS;

CHITOSAN; INSULIN; MACROGOL; POLYMETHACRYLIC ACID; PROTEINASE; THIOL; ENZYME INHIBITOR; MACROGOL DERIVATIVE; NANOPARTICLE; POLYMETHACRYLIC ACID DERIVATIVE; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GLUCOSE MONITORING; CELL STRAIN CACO 2; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TRANSPORT; ENCAPSULATION; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; HYDROGEL; IN VITRO STUDY; INTESTINE; MUCOADHESION; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; STREPTOZOCIN DIABETES; ANIMAL; CELL MEMBRANE PERMEABILITY; CHEMISTRY; CIRCULAR DICHROISM; DRUG EFFECT; HUMAN; HYPOGLYCEMIA; IMPEDANCE; INFRARED SPECTROSCOPY; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; PH; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ANIMALIA; RATTUS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CHITOSAN; CIRCULAR DICHROISM; DRUG DELIVERY SYSTEMS; ELECTRIC IMPEDANCE; ENZYME INHIBITORS; HUMANS; HYDROGEL; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIA; INSULIN; INTESTINES; MALE; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS; RATS; RATS, WISTAR; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SULFHYDRYL COMPOUNDS;

EID: 77956631702     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.02.007     Document Type: Article

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