-
1
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
DOI 10.1038/372425a0
-
Y. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold & J. M. Friedman: Positional cloning of the mouse obese gene and its human homolog. Nature, 372, 425-432 (1994) (Pubitemid 24365442)
-
(1994)
Nature
, vol.372
, Issue.6505
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
2
-
-
0028845877
-
Leptin levels in human and rodent - Measurement of plasma leptin and Ob RNA in obese and weight-rdeuced subjects
-
M. Maffei, J. Halaas, E. Ravussin, R. E. Pratley, G. H. Lee, Y. Zhang, H. Fei, S. Kim, R. Lallone, S. Ranganathan, P. A. Kern & J. M. Friedman: Leptin levels in human and rodent - measurement of plasma leptin and Ob RNA in obese and weight-rdeuced subjects. Nat Med, 1, 1155-1161 (1995)
-
(1995)
Nat Med
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
Pratley, R.E.4
Lee, G.H.5
Zhang, Y.6
Fei, H.7
Kim, S.8
Lallone, R.9
Ranganathan, S.10
Kern, P.A.11
Friedman, J.M.12
-
3
-
-
0029048408
-
Recombinant mouse Ob protein - Evidence for a peripheral signal linking adiposity and central neural networks
-
L. A. Campfield, F. J. Smith, Y. Guisez, R. Devos & P. Burn: Recombinant mouse Ob protein - Evidence for a peripheral signal linking adiposity and central neural networks. Science, 269, 546-549 (1995)
-
(1995)
Science
, vol.269
, pp. 546-549
-
-
Campfield, L.A.1
Smith, F.J.2
Guisez, Y.3
Devos, R.4
Burn, P.5
-
4
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
DOI 10.1038/27376
-
J. M. Friedman & J. L. Halaas: Leptin and the regulation of body weight in mammals. Nature, 395, 763-770 (1998) (Pubitemid 28485436)
-
(1998)
Nature
, vol.395
, Issue.6704
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
5
-
-
0029073613
-
Weight-reducing effects of the plasmaprotein encoded by the obese gene
-
J. L. Halaas, K. S. Gajiwala, M. Maffei, S. L. Cohen, B. T. Chait, D. Rabinowitz, R. L. Lallone, S. K. Burley & J. M. Friedman: Weight-reducing effects of the plasmaprotein encoded by the obese gene. Science, 269, 543-546 (1995)
-
(1995)
Science
, vol.269
, pp. 543-546
-
-
Halaas, J.L.1
Gajiwala, K.S.2
Maffei, M.3
Cohen, S.L.4
Chait, B.T.5
Rabinowitz, D.6
Lallone, R.L.7
Burley, S.K.8
Friedman, J.M.9
-
6
-
-
0029066265
-
Effects of the obese gene-product on body-weight regulation in ob/ob mice
-
M. A. Pelleymounter, M. J. Cullen, M. B. Baker, R. Hecht, D. Winters, T. Boone & F. Collins: Effects of the obese gene-product on body-weight regulation in ob/ob mice. Science, 269, 540-543 (1995)
-
(1995)
Science
, vol.269
, pp. 540-543
-
-
Pelleymounter, M.A.1
Cullen, M.J.2
Baker, M.B.3
Hecht, R.4
Winters, D.5
Boone, T.6
Collins, F.7
-
7
-
-
0030007116
-
Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction
-
DOI 10.1038/nm0596-585
-
J. A. Cioffi, A. W. Shafer, T. J. Zupancic, J. SmithGbur, A. Mikhail, D. Platika & H. R. Snodgrass: Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction. Nat Med, 2, 585-589 (1996) (Pubitemid 26151519)
-
(1996)
Nature Medicine
, vol.2
, Issue.5
, pp. 585-589
-
-
Cioffi, J.A.1
Shafer, A.W.2
Zupancic, T.J.3
Smith-Gbur, J.4
Mikhail, A.5
Platika, D.6
Snodgrass, H.R.7
-
8
-
-
0141737573
-
Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
-
P. Ducy, M. Amling, S. Takeda, M. Priemel, A. F. Schilling, F. T. Beil, J. H. Shen, C. Vinson, J. M. Rueger & G. Karsenty: Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass. Cell, 100, 197-207 (2000) (Pubitemid 30064908)
-
(2000)
Cell
, vol.100
, Issue.2
, pp. 197-207
-
-
Ducy, P.1
Amling, M.2
Takeda, S.3
Priemel, M.4
Schilling, A.F.5
Beil, F.T.6
Shen, J.7
Vinson, C.8
Rueger, J.M.9
Karsenty, G.10
-
9
-
-
0036847619
-
Leptin regulates bone formation via the sympathetic nervous system
-
DOI 10.1016/S0092-8674(02)01049-8
-
S. Takeda, F. Elefteriou, R. Levasseur, X. Y. Liu, L. P. Zhao, K. L. Parker, D. Armstrong, P. Ducy & G. Karsenty: Leptin regulates bone formation via the sympathetic nervous system. Cell, 111, 305-317 (2002) (Pubitemid 35345151)
-
(2002)
Cell
, vol.111
, Issue.3
, pp. 305-317
-
-
Takeda, S.1
Elefteriou, F.2
Levasseur, R.3
Liu, X.4
Zhao, L.5
Parker, K.L.6
Armstrong, D.7
Ducy, P.8
Karsenty, G.9
-
10
-
-
0033782028
-
Leptin in the regulation of immunity, inflammation, and hematopoiesis
-
G. Fantuzzi & R. Faggioni: Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukocyte Biol, 68, 437-446 (2000)
-
(2000)
J Leukocyte Biol
, vol.68
, pp. 437-446
-
-
Fantuzzi, G.1
Faggioni, R.2
-
11
-
-
0032508682
-
Biological action of leptin as an angiogenic factor
-
DOI 10.1126/science.281.5383.1683
-
M. R. Sierra-Honigmann, A. K. Nath, C. Murakami, G. Garcia-Cardena, A. Papapetropoulos, W. C. Sessa, L. A. Madge, J. S. Schechner, M. B. Schwabb, P. J. Polverini & J. R. Flores-Riveros: Biological action of leptin as an angiogenic factor. Science, 281, 1683-1686 (1998) (Pubitemid 28435586)
-
(1998)
Science
, vol.281
, Issue.5383
, pp. 1683-1686
-
-
Sierra-Honigmann, M.R.1
Nath, A.K.2
Murakami, C.3
Garcia-Cardena, G.4
Papapetropoulos, A.5
Sessa, W.C.6
Madge, L.A.7
Schechner, J.S.8
Schwabb, M.B.9
Polverini, P.J.10
Flores-Riveros, J.R.11
-
12
-
-
0032572722
-
Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression
-
DOI 10.1038/29795
-
G. M. Lord, G. Matarese, L. K. Howard, R. J. Baker, S. R. Bloom & R. I. Lechler: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature, 394, 897-901 (1998) (Pubitemid 28410912)
-
(1998)
Nature
, vol.394
, Issue.6696
, pp. 897-901
-
-
Lord, G.M.1
Matarese, G.2
Howard, J.K.3
Baker, R.J.4
Bloom, S.R.5
Lechler, R.I.6
-
14
-
-
34948825485
-
Disruption of leptin receptor expression in the pancreas directly affects β cell growth and function in mice
-
DOI 10.1172/JCI30910
-
T. Morioka, E. Asilmaz, J. Hu, J. F. Dishinger, A. J. Kurpad, C. F. Elias, H. Li, J. K. Elmquist, R. T. Kennedy & R. N. Kulkarni: Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest, 117, 2860-2868 (2007) (Pubitemid 47529616)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.10
, pp. 2860-2868
-
-
Morioka, T.1
Asilmaz, E.2
Hu, J.3
Dishinger, J.F.4
Kurpad, A.J.5
Elias, C.F.6
Li, H.7
Elmquist, J.K.8
Kennedy, R.T.9
Kulkarni, R.N.10
-
15
-
-
32644436318
-
Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo
-
DOI 10.1210/en.2005-0731
-
W. Huang, N. Dedousis, A. Bandi, G. D. Lopaschuk & R. M. O'Doherty: Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo. Endocrinology, 147, 1480-1487 (2006) (Pubitemid 43244383)
-
(2006)
Endocrinology
, vol.147
, Issue.3
, pp. 1480-1487
-
-
Huang, W.1
Dedousis, N.2
Bandi, A.3
Lopaschuk, G.D.4
O'Doherty, R.M.5
-
16
-
-
17844373625
-
Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis
-
DOI 10.1016/j.cmet.2005.02.001, PII S1550413105000549
-
S. H. Bates, R. N. Kulkarni, M. Seifert & M. G. Myers: Roles for leptin receptor/STAT3-dependent and - independent signals in the regulation of glucose homeostasis. Cell Metab, 1, 169-178 (2005) (Pubitemid 43960601)
-
(2005)
Cell Metabolism
, vol.1
, Issue.3
, pp. 169-178
-
-
Bates, S.H.1
Kulkarni, R.N.2
Seifert, M.3
Myers Jr., M.G.4
-
17
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
DOI 10.1016/0092-8674(95)90151-5
-
L. A. Tartaglia, M. Dembski, X. Weng, N. H. Deng, J. Culpepper, R. Devos, G. J. Richards, L. A. Campfield, F. T. Clark, J. Deeds, C. Muir, S. Sanker, A. Moriarty, K. J. Moore, J. S. Smutko, G. G. Mays, E. A. Woolf, C. A. Monroe & R. I. Tepper: Identification and expression cloning of a leptin receptor, OB-R. Cell, 83, 1263-1271 (1995) (Pubitemid 26007816)
-
(1995)
Cell
, vol.83
, Issue.7
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
Deng, N.4
Culpepper, J.5
Devos, R.6
Richards, G.J.7
Campfield, L.A.8
Clark, F.T.9
Deeds, J.10
Muir, C.11
Sanker, S.12
Moriarty, A.13
Moore, K.J.14
Smutko, J.S.15
Mays, G.G.16
Woolf, E.A.17
Monroe, C.A.18
Tepper, R.I.19
-
18
-
-
0031886385
-
Localization of leptin binding domain in the leptin receptor
-
T. M. Fong, R. R. C. Huang, M. R. Tota, C. Mao, T. Smith, J. Varnerin, V. V. Karpitskiy, J. E. Krause & L. H. T. Van der Ploeg: Localization of leptin binding domain in the leptin receptor. Mol Pharmacol, 53, 234-240 (1998) (Pubitemid 28099733)
-
(1998)
Molecular Pharmacology
, vol.53
, Issue.2
, pp. 234-240
-
-
Fong, T.M.1
Huang, R.-R.C.2
Tota, M.R.3
Mao, C.4
Smith, T.5
Varnerin, J.6
Karpitskiy, V.V.7
Krause, J.E.8
Van Der Ploeg, L.H.T.9
-
19
-
-
20744460050
-
Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains
-
DOI 10.1074/jbc.M413308200
-
L. Zabeau, D. Defeau, H. Iserentant, J. Vandekerckhove, F. Peelman & J. Tavernier: Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains. J Biol Chem, 280, 22632-22640 (2005) (Pubitemid 40853167)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.24
, pp. 22632-22640
-
-
Zabeau, L.1
Defeau, D.2
Iserentant, H.3
Vandekerckhove, J.4
Peelman, F.5
Tavernier, J.6
-
20
-
-
0347286631
-
Functional Analysis of Leptin Receptor Activation Using a Janus Kinase/Signal Transducer and Activator of Transcription Complementation Assay
-
DOI 10.1210/me.2003-0078
-
L. Zabeau, D. Defeau, J. Van der Heyden, H. Iserentant, J. Vandekerckhove & J. Tavernier: Functional analysis of leptin receptor activation using a Janus kinase/signal transducer and activator of transcription complementation assay. Mol Endocrinol, 18, 150-161 (2004) (Pubitemid 38073161)
-
(2004)
Molecular Endocrinology
, vol.18
, Issue.1
, pp. 150-161
-
-
Zabeau, L.1
Defeau, D.2
Van Der Heyden, J.3
Iserentant, H.4
Vandekerckhove, J.5
Tavernier, J.6
-
21
-
-
0037862102
-
The ins and outs of leptin receptor activation
-
DOI 10.1016/S0014-5793(03)00440-X
-
L. Zabeau, D. Lavens, F. Peelman, S. Eyckerman, J. Vandekerckhove & J. Tavernier: The ins and outs of leptin receptor activation. FEBS Lett, 546, 45-50 (2003) (Pubitemid 36782280)
-
(2003)
FEBS Letters
, vol.546
, Issue.1
, pp. 45-50
-
-
Zabeau, L.1
Lavens, D.2
Peelman, F.3
Eyckerman, S.4
Vandekerckhove, J.5
Tavernier, J.6
-
22
-
-
0029776030
-
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
-
DOI 10.1073/pnas.93.16.8374
-
H. Baumann, K. K. Morella, D. W. White, M. Dembski, P. S. Bailon, H. K. Kim, C. F. Lai & L. A. Tartaglia: The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA, 93, 8374-8378 (1996) (Pubitemid 26269565)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.16
, pp. 8374-8378
-
-
Baumann, H.1
Morella, K.K.2
White, D.W.3
Dembski, M.4
Bailon, P.S.5
Kim, H.6
Lai, C.-F.7
Tartaglia, L.A.8
-
23
-
-
13344259300
-
Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
-
DOI 10.1016/S0092-8674(00)81294-5
-
H. Chen, O. Charlat, L. A. Tartaglia, E. A. Woolf, X. Weng, S. J. Ellis, N. D. Lakey, J. Culpepper, K. J. Moore, R. E. Breitbart, G. M. Duyk, R. I. Tepper & J. P. Morgenstern: Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell, 84, 491-495 (1996) (Pubitemid 26060722)
-
(1996)
Cell
, vol.84
, Issue.3
, pp. 491-495
-
-
Chen, H.1
Charlat, O.2
Tartaglia, L.A.3
Woolf, E.A.4
Weng, X.5
Ellis, S.J.6
Lakey, N.D.7
Culpepper, J.8
More, K.J.9
Breitbart, R.E.10
Duyk, G.M.11
Tepper, R.I.12
Morgenstern, J.P.13
-
24
-
-
0030028959
-
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
-
S. C. Chua, W. K. Chung, X. S. WuPeng, Y. Y. Zhang, S. M. Liu, L. Tartaglia & R. L. Leibel: Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science, 271, 994-996 (1996) (Pubitemid 26066874)
-
(1996)
Science
, vol.271
, Issue.5251
, pp. 994-996
-
-
Chua Jr., S.C.1
Chung, W.K.2
Wu-Peng, X.S.3
Zhang, Y.4
Liu, S.-M.5
Tartaglia, L.6
Leibel, R.L.7
-
25
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
DOI 10.1038/379632a0
-
G. H. Lee, R. Proenca, J. M. Montez, K. M. Carroll, J. G. Darvishzadeh, J. I. Lee & J. M. Friedman: Abnormal splicing of the leptin receptor in diabetic mice. Nature, 379, 632-635 (1996) (Pubitemid 26053452)
-
(1996)
Nature
, vol.379
, Issue.6566
, pp. 632-635
-
-
Lee, G.-H.1
Proenca, R.2
Montez, J.M.3
Carroll, K.M.4
Darvishzadeh, J.G.5
Lee, J.I.6
Friedman, J.M.7
-
26
-
-
0034776770
-
Selective deletion of leptin receptor in neurons leads to obesity
-
DOI 10.1172/JCI200113914
-
P. Cohen, C. Zhao, X. Cai, J. M. Montez, S. C. Rohani, P. Feinstein, P. Mombaerts & J. M. Friedman: Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest, 108, 1113-21 (2001) (Pubitemid 32995369)
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.8
, pp. 1113-1121
-
-
Cohen, P.1
Zhao, C.2
Cai, X.3
Montez, J.M.4
Rohani, S.C.5
Feinstein, P.6
Mombaerts, P.7
Friedman, J.M.8
-
27
-
-
31044451078
-
Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes
-
DOI 10.1172/JCI24059
-
C. de Luca, T. J. Kowalski, Y. Zhang, J. K. Elmquist, C. Lee, M. W. Kilimann, T. Ludwig, S.-M. Liu & S. C. Chua: Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest, 115, 3484-3493 (2005) (Pubitemid 43121836)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.12
, pp. 3484-3493
-
-
De Luca, C.1
Kowalski, T.J.2
Zhang, Y.3
Elmquist, J.K.4
Lee, C.5
Kilimann, M.W.6
Ludwig, T.7
Liu, S.-M.8
Chua Jr., S.C.9
-
28
-
-
0037733115
-
k) rats
-
DOI 10.1210/en.2002-0115
-
G. J. Morton, K. D. Niswender, C. J. Rhodes, M. G. Myers, J. E. Blevins, D. G. Baskin & M. W. Schwartz: Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology, 144, 2016-2024 (2003) (Pubitemid 36543342)
-
(2003)
Endocrinology
, vol.144
, Issue.5
, pp. 2016-2024
-
-
Morton, G.J.1
Niswender, K.D.2
Rhodes, C.J.3
Myers Jr., M.G.4
Blevins, J.E.5
Baskin, D.G.6
Schwartz, M.W.7
-
29
-
-
0035145908
-
Transgenic complementation of leptin-receptor deficiency
-
T. J. Kowalski, S.-M. Liu, R. L. Leibel & S. C. Chua: Transgenic Complementation of Leptin-Receptor Deficiency. Diabetes, 50, 425-435 (2001)
-
(2001)
Diabetes
, vol.50
, pp. 425-435
-
-
Kowalski, T.J.1
Liu, S.-M.2
Leibel, R.L.3
Chua, S.C.4
-
30
-
-
65549098301
-
The ventral premammillary nucleus links fasting- induced changes in leptin levels and coordinated luteinizing hormone secretion
-
J. Donato, R. J. Silva, L. V. Sita, S. Lee, C. Lee, S. Lacchini, J. C. Bittencourt, C. R. Franci, N. S. Canteras & C. F. Elias: The Ventral Premammillary Nucleus Links Fasting- Induced Changes in Leptin Levels and Coordinated Luteinizing Hormone Secretion. J Neurosci, 29, 5240-5250 (2009)
-
(2009)
J Neurosci
, vol.29
, pp. 5240-5250
-
-
Donato, J.1
Silva, R.J.2
Sita, L.V.3
Lee, S.4
Lee, C.5
Lacchini, S.6
Bittencourt, J.C.7
Franci, C.R.8
Canteras, N.S.9
Elias, C.F.10
-
31
-
-
0031963436
-
Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
-
M. L. Hakansson, H. Brown, N. Ghilardi, R. C. Skoda & B. Meister: Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci, 18, 559-572 (1998) (Pubitemid 28046812)
-
(1998)
Journal of Neuroscience
, vol.18
, Issue.1
, pp. 559-572
-
-
Hakansson, M.-L.1
Brown, H.2
Ghilardi, N.3
Skoda, R.C.4
Meister, B.5
-
32
-
-
77951528099
-
Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala
-
R. L. Leshan, D. M. Opland, G. W. Louis, G. M. Leinninger, C. M. Patterson, C. J. Rhodes, H. Munzberg & M. G. Myers: Ventral Tegmental Area Leptin Receptor Neurons Specifically Project to and Regulate Cocaine- and Amphetamine-Regulated Transcript Neurons of the Extended Central Amygdala. J Neurosci, 30, 5713-5723 (2010)
-
(2010)
J Neurosci
, vol.30
, pp. 5713-5723
-
-
Leshan, R.L.1
Opland, D.M.2
Louis, G.W.3
Leinninger, G.M.4
Patterson, C.M.5
Rhodes, C.J.6
Munzberg, H.7
Myers, M.G.8
-
33
-
-
67849092898
-
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
-
G. M. Leinninger, Y. H. Jo, R. L. Leshan, G. W. Louis, H. Y. Yang, J. G. Barrera, H. Wilson, D. M. Opland, M. A. Faouzi, Y. S. Gong, J. C. Jones, C. J. Rhodes, S. Chua, S. Diano, T. L. Horvath, R. J. Seeley, J. B. Becker, H. Munzberg & M. G. Myers: Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding. Cell Metab, 10, 89-98 (2009)
-
(2009)
Cell Metab
, vol.10
, pp. 89-98
-
-
Leinninger, G.M.1
Jo, Y.H.2
Leshan, R.L.3
Louis, G.W.4
Yang, H.Y.5
Barrera, J.G.6
Wilson, H.7
Opland, D.M.8
Faouzi, M.A.9
Gong, Y.S.10
Jones, J.C.11
Rhodes, C.J.12
Chua, S.13
Diano, S.14
Horvath, T.L.15
Seeley, R.J.16
Becker, J.B.17
Munzberg, H.18
Myers, M.G.19
-
34
-
-
79959550905
-
Leptin receptor neurons in the lateral hypothalamus regulate the mesolimbic dopamine system and energy balance
-
G. M. Leinninger, Y. H. Jo, R. L. Leshan, G. W. Louis, H. Y. Yang, J. G. Barrera, H. Wilson, J. C. Jones, C. J. Rhodes, S. Chua, S. Diano, T. L. Horvath, R. J. Seeley, J. B. Becker, H. Munzberg & M. G. Myers: Leptin Receptor Neurons in the Lateral Hypothalamus Regulate the Mesolimbic Dopamine System and Energy Balance. Diabetes, 58, A396-A396 (2009)
-
(2009)
Diabetes
, vol.58
-
-
Leinninger, G.M.1
Jo, Y.H.2
Leshan, R.L.3
Louis, G.W.4
Yang, H.Y.5
Barrera, J.G.6
Wilson, H.7
Jones, J.C.8
Rhodes, C.J.9
Chua, S.10
Diano, S.11
Horvath, T.L.12
Seeley, R.J.13
Becker, J.B.14
Munzberg, H.15
Myers, M.G.16
-
35
-
-
58749086043
-
The geometry of leptin action in the brain: More complicated than a simple ARC
-
M. G. Myers, H. Munzberg, G. M. Leinninger & R. L. Leshan: The Geometry of Leptin Action in the Brain: More Complicated Than a Simple ARC. Cell Metab, 9, 117-123 (2009)
-
(2009)
Cell Metab
, vol.9
, pp. 117-123
-
-
Myers, M.G.1
Munzberg, H.2
Leinninger, G.M.3
Leshan, R.L.4
-
36
-
-
66149141484
-
Leptin targets in the mouse brain
-
M. M. Scott, J. L. Lachey, S. M. Sternson, C. E. Lee, C. F. Elias, J. M. Friedman & J. K. Elmquist: Leptin Targets in the Mouse Brain. J Comp Neurol, 514, 518-532 (2009)
-
(2009)
J Comp Neurol
, vol.514
, pp. 518-532
-
-
Scott, M.M.1
Lachey, J.L.2
Sternson, S.M.3
Lee, C.E.4
Elias, C.F.5
Friedman, J.M.6
Elmquist, J.K.7
-
37
-
-
0029739970
-
Identification of targets of leptin action in rat hypothalamus
-
M. W. Schwartz, R. J. Seeley, L. A. Campfield, P. Burn & D. G. Baskin: Identification of targets of leptin action in rat hypothalamus. J Clin Invest, 98, 1101-1106 (1996) (Pubitemid 26299921)
-
(1996)
Journal of Clinical Investigation
, vol.98
, Issue.5
, pp. 1101-1106
-
-
Schwartz, M.W.1
Seeley, R.J.2
Campfield, L.A.3
Burn, P.4
Baskin, D.G.5
-
38
-
-
0032130554
-
Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
-
T. M. Hahn, J. F. Breininger, D. G. Baskin & M. W. Schwartz: Coexpression of Agrp and NPY in fastingactivated hypothalamic neurons. Nat Neurosci, 1, 271-272 (1998) (Pubitemid 128652670)
-
(1998)
Nature Neuroscience
, vol.1
, Issue.4
, pp. 271-272
-
-
Hahn, T.M.1
Breininger, J.F.2
Baskin, D.G.3
Schwartz, M.W.4
-
39
-
-
0033818103
-
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
-
A. S. Chen, D. J. Marsh, M. E. Trumbauer, E. G. Frazier, X. M. Guan, H. Yu, C. I. Rosenblum, A. Vongs, Y. Feng, L. H. Cao, J. M. Metzger, A. M. Strack, R. E. Camacho, T. N. Mellin, C. N. Nunes, W. Min, J. Fisher, S. Gopal-Truter, D. E. MacIntyre, H. Y. Chen & L. H. T. Van der Ploeg: Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet, 26, 97-102 (2000)
-
(2000)
Nat Genet
, vol.26
, pp. 97-102
-
-
Chen, A.S.1
Marsh, D.J.2
Trumbauer, M.E.3
Frazier, E.G.4
Guan, X.M.5
Yu, H.6
Rosenblum, C.I.7
Vongs, A.8
Feng, Y.9
Cao, L.H.10
Metzger, J.M.11
Strack, A.M.12
Camacho, R.E.13
Mellin, T.N.14
Nunes, C.N.15
Min, W.16
Fisher, J.17
Gopal-Truter, S.18
MacIntyre, D.E.19
Chen, H.Y.20
Van Der Ploeg, L.H.T.21
more..
-
40
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
D. Huszar, C. A. Lynch, V. FairchildHuntress, J. H. Dunmore, Q. Fang, L. R. Berkemeier, W. Gu, R. A. Kesterson, B. A. Boston, R. D. Cone, F. J. Smith, L. A. Campfield, P. Burn & F. Lee: Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell, 88, 131-141 (1997) (Pubitemid 27180337)
-
(1997)
Cell
, vol.88
, Issue.1
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
Gu, W.7
Kesterson, R.A.8
Boston, B.A.9
Cone, R.D.10
Smith, F.J.11
Campfield, L.A.12
Burn, P.13
Frank, L.14
-
41
-
-
0030729210
-
Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
-
DOI 10.1210/en.138.11.5063
-
J. E. Thornton, C. C. Cheung, D. K. Clifton & R. A. Steiner: Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice. Endocrinology, 138, 5063-5066 (1997) (Pubitemid 27460950)
-
(1997)
Endocrinology
, vol.138
, Issue.11
, pp. 5063-5066
-
-
Thornton, J.E.1
Cheung, C.C.2
Clifton, D.K.3
Steiner, R.A.4
-
42
-
-
0030928715
-
Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
-
DOI 10.1210/en.138.10.4489
-
C. C. Cheung, D. K. Clifton & R. A. Steiner: Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology, 138, 4489-4492 (1997) (Pubitemid 27408500)
-
(1997)
Endocrinology
, vol.138
, Issue.10
, pp. 4489-4492
-
-
Cheung, C.C.1
Clifton, D.K.2
Steiner, R.A.3
-
43
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
DOI 10.1038/35078085
-
M. A. Cowley, J. L. Smart, M. Rubinstein, M. G. Cordan, S. Diano, T. L. Horvath, R. D. Cone & M. J. Low: Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature, 411, 480-484 (2001) (Pubitemid 32494394)
-
(2001)
Nature
, vol.411
, Issue.6836
, pp. 480-484
-
-
Cowley, M.A.1
Smart, J.L.2
Rubinstein, M.3
Cerdan, M.G.4
Diano, S.5
Horvath, T.L.6
Cone, R.D.7
Low, M.J.8
-
44
-
-
66049133685
-
Leptin-dependent control of glucose balance and locomotor activity by POMC neurons
-
L. Huo, K. Gamber, S. Greeley, J. Silva, N. Huntoon, X.-H. Leng & C. Bjørbæk: Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons. Cell Metab, 9, 537-547 (2009)
-
(2009)
Cell Metab
, vol.9
, pp. 537-547
-
-
Huo, L.1
Gamber, K.2
Greeley, S.3
Silva, J.4
Huntoon, N.5
Leng, X.-H.6
Bjørbæk, C.7
-
45
-
-
33847319765
-
Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons
-
P. J. Enriori, A. E. Evans, P. Sinnayah, E. E. Jobst, L. Tonelli-Lemos, S. K. Billes, M. M. Glavas, B. E. Grayson, M. Perello, E. A. Nillni, K. L. Grove & M. A. Cowley: Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab, 5, 181-194 (2007)
-
(2007)
Cell Metab
, vol.5
, pp. 181-194
-
-
Enriori, P.J.1
Evans, A.E.2
Sinnayah, P.3
Jobst, E.E.4
Tonelli-Lemos, L.5
Billes, S.K.6
Glavas, M.M.7
Grayson, B.E.8
Perello, M.9
Nillni, E.A.10
Grove, K.L.11
Cowley, M.A.12
-
46
-
-
0030764741
-
Antagonism of Central Melanocortin receptors in vitro and in vivo by agouti-related protein
-
DOI 10.1126/science.278.5335.135
-
M. M. Ollmann, B. D. Wilson, Y. K. Yang, J. A. Kerns, Y. R. Chen, I. Gantz & G. S. Barsh: Antagonism of central melanocortin receptors in vitro and in vivo by Agoutirelated protein. Science, 278, 135-138 (1997) (Pubitemid 27446294)
-
(1997)
Science
, vol.278
, Issue.5335
, pp. 135-138
-
-
Ollmann, M.M.1
Wilson, B.D.2
Yang, Y.-K.3
Kerns, J.A.4
Chen, Y.5
Gantz, I.6
Barsh, G.S.7
-
47
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
DOI 10.1016/j.neuron.2004.06.004, PII S089662730400354X
-
N. Balthasar, R. Coppari, J. McMinn, S. M. Liu, C. E. Lee, V. Tang, C. D. Kenny, R. A. McGovern, S. C. Chua, J. K. Elmquist & B. B. Lowell: Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron, 42, 983-991 (2004) (Pubitemid 38798236)
-
(2004)
Neuron
, vol.42
, Issue.6
, pp. 983-991
-
-
Balthasar, N.1
Coppari, R.2
McMinn, J.3
Liu, S.M.4
Lee, C.E.5
Tang, V.6
Kenny, C.D.7
McGovern, R.A.8
Chua Jr., S.C.9
Elmquist, J.K.10
Lowell, B.B.11
-
48
-
-
41549111593
-
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
-
DOI 10.1210/en.2007-1132
-
E. van de Wall, R. Leshan, A. W. Xu, N. Balthasar, R. Coppari, S. M. Liu, Y. H. Jo, R. G. MacKenzie, D. B. Allison, N. J. Dun, J. Elmquist, B. B. Lowell, G. S. Barsh, C. de Luca, M. G. Myers, G. J. Schwartz & S. C. Chua: Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology, 149, 1773-1785 (2008) (Pubitemid 351468315)
-
(2008)
Endocrinology
, vol.149
, Issue.4
, pp. 1773-1785
-
-
Van De Wall, E.1
Leshan, R.2
Xu, A.W.3
Balthasar, N.4
Coppari, R.5
Shun, M.L.6
Young, H.J.7
MacKenzie, R.G.8
Allison, D.B.9
Dun, N.J.10
Elmquist, J.11
Lowell, B.B.12
Barsh, G.S.13
De Luca, C.14
Myers Jr., M.G.15
Schwartz, G.J.16
Chua Jr., S.C.17
-
49
-
-
27744457512
-
Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting
-
DOI 10.1038/nn1550, PII N1550
-
S. M. Sternson, G. M. G. Shepherd & J. M. Friedman: Topographic mapping of VMH [rarr] arcuate nucleus microcircuits and their reorganization by fasting. Nat Neurosci, 8, 1356-1363 (2005) (Pubitemid 41630424)
-
(2005)
Nature Neuroscience
, vol.8
, Issue.10
, pp. 1356-1363
-
-
Sternson, S.M.1
Shepherd, G.M.G.2
Friedman, J.M.3
-
50
-
-
30644473109
-
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
-
DOI 10.1016/j.neuron.2005.12.021, PII S0896627305011347
-
H. Dhillon, J. M. Zigman, C. P. Ye, C. E. Lee, R. A. McGovern, V. S. Tang, C. D. Kenny, L. M. Christiansen, R. D. White, E. A. Edelstein, R. Coppari, N. Balthasar, M. A. Cowley, S. Chua, J. K. Elmquist & B. B. Lowelll: Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron, 49, 191-203 (2006) (Pubitemid 43089637)
-
(2006)
Neuron
, vol.49
, Issue.2
, pp. 191-203
-
-
Dhillon, H.1
Zigman, J.M.2
Ye, C.3
Lee, C.E.4
McGovern, R.A.5
Tang, V.6
Kenny, C.D.7
Christiansen, L.M.8
White, R.D.9
Edelstein, E.A.10
Coppari, R.11
Balthasar, N.12
Cowley, M.A.13
Chua Jr., S.14
Elmquist, J.K.15
Lowell, B.B.16
-
51
-
-
1842529267
-
Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin
-
DOI 10.1126/science.1089459
-
S. Pinto, A. G. Roseberry, H. Liu, S. Diano, M. Shanabrough, X. Cai, J. M. Friedman & T. L. Horvath: Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin. Science, 304, 110-115 (2004) (Pubitemid 38451468)
-
(2004)
Science
, vol.304
, Issue.5667
, pp. 110-115
-
-
Pinto, S.1
Roseberry, A.G.2
Liu, H.3
Diano, S.4
Shanabrough, M.5
Cai, X.6
Friedman, J.M.7
Horvath, T.L.8
-
52
-
-
38749135486
-
Hypothalamic Neural Projections Are Permanently Disrupted in Diet-Induced Obese Rats
-
DOI 10.1016/j.cmet.2007.12.001, PII S1550413107003749
-
S. G. Bouret, J. N. Gorski, C. M. Patterson, S. Chen, B. E. Levin & R. B. Simerly: Hypothalamic Neural Projections Are Permanently Disrupted in Diet-Induced Obese Rats. Cell Metab, 7, 179-185 (2008) (Pubitemid 351181005)
-
(2008)
Cell Metabolism
, vol.7
, Issue.2
, pp. 179-185
-
-
Bouret, S.G.1
Gorski, J.N.2
Patterson, C.M.3
Chen, S.4
Levin, B.E.5
Simerly, R.B.6
-
53
-
-
0030965884
-
Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
-
V. Emilsson, Y. L. Liu, M. A. Cawthorne, N. M. Morton & M. Davenport: Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes, 46, 313-316 (1997) (Pubitemid 27272267)
-
(1997)
Diabetes
, vol.46
, Issue.2
, pp. 313-316
-
-
Emilsson, V.1
Liu, Y.-L.2
Cawthorne, M.A.3
Morton, N.M.4
Davenport, M.5
-
54
-
-
2642653233
-
Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice
-
R. N. Kulkarni, Z. L. Wang, R. M. Wang, J. D. Hurley, D. M. Smith, M. A. Ghatei, D. J. Withers, J. V. Gardiner, C. J. Bailey & S. R. Bloom: Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest, 100, 2729-2736 (1997) (Pubitemid 28007540)
-
(1997)
Journal of Clinical Investigation
, vol.100
, Issue.11
, pp. 2729-2736
-
-
Kulkarni, R.N.1
Wang, Z.-L.2
Wang, R.-M.3
Hurley, J.D.4
Smith, D.M.5
Ghatei, M.A.6
Withers, D.J.7
Gardiner, J.V.8
Bailey, C.J.9
Bloom, S.R.10
-
55
-
-
0033580938
-
Novel form of lipolysis induced by leptin
-
M. Y. Wang, Y. Lee & R. H. Unger: Novel form of lipolysis induced by leptin. J Biol Chem, 274, 17541-17544 (1999)
-
(1999)
J Biol Chem
, vol.274
, pp. 17541-17544
-
-
Wang, M.Y.1
Lee, Y.2
Unger, R.H.3
-
56
-
-
70149108302
-
Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway
-
L. Jiang, Q. Wang, Y. Yu, F. Zhao, P. Huang, R. Zeng, R. Z. Qi, W. Li & Y. Liu: Leptin Contributes to the Adaptive Responses of Mice to High-Fat Diet Intake through Suppressing the Lipogenic Pathway. Plos One, 4, e6884 (2009)
-
(2009)
Plos One
, vol.4
-
-
Jiang, L.1
Wang, Q.2
Yu, Y.3
Zhao, F.4
Huang, P.5
Zeng, R.6
Qi, R.Z.7
Li, W.8
Liu, Y.9
-
57
-
-
29144510014
-
Fat storage in adipocytes requires inactivation of leptin's paracrine activity: Implications for treatment of human obesity
-
DOI 10.1073/pnas.0509001102
-
M. Y. Wang, L. Orci, M. Ravazzola & R. H. Unger: Fat storage in adipocytes requires inactivation of leptin's paracrine activity: Implications for treatment of human obesity. Proc Natl Acad Sci USA, 102, 18011-18016 (2005) (Pubitemid 41798493)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.50
, pp. 18011-18016
-
-
Wang, M.-Y.1
Orci, L.2
Ravazzola, M.3
Unger, R.H.4
-
58
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
-
DOI 10.1038/415339a
-
Y. Minokoshi, Y. B. Kim, O. D. Peroni, L. G. D. Fryer, C. Muller, D. Carling & B. B. Kahn: Leptin stimulates fattyacid oxidation by activating AMP-activated protein kinase. Nature, 415, 339-343 (2002) (Pubitemid 34087557)
-
(2002)
Nature
, vol.415
, Issue.6869
, pp. 339-343
-
-
Minokoshi, Y.1
Kim, Y.-B.2
Peroni, O.D.3
Fryer, L.G.D.4
Muller, C.5
Carling, D.6
Kahn, B.B.7
-
59
-
-
1842405349
-
Leptin directly alters lipid partitioning in skeletal muscle
-
D. M. Muoio, G. L. Dohn, F. T. Fiedorek, E. B. Tapscott & R. A. Coleman: Leptin directly alters lipidpartitioning in skeletal muscle. Diabetes, 46, 1360-1363 (1997) (Pubitemid 27315287)
-
(1997)
Diabetes
, vol.46
, Issue.8
, pp. 1360-1363
-
-
Muoio, D.M.1
Lynis Dohn, G.2
Fiedorek Jr., F.T.3
Tapscott, E.B.4
Coleman, R.A.5
-
60
-
-
0035937174
-
Liporegulation in diet-induced obesity - The antisteatotic role of hyperleptinemia
-
Y. Lee, M. Y. Wang, T. Kakuma, Z. W. Wang, E. Babcock, K. McCorkle, M. Higa, Y. T. Zhou & R. H. Unger: Liporegulation in diet-induced obesity - The antisteatotic role of hyperleptinemia. J Biol Chem, 276, 5629-5635 (2001)
-
(2001)
J Biol Chem
, vol.276
, pp. 5629-5635
-
-
Lee, Y.1
Wang, M.Y.2
Kakuma, T.3
Wang, Z.W.4
Babcock, E.5
McCorkle, K.6
Higa, M.7
Zhou, Y.T.8
Unger, R.H.9
-
61
-
-
2542444292
-
Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity
-
DOI 10.1074/jbc.M401546200
-
W. Huang, N. Dedousis, B. A. Bhatt & R. M. O'Doherty: Impaired activation of phosphatidylinositol 3- kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. J Biol Chem, 279, 21695-21700 (2004) (Pubitemid 38679354)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.21
, pp. 21695-21700
-
-
Huang, W.1
Dedousis, N.2
Bhatt, B.A.3
O'Doherty, R.M.4
-
62
-
-
34547126211
-
Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities
-
DOI 10.1210/en.2007-0261
-
K. Y. Guo, J. E. McMinn, T. Ludwig, Y. H. Yu, G. Q. Yang, L. Chen, D. Loh, C. Li, S. Chua & Y. Y. Zhang: Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities. Endocrinology, 148, 3987-3997 (2007) (Pubitemid 47105835)
-
(2007)
Endocrinology
, vol.148
, Issue.8
, pp. 3987-3997
-
-
Guo, K.1
McMinn, J.E.2
Ludwig, T.3
Yu, Y.-H.4
Yang, G.5
Chen, L.6
Loh, D.7
Li, C.8
Chua Jr., S.9
Zhang, Y.10
-
63
-
-
73649112416
-
Leptin: A critical regulator of CD4+ T-cell polarization in vitro and in vivo
-
A. Batra, B. Okur, R. Glauben, U. Erben, J. Ihbe, T. Stroh, I. Fedke, H.-D. Chang, M. Zeitz & B. Siegmund: Leptin: A Critical Regulator of CD4+ T-cell Polarization in Vitro and in Vivo. Endocrinology, 151, 56-62 (2010)
-
(2010)
Endocrinology
, vol.151
, pp. 56-62
-
-
Batra, A.1
Okur, B.2
Glauben, R.3
Erben, U.4
Ihbe, J.5
Stroh, T.6
Fedke, I.7
Chang, H.-D.8
Zeitz, M.9
Siegmund, B.10
-
64
-
-
0034628016
-
Human leptin enhances activation and proliferation of human circulating T lymphocytes
-
DOI 10.1006/cimm.1999.1594
-
C. Martín-Romero, J. Santos-Alvarez, R. Goberna & V. Sánchez-Margalet: Human Leptin Enhances Activation and Proliferation of Human Circulating T Lymphocytes. Cell Immunol, 199, 15-24 (2000) (Pubitemid 30118591)
-
(2000)
Cellular Immunology
, vol.199
, Issue.1
, pp. 15-24
-
-
Martin-Romero, C.1
Santos-Alvarez, J.2
Goberna, R.3
Sanchez-Margalet, V.4
-
65
-
-
0038723695
-
Role of leptin as an immunomodulator of blood mononuclear cells: Mechanisms of action
-
DOI 10.1046/j.1365-2249.2003.02190.x
-
V. Sanchez-Margalet, C. MartÍN-Romero, J. Santos- Alvarez, R. Goberna, S. Najib & C. Gonzalez-Yanes: Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin Exp Immunol, 133, 11-19 (2003) (Pubitemid 36791936)
-
(2003)
Clinical and Experimental Immunology
, vol.133
, Issue.1
, pp. 11-19
-
-
Sanchez-Margalet, V.1
Martin-Romero, C.2
Santos-Alvarez, J.3
Goberna, R.4
Najib, S.5
Gonzalez-Yanes, C.6
-
66
-
-
33847312289
-
A Key Role of Leptin in the Control of Regulatory T Cell Proliferation
-
DOI 10.1016/j.immuni.2007.01.011, PII S1074761307001410
-
V. de Rosa, C. Procaccini, G. Calì, G. Pirozzi, S. Fontana, S. Zappacosta, A. La Cava & G. Matarese: A Key Role of Leptin in the Control of Regulatory T Cell Proliferation. Immunity, 26, 241-255 (2007) (Pubitemid 46329441)
-
(2007)
Immunity
, vol.26
, Issue.2
, pp. 241-255
-
-
De Rosa, V.1
Procaccini, C.2
Cali, G.3
Pirozzi, G.4
Fontana, S.5
Zappacosta, S.6
La Cava, A.7
Matarese, G.8
-
67
-
-
13444267906
-
Leptin, immune responses and autoimmune disease. Perspectives on the use of leptin antagonists
-
DOI 10.2174/1381612053382070
-
F. Peelman, H. Iserentant, S. Eyckerman, L. Zabeau & J. Tavernier: Leptin, immune responses and autoimmune disease. Perspectives on the use of leptin antagonists. Curr Pharm Des, 11, 539-548 (2005) (Pubitemid 40207761)
-
(2005)
Current Pharmaceutical Design
, vol.11
, Issue.4
, pp. 539-548
-
-
Peelman, F.1
Iserentant, H.2
Eyckerman, S.3
Zabeau, L.4
Tavernier, J.5
-
68
-
-
0036533493
-
Balancing susceptibility to infection and autoimmunity: A role for leptin?
-
DOI 10.1016/S1471-4906(02)02188-9, PII S1471490602021889
-
G. Matarese, A. La Cava, V. Sanna, G. M. Lord, R. I. Lechler, S. Fontana & S. Zappacosta: Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol, 23, 182-187 (2002) (Pubitemid 34260933)
-
(2002)
Trends in Immunology
, vol.23
, Issue.4
, pp. 182-187
-
-
Matarese, G.1
La Cava, A.2
Sanna, V.3
Lord, G.M.4
Lechler, R.I.5
Fontana, S.6
Zappacosta, S.7
-
69
-
-
2442618838
-
The weight of leptin in immunity
-
A. La Cava & G. Matarese: The weight of leptin in immunity. Nat Rev Immunol, 4, 371-379 (2004) (Pubitemid 38649279)
-
(2004)
Nature Reviews Immunology
, vol.4
, Issue.5
, pp. 371-379
-
-
La Cava, A.1
Matarese, G.2
-
70
-
-
0032741972
-
Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
-
J. K. Howard, G. M. Lord, G. Matarese, S. Vendetti, M. A. Ghatei, M. A. Ritter, R. I. Lechler & S. R. Bloom: Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest, 104, 1051-1059 (1999) (Pubitemid 29536315)
-
(1999)
Journal of Clinical Investigation
, vol.104
, Issue.8
, pp. 1051-1059
-
-
Howard, J.K.1
Lord, G.M.2
Matarese, G.3
Vendetti, S.4
Ghatei, M.A.5
Ritter, M.A.6
Lechler, R.I.7
Bloom, S.R.8
-
71
-
-
0037080196
-
Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis
-
N. Busso, A. So, V. Chobaz-Peclat, C. Morard, E. Martinez-Soria, D. Talabot-Ayer & C. Gabay: Leptin Signaling Deficiency Impairs Humoral and Cellular Immune Responses and Attenuates Experimental Arthritis. J Immunol, 168, 875-882 (2002) (Pubitemid 34049591)
-
(2002)
Journal of Immunology
, vol.168
, Issue.2
, pp. 875-882
-
-
Busso, N.1
So, A.2
Chobaz-Peclat, V.3
Morard, C.4
Martinez-Soria, E.5
Talabot-Ayer, D.6
Gabay, C.7
-
72
-
-
0036319605
-
Leptin levels are associated with immune response in malnourished infants
-
DOI 10.1210/jc.87.7.3040
-
A. Palacio, M. Lopez, F. Perez-Bravo, F. Monkeberg & L. Schlesinger: Leptin Levels Are Associated with Immune Response in Malnourished Infants. J Clin Endocrinol Metab, 87, 3040-3046 (2002) (Pubitemid 34816342)
-
(2002)
Journal of Clinical Endocrinology and Metabolism
, vol.87
, Issue.7
, pp. 3040-3046
-
-
Palacio, A.1
Lopez, M.2
Perez-Bravo, F.3
Monkeberg, F.4
Schlesinger, L.5
-
73
-
-
0031436148
-
Divergent signaling capacities of the long and short isoforms of the leptin receptor
-
DOI 10.1074/jbc.272.51.32686
-
C. Bjorbaek, S. Uotani, B. da Silva & J. S. Flier: Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem, 272, 32686-32695 (1997) (Pubitemid 28011961)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.51
, pp. 32686-32695
-
-
Bjorbaek, C.1
Uotani, S.2
Da Silva, B.3
Flier, J.S.4
-
74
-
-
0031550523
-
A short form of leptin receptor performs signal transduction
-
DOI 10.1006/bbrc.1996.6030
-
T. Murakami, T. Yamashita, M. Iida, M. Kuwajima & K. Shima: A short form of leptin receptor performs signal transduction. Biochem. Biophys. Res. Commun, 231, 26-29 (1997) (Pubitemid 27212103)
-
(1997)
Biochemical and Biophysical Research Communications
, vol.231
, Issue.1
, pp. 26-29
-
-
Murakami, T.1
Yamashita, T.2
Iida, M.3
Kuwajima, M.4
Shima, K.5
-
75
-
-
0036828842
-
Regulation of Jak kinases by intracellular leptin receptor sequences
-
DOI 10.1074/jbc.M205148200
-
C. Kloek, A. K. Haq, S. L. Dunn, H. J. Lavery, A. S. Banks & M. G. Myers: Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem, 277, 41547-41555 (2002) (Pubitemid 35257458)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.44
, pp. 41547-41555
-
-
Kloek, C.1
Haq, A.K.2
Dunn, S.L.3
Lavery, H.J.4
Banks, A.S.5
Myers Jr., M.G.6
-
76
-
-
0036219070
-
Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers
-
DOI 10.1210/me.16.4.859
-
G. Bahrenberg, I. Behrmann, A. Barthel, P. Hekerman, P. C. Heinrich, H. G. Joost & W. Becker: Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. Mol Endocrinol, 16, 859-872 (2002) (Pubitemid 34297753)
-
(2002)
Molecular Endocrinology
, vol.16
, Issue.4
, pp. 859-872
-
-
Bahrenberg, G.1
Behrmann, I.2
Barthel, A.3
Hekerman, P.4
Heinrich, P.C.5
Joost, H.-G.6
Becker, W.7
-
77
-
-
0036168190
-
Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity
-
DOI 10.1210/en.143.3.775
-
S. M. Hileman, D. D. Pierroz, H. Masuzaki, C. Bjorbaek, K. El-Haschimi, W. A. Banks & J. S. Flier: Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology, 143, 775-783 (2002) (Pubitemid 34164025)
-
(2002)
Endocrinology
, vol.143
, Issue.3
, pp. 775-783
-
-
Hileman, S.M.1
Pierroz, D.D.2
Masuzaki, H.3
Bjorbk, C.4
El-Haschimi, K.5
Banks, W.A.6
Flier, J.S.7
-
78
-
-
17744388106
-
Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells
-
DOI 10.1210/en.141.6.1955
-
S. M. Hileman, J. Tornoe, J. S. Flier & C. Bjorbaek: Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells. Endocrinology, 141, 1955-1961 (2000) (Pubitemid 32274343)
-
(2000)
Endocrinology
, vol.141
, Issue.6
, pp. 1955-1961
-
-
Hileman, S.M.1
Tornoe, J.2
Flier, J.S.3
Bjorbaek, C.4
-
79
-
-
0033008075
-
Functional properties of leptin receptor isoforms: Internalization and degradation of leptin and ligand-induced receptor downregulation
-
DOI 10.2337/diabetes.48.2.279
-
S. Uotani, C. Bjorbaek, J. Tornoe & J. S. Flier: Functional properties of leptin receptor isoforms internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes, 48, 279-286 (1999) (Pubitemid 29061099)
-
(1999)
Diabetes
, vol.48
, Issue.2
, pp. 279-286
-
-
Uotani, S.1
Bjorbaek, C.2
Tornoe, J.3
Flier, J.S.4
-
80
-
-
0034801977
-
Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors
-
DOI 10.1210/en.142.10.4389
-
M. Maamra, M. Bidlingmaier, M. C. Postel-Vinay, Z. Wu, C. J. Strasburger & R. J. Ross: Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology, 142, 4389-93 (2001) (Pubitemid 32907068)
-
(2001)
Endocrinology
, vol.142
, Issue.10
, pp. 4389-4393
-
-
Maamra, M.1
Bidlingmaier, M.2
Postel-Vinay, M.-C.3
Wu, Z.4
Strasburger, C.J.5
Ross, R.J.M.6
-
81
-
-
0037195916
-
Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo
-
DOI 10.1074/jbc.M205825200
-
H. F. Ge, L. Huang, T. Pourbahrami & C. Li: Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem, 277, 45898-45903 (2002) (Pubitemid 35417571)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.48
, pp. 45898-45903
-
-
Ge, H.1
Huang, L.2
Pourbahrami, T.3
Li, C.4
-
82
-
-
79952811396
-
RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding
-
in press
-
J. Wauman, L. de Ceuninck, N. Vanderroost, S. Lievens & J. Tavernier: RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding. J Cell Sci, in press, (2010)
-
(2010)
J Cell Sci
-
-
Wauman, J.1
De Ceuninck, L.2
Vanderroost, N.3
Lievens, S.4
Tavernier, J.5
-
83
-
-
0034005470
-
Free and protein bound leptin are distinct and independently controlled factors in energy regulation
-
G. Brabant, R. Horn, A. von zur Muhlen, B. Mayr, U. Wurster, F. Heidenreich, D. Schnabel, A. Gruters-Kieslich, T. Zimmermann-Belsing & U. Feldt-Rasmussen: Free and protein bound leptin are distinct and independently controlled factors in energy regulation. Diabetologia, 43, 438-42 (2000) (Pubitemid 30237951)
-
(2000)
Diabetologia
, vol.43
, Issue.4
, pp. 438-442
-
-
Brabant, G.1
Horn, R.2
Von Zur Muhlen, A.3
Mayr, B.4
Wurster, U.5
Heidenreich, F.6
Schnabel, D.7
Gruters-Kieslich, A.8
Zimmermann-Belsing, T.9
Feldt-Rasmussen, U.10
-
84
-
-
34548175209
-
High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice
-
DOI 10.1074/jbc.M704053200
-
S. E. Cohen, E. Kokkotou, S. B. Biddinger, T. Kondo, R. Gebhardt, J. Kratzsch, C. S. Mantzoros & C. R. Kahn: High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem, 282, 23672-8 (2007) (Pubitemid 47311938)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.32
, pp. 23672-23678
-
-
Cohen, S.E.1
Kokkotou, E.2
Biddinger, S.B.3
Kondo, T.4
Gebhardt, R.5
Kratzsch, J.6
Mantzoros, C.S.7
Kahn, C.R.8
-
85
-
-
77955458427
-
Reduced body weight and increased energy expenditure in transgenic mice over- expressing soluble leptin receptor
-
P.-H. Lou, G. Yang, L. Huang, Y. Cui, T. Pourbahrami, G. K. Radda, C. Li & W. Han: Reduced Body Weight and Increased Energy Expenditure in Transgenic Mice Over- Expressing Soluble Leptin Receptor. Plos One, 5, e11669 (2010)
-
(2010)
Plos One
, vol.5
-
-
Lou, P.-H.1
Yang, G.2
Huang, L.3
Cui, Y.4
Pourbahrami, T.5
Radda, G.K.6
Li, C.7
Han, W.8
-
86
-
-
2542450776
-
Modulation of direct leptin signaling by soluble leptin receptor
-
DOI 10.1210/me.2004-0027
-
G. Q. Yang, H. F. Ge, A. Boucher, X. X. Yu & C. Li: Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol, 18, 1354-1362 (2004) (Pubitemid 38692175)
-
(2004)
Molecular Endocrinology
, vol.18
, Issue.6
, pp. 1354-1362
-
-
Yang, G.1
Ge, H.2
Boucher, A.3
Yu, X.4
Li, C.5
-
87
-
-
37349060346
-
Soluble receptor inhibits leptin transport
-
DOI 10.1002/jcp.21195
-
H. Tu, A. J. Kastin, H. Hsuchou & W. Pan: Soluble receptor inhibits leptin transport. J Cell Physiol, 214, 301-305 (2008) (Pubitemid 350308985)
-
(2008)
Journal of Cellular Physiology
, vol.214
, Issue.2
, pp. 301-305
-
-
Tu, H.1
Kastin, A.J.2
Hsuchou, H.3
Pan, W.4
-
88
-
-
69549088269
-
The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo
-
J. J. Zhang & P. J. Scarpace: The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo. Br J Pharmacol, 158, 475-482 (2009)
-
(2009)
Br J Pharmacol
, vol.158
, pp. 475-482
-
-
Zhang, J.J.1
Scarpace, P.J.2
-
89
-
-
0030956390
-
The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
-
DOI 10.1210/me.11.4.393
-
N. Ghilardi & R. C. Skoda: The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol, 11, 393-399 (1997) (Pubitemid 27147006)
-
(1997)
Molecular Endocrinology
, vol.11
, Issue.4
, pp. 393-399
-
-
Ghilardi, N.1
Skoda, R.C.2
-
90
-
-
0030793449
-
Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding
-
DOI 10.1074/jbc.272.29.18304
-
R. Devos, Y. Guisez, J. VanderHeyden, D. W. White, M. Kalai, M. Fountoulakis & G. Plaetinck: Ligandindependent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. J Biol Chem, 272, 18304-18310 (1997) (Pubitemid 27306421)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.29
, pp. 18304-18310
-
-
Devos, R.1
Guisez, Y.2
Van Der Heyden, J.3
White, D.W.4
Kalai, M.5
Fountoulakis, M.6
Plaetinck, G.7
-
91
-
-
0033135272
-
Evidence for ligand-independent homo-oligomerization of leptin receptor (OB-R) isoforms: A proposed mechanism permitting productive long-form signaling in the presence of excess short-form expression
-
DOI 10.1002/(SICI)1097-4644(19990501) 73:2<278::AID-JCB13>3.0.CO;2- W
-
D. W. White & L. A. Tartaglia: Evidence for ligandindependent homo-oligomerization of leptin receptor (OBR) isoforms: A proposed mechanism permitting productive long-form signaling in the presence of excess short-form expression. J Cell Biochem, 73, 278-288 (1999) (Pubitemid 29160194)
-
(1999)
Journal of Cellular Biochemistry
, vol.73
, Issue.2
, pp. 278-288
-
-
White, D.W.1
Tartaglia, L.A.2
-
92
-
-
33646493330
-
Techniques: New pharmacological perspectives for the leptin receptor
-
F. Peelman, C. Couturier, J. Dam, L. Zabeau, J. Tavernier & R. Jockers: Techniques: New pharmacological perspectives for the leptin receptor. Trends Pharmacol Sci, 27, 218-225 (2006)
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 218-225
-
-
Peelman, F.1
Couturier, C.2
Dam, J.3
Zabeau, L.4
Tavernier, J.5
Jockers, R.6
-
93
-
-
0038374250
-
Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers
-
DOI 10.1074/jbc.M302002200
-
C. Couturier & R. Jockers: Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers. J Biol Chem, 278, 26604-26611 (2003) (Pubitemid 36876805)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.29
, pp. 26604-26611
-
-
Couturier, C.1
Jockers, R.2
-
94
-
-
77952956961
-
Evidence for leptin receptor isoforms heteromerization at the cell surface
-
J. Bacart, A. Leloire, A. Levoye, P. Froguel, R. Jockers & C. Couturier: Evidence for leptin receptor isoforms heteromerization at the cell surface. FEBS Lett, 584, 2213-2217 (2010)
-
(2010)
FEBS Lett
, vol.584
, pp. 2213-2217
-
-
Bacart, J.1
Leloire, A.2
Levoye, A.3
Froguel, P.4
Jockers, R.5
Couturier, C.6
-
95
-
-
33744959239
-
Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin leptin receptor complex
-
DOI 10.1074/jbc.M512622200
-
F. Peelman, H. Iserentant, A. S. de Smet, J. Vandekerckhove, L. Zabeau & J. Tavernier: Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin:leptin receptor complex. J Biol Chem, 281, 15496-15504 (2006) (Pubitemid 43855142)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.22
, pp. 15496-15504
-
-
Peelman, F.1
Iserentant, H.2
De Smet, A.-S.3
Vandekerckhove, J.4
Zabeau, L.5
Tavernier, J.6
-
96
-
-
7644244103
-
Determination of the transphosphorylation sites of Jak2 kinase
-
DOI 10.1016/j.bbrc.2004.10.071, PII S0006291X0402368X
-
T. Matsuda, J. Feng, B. A. Witthuhn, Y. Sekine & J. N. Ihle: Determination of the transphosphorylation sites of Jak2 kinase. Biochem. Biophys. Res. Commun, 325, 586-594 (2004) (Pubitemid 39458035)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.325
, Issue.2
, pp. 586-594
-
-
Matsuda, T.1
Feng, J.2
Witthuhn, B.A.3
Sekine, Y.4
Ihle, J.N.5
-
97
-
-
0030953469
-
1007 in the kinase activation loop
-
J. Feng, B. A. Witthuhn, T. Matsuda, F. Kohlhuber, I. M. Kerr & J. N. Ihle: Activation of Jak2 catalytic activity requires phosphorylation of Y-1007 in the kinase activation loop. Mol Cell Biol, 17, 2497-2501 (1997) (Pubitemid 27175130)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.5
, pp. 2497-2501
-
-
Feng, J.1
Witthuhn, B.A.2
Matsuda, T.3
Kohlhuber, F.4
Kerr, I.M.5
Ihle, J.N.6
-
98
-
-
0034640508
-
Activation of downstream signals by the long form of the leptin receptor
-
DOI 10.1074/jbc.275.19.14563
-
A. S. Banks, S. M. Davis, S. H. Bates & M. G. Myers: Activation of downstream signals by the long form of the leptin receptor. J Biol Chem, 275, 14563-14572 (2000) (Pubitemid 30339746)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.19
, pp. 14563-14572
-
-
Banks, A.S.1
Davis, S.M.2
Bates, S.H.3
Myers Jr., M.G.4
-
99
-
-
0031040793
-
Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization
-
DOI 10.1074/jbc.272.7.4065
-
D. W. White, K. K. Kuropatwinski, R. Devos, H. Baumann & L. A. Tartaglia: Leptin receptor (OB-R) signaling - Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J Biol Chem, 272, 4065-4071 (1997) (Pubitemid 27078469)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.7
, pp. 4065-4071
-
-
White, D.W.1
Kuropatwinski, K.K.2
Devos, R.3
Baumann, H.4
Tartaglia, L.A.5
-
100
-
-
11444250092
-
Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines
-
DOI 10.1111/j.1432-1033.2004.04391.x
-
P. Hekerman, J. Zeidler, S. Bamberg-Lemper, H. Knobelspies, D. Lavens, J. Tavernier, H. G. Joost & W. Becker: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. Febs J, 272, 109-119 (2005) (Pubitemid 40083071)
-
(2005)
FEBS Journal
, vol.272
, Issue.1
, pp. 109-119
-
-
Hekerman, P.1
Zeidler, J.2
Bamberg-Lemper, S.3
Knobelspies, H.4
Lavens, D.5
Tavernier, J.6
Joost, H.-G.7
Becker, W.8
-
101
-
-
57449099877
-
Tyrosinedependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis
-
L. Jiang, J. You, X. X. Yu, L. Gonzalez, Y. Yu, Q. Wang, G. Q. Yang, W. J. Li, C. Li & Y. Liu: Tyrosinedependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc Natl Acad Sci USA, 105, 18619-18624 (2008)
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 18619-18624
-
-
Jiang, L.1
You, J.2
Yu, X.X.3
Gonzalez, L.4
Yu, Y.5
Wang, Q.6
Yang, G.Q.7
Li, W.J.8
Li, C.9
Liu, Y.10
-
102
-
-
77951153669
-
Insufficiency of Janus Kinase 2-autonomous leptin receptor signals for most physiologic leptin actions
-
S. Robertson, R. Ishida-Takahashi, I. Tawara, J. Hu, C. M. Patterson, J. C. Jones, R. N. Kulkarni & M. G. Myers: Insufficiency of Janus Kinase 2-autonomous Leptin Receptor Signals for Most Physiologic Leptin Actions. Diabetes, 59, 782-790 (2010)
-
(2010)
Diabetes
, vol.59
, pp. 782-790
-
-
Robertson, S.1
Ishida-Takahashi, R.2
Tawara, I.3
Hu, J.4
Patterson, C.M.5
Jones, J.C.6
Kulkarni, R.N.7
Myers, M.G.8
-
103
-
-
57649137956
-
Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways
-
L. Jiang, Z. Q. Li & L. Y. Rui: Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways. J Biol Chem, 283, 28066-28073 (2008)
-
(2008)
J Biol Chem
, vol.283
, pp. 28066-28073
-
-
Jiang, L.1
Li, Z.Q.2
Rui, L.Y.3
-
104
-
-
0028931604
-
Choice of stats and other substrates specified by modular tyrosine-based motifs in cytokine receptors
-
N. Stahl, T. J. Farruggella, T. G. Boulton, Z. Zhong, J. E. Darnell & G. D. Yancopoulos: Choice of Stats and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors. Science, 267, 1349-1353 (1995)
-
(1995)
Science
, vol.267
, pp. 1349-1353
-
-
Stahl, N.1
Farruggella, T.J.2
Boulton, T.G.3
Zhong, Z.4
Darnell, J.E.5
Yancopoulos, G.D.6
-
105
-
-
0029739826
-
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
-
DOI 10.1038/ng0996-95
-
C. Vaisse, J. L. Halaas, C. M. Horvath, J. E. Darnell, M. Stoffel & J. M. Friedman: Leptin activation of Stat3 in the hypothalamus of wildtype and ob/ob mice but not db/db mice. Nat Genet, 14, 95-97 (1996) (Pubitemid 26301554)
-
(1996)
Nature Genetics
, vol.14
, Issue.1
, pp. 95-97
-
-
Vaisse, C.1
Halaas, J.L.2
Horvath, C.M.3
Dernell Jr., J.E.4
Stoffel, M.5
Friedman, J.M.6
-
106
-
-
0034657231
-
Identification and expression analysis of leptin-regulated immediate early response and late target genes
-
DOI 10.1042/0264-6021:3480055
-
W. Waelput, A. Verhee, D. Broekaert, S. Eyckerman, J. Vandekerckhove, J. H. Beattie & J. Tavernier: Identification and expression analysis of leptin-regulated immediate early response and late target genes. Biochem J, 348 Pt 1, 55-61 (2000) (Pubitemid 30312130)
-
(2000)
Biochemical Journal
, vol.348
, Issue.1
, pp. 55-61
-
-
Waelput, W.1
Verhee, A.2
Broekaert, D.3
Eyckerman, S.4
Vandekerckhove, J.5
Beattie, J.H.6
Tavernier, J.7
-
107
-
-
0037453270
-
Determination of leptin signaling pathways in human and murine keratinocytes
-
DOI 10.1016/S0006-291X(03)00480-7
-
I. Goren, J. Pfeilschifter & S. Frank: Determination of leptin signaling pathways in human and murine keratinocytes. Biochem. Biophys. Res. Commun, 303, 1080-1085 (2003) (Pubitemid 36390255)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.303
, Issue.4
, pp. 1080-1085
-
-
Goren, I.1
Pfeilschifter, J.2
Frank, S.3
-
108
-
-
0029117304
-
Maximal activation of transcription by STAT1 and STAT3 requires both tyrosine and serine phosporylation
-
Z. L. Wen, Z. Zhong & J. E. Darnell: Maximal activation of transcription by STAT1 and STAT3 requires both tyrosine and serine phosporylation. Cell, 82, 241-250 (1995)
-
(1995)
Cell
, vol.82
, pp. 241-250
-
-
Wen, Z.L.1
Zhong, Z.2
Darnell, J.E.3
-
109
-
-
0347624595
-
Essential Role of STAT3 in Postnatal Survival and Growth Revealed by Mice Lacking STAT3 Serine 727 Phosphorylation
-
DOI 10.1128/MCB.24.1.407-419.2004
-
Y. H. Shen, K. Schlessinger, X. J. Zhu, E. Meffre, F. Quimby, D. E. Levy & J. E. Darnell: Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylatione. Mol Cell Biol, 24, 407-419 (2004) (Pubitemid 38010065)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.1
, pp. 407-419
-
-
Shen, Y.1
Schlessinger, K.2
Zhu, X.3
Meffre, E.4
Quimby, F.5
Levy, D.E.6
Darnell Jr., J.E.7
-
110
-
-
0028942656
-
Requirement of serine phosphorylation for formation of STAT-promoter complexes
-
X. K. Zhang, J. Blenis, H. C. Li, C. Schindler & S. Chenkiang: Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science, 267, 1990-1994 (1995)
-
(1995)
Science
, vol.267
, pp. 1990-1994
-
-
Zhang, X.K.1
Blenis, J.2
Li, H.C.3
Schindler, C.4
Chenkiang, S.5
-
111
-
-
52049122570
-
C-Jun NH2- terminal kinase mediates leptin-stimulated androgenindependent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt
-
T. Miyazaki, J. D. Bub & Y. Iwamoto: c-Jun NH2- terminal kinase mediates leptin-stimulated androgenindependent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt. Biochim. Biophys. Acta, 1782, 593-604 (2008)
-
(2008)
Biochim. Biophys. Acta
, vol.1782
, pp. 593-604
-
-
Miyazaki, T.1
Bub, J.D.2
Iwamoto, Y.3
-
112
-
-
0037096988
-
727 phosphorylation and DNA binding
-
DOI 10.1042/BJ20020295
-
L. O'Rourke & P. R. Shepherd: Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages: role in regulating STAT3 Ser(727) phosphorylation and DNA binding. Biochemical J, 364, 875-879 (2002) (Pubitemid 34680866)
-
(2002)
Biochemical Journal
, vol.364
, Issue.3
, pp. 875-879
-
-
O'Rourke, L.1
Shepherd, P.R.2
-
113
-
-
77958471611
-
Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation
-
H. Iwasaki, J. C. Kovacic, M. Olive, J. K. Beers, T. Yoshimoto, M. F. Crook, L. H. Tonelli & E. G. Nabel: Disruption of Protein Arginine N-Methyltransferase 2 Regulates Leptin Signaling and Produces Leanness In Vivo Through Loss of STAT3 Methylation. Circ Res, 107, 992-1001 (2010)
-
(2010)
Circ Res
, vol.107
, pp. 992-1001
-
-
Iwasaki, H.1
Kovacic, J.C.2
Olive, M.3
Beers, J.K.4
Yoshimoto, T.5
Crook, M.F.6
Tonelli, L.H.7
Nabel, E.G.8
-
114
-
-
12244251445
-
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
-
DOI 10.1126/science.1105166
-
Z.-l. Yuan, Y.-j. Guan, D. Chatterjee & Y. E. Chin: Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue. Science, 307, 269-273 (2005) (Pubitemid 40116244)
-
(2005)
Science
, vol.307
, Issue.5707
, pp. 269-273
-
-
Yuan, Z.-L.1
Guan, Y.-J.2
Chatterjee, D.3
Chin, Y.E.4
-
115
-
-
0037456304
-
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
-
DOI 10.1038/nature01388
-
S. H. Bates, W. H. Stearns, T. A. Dundon, M. Schubert, A. W. K. Tso, Y. P. Wang, A. S. Banks, H. J. Lavery, A. K. Haq, E. Maratos-Flier, B. G. Neel, M. W. Schwartz & M. G. Myers: STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature, 421, 856-859 (2003) (Pubitemid 36254146)
-
(2003)
Nature
, vol.421
, Issue.6925
, pp. 856-859
-
-
Bates, S.H.1
Stearns, W.H.2
Dundon, T.A.3
Schubert, M.4
Tso, A.W.K.5
Wang, Y.6
Banks, A.S.7
Lavery, H.J.8
Haq, A.K.9
Maratos-Flier, E.10
Neel, B.G.11
Schwartz, M.W.12
Myers Jr., M.G.13
-
116
-
-
10744232925
-
Essential Role of STAT3 in Body Weight and Glucose Homeostasis
-
DOI 10.1128/MCB.24.1.258-269.2004
-
Y. X. Cui, L. Huang, F. Elefteriou, G. Q. Yang, J. M. Shelton, J. E. Giles, O. K. Oz, T. Pourbahrami, C. Y. H. Lu, J. A. Richardson, G. Karsenty & C. Li: Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol, 24, 258-269 (2004) (Pubitemid 38010052)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.1
, pp. 258-269
-
-
Cui, Y.1
Huang, L.2
Elefteriou, F.3
Yang, G.4
Shelton, J.M.5
Giles, J.E.6
Oz, O.K.7
Pourbahrami, T.8
Lu, C.Y.H.9
Richardson, J.A.10
Karsenty, G.11
Li, C.12
-
117
-
-
1842584949
-
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
-
DOI 10.1073/pnas.0303992101
-
Q. Gao, M. J. Wolfgang, S. Neschen, K. Morino, T. L. Horvath, G. I. Shulman & X. Y. Fu: Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci USA, 101, 4661-4666 (2004) (Pubitemid 38437467)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.13
, pp. 4661-4666
-
-
Gao, Q.1
Wolfgang, M.J.2
Neschen, S.3
Morino, K.4
Horvath, T.L.5
Shulman, G.I.6
Fu, X.-Y.7
-
118
-
-
9444264702
-
LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin
-
DOI 10.2337/diabetes.53.12.3067
-
S. H. Bates, T. A. Dundon, M. Seifert, M. Carlson, E. Maratos-Filer & M. G. Myers: LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes, 53, 3067-3073 (2004) (Pubitemid 39564480)
-
(2004)
Diabetes
, vol.53
, Issue.12
, pp. 3067-3073
-
-
Bates, S.H.1
Dundon, T.A.2
Seifert, M.3
Carlson, M.4
Maratos-Flier, E.5
Myers Jr., M.G.6
-
119
-
-
33745362866
-
Critical role of STAT3 in leptin's metabolic actions
-
DOI 10.1016/j.cmet.2006.04.014, PII S1550413106001549
-
C. Buettner, A. Pocai, E. D. Muse, A. M. Etgen, M. G. Myers Jr & L. Rossetti: Critical role of STAT3 in leptin's metabolic actions. Cell Metab, 4, 49-60 (2006) (Pubitemid 43942253)
-
(2006)
Cell Metabolism
, vol.4
, Issue.1
, pp. 49-60
-
-
Buettner, C.1
Pocai, A.2
Muse, E.D.3
Etgen, A.M.4
Myers Jr., M.G.5
Rossetti, L.6
-
120
-
-
0038747134
-
Role of signal transducer and activator of transcription 3 in regulation of hypothalamic Proopiomelanocortin gene expression by leptin
-
DOI 10.1210/en.2002-221037
-
H. Munzberg, L. H. Huo, E. A. Nillni, A. N. Hollenberg & C. Bjorbaek: Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology, 144, 2121-2131 (2003) (Pubitemid 36543352)
-
(2003)
Endocrinology
, vol.144
, Issue.5
, pp. 2121-2131
-
-
Munzberg, H.1
Huo, L.2
Nillni, E.A.3
Hollenberg, A.N.4
Bjorbaek, C.5
-
121
-
-
33845867730
-
Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased Pomc expression, mild obesity, and defects in compensatory refeeding
-
DOI 10.1210/en.2006-1119
-
A. W. Xu, L. Ste-Marie, C. B. Kaelin & G. S. Barsh: Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased Pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology, 148, 72-80 (2007) (Pubitemid 46021439)
-
(2007)
Endocrinology
, vol.148
, Issue.1
, pp. 72-80
-
-
Xu, A.W.1
Ste-Marie, L.2
Kaelin, C.B.3
Barsh, G.S.4
-
122
-
-
46349110307
-
Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis
-
DOI 10.1210/en.2007-0945
-
L. Gong, F. Yao, K. Hockman, H. H. Heng, G. J. Morton, K. Takeda, S. Akira, M. J. Low, M. Rubinstein & R. G. MacKenzie: Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Endocrinology, 149, 3346-3354 (2008) (Pubitemid 351919579)
-
(2008)
Endocrinology
, vol.149
, Issue.7
, pp. 3346-3354
-
-
Gong, L.1
Yao, F.2
Hockman, K.3
Heng, H.H.4
Morton, G.J.5
Takeda, K.6
Akira, S.7
Low, M.J.8
Rubinstein, M.9
MacKenzie, R.G.10
-
123
-
-
33749350398
-
Signal transducer and activator of transcription (Stat) binding sites but not Stat3 are required for fasting-induced transcription of Agouti-related protein messenger ribonucleic acid
-
DOI 10.1210/me.2006-0107
-
C. B. Kaelin, L. J. Gong, A. W. Xu, F. Y. Yao, K. Hockman, G. J. Morton, M. W. Schwartz, G. S. Barsh & R. G. MacKenzie: Signal transducer and activator of transcription (Stat) binding sites but not Stat3 are required for fasting-induced transcription of Agouti-related protein messenger ribonucleic acid. Mol Endocrinol, 20, 2591-2602 (2006) (Pubitemid 44496426)
-
(2006)
Molecular Endocrinology
, vol.20
, Issue.10
, pp. 2591-2602
-
-
Kaelin, C.B.1
Gong, L.2
Xu, A.W.3
Yao, F.4
Hockman, K.5
Morton, G.J.6
Schwartz, M.W.7
Barsh, G.S.8
MacKenzie, R.G.9
-
124
-
-
0035172040
-
Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling
-
M. Harris, C. Aschkenasi, C. F. Elias, A. Chandrankunnel, E. A. Nillni, C. Bjorbaek, J. K. Elmquist, J. S. Flier & A. N. Hollenberg: Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest, 107, 111-120 (2001) (Pubitemid 32047420)
-
(2001)
Journal of Clinical Investigation
, vol.107
, Issue.1
, pp. 111-120
-
-
Harris, M.1
Aschkenasi, C.2
Elias, C.F.3
Chandrankunnel, A.4
Nillni, E.A.5
Bjorbaek, C.6
Elmquist, J.K.7
Flier, J.S.8
Hollenberg, A.N.9
-
125
-
-
2042506366
-
Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo
-
DOI 10.1210/en.2003-1312
-
F. Guo, K. Bakal, Y. Minokoshi & A. N. Hollenberg: Leptin Signaling Targets the Thyrotropin-Releasing Hormone Gene Promoter in Vivo. Endocrinology, 145, 2221-2227 (2004) (Pubitemid 38535051)
-
(2004)
Endocrinology
, vol.145
, Issue.5
, pp. 2221-2227
-
-
Guo, F.1
Bakal, K.2
Minokoshi, Y.3
Hollenberg, A.N.4
-
126
-
-
11144358404
-
Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin
-
DOI 10.1210/en.2003-1242
-
L. H. Huo, H. Munzberg, E. A. Nillni & C. Bjorbaek: Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin. Endocrinology, 145, 2516-2523 (2004) (Pubitemid 38535079)
-
(2004)
Endocrinology
, vol.145
, Issue.5
, pp. 2516-2523
-
-
Huo, L.1
Munzberg, H.2
Nillni, E.A.3
Bjorbaek, C.4
-
127
-
-
34250338799
-
Leptin induces inflammation-related genes inRINm5F insulinoma cells
-
P. Hekerman, J. Zeidler, S. Korfmacher, S. Bamberg- Lemper, H. Knobelspies, L. Zabeau, J. Tavernier & W. Becker: Leptin induces inflammation-related genes inRINm5F insulinoma cells. Bmc Molecular Biology, 8, 41 (2007)
-
(2007)
Bmc Molecular Biology
, vol.8
, pp. 41
-
-
Hekerman, P.1
Zeidler, J.2
Korfmacher, S.3
Bamberg- Lemper, S.4
Knobelspies, H.5
Zabeau, L.6
Tavernier, J.7
Becker, W.8
-
128
-
-
0001421697
-
985
-
DOI 10.1074/jbc.M007577200
-
C. Bjorbaek, H. J. Lavery, S. H. Bates, R. K. Olson, S. M. Davis, J. S. Flier & M. G. Myers: SOCS3 mediates feedback inhibition of the leptin receptor via Tyr(985). J Biol Chem, 275, 40649-40657 (2000) (Pubitemid 32064706)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.51
, pp. 40649-40657
-
-
Bjorbaek, C.1
Lavery, H.J.2
Bates, S.H.3
Olson, R.K.4
Davis, S.M.5
Flier, J.S.6
Myers Jr., M.G.7
-
129
-
-
0032014178
-
Identification of SOCS-3 as a potential mediator of central leptin resistance
-
C. Bjorbaek, J. K. Elmquist, J. D. Frantz, S. E. Shoelson & J. S. Flier: Identification of SOCS-3 as a potential mediator of central leptin resistance. Molecular Cell, 1, 619-625 (1998) (Pubitemid 128374698)
-
(1998)
Molecular Cell
, vol.1
, Issue.4
, pp. 619-625
-
-
Bjorbaek, C.1
Elmquist, J.K.2
Frantz, J.D.3
Shoelson, S.E.4
Flier, J.S.5
-
130
-
-
40849124301
-
Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons
-
DOI 10.1210/me.2007-0389
-
M. L. Piper, E. K. Unger, M. G. Myers & A. W. Xu: Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol, 22, 751-759 (2008) (Pubitemid 351397800)
-
(2008)
Molecular Endocrinology
, vol.22
, Issue.3
, pp. 751-759
-
-
Piper, M.L.1
Unger, E.K.2
Myers Jr., M.G.3
Xu, A.W.4
-
131
-
-
0030015417
-
Defective STAT signaling by the leptin receptor in diabetic mice
-
DOI 10.1073/pnas.93.13.6231
-
N. Ghilardi, S. Ziegler, A. Wiestner, R. Stoffel, M. H. Heim & R. C. Skoda: Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA, 93, 6231-6235 (1996) (Pubitemid 26230287)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.13
, pp. 6231-6235
-
-
Ghilardi, N.1
Ziegler, S.2
Wiestner, A.3
Stoffel, R.4
Heim, M.H.5
Skoda, R.C.6
-
132
-
-
10544236913
-
Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells
-
DOI 10.1210/en.137.11.5178
-
C. I. Rosenblum, M. Tota, D. Cully, T. Smith, R. Collum, S. Qureshi, J. F. Hess, M. S. Phillips, P. J. Hey, A. Vongs, T. M. Fong, L. Xu, H. Y. Chen, R. G. Smith, C. Schindler & L. H. T. VanderPloeg: Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); Reduced expression of the rat fatty leptin receptor in transfected cells. Endocrinology, 137, 5178-5181 (1996) (Pubitemid 26403367)
-
(1996)
Endocrinology
, vol.137
, Issue.11
, pp. 5178-5181
-
-
Rosenblum, C.I.1
Tota, M.2
Cully, D.3
Smith, T.4
Collum, R.5
Qureshi, S.6
Hess, J.F.7
Phillips, M.S.8
Hey, P.J.9
Vongs, A.10
Fong, T.M.11
Xu, L.12
Chen, H.Y.13
Smith, R.G.14
Schindler, C.15
Van Der Ploeg, L.H.T.16
-
133
-
-
35648968069
-
The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms
-
DOI 10.1074/jbc.M702838200
-
Y. Gong, R. Ishida-Takahashi, E. C. Villanueva, D. C. Fingar, H. Muenzberg & M. G. Myers: The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem, 282, 31019-31027 (2007) (Pubitemid 350035238)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.42
, pp. 31019-31027
-
-
Gong, Y.1
Ishida-Takahashi, R.2
Villanueva, E.C.3
Fingar, D.C.4
Munzberg, H.5
Myers Jr., M.G.6
-
134
-
-
34247102713
-
Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration
-
DOI 10.1016/j.neulet.2007.02.074, PII S0304394007002431
-
J. Mutze, J. Roth, R. Gerstberger & T. Hubschle: Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration. Neurosci Lett, 417, 286-291 (2007) (Pubitemid 46589788)
-
(2007)
Neuroscience Letters
, vol.417
, Issue.3
, pp. 286-291
-
-
Mutze, J.1
Roth, J.2
Gerstberger, R.3
Hubschle, T.4
-
135
-
-
33646570845
-
Analysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategy
-
DOI 10.1016/j.febslet.2006.04.094, PII S001457930600576X
-
T. Montoye, J. Piessevaux, D. Lavens, J. Wauman, D. Catteeuw, J. Vandekerckhove, I. Lemmens & J. Tavernier: Analysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategy. FEBS Lett, 580, 3301-7 (2006) (Pubitemid 43729669)
-
(2006)
FEBS Letters
, vol.580
, Issue.13
, pp. 3301-3307
-
-
Montoye, T.1
Piessevaux, J.2
Lavens, D.3
Wauman, J.4
Catteeuw, D.5
Vandekerckhove, J.6
Lemmens, I.7
Tavernier, J.8
-
136
-
-
45749150715
-
Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity
-
J. Y. Lee, H. Muenzberg, O. Gavrilova, J. A. Reed, D. Berryman, E. C. Villanueva, G. W. Louis, G. M. Leinninger, S. Bertuzzi, R. J. Seeley, G. W. Robinson, M. G. Myers & L. Hennighausen: Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity. Plos One, 3, 13 (2008)
-
(2008)
Plos One
, vol.3
, pp. 13
-
-
Lee, J.Y.1
Muenzberg, H.2
Gavrilova, O.3
Reed, J.A.4
Berryman, D.5
Villanueva, E.C.6
Louis, G.W.7
Leinninger, G.M.8
Bertuzzi, S.9
Seeley, R.J.10
Robinson, G.W.11
Myers, M.G.12
Hennighausen, L.13
-
137
-
-
0000430395
-
Divergent roles of SHP-2 in ERK activation by leptin receptors
-
C. Bjorbaek, R. M. Buchholz, S. M. Davis, S. H. Bates, D. D. Pierroz, H. Gu, B. G. Neel, M. G. Myers & J. S. Flier: Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem, 276, 4747-4755 (2001)
-
(2001)
J Biol Chem
, vol.276
, pp. 4747-4755
-
-
Bjorbaek, C.1
Buchholz, R.M.2
Davis, S.M.3
Bates, S.H.4
Pierroz, D.D.5
Gu, H.6
Neel, B.G.7
Myers, M.G.8
Flier, J.S.9
-
138
-
-
0032568515
-
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor
-
DOI 10.1073/pnas.95.11.6061
-
L. R. Carpenter, T. J. Farruggella, A. Symes, M. L. Karow, G. D. Yancopoulos & N. Stahl: Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor. Proc Natl Acad Sci U S A, 95, 6061-6 (1998) (Pubitemid 28248964)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.11
, pp. 6061-6066
-
-
Carpenter, L.R.1
Farruggella, T.J.2
Symes, A.3
Karow, M.L.4
Yancopoulos, G.D.5
Stahl, N.6
-
139
-
-
0033578334
-
Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction
-
DOI 10.1073/pnas.96.17.9677
-
C. Li & J. M. Friedman: Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc Natl Acad Sci U S A, 96, 9677-82 (1999) (Pubitemid 29398791)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.17
, pp. 9677-9682
-
-
Li, C.1
Friedman, J.M.2
-
140
-
-
62749109421
-
Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin
-
K. Rahmouni, C. D. Sigmund, W. G. Haynes & A. L. Mark: Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes, 58, 536-42 (2009)
-
(2009)
Diabetes
, vol.58
, pp. 536-542
-
-
Rahmouni, K.1
Sigmund, C.D.2
Haynes, W.G.3
Mark, A.L.4
-
141
-
-
8644268830
-
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
-
DOI 10.1073/pnas.0405041101
-
E. E. Zhang, E. Chapeau, K. Hagihara & G. S. Feng: Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci U S A, 101, 16064-9 (2004) (Pubitemid 39507927)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.45
, pp. 16064-16069
-
-
Zhang, E.E.1
Chapeau, E.2
Hagihara, K.3
Feng, G.-S.4
-
142
-
-
77949673935
-
PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
-
R. Banno, D. Zimmer, B. C. de Jonghe, M. Atienza, K. Rak, W. Yang & K. K. Bence: PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. The J Clin Invest, 120, 720-734 (2010)
-
(2010)
The J Clin Invest
, vol.120
, pp. 720-734
-
-
Banno, R.1
Zimmer, D.2
De Jonghe, B.C.3
Atienza, M.4
Rak, K.5
Yang, W.6
Bence, K.K.7
-
143
-
-
0033180532
-
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
-
DOI 10.1016/S0896-6273(01)80035-0
-
C. F. Elias, C. Aschkenasi, C. Lee, J. Kelly, R. S. Ahima, C. Bjorbaek, J. S. Flier, C. B. Saper & J. K. Elmquist: Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron, 23, 775-786 (1999) (Pubitemid 29411566)
-
(1999)
Neuron
, vol.23
, Issue.4
, pp. 775-786
-
-
Elias, C.F.1
Aschkenasi, C.2
Lee, C.3
Kelly, J.4
Ahima, R.S.5
Bjorbaek, C.6
Flier, J.S.7
Saper, C.B.8
Elmquist, J.K.9
-
144
-
-
33845672095
-
Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1
-
H. Cui, F. Cai & D. D. Belsham: Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1. FASEB J., 20, 2654-2656 (2006)
-
(2006)
FASEB J.
, vol.20
, pp. 2654-2656
-
-
Cui, H.1
Cai, F.2
Belsham, D.D.3
-
145
-
-
33846128443
-
Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling
-
DOI 10.1523/JNEUROSCI.3168-06.2007
-
H. Munzberg, E. E. Jobst, S. H. Bates, J. Jones, E. Villanueva, R. Leshan, M. Bjornholm, J. Elmquist, M. Sleeman, M. A. Cowley & M. G. Myers: Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. J Neurosci, 27, 69-74 (2007) (Pubitemid 46089960)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.1
, pp. 69-74
-
-
Munzberg, H.1
Jobst, E.E.2
Bates, S.H.3
Jones, J.4
Villanueva, E.5
Leshan, R.6
Bjornholm, M.7
Elmquist, J.8
Sleeman, M.9
Cowley, M.A.10
Myers Jr., M.G.11
-
146
-
-
34248227278
-
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function
-
DOI 10.1172/JCI30688
-
M. Bjornholm, H. Munzberg, R. L. Leshan, E. C. Villanueva, S. H. Bates, G. W. Louis, J. C. Jones, R. Ishida-Takahashi, C. Bjorbaek & M. G. Myers: Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest, 117, 1354-1360 (2007) (Pubitemid 46718423)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.5
, pp. 1354-1360
-
-
Bjornholm, M.1
Munzberg, H.2
Leshan, R.L.3
Villanueva, E.C.4
Bates, S.H.5
Louis, G.W.6
Jones, J.C.7
Ishida-Takahashi, R.8
Bjorbaek, C.9
Myers Jr., M.G.10
-
147
-
-
77949415378
-
Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance
-
J. You, Y. Yu, L. Jiang, W. Li, X. Yu, L. Gonzalez, G. Yang, Z. Ke, W. Li, C. Li & Y. Liu: Signaling through Tyr985 of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance. Mol. Cell. Biol., 30, 1650-1659 (2010)
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 1650-1659
-
-
You, J.1
Yu, Y.2
Jiang, L.3
Li, W.4
Yu, X.5
Gonzalez, L.6
Yang, G.7
Ke, Z.8
Li, W.9
Li, C.10
Liu, Y.11
-
148
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
DOI 10.1126/science.1124147
-
D. Cota, K. Proulx, K. A. B. Smith, S. C. Kozma, G. Thomas, S. C. Woods & R. J. Seeley: Hypothalamic mTOR signaling regulates food intake. Science, 312, 927-930 (2006) (Pubitemid 43727328)
-
(2006)
Science
, vol.312
, Issue.5775
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Blake Smith, K.A.3
Kozma, S.C.4
Thomas, G.5
Woods, S.C.6
Seeley, R.J.7
-
149
-
-
70349315117
-
Complex regulationof mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status
-
E. C. Villanueva, H. Munzberg, D. Cota, R. L. Leshan, K. Kopp, R. Ishida-Takahashi, J. C. Jones, D. C. Fingar, R. J. Seeley & M. G. Myers: Complex Regulationof Mammalian Target of Rapamycin Complex 1 in the Basomedial Hypothalamus by Leptin and Nutritional Status. Endocrinology, 150, 4541-4551 (2009)
-
(2009)
Endocrinology
, vol.150
, pp. 4541-4551
-
-
Villanueva, E.C.1
Munzberg, H.2
Cota, D.3
Leshan, R.L.4
Kopp, K.5
Ishida-Takahashi, R.6
Jones, J.C.7
Fingar, D.C.8
Seeley, R.J.9
Myers, M.G.10
-
150
-
-
49049114337
-
The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
-
D. Cota, E. K. Matter, S. C. Woods & R. J. Seeley: The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci, 28, 7202-7208 (2008)
-
(2008)
J Neurosci
, vol.28
, pp. 7202-7208
-
-
Cota, D.1
Matter, E.K.2
Woods, S.C.3
Seeley, R.J.4
-
151
-
-
13844280463
-
Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells
-
DOI 10.1016/j.bbrc.2004.12.195, PII S0006291X04028761
-
H.-J. Shin, J. Oh, S. M. Kang, J. H. Lee, M.-J. Shin, K.-C. Hwang, Y. Jang & J. H. Chung: Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells. Biochem. Biophys. Res. Commun, 329, 18-24 (2005) (Pubitemid 40255414)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.329
, Issue.1
, pp. 18-24
-
-
Shin, H.-J.1
Oh, J.2
Kang, S.M.3
Lee, J.H.4
Shin, M.-J.5
Hwang, K.-C.6
Jang, Y.7
Chung, J.H.8
-
152
-
-
41649087434
-
Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways
-
DOI 10.1210/me.2007-0414
-
J. Wauman, A. S. de Smet, D. Catteeuw, D. Belsham & J. Tavernier: Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways. Mol Endocrinol, 22, 965-977 (2008) (Pubitemid 351482831)
-
(2008)
Molecular Endocrinology
, vol.22
, Issue.4
, pp. 965-977
-
-
Wauman, J.1
De Smet, A.-S.2
Dominiek Catteeuw, D.B.3
Tavernier, J.4
-
153
-
-
6344243617
-
SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
-
C. J. Duan, M. H. Li & L. Y. Rui: SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. J Biol Chem, 279, 43684-43691 (2004)
-
(2004)
J Biol Chem
, vol.279
, pp. 43684-43691
-
-
Duan, C.J.1
Li, M.H.2
Rui, L.Y.3
-
154
-
-
0030828823
-
12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
-
DOI 10.1007/s001250050832
-
M. Kellerer, M. Koch, E. Metzinger, J. Mushack, E. Capp & H. U. Haring: Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia, 40, 1358-1362 (1997) (Pubitemid 27469678)
-
(1997)
Diabetologia
, vol.40
, Issue.11
, pp. 1358-1362
-
-
Kellerer, M.1
Koch, M.2
Metzinger, E.3
Mushack, J.4
Capp, E.5
Haring, H.U.6
-
155
-
-
34548370733
-
813 phosphorylation-dependent and -independent mechanisms
-
DOI 10.1210/me.2007-0111
-
Z. Q. Li, Y. J. Zhou, C. Carter-Su, M. G. Myers & L. Rui: SH2B1 enhances leptin signaling by both janus kinase 2 Tyr(813) phosphorylation- dependent and -independent mechanisms. Mol Endocrinol, 21, 2270-2281 (2007) (Pubitemid 47347387)
-
(2007)
Molecular Endocrinology
, vol.21
, Issue.9
, pp. 2270-2281
-
-
Li, Z.1
Zhou, Y.2
Carter-Su, C.3
Myers Jr., M.G.4
Rui, L.5
-
156
-
-
25144523930
-
Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
-
D. C. Ren, M. H. Li, C. J. Duan & L. Y. Rui: Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab, 2, 95-104 (2005)
-
(2005)
Cell Metab
, vol.2
, pp. 95-104
-
-
Ren, D.C.1
Li, M.H.2
Duan, C.J.3
Rui, L.Y.4
-
157
-
-
33846822094
-
Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
-
DOI 10.1172/JCI29417
-
D. C. Ren, Y. J. Zhou, D. Morris, M. H. Li, Z. Q. Li & L. Y. Rui: Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest, 117, 397-406 (2007) (Pubitemid 46203968)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.2
, pp. 397-406
-
-
Ren, D.1
Zhou, Y.2
Morris, D.3
Li, M.4
Li, Z.5
Rui, L.6
-
158
-
-
33745576798
-
Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
-
DOI 10.1038/nn1731, PII N1731
-
M.-S. Kim, Y. K. Pak, P.-G. Jang, C. Namkoong, Y.- S. Choi, J.-C. Won, K.-S. Kim, S.-W. Kim, H.-S. Kim, J.- Y. Park, Y.-B. Kim & K.-U. Lee: Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat Neurosci, 9, 901-906 (2006) (Pubitemid 43980504)
-
(2006)
Nature Neuroscience
, vol.9
, Issue.7
, pp. 901-906
-
-
Kim, M.-S.1
Pak, Y.K.2
Jang, P.-G.3
Namkoong, C.4
Choi, Y.-S.5
Won, J.-C.6
Kim, K.-S.7
Kim, S.-W.8
Kim, H.-S.9
Park, J.-Y.10
Kim, Y.-B.11
Lee, K.-U.12
-
159
-
-
33646590947
-
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
-
T. Kitamura, Y. Feng, Y. I. Kitamura, S. C. Chua, Jr., A. W. Xu, G. S. Barsh, L. Rossetti & D. Accili: Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med, 12, 534-40 (2006)
-
(2006)
Nat Med
, vol.12
, pp. 534-540
-
-
Kitamura, T.1
Feng, Y.2
Kitamura, Y.I.3
Chua Jr., S.C.4
Xu, A.W.5
Barsh, G.S.6
Rossetti, L.7
Accili, D.8
-
160
-
-
63649158684
-
FoxO1 inhibits leptin regulation of proopiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
-
G. Yang, C. Y. Lim, C. Li, X. Xiao, G. K. Radda, X. Cao & W. Han: FoxO1 inhibits leptin regulation of proopiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1. J Biol Chem, 284, 3719-27 (2009)
-
(2009)
J Biol Chem
, vol.284
, pp. 3719-3727
-
-
Yang, G.1
Lim, C.Y.2
Li, C.3
Xiao, X.4
Radda, G.K.5
Cao, X.6
Han, W.7
-
161
-
-
33745747676
-
A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells
-
DOI 10.1038/sj.emboj.7601118, PII 7601118
-
K. Ning, L. C. Miller, H. A. Laidlaw, L. A. Burgess, N. M. Perera, C. P. Downes, N. R. Leslie & M. L. J. Ashford: A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic [beta]- cells. EMBO J, 25, 2377-2387 (2006) (Pubitemid 44012221)
-
(2006)
EMBO Journal
, vol.25
, Issue.11
, pp. 2377-2387
-
-
Ning, K.1
Miller, L.C.2
Laidlaw, H.A.3
Burgess, L.A.4
Perera, N.M.5
Downes, C.P.6
Leslie, N.R.7
Ashford, M.L.J.8
-
162
-
-
66149101629
-
Leptindependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels
-
K. Ning, L. C. Miller, H. A. Laidlaw, K. R. Watterson, J. Gallagher, C. Sutherland & M. L. J. Ashford: Leptindependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels. J Biol Chem, 284, 9331-9340 (2009)
-
(2009)
J Biol Chem
, vol.284
, pp. 9331-9340
-
-
Ning, K.1
Miller, L.C.2
Laidlaw, H.A.3
Watterson, K.R.4
Gallagher, J.5
Sutherland, C.6
Ashford, M.L.J.7
-
163
-
-
0036321620
-
A phosphatidylinositol 3-kinase-phosphodiesterase 3b-cyclic AMP pathway in hypothalamic action of leptin on feeding
-
DOI 10.1038/nn885
-
A. Z. Zhao, J. N. Huan, S. Gupta, R. Pal & A. Sahu: A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat Neurosci, 5, 727-8 (2002) (Pubitemid 34827588)
-
(2002)
Nature Neuroscience
, vol.5
, Issue.8
, pp. 727-728
-
-
Zhao, A.Z.1
Huan, J.-N.2
Gupta, S.3
Pal, R.4
Sahu, A.5
-
164
-
-
77953693953
-
A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus
-
A. Sahu: A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus. Neurosci Lett, 479, 18-21 (2010)
-
(2010)
Neurosci Lett
, vol.479
, pp. 18-21
-
-
Sahu, A.1
-
165
-
-
0034699544
-
IRS-2 pathways integrate female reproduction and energy homeostasis
-
D. J. Burks, J. F. de Mora, M. Schubert, D. J. Withers, M. G. Myers, H. H. Towery, S. L. Altamuro, C. L. Flint & M. F. White: IRS-2 pathways integrate female reproduction and energy homeostasis. Nature, 407, 377-382 (2000)
-
(2000)
Nature
, vol.407
, pp. 377-382
-
-
Burks, D.J.1
De Mora, J.F.2
Schubert, M.3
Withers, D.J.4
Myers, M.G.5
Towery, H.H.6
Altamuro, S.L.7
Flint, C.L.8
White, M.F.9
-
166
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
DOI 10.1038/36116
-
D. J. Withers, J. S. Gutierrez, H. Towery, D. J. Burks, J. M. Ren, S. Previs, Y. T. Zhang, D. Bernal, S. Pons, G. I. Shulman, S. Bonner-Weir & M. F. White: Disruption of IRS-2 causes type 2 diabetes in mice. Nature, 391, 900-904 (1998) (Pubitemid 28157668)
-
(1998)
Nature
, vol.391
, Issue.6670
, pp. 900-904
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.-M.5
Previs, S.6
Zhang, Y.7
Bernal, D.8
Pons, S.9
Shulman, G.I.10
Bonner-Weir, S.11
White, M.F.12
-
167
-
-
9644260562
-
Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
-
DOI 10.1172/JCI200421484
-
N. Kubota, Y. Terauchi, K. Tobe, W. Yano, R. Suzuki, K. Ueki, I. Takamoto, H. Satoh, T. Maki, T. Kubota, M. Moroi, M. Okada-Iwabu, O. Ezaki, R. Nagai, Y. Ueta, T. Kadowaki & T. Noda: Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest, 114, 917-27 (2004) (Pubitemid 39578719)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.7
, pp. 917-927
-
-
Kubota, N.1
Terauchi, Y.2
Tobe, K.3
Yano, W.4
Suzuki, R.5
Ueki, K.6
Takamoto, I.7
Satoh, H.8
Maki, T.9
Kubota, T.10
Moroi, M.11
Okada-Iwabu, M.12
Ezaki, O.13
Nagai, R.14
Ueta, Y.15
Kadowaki, T.16
Noda, T.17
-
168
-
-
9644260563
-
Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes
-
DOI 10.1172/JCI200422217
-
X. Lin, A. Taguchi, S. Park, J. A. Kushner, F. Li, Y. Li & M. F. White: Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest, 114, 908-16 (2004) (Pubitemid 39578718)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.7
, pp. 908-916
-
-
Lin, X.1
Taguchi, A.2
Park, S.3
Kushner, J.A.4
Li, F.5
Li, Y.6
White, M.F.7
-
169
-
-
20144389727
-
The role of insulin receptor substrate 2 in hypothalamic and β cell function
-
DOI 10.1172/JCI200524445
-
A. I. Choudhury, H. Heffron, M. A. Smith, H. Al- Qassab, A. W. Xu, C. Selman, M. Simmgen, M. Clements, M. Claret, G. MacColl, D. C. Bedford, K. Hisadome, I. Diakonov, V. Moosajee, J. D. Bell, J. R. Speakman, R. L. Batterham, G. S. Barsh, M. L. J. Ashford & D. J. Withers: The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest, 115, 940-950 (2005) (Pubitemid 40489398)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.4
, pp. 940-950
-
-
Choudhury, A.I.1
Heffron, H.2
Smith, M.A.3
Al-Qassab, H.4
Xu, A.W.5
Selman, C.6
Simmgen, M.7
Clements, M.8
Claret, M.9
MacColl, G.10
Bedford, D.C.11
Hisadome, K.12
Diakonov, I.13
Moosajee, V.14
Bell, J.D.15
Speakman, J.R.16
Batterham, R.L.17
Barsh, G.S.18
Ashford, M.L.J.19
Withers, D.J.20
more..
-
170
-
-
43049116846
-
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
-
DOI 10.1172/JCI32964
-
J. W. Hill, K. W. Williams, C. P. Ye, J. Luo, N. Balthasar, R. Coppari, M. A. Cowley, L. C. Cantley, B. B. Lowell & J. K. Elmquist: Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest, 118, 1796-1805 (2008) (Pubitemid 351632382)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.5
, pp. 1796-1805
-
-
Hill, J.W.1
Williams, K.W.2
Ye, C.3
Luo, J.4
Balthasar, N.5
Coppari, R.6
Cowley, M.A.7
Cantley, L.C.8
Lowell, B.B.9
Elmquist, J.K.10
-
171
-
-
33644665508
-
Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling
-
DOI 10.1152/ajpendo.00094.2005
-
C. D. Morrison, G. J. Morton, K. D. Niswender, R. W. Gelling & M. W. Schwartz: Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism thatrequires phosphatidylinositol 3-OH-kinase signaling. Am J Physiol, 289, E1051-E1057 (2005) (Pubitemid 43772054)
-
(2005)
American Journal of Physiology - Endocrinology and Metabolism
, vol.289
, Issue.6
-
-
Morrison, C.D.1
Morton, G.J.2
Niswender, K.D.3
Gelling, R.W.4
Schwartz, M.W.5
-
172
-
-
34249829624
-
Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway
-
DOI 10.1210/en.2006-1240
-
D. Kohno, M. Nakata, F. Maekawa, K. Fujiwara, Y. Maejima, M. Kuramochi, T. Shimazaki, H. Okano, T. Onaka & T. Yada: Leptin Suppresses Ghrelin-Induced Activation of Neuropeptide Y Neurons in the Arcuate Nucleus via Phosphatidylinositol 3-Kinase- and Phosphodiesterase 3-Mediated Pathway. Endocrinology, 148, 2251-2263 (2007) (Pubitemid 46997030)
-
(2007)
Endocrinology
, vol.148
, Issue.5
, pp. 2251-2263
-
-
Kohno, D.1
Nakata, M.2
Maekawa, F.3
Fujiwara, K.4
Maejima, Y.5
Kuramochi, M.6
Shimazaki, T.7
Okano, H.8
Onaka, T.9
Yada, T.10
-
173
-
-
12944261926
-
Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation
-
S. Mirshamsi, H. Laidlaw, K. Ning, E. Anderson, L. Burgess, A. Gray, C. Sutherland & M. Ashford: Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. BMC Neurosci, 5, 54 (2004)
-
(2004)
BMC Neurosci
, vol.5
, pp. 54
-
-
Mirshamsi, S.1
Laidlaw, H.2
Ning, K.3
Anderson, E.4
Burgess, L.5
Gray, A.6
Sutherland, C.7
Ashford, M.8
-
174
-
-
0034681407
-
Essential role of phosphoinositide 3-kinase in leptin-induced K(ATP) channel activation in the rat CRI-G1 insulinoma cell line
-
DOI 10.1074/jbc.275.7.4660
-
J. Harvey, N. G. McKay, K. S. Walker, J. Van der Kaay, C. P. Downes & M. L. J. Ashford: Essential Role of Phosphoinositide 3-Kinase in Leptin-inducedK ATP Channel Activation in the Rat CRI-G1 Insulinoma Cell Line. J Biol Chem, 275, 4660-4669 (2000) (Pubitemid 30108852)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.7
, pp. 4660-4669
-
-
Harvey, J.1
McKay, N.G.2
Walker, K.S.3
Van Der Kaay, J.4
Downes, C.P.5
Ashford, M.L.J.6
-
175
-
-
40849083773
-
Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice
-
DOI 10.1210/en.2007-1307
-
A. S. Metlakunta, M. Sahu & A. Sahu: Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice. Endocrinology, 149, 1121-8 (2008) (Pubitemid 351397951)
-
(2008)
Endocrinology
, vol.149
, Issue.3
, pp. 1121-1128
-
-
Metlakunta, A.S.1
Sahu, M.2
Sahu, A.3
-
176
-
-
0035950093
-
Intracellular signalling: Key enzyme in leptin-induced anorexia
-
K. D. Niswender, G. J. Morton, W. H. Stearns, C. J. Rhodes, M. G. Myers & M. W. Schwartz: Intracellular signalling - Key enzyme in leptin-induced anorexia. Nature, 413, 794-795 (2001) (Pubitemid 33026839)
-
(2001)
Nature
, vol.413
, Issue.6858
, pp. 794-795
-
-
Niswender, K.D.1
Morton, G.J.2
Stearns, W.H.3
Rhodes, C.J.4
Myers Jr., M.G.5
Schwartz, M.W.6
-
177
-
-
36448941416
-
Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation
-
DOI 10.1016/j.cmet.2007.10.012, PII S1550413107003051
-
L. Plum, E. Rother, H. Munzberg, F. T. Wunderlich, D. A. Morgan, B. Hampel, M. Shanabrough, R. Janoschek, A. C. Konner, J. Alber, A. Suzuki, W. Krone, T. L. Horvath, K. Rahmouni & J. C. Bruning: Enhanced leptinstimulated PI3K activation in the CNS promotes white adipose tissue transdifferentiation. Cell Metab, 6, 431-45 (2007) (Pubitemid 350163053)
-
(2007)
Cell Metabolism
, vol.6
, Issue.6
, pp. 431-445
-
-
Plum, L.1
Rother, E.2
Munzberg, H.3
Wunderlich, F.T.4
Morgan, D.A.5
Hampel, B.6
Shanabrough, M.7
Janoschek, R.8
Konner, A.C.9
Alber, J.10
Suzuki, A.11
Krone, W.12
Horvath, T.L.13
Rahmouni, K.14
Bruning, J.C.15
-
178
-
-
33745819212
-
ATP channel activation and leads to diet-sensitive obesity
-
DOI 10.1172/JCI27123
-
L. Plum, X. S. Ma, B. Hampel, N. Balthasar, R. Coppari, H. Munzberg, M. Shanabrough, D. Burdakov, E. Rother, R. Janoschek, J. Alber, B. F. Belgardt, L. Koch, J. Seibler, F. Schwenk, C. Fekete, A. Suzuki, T. W. Mak, W. Krone, T. L. Horvath, F. M. Ashcroft & J. C. Bruning: Enhanced PIP3 signaling in POMC neurons causes K-ATP channel activation and leads to diet-sensitive obesity. J Clin Invest, 116, 1886-1901 (2006) (Pubitemid 44033313)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.7
, pp. 1886-1901
-
-
Plum, L.1
Ma, X.2
Hampel, B.3
Balthasar, N.4
Coppari, R.5
Munzberg, H.6
Shanabrough, M.7
Burdakov, D.8
Rother, E.9
Janoschek, R.10
Alber, J.11
Belgardt, B.F.12
Koch, L.13
Seibler, J.14
Schwenk, F.15
Fekete, C.16
Suzuki, A.17
Mak, T.W.18
Krone, W.19
Horvath, T.L.20
Ashcroft, F.M.21
Bruning, J.C.22
more..
-
179
-
-
41549108590
-
PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response
-
DOI 10.1016/j.cmet.2008.01.006, PII S1550413108000077
-
B. F. Belgardt, A. Husch, E. Rother, M. B. Ernst, F. T. Wunderlich, B. Hampel, T. Klockener, D. Alessi, P. Kloppenburg & J. C. Bruning: PDK1 deficiency in POMCExpressing cells reveals FOXO1-dependent and - independent pathways in control of energy homeostasis and stress response. Cell Metab, 7, 291-301 (2008) (Pubitemid 351467391)
-
(2008)
Cell Metabolism
, vol.7
, Issue.4
, pp. 291-301
-
-
Belgardt, B.F.1
Husch, A.2
Rother, E.3
Ernst, M.B.4
Wunderlich, F.T.5
Hampel, B.6
Klockener, T.7
Alessi, D.8
Kloppenburg, P.9
Bruning, J.C.10
-
180
-
-
16844369740
-
PI3K integrates the action of insulin and leptin on hypothalamic neurons
-
DOI 10.1172/JCI200524301
-
A. W. Xu, C. B. Kaelin, K. Takeda, S. Akira, M. W. Schwartz & G. S. Barsh: PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest, 115, 951-8 (2005) (Pubitemid 40489399)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.4
, pp. 951-958
-
-
Xu, A.W.1
Kaelin, C.B.2
Takeda, K.3
Akira, S.4
Schwartz, M.W.5
Barsh, G.S.6
-
181
-
-
0034457883
-
In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
-
DOI 10.1210/en.141.7.2328
-
Y.-B. Kim, S. Uotani, D. D. Pierroz, J. S. Flier & B. B. Kahn: In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin. Endocrinology, 141, 2328-2339 (2000) (Pubitemid 32269051)
-
(2000)
Endocrinology
, vol.141
, Issue.7
, pp. 2328-2339
-
-
Kim, Y.-B.1
Uotani, S.2
Pierroz, D.D.3
Flier, J.S.4
Kahn, B.B.5
-
182
-
-
0037288941
-
Insulin and leptin revisited: Adiposity signals with overlapping physiological and intracellular signaling capabilities
-
DOI 10.1016/S0091-3022(02)00105-X
-
K. D. Niswender & M. W. Schwartz: Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Frontiers in Neuroendocrinology, 24, 1-10 (2003) (Pubitemid 36263453)
-
(2003)
Frontiers in Neuroendocrinology
, vol.24
, Issue.1
, pp. 1-10
-
-
Niswender, K.D.1
Schwartz, M.W.2
-
183
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
J. C. Bruning, D. Gautam, D. J. Burks, J. Gillette, M. Schubert, P. C. Orban, R. Klein, W. Krone, D. Muller- Wieland & C. R. Kahn: Role of Brain Insulin Receptor in Control of Body Weight and Reproduction. Science, 289, 2122-2125 (2000)
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Bruning, J.C.1
Gautam, D.2
Burks, D.J.3
Gillette, J.4
Schubert, M.5
Orban, P.C.6
Klein, R.7
Krone, W.8
Muller- Wieland, D.9
Kahn, C.R.10
-
184
-
-
30044447631
-
Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
-
G. J. Morton, R. W. Gelling, K. D. Niswender, C. D. Morrison, C. J. Rhodes & M. W. Schwartz: Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab, 2, 411-420 (2005)
-
(2005)
Cell Metab
, vol.2
, pp. 411-420
-
-
Morton, G.J.1
Gelling, R.W.2
Niswender, K.D.3
Morrison, C.D.4
Rhodes, C.J.5
Schwartz, M.W.6
-
185
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
-
B. B. Kahn, T. Alquier, D. Carling & D. G. Hardie: AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab, 1, 15-25 (2005) (Pubitemid 43960587)
-
(2005)
Cell Metabolism
, vol.1
, Issue.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
186
-
-
34547651092
-
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
-
DOI 10.1172/JCI31516
-
M. Claret, M. A. Smith, R. L. Batterham, C. Selman, A. I. Choudhury, L. G. D. Fryer, M. Clements, H. Al- Qassab, H. Heffron, A. W. Xu, J. R. Speakman, G. S. Barsh, B. Viollet, S. Vaulont, M. L. J. Ashford, D. Carling & D. J. Withers: AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest, 117, 2325-2336 (2007) (Pubitemid 47219577)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.8
, pp. 2325-2336
-
-
Claret, M.1
Smith, M.A.2
Batterham, R.L.3
Selman, C.4
Choudhury, A.I.5
Fryer, L.G.D.6
Clements, M.7
Al-Qassab, H.8
Heffron, H.9
Xu, A.W.10
Speakman, J.R.11
Barsh, G.S.12
Viollet, B.13
Vaulont, S.14
Ashford, M.L.J.15
Carling, D.16
Withers, D.J.17
-
187
-
-
33750333938
-
Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway
-
DOI 10.1016/j.bbrc.2006.10.015, PII S0006291X06022480
-
S. Uotani, T. Abe & Y. Yamaguchi: Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2- dependent pathway. Biochem. Biophys. Res. Commun, 351, 171-175 (2006) (Pubitemid 44635422)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.351
, Issue.1
, pp. 171-175
-
-
Uotani, S.1
Abe, T.2
Yamaguchi, Y.3
-
188
-
-
1842582870
-
AMP-activated Protein Kinase Plays a Role in the Control of Food Intake
-
DOI 10.1074/jbc.C300557200
-
U. Andersson, K. Filipsson, C. R. Abbott, A. Woods, K. Smith, S. R. Bloom, D. Carling & C. J. Small: AMPactivated protein kinase plays a role in the control of food intake. J Biol Chem, 279, 12005-8 (2004) (Pubitemid 38445761)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.13
, pp. 12005-12008
-
-
Andersson, U.1
Filipsson, K.2
Abbott, C.R.3
Woods, A.4
Smith, K.5
Bloom, S.R.6
Carling, D.7
Small, C.J.8
-
189
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
DOI 10.1038/nature02440
-
Y. Minokoshi, T. Alquier, N. Furukawa, Y. B. Kim, A. Lee, B. Xue, J. Mu, F. Foufelle, P. Ferre, M. J. Birnbaum, B. J. Stuck & B. B. Kahn: AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature, 428, 569-74 (2004) (Pubitemid 38480541)
-
(2004)
Nature
, vol.428
, Issue.6982
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
Furukawa, H.3
Kim, Y.-B.4
Lee, A.5
Xue, B.6
Mu, J.7
Foufelle, F.8
Ferre, P.9
Birnbaum, M.J.10
Stuck, B.J.11
Kahn, B.B.12
-
190
-
-
36849071229
-
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake
-
DOI 10.1073/pnas.0708385104
-
S. Gao, K. P. Kinzig, S. Aja, K. A. Scott, W. Keung, S. Kelly, K. Strynadka, S. Chohnan, W. W. Smith, K. L. K. Tamashiro, E. E. Ladenheim, G. V. Ronnett, Y. Tu, M. J. Birnbaum, G. D. Lopaschuk & T. H. Moran: Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci USA, 104, 17358-17363 (2007) (Pubitemid 350219847)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.44
, pp. 17358-17363
-
-
Gao, S.1
Kinzig, K.P.2
Aja, S.3
Scott, K.A.4
Keung, W.5
Kelly, S.6
Strynadka, K.7
Chohnan, S.8
Smith, W.W.9
Tamashiro, K.L.K.10
Ladenheim, E.E.11
Ronnett, G.V.12
Tu, Y.13
Birnbaum, M.J.14
Lopaschuk, G.D.15
Moran, T.H.16
-
191
-
-
42649105456
-
Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance
-
DOI 10.1016/j.cmet.2008.02.011, PII S1550413108000703
-
K. A. Anderson, T. J. Ribar, F. M. Lin, P. K. Noeldner, M. F. Green, M. J. Muehlbauer, L. A. Witters, B. E. Kemp & A. R. Means: Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab, 7, 377-388 (2008) (Pubitemid 351598022)
-
(2008)
Cell Metabolism
, vol.7
, Issue.5
, pp. 377-388
-
-
Anderson, K.A.1
Ribar, T.J.2
Lin, F.3
Noeldner, P.K.4
Green, M.F.5
Muehlbauer, M.J.6
Witters, L.A.7
Kemp, B.E.8
Means, A.R.9
-
192
-
-
53549133638
-
The Creb1 coactivator Crtc1 is required for energy balance and fertility
-
J. Y. Altarejos, N. Goebel, M. D. Conkright, H. Inotiel, J. X. Xie, C. M. Arias, P. E. Sawchenko & M. Montminy: The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med, 14, 1112-1117 (2008)
-
(2008)
Nat Med
, vol.14
, pp. 1112-1117
-
-
Altarejos, J.Y.1
Goebel, N.2
Conkright, M.D.3
Inotiel, H.4
Xie, J.X.5
Arias, C.M.6
Sawchenko, P.E.7
Montminy, M.8
-
193
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
-
DOI 10.1038/nature03967, PII N03967
-
S. H. Koo, L. Flechner, L. Qi, X. M. Zhang, R. A. Screaton, S. Jeffries, S. Hedrick, W. Xu, F. Boussouar, P. Brindle, H. Takemori & M. Montminy: The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature, 437, 1109-1114 (2005) (Pubitemid 41509342)
-
(2005)
Nature
, vol.437
, Issue.7062
, pp. 1109-1114
-
-
Koo, S.-H.1
Flechner, L.2
Qi, L.3
Zhang, X.4
Screaton, R.A.5
Jeffries, S.6
Hedrick, S.7
Xu, W.8
Boussouar, F.9
Brindle, P.10
Takemori, H.11
Montminy, M.12
-
194
-
-
56449115916
-
Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis
-
C. Blouet, H. Ono & G. J. Schwartz: Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis. Cell Metab, 8, 459-467 (2008)
-
(2008)
Cell Metab
, vol.8
, pp. 459-467
-
-
Blouet, C.1
Ono, H.2
Schwartz, G.J.3
-
195
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
DOI 10.1038/ncb839
-
K. Inoki, Y. Li, T. Q. Zhu, J. Wu & K. L. Guan: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol, 4, 648-657 (2002) (Pubitemid 34993700)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.9
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.-L.5
-
196
-
-
0345167800
-
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
-
DOI 10.1016/S0092-8674(03)00929-2
-
K. Inoki, T. Q. Zhu & K. L. Guan: TSC2 mediates cellular energy response to control cell growth and survival. Cell, 115, 577-590 (2003) (Pubitemid 37506046)
-
(2003)
Cell
, vol.115
, Issue.5
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.-L.3
-
197
-
-
63449109316
-
Critical role for hypothalamic mTOR activity in energy balance
-
H. Mori, K. Inoki, H. Munzberg, D. Opland, M. Faouzi, E. C. Villanueva, T. Ikenoue, D. Kwiatkowski, O. A. MacDougald, M. G. Myers & K. L. Guan: Critical Role for Hypothalamic mTOR Activity in Energy Balance. Cell Metab, 9, 362-374 (2009)
-
(2009)
Cell Metab
, vol.9
, pp. 362-374
-
-
Mori, H.1
Inoki, K.2
Munzberg, H.3
Opland, D.4
Faouzi, M.5
Villanueva, E.C.6
Ikenoue, T.7
Kwiatkowski, D.8
MacDougald, O.A.9
Myers, M.G.10
Guan, K.L.11
-
198
-
-
78049518304
-
Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition
-
S. K. Chun & Y.-H. Jo: Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition. J Neurophysiol 104, 2321-2328 (2010)
-
(2010)
J Neurophysiol
, vol.104
, pp. 2321-2328
-
-
Chun, S.K.1
Jo, Y.-H.2
-
199
-
-
3142546889
-
Low levels of expression of leptin receptor at the cell surface result from constitutive endocytosis and intracellular retention in the biosynthetic pathway
-
DOI 10.1074/jbc.M400508200
-
S. Belouzard, D. Delcroix & Y. Rouille: Low levels of expression of leptin receptor at the cell surface result from constitutive endocytosis and intracellular retention in the biosynthetic pathway. J Biol Chem, 279, 28499-28508 (2004) (Pubitemid 38900132)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.27
, pp. 28499-28508
-
-
Belouzard, S.1
Delcroix, D.2
Rouille, Y.3
-
200
-
-
0033597897
-
Subcellular localization and internalization of the four human leptin receptor isoforms
-
V. A. Barr, K. Lane & S. I. Taylor: Subcellular localization and internalization of the four human leptin receptor isoforms. J Biol Chem, 274, 21416-21424 (1999)
-
(1999)
J Biol Chem
, vol.274
, pp. 21416-21424
-
-
Barr, V.A.1
Lane, K.2
Taylor, S.I.3
-
201
-
-
0034639235
-
Expression and intracellular localization of leptin receptor long isoform-GFP chimera
-
A. Lundin, H. Rondahl, E. Walum & M. Wilcke: Expression and intracellular localization of leptin receptor long isoform-GFP chimera. Biochimica Et Biophysica Acta-Molecular Cell Research, 1499, 130-138 (2000)
-
(2000)
Biochimica et Biophysica Acta-Molecular Cell Research
, vol.1499
, pp. 130-138
-
-
Lundin, A.1
Rondahl, H.2
Walum, E.3
Wilcke, M.4
-
202
-
-
33644864967
-
Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis
-
DOI 10.1038/sj.emboj.7600989, PII 7600989
-
S. Belouzard & Y. Rouille: Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis. Embo J, 25, 932-942 (2006) (Pubitemid 43372108)
-
(2006)
EMBO Journal
, vol.25
, Issue.5
, pp. 932-942
-
-
Belouzard, S.1
Rouille, Y.2
-
203
-
-
67651112055
-
Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status
-
S. E. Mitchell, R. Nogueiras, A. Morris, S. Tovar, C. Grant, M. Cruickshank, D. V. Rayner, C. Dieguez & L. M. Williams: Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status. J Physiol, 587, 3573-3585 (2009)
-
(2009)
J Physiol
, vol.587
, pp. 3573-3585
-
-
Mitchell, S.E.1
Nogueiras, R.2
Morris, A.3
Tovar, S.4
Grant, C.5
Cruickshank, M.6
Rayner, D.V.7
Dieguez, C.8
Williams, L.M.9
-
204
-
-
63149175815
-
Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling
-
S. J. Seo, D. F. Guo, K. Bugge, D. A. Morgan, K. Rahmouni & V. C. Sheffield: Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Hum Mol Genet, 18, 1323-1331 (2009)
-
(2009)
Hum Mol Genet
, vol.18
, pp. 1323-1331
-
-
Seo, S.J.1
Guo, D.F.2
Bugge, K.3
Morgan, D.A.4
Rahmouni, K.5
Sheffield, V.C.6
-
205
-
-
41849134729
-
Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
-
DOI 10.1172/JCI32357
-
K. Rahmouni, M. A. Fath, S. Seo, D. R. Thedens, C. J. Berry, R. Weiss, D. Y. Nishimura & V. C. Sheffield: Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome. J Clin Invest, 118, 1458-1467 (2008) (Pubitemid 351500439)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.4
, pp. 1458-1467
-
-
Rahmouni, K.1
Fath, M.A.2
Seo, S.3
Thedens, D.R.4
Berry, C.J.5
Weiss, R.6
Nishimura, D.Y.7
Sheffield, V.C.8
-
206
-
-
37649014797
-
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity
-
C. Couturier, C. Sarkis, K. Séron, S. Belouzard, P. Chen, A. Lenain, L. Corset, J. Dam, V. Vauthier, A. Dubart, J. Mallet, P. Froguel, Y. Rouillé & R. Jockers: Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. Proc Natl Acad Sci USA, 104, 19476-19481 (2007)
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19476-19481
-
-
Couturier, C.1
Sarkis, C.2
Séron, K.3
Belouzard, S.4
Chen, P.5
Lenain, A.6
Corset, L.7
Dam, J.8
Vauthier, V.9
Dubart, A.10
Mallet, J.11
Froguel, P.12
Rouillé, Y.13
Jockers, R.14
-
207
-
-
64149130937
-
Leptin resistance: A predisposing factor for diet-induced obesity
-
P. J. Scarpace & Y. Zhang: Leptin resistance: a predisposing factor for diet-induced obesity. Am J Physiol Regul Integr Comp Physiol, 296, R493-500 (2009)
-
(2009)
Am J Physiol Regul Integr Comp Physiol
, vol.296
-
-
Scarpace, P.J.1
Zhang, Y.2
-
208
-
-
15444366416
-
1138 of the leptin receptor and suppressor of cytokine signaling 3
-
DOI 10.1210/me.2004-0353
-
S. L. Dunn, M. Bjornholm, S. H. Bates, Z. B. Chen, M. Seifert & M. G. Myers: Feedback inhibition of leptin receptor/Jak2 signaling via Tyr(1138) of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol, 19, 925-938 (2005) (Pubitemid 40397057)
-
(2005)
Molecular Endocrinology
, vol.19
, Issue.4
, pp. 925-938
-
-
Dunn, S.L.1
Bjornholm, M.2
Bates, S.H.3
Chen, Z.4
Seifert, M.5
Myers Jr., M.G.6
-
209
-
-
0034548763
-
Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor
-
S. Eyckerman, D. Broekaert, A. Verhee, J. Vandekerckhove & J. Tavernier: Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor. FEBS Lett, 486, 33-7 (2000)
-
(2000)
FEBS Lett
, vol.486
, pp. 33-37
-
-
Eyckerman, S.1
Broekaert, D.2
Verhee, A.3
Vandekerckhove, J.4
Tavernier, J.5
-
210
-
-
0033569730
-
The role of SOCS-3 in leptin signaling and leptin resistance
-
C. Bjorbaek, K. El-Haschimi, J. D. Frantz & J. S. Flier: The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem, 274, 30059-30065 (1999)
-
(1999)
J Biol Chem
, vol.274
, pp. 30059-30065
-
-
Bjorbaek, C.1
El-Haschimi, K.2
Frantz, J.D.3
Flier, J.S.4
-
211
-
-
9244219587
-
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
-
DOI 10.1210/en.2004-0726
-
H. Munzberg, J. S. Flier & C. Bjorbaek: Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology, 145, 4880-4889 (2004) (Pubitemid 39551104)
-
(2004)
Endocrinology
, vol.145
, Issue.11
, pp. 4880-4889
-
-
Munzberg, H.1
Flier, J.S.2
Bjorbaek, C.3
-
212
-
-
3142723983
-
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
-
DOI 10.1038/nm1071
-
H. Mori, R. Hanada, T. Hanada, D. Aki, R. Mashima, H. Nishinakamura, T. Torisu, K. R. Chien, H. Yasukawa & A. Yoshimura: Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med, 10, 739-743 (2004) (Pubitemid 38937640)
-
(2004)
Nature Medicine
, vol.10
, Issue.7
, pp. 739-743
-
-
Mori, H.1
Hanada, R.2
Hanada, T.3
Aki, D.4
Mashima, R.5
Nishinakamura, H.6
Torisu, T.7
Chien, K.R.8
Yasukawa, H.9
Yoshimura, A.10
-
213
-
-
3142782772
-
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
-
DOI 10.1038/nm1072
-
J. K. Howard, B. J. Cave, L. J. Oksanen, I. Tzameli, C. Bjorbaek & J. S. Flier: Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med, 10, 734-738 (2004) (Pubitemid 38937639)
-
(2004)
Nature Medicine
, vol.10
, Issue.7
, pp. 734-738
-
-
Howard, J.K.1
Cave, B.J.2
Oksanen, L.J.3
Tzameli, I.4
Bjoorbaek, C.5
Flier, J.S.6
-
214
-
-
33746537247
-
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
-
DOI 10.1016/j.cmet.2006.06.010, PII S1550413106002427
-
P. Kievit, J. K. Howard, M. K. Badman, N. Balthasar, R. Coppari, H. Mori, C. E. Lee, J. K. Elmquist, A. Yoshimura & J. S. Flier: Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab, 4, 123-132 (2006) (Pubitemid 44138722)
-
(2006)
Cell Metabolism
, vol.4
, Issue.2
, pp. 123-132
-
-
Kievit, P.1
Howard, J.K.2
Badman, M.K.3
Balthasar, N.4
Coppari, R.5
Mori, H.6
Lee, C.E.7
Elmquist, J.K.8
Yoshimura, A.9
Flier, J.S.10
-
215
-
-
77951194676
-
Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis
-
A. S. Reed, E. K. Unger, L. E. Olofsson, M. L. Piper, M. G. Myers & A. W. Xu: Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis. Diabetes, 59, 894-906 (2010)
-
(2010)
Diabetes
, vol.59
, pp. 894-906
-
-
Reed, A.S.1
Unger, E.K.2
Olofsson, L.E.3
Piper, M.L.4
Myers, M.G.5
Xu, A.W.6
-
216
-
-
33745510082
-
A complex interaction pattern of CIS and SOCS2 with the leptin receptor
-
DOI 10.1242/jcs.02947
-
D. Lavens, T. Montoye, J. Piessevaux, L. Zabeau, J. Vandekerckhove, K. Gevaert, W. Becker, S. Eyckerman & J. Tavernier: A complex interaction pattern of CIS and SOCS2 with the leptin receptor. J Cell Sci, 119, 2214-2224 (2006) (Pubitemid 43960311)
-
(2006)
Journal of Cell Science
, vol.119
, Issue.11
, pp. 2214-2224
-
-
Lavens, D.1
Montoye, T.2
Piessevaux, J.3
Zabeau, L.4
Vandekerchove, J.5
Gevaert, K.6
Becker, W.7
Eyckerman, S.8
Tavernier, J.9
-
217
-
-
33845947684
-
Functional cross-modulation between SOCS proteins can stimulate cytokine signaling
-
DOI 10.1074/jbc.M600776200
-
J. Piessevaux, D. Lavens, T. Montoye, J. Wauman, D. Catteeuw, J. Vandekerckhove, D. Belsham, F. Peelman & J. Tavernier: Functional cross-modulation between SOCS proteins can stimulate cytokine signaling. J Biol Chem, 281, 32953-66 (2006) (Pubitemid 46036680)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.44
, pp. 32953-32966
-
-
Piessevaux, J.1
Lavens, D.2
Montoye, T.3
Wauman, J.4
Catteeuw, D.5
Vandekerckhove, J.6
Belsham, D.7
Peelman, F.8
Tavernier, J.9
-
218
-
-
0037201559
-
Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line
-
DOI 10.1016/S0303-7207(02)00178-8, PII S0303720702001788
-
W. Kaszubska, H. D. Falls, V. G. Schaefer, D. Haasch, L. Frost, P. Hessler, P. E. Kroeger, D. W. White, M. R. Jirousek & J. M. Trevillyan: Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line. Mol Cell Endocrinol, 195, 109-118 (2002) (Pubitemid 35287166)
-
(2002)
Molecular and Cellular Endocrinology
, vol.195
, Issue.1-2
, pp. 109-118
-
-
Kaszubska, W.1
Falls, H.D.2
Schaefer, V.G.3
Haasch, D.4
Frost, L.5
Hessler, P.6
Kroeger, P.E.7
White, D.W.8
Jirousek, M.R.9
Trevillyan, J.M.10
-
219
-
-
18344379861
-
PTP1B regulates leptin signal transduction in vivo
-
DOI 10.1016/S1534-5807(02)00148-X
-
J. M. Zabolotny, K. K. Bence-Hanulec, A. Stricker- Krongrad, F. Haj, Y. Wang, Y. Minokoshi, Y.-B. Kim, J. K. Elmquist, L. A. Tartaglia, B. B. Kahn & B. G. Neel: PTP1B Regulates Leptin Signal Transduction In Vivo. Dev Cell, 2, 489-495 (2002) (Pubitemid 34436576)
-
(2002)
Developmental Cell
, vol.2
, Issue.4
, pp. 489-495
-
-
Zabolotny, J.M.1
Bence-Hanulec, K.K.2
Stricker-Krongrad, A.3
Haj, F.4
Wang, Y.5
Minokoshi, Y.6
Kim, Y.-B.7
Elmquist, J.K.8
Tartaglia, L.A.9
Kahn, B.B.10
Neel, B.G.11
-
220
-
-
33746810001
-
Neuronal PTP1B regulates body weight, adiposity and leptin action
-
DOI 10.1038/nm1435, PII NM1435
-
K. K. Bence, M. Delibegovic, B. Xue, C. Z. Gorgun, G. S. Hotamisligil, B. G. Neel & B. B. Kahn: Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med, 12, 917-924 (2006) (Pubitemid 44175143)
-
(2006)
Nature Medicine
, vol.12
, Issue.8
, pp. 917-924
-
-
Bence, K.K.1
Delibegovic, M.2
Xue, B.3
Gorgun, C.Z.4
Hotamisligil, G.S.5
Neel, B.G.6
Kahn, B.B.7
-
221
-
-
0036228770
-
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
-
DOI 10.1016/S1534-5807(02)00149-1
-
A. Cheng, N. Uetani, P. D. Simoncic, V. P. Chaubey, A. Lee-Loy, C. J. McGlade, B. P. Kennedy & M. L. Tremblay: Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B. Dev Cell, 2, 497-503 (2002) (Pubitemid 34436577)
-
(2002)
Developmental Cell
, vol.2
, Issue.4
, pp. 497-503
-
-
Cheng, A.1
Uetani, N.2
Simoncic, P.D.3
Chaubey, V.P.4
Lee-Loy, A.5
McGlade, C.J.6
Kennedy, B.P.7
Tremblay, M.L.8
-
222
-
-
47949090359
-
Saad: Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats
-
P. K. Picardi, V. C. Calegari, P. de Oliveira Prada, J. Contin Moraes, E. Araujo, M. C. C. Gomes Marcondes, M. Ueno, J. B. C. Carvalheira, L. A. Velloso & M. J. Abdalla Saad: Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats. Endocrinology, 149, 3870-3880 (2008)
-
(2008)
Endocrinology
, Issue.149
, pp. 3870-3880
-
-
Picardi, P.K.1
Calegari, V.C.2
De Oliveira Prada, P.3
Contin Moraes, J.4
Araujo, E.5
Gomes Marcondes, M.C.C.6
Ueno, M.7
Carvalheira, J.B.C.8
Velloso, L.A.9
Abdalla, M.J.10
-
223
-
-
33845882537
-
Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age
-
DOI 10.1210/en.2006-0672
-
C. D. Morrison, C. L. White, Z. Wang, S.-Y. Lee, D. S. Lawrence, W. T. Cefalu, Z.-Y. Zhang & T. W. Gettys: Increased Hypothalamic Protein Tyrosine Phosphatase 1B Contributes to Leptin Resistance with Age. Endocrinology, 148, 433-440 (2007) (Pubitemid 46021475)
-
(2007)
Endocrinology
, vol.148
, Issue.1
, pp. 433-440
-
-
Morrison, C.D.1
White, C.L.2
Wang, Z.3
Lee, S.-Y.4
Lawrence, D.S.5
Cefalu, W.T.6
Zhang, Z.-Y.7
Gettys, T.W.8
-
224
-
-
60849120123
-
HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms
-
C. L. White, A. Whittington, M. J. Barnes, Z. Wang, G. A. Bray & C. D. Morrison: HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. Am J Physiol Endocrinol Metab, 296, E291-299 (2009)
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
-
-
White, C.L.1
Whittington, A.2
Barnes, M.J.3
Wang, Z.4
Bray, G.A.5
Morrison, C.D.6
-
225
-
-
47249148827
-
Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammation in Vivo
-
J. M. Zabolotny, Y.-B. Kim, L. A. Welsh, E. E. Kershaw, B. G. Neel & B. B. Kahn: Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammation in Vivo. J Biol Chem, 283, 14230-14241 (2008)
-
(2008)
J Biol Chem
, vol.283
, pp. 14230-14241
-
-
Zabolotny, J.M.1
Kim, Y.-B.2
Welsh, L.A.3
Kershaw, E.E.4
Neel, B.G.5
Kahn, B.B.6
-
226
-
-
0033931981
-
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
-
K. El-Haschimi, D. D. Pierroz, S. M. Hileman, C. Bjorbaek & J. S. Flier: Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest, 105, 1827-1832 (2000) (Pubitemid 30421764)
-
(2000)
Journal of Clinical Investigation
, vol.105
, Issue.12
, pp. 1827-1832
-
-
El-Haschimi, K.1
Pierroz, D.D.2
Hileman, S.M.3
Bjorbaek, C.4
Flier, J.S.5
-
227
-
-
0030594830
-
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
-
DOI 10.1016/S0140-6736(96)03173-X
-
J. F. Caro, J. W. Kolaczynski, M. R. Nyce, J. P. Ohannesian, I. Opentanova, W. H. Goldman, R. B. Lynn, P. L. Zhang, M. K. Sinha & R. V. Considine: Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance. Lancet, 348, 159-161 (1996) (Pubitemid 26238099)
-
(1996)
Lancet
, vol.348
, Issue.9021
, pp. 159-161
-
-
Caro, J.F.1
Kolaczynski, J.W.2
Nyce, M.R.3
Ohannesian, J.P.4
Opentanova, I.5
Goldman, W.H.6
Lynn, R.B.7
Zhang, P.-L.8
Sinha, M.K.9
Considine, R.V.10
-
228
-
-
0029881125
-
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
-
DOI 10.1038/nm0596-589
-
M. W. Schwartz, E. Peskind, M. Raskind, E. J. Boyko & D. Porte: Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans. Nat Med, 2, 589-593 (1996) (Pubitemid 26151520)
-
(1996)
Nature Medicine
, vol.2
, Issue.5
, pp. 589-593
-
-
Schwartz, M.W.1
Peskind, E.2
Raskind, M.3
Boyko, E.J.4
Porte Jr., D.5
-
229
-
-
0029864416
-
Leptin enters the brain by a saturable system independent of insulin
-
DOI 10.1016/0196-9781(96)00025-3
-
W. A. Banks, A. J. Kastin, W. T. Huang, J. B. Jaspan & L. M. Maness: Leptin enters the brain by a saturable system independent of insulin. Peptides, 17, 305-311 (1996) (Pubitemid 26124406)
-
(1996)
Peptides
, vol.17
, Issue.2
, pp. 305-311
-
-
Banks, W.A.1
Kastin, A.J.2
Huang, W.3
Jaspan, J.B.4
Maness, L.M.5
-
230
-
-
0033395851
-
Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor
-
DOI 10.1016/S0196-9781(99)00156-4, PII S0196978199001564
-
A. J. Kastin, W. H. Pan, L. M. Maness, R. J. Koletsky & P. Ernsberger: Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides, 20, 1449-1453 (1999) (Pubitemid 30069891)
-
(1999)
Peptides
, vol.20
, Issue.12
, pp. 1449-1453
-
-
Kastin, A.J.1
Pan, W.2
Maness, L.M.3
Koletsky, R.J.4
Ernsberger, P.5
-
231
-
-
30444460361
-
Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors
-
DOI 10.1002/glia.20239
-
O. Cheunsuang & R. Morris: Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide YY1 receptors. Glia, 52, 228-233 (2005) (Pubitemid 43076153)
-
(2005)
GLIA
, vol.52
, Issue.3
, pp. 228-233
-
-
Cheunsuang, O.1
Morris, R.2
-
232
-
-
35549009434
-
Differential accessibility of circulating leptin to individual hypothalamic sites
-
DOI 10.1210/en.2007-0655
-
M. Faouzi, R. Leshan, M. Bjornholm, T. Hennessey, J. Jones & H. Munzberg: Differential accessibility of circulating leptin to individual hypothalamic sites. Endocrinology, 148, 5414-5423 (2007) (Pubitemid 350012627)
-
(2007)
Endocrinology
, vol.148
, Issue.11
, pp. 5414-5423
-
-
Faouzi, M.1
Leshan, R.2
Bjornholm, M.3
Hennessey, T.4
Jones, J.5
Munzberg, H.6
-
233
-
-
33750043782
-
Development of leptin antagonists and their potential use in experimental biology and medicine
-
DOI 10.1016/j.tem.2006.09.006, PII S1043276006001780
-
A. Gertler: Development of leptin antagonists and their potential use in experimental biology and medicine. Trends Endocrinol Metab, 17, 372-378 (2006) (Pubitemid 44584733)
-
(2006)
Trends in Endocrinology and Metabolism
, vol.17
, Issue.9
, pp. 372-378
-
-
Gertler, A.1
-
234
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
DOI 10.1038/nrm2199, PII NRM2199
-
D. Ron & P. Walter: Signal integration in the endoplasmic reticulum unfolded protein response. Nat Res Mol Cell Biol, 8, 519-529 (2007) (Pubitemid 46985379)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.7
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
235
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
DOI 10.1126/science.1103160
-
U. Ozcan, Q. Cao, E. Yilmaz, A.-H. Lee, N. N. Iwakoshi, E. Ozdelen, G. Tuncman, C. Gorgun, L. H. Glimcher & G. S. Hotamisligil: Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes. Science, 306, 457-461 (2004) (Pubitemid 39372439)
-
(2004)
Science
, vol.306
, Issue.5695
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.-H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
236
-
-
57849115277
-
Endoplasmic reticulum stress plays a central role in development of leptin resistance
-
L. Ozcan, A. S. Ergin, A. Lu, J. Chung, S. Sarkar, D. Nie, M. G. Myers Jr & U. Ozcan: Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance. Cell Metab, 9, 35-51 (2009)
-
(2009)
Cell Metab
, vol.9
, pp. 35-51
-
-
Ozcan, L.1
Ergin, A.S.2
Lu, A.3
Chung, J.4
Sarkar, S.5
Nie, D.6
Myers Jr., M.G.7
Ozcan, U.8
-
237
-
-
52949096557
-
Hypothalamic IKK[beta]/NF-[kappa]B and ER stress link overnutrition to energy imbalance and obesity
-
X. Zhang, G. Zhang, H. Zhang, M. Karin, H. Bai & D. Cai: Hypothalamic IKK[beta]/NF-[kappa]B and ER Stress Link Overnutrition to Energy Imbalance and Obesity. Cell, 135, 61-73 (2008)
-
(2008)
Cell
, vol.135
, pp. 61-73
-
-
Zhang, X.1
Zhang, G.2
Zhang, H.3
Karin, M.4
Bai, H.5
Cai, D.6
-
238
-
-
56749112559
-
Endoplasmic reticulum stress induces leptin resistance
-
T. Hosoi, M. Sasaki, T. Miyahara, C. Hashimoto, S. Matsuo, M. Yoshii & K. Ozawa: Endoplasmic Reticulum Stress Induces Leptin Resistance. Mol Pharmacol, 74, 1610-1619 (2008)
-
(2008)
Mol Pharmacol
, vol.74
, pp. 1610-1619
-
-
Hosoi, T.1
Sasaki, M.2
Miyahara, T.3
Hashimoto, C.4
Matsuo, S.5
Yoshii, M.6
Ozawa, K.7
-
239
-
-
77956827261
-
IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition
-
E. R. Ropelle, M. B. Flores, D. E. Cintra, G. Z. Rocha, J. R. Pauli, J. Morari, C. T. de Souza, J. C. Moraes, P. O. Prada, D. Guadagnini, R. M. Marin, A. G. Oliveira, T. M. Augusto, H. F. Carvalho, L. A. Velloso, M. J. A. Saad & J. B. C. Carvalheira: IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKbeta and ER Stress Inhibition. PLoS Biol, 8, e1000465 (2010)
-
(2010)
PLoS Biol
, vol.8
-
-
Ropelle, E.R.1
Flores, M.B.2
Cintra, D.E.3
Rocha, G.Z.4
Pauli, J.R.5
Morari, J.6
De Souza, C.T.7
Moraes, J.C.8
Prada, P.O.9
Guadagnini, D.10
Marin, R.M.11
Oliveira, A.G.12
Augusto, T.M.13
Carvalho, H.F.14
Velloso, L.A.15
Saad, M.J.A.16
Carvalheira, J.B.C.17
-
240
-
-
24944438230
-
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
-
DOI 10.1210/en.2004-1520
-
C. T. de Souza, E. P. Araujo, S. Bordin, R. Ashimine, R. L. Zollner, A. C. Boschero, M. J. A. Saad & L. A. Velloso: Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus. Endocrinology, 146, 4192-4199 (2005) (Pubitemid 41324012)
-
(2005)
Endocrinology
, vol.146
, Issue.10
, pp. 4192-4199
-
-
De Souza, C.T.1
Araujo, E.P.2
Bordin, S.3
Ashimine, R.4
Zollner, R.L.5
Boschero, A.C.6
Saad, M.J.A.7
Velloso, L.A.8
-
241
-
-
58849149821
-
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity
-
M. Milanski, G. Degasperi, A. Coope, J. Morari, R. Denis, D. E. Cintra, D. M. L. Tsukumo, G. Anhe, M. E. Amaral, H. K. Takahashi, R. Curi, H. C. Oliveira, J. B. C. Carvalheira, S. Bordin, M. J. Saad & L. A. Velloso: Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity. J. Neurosci., 29, 359-370 (2009)
-
(2009)
J. Neurosci.
, vol.29
, pp. 359-370
-
-
Milanski, M.1
Degasperi, G.2
Coope, A.3
Morari, J.4
Denis, R.5
Cintra, D.E.6
Tsukumo, D.M.L.7
Anhe, G.8
Amaral, M.E.9
Takahashi, H.K.10
Curi, R.11
Oliveira, H.C.12
Carvalheira, J.B.C.13
Bordin, S.14
Saad, M.J.15
Velloso, L.A.16
-
242
-
-
70349484212
-
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
-
A. Kleinridders, D. Schenten, A. C. Könner, B. F. Belgardt, J. Mauer, T. Okamura, F. T. Wunderlich, R. Medzhitov & J. C. Brüning: MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity. Cell Metab, 10, 249-259 (2009)
-
(2009)
Cell Metab
, vol.10
, pp. 249-259
-
-
Kleinridders, A.1
Schenten, D.2
Könner, A.C.3
Belgardt, B.F.4
Mauer, J.5
Okamura, T.6
Wunderlich, F.T.7
Medzhitov, R.8
Brüning, J.C.9
-
243
-
-
20644451194
-
Are STATS arginine-methylated?
-
DOI 10.1074/jbc.C400606200
-
W. Komyod,U.M. Bauer, P.C. Heinrich, S. Haan, I. Behrmann: Are STATs arginine-methylated? J Biol Chem, 280, 21700-21705 (2005) (Pubitemid 40834298)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.23
, pp. 21700-21705
-
-
Komyod, W.1
Bauer, U.-M.2
Heinrich, P.C.3
Haan, S.4
Behrmann, I.5
|