메뉴 건너뛰기




Volumn 16, Issue 7, 2011, Pages 2771-2793

Leptin receptor signaling: Pathways to leptin resistance

Author keywords

AMPK; ER stress; JAK STAT; Leptin receptor activation; Leptin receptor signaling; Leptin resistance; MAPK; PI3K; PTP1B; Review; SOCS3

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; JANUS KINASE; LEPTIN; LEPTIN RECEPTOR; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT PROTEIN; TARGET OF RAPAMYCIN KINASE;

EID: 79959565386     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3885     Document Type: Article
Times cited : (143)

References (243)
  • 1
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • DOI 10.1038/372425a0
    • Y. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold & J. M. Friedman: Positional cloning of the mouse obese gene and its human homolog. Nature, 372, 425-432 (1994) (Pubitemid 24365442)
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 3
    • 0029048408 scopus 로고
    • Recombinant mouse Ob protein - Evidence for a peripheral signal linking adiposity and central neural networks
    • L. A. Campfield, F. J. Smith, Y. Guisez, R. Devos & P. Burn: Recombinant mouse Ob protein - Evidence for a peripheral signal linking adiposity and central neural networks. Science, 269, 546-549 (1995)
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 4
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • DOI 10.1038/27376
    • J. M. Friedman & J. L. Halaas: Leptin and the regulation of body weight in mammals. Nature, 395, 763-770 (1998) (Pubitemid 28485436)
    • (1998) Nature , vol.395 , Issue.6704 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 10
    • 0033782028 scopus 로고    scopus 로고
    • Leptin in the regulation of immunity, inflammation, and hematopoiesis
    • G. Fantuzzi & R. Faggioni: Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukocyte Biol, 68, 437-446 (2000)
    • (2000) J Leukocyte Biol , vol.68 , pp. 437-446
    • Fantuzzi, G.1    Faggioni, R.2
  • 12
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression
    • DOI 10.1038/29795
    • G. M. Lord, G. Matarese, L. K. Howard, R. J. Baker, S. R. Bloom & R. I. Lechler: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature, 394, 897-901 (1998) (Pubitemid 28410912)
    • (1998) Nature , vol.394 , Issue.6696 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3    Baker, R.J.4    Bloom, S.R.5    Lechler, R.I.6
  • 15
    • 32644436318 scopus 로고    scopus 로고
    • Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo
    • DOI 10.1210/en.2005-0731
    • W. Huang, N. Dedousis, A. Bandi, G. D. Lopaschuk & R. M. O'Doherty: Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo. Endocrinology, 147, 1480-1487 (2006) (Pubitemid 43244383)
    • (2006) Endocrinology , vol.147 , Issue.3 , pp. 1480-1487
    • Huang, W.1    Dedousis, N.2    Bandi, A.3    Lopaschuk, G.D.4    O'Doherty, R.M.5
  • 16
    • 17844373625 scopus 로고    scopus 로고
    • Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis
    • DOI 10.1016/j.cmet.2005.02.001, PII S1550413105000549
    • S. H. Bates, R. N. Kulkarni, M. Seifert & M. G. Myers: Roles for leptin receptor/STAT3-dependent and - independent signals in the regulation of glucose homeostasis. Cell Metab, 1, 169-178 (2005) (Pubitemid 43960601)
    • (2005) Cell Metabolism , vol.1 , Issue.3 , pp. 169-178
    • Bates, S.H.1    Kulkarni, R.N.2    Seifert, M.3    Myers Jr., M.G.4
  • 19
    • 20744460050 scopus 로고    scopus 로고
    • Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains
    • DOI 10.1074/jbc.M413308200
    • L. Zabeau, D. Defeau, H. Iserentant, J. Vandekerckhove, F. Peelman & J. Tavernier: Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains. J Biol Chem, 280, 22632-22640 (2005) (Pubitemid 40853167)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.24 , pp. 22632-22640
    • Zabeau, L.1    Defeau, D.2    Iserentant, H.3    Vandekerckhove, J.4    Peelman, F.5    Tavernier, J.6
  • 20
    • 0347286631 scopus 로고    scopus 로고
    • Functional Analysis of Leptin Receptor Activation Using a Janus Kinase/Signal Transducer and Activator of Transcription Complementation Assay
    • DOI 10.1210/me.2003-0078
    • L. Zabeau, D. Defeau, J. Van der Heyden, H. Iserentant, J. Vandekerckhove & J. Tavernier: Functional analysis of leptin receptor activation using a Janus kinase/signal transducer and activator of transcription complementation assay. Mol Endocrinol, 18, 150-161 (2004) (Pubitemid 38073161)
    • (2004) Molecular Endocrinology , vol.18 , Issue.1 , pp. 150-161
    • Zabeau, L.1    Defeau, D.2    Van Der Heyden, J.3    Iserentant, H.4    Vandekerckhove, J.5    Tavernier, J.6
  • 24
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    • S. C. Chua, W. K. Chung, X. S. WuPeng, Y. Y. Zhang, S. M. Liu, L. Tartaglia & R. L. Leibel: Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science, 271, 994-996 (1996) (Pubitemid 26066874)
    • (1996) Science , vol.271 , Issue.5251 , pp. 994-996
    • Chua Jr., S.C.1    Chung, W.K.2    Wu-Peng, X.S.3    Zhang, Y.4    Liu, S.-M.5    Tartaglia, L.6    Leibel, R.L.7
  • 29
    • 0035145908 scopus 로고    scopus 로고
    • Transgenic complementation of leptin-receptor deficiency
    • T. J. Kowalski, S.-M. Liu, R. L. Leibel & S. C. Chua: Transgenic Complementation of Leptin-Receptor Deficiency. Diabetes, 50, 425-435 (2001)
    • (2001) Diabetes , vol.50 , pp. 425-435
    • Kowalski, T.J.1    Liu, S.-M.2    Leibel, R.L.3    Chua, S.C.4
  • 31
    • 0031963436 scopus 로고    scopus 로고
    • Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
    • M. L. Hakansson, H. Brown, N. Ghilardi, R. C. Skoda & B. Meister: Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci, 18, 559-572 (1998) (Pubitemid 28046812)
    • (1998) Journal of Neuroscience , vol.18 , Issue.1 , pp. 559-572
    • Hakansson, M.-L.1    Brown, H.2    Ghilardi, N.3    Skoda, R.C.4    Meister, B.5
  • 32
    • 77951528099 scopus 로고    scopus 로고
    • Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala
    • R. L. Leshan, D. M. Opland, G. W. Louis, G. M. Leinninger, C. M. Patterson, C. J. Rhodes, H. Munzberg & M. G. Myers: Ventral Tegmental Area Leptin Receptor Neurons Specifically Project to and Regulate Cocaine- and Amphetamine-Regulated Transcript Neurons of the Extended Central Amygdala. J Neurosci, 30, 5713-5723 (2010)
    • (2010) J Neurosci , vol.30 , pp. 5713-5723
    • Leshan, R.L.1    Opland, D.M.2    Louis, G.W.3    Leinninger, G.M.4    Patterson, C.M.5    Rhodes, C.J.6    Munzberg, H.7    Myers, M.G.8
  • 35
    • 58749086043 scopus 로고    scopus 로고
    • The geometry of leptin action in the brain: More complicated than a simple ARC
    • M. G. Myers, H. Munzberg, G. M. Leinninger & R. L. Leshan: The Geometry of Leptin Action in the Brain: More Complicated Than a Simple ARC. Cell Metab, 9, 117-123 (2009)
    • (2009) Cell Metab , vol.9 , pp. 117-123
    • Myers, M.G.1    Munzberg, H.2    Leinninger, G.M.3    Leshan, R.L.4
  • 38
    • 0032130554 scopus 로고    scopus 로고
    • Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    • T. M. Hahn, J. F. Breininger, D. G. Baskin & M. W. Schwartz: Coexpression of Agrp and NPY in fastingactivated hypothalamic neurons. Nat Neurosci, 1, 271-272 (1998) (Pubitemid 128652670)
    • (1998) Nature Neuroscience , vol.1 , Issue.4 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 41
    • 0030729210 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
    • DOI 10.1210/en.138.11.5063
    • J. E. Thornton, C. C. Cheung, D. K. Clifton & R. A. Steiner: Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice. Endocrinology, 138, 5063-5066 (1997) (Pubitemid 27460950)
    • (1997) Endocrinology , vol.138 , Issue.11 , pp. 5063-5066
    • Thornton, J.E.1    Cheung, C.C.2    Clifton, D.K.3    Steiner, R.A.4
  • 42
    • 0030928715 scopus 로고    scopus 로고
    • Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
    • DOI 10.1210/en.138.10.4489
    • C. C. Cheung, D. K. Clifton & R. A. Steiner: Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology, 138, 4489-4492 (1997) (Pubitemid 27408500)
    • (1997) Endocrinology , vol.138 , Issue.10 , pp. 4489-4492
    • Cheung, C.C.1    Clifton, D.K.2    Steiner, R.A.3
  • 43
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • DOI 10.1038/35078085
    • M. A. Cowley, J. L. Smart, M. Rubinstein, M. G. Cordan, S. Diano, T. L. Horvath, R. D. Cone & M. J. Low: Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature, 411, 480-484 (2001) (Pubitemid 32494394)
    • (2001) Nature , vol.411 , Issue.6836 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5    Horvath, T.L.6    Cone, R.D.7    Low, M.J.8
  • 44
  • 46
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of Central Melanocortin receptors in vitro and in vivo by agouti-related protein
    • DOI 10.1126/science.278.5335.135
    • M. M. Ollmann, B. D. Wilson, Y. K. Yang, J. A. Kerns, Y. R. Chen, I. Gantz & G. S. Barsh: Antagonism of central melanocortin receptors in vitro and in vivo by Agoutirelated protein. Science, 278, 135-138 (1997) (Pubitemid 27446294)
    • (1997) Science , vol.278 , Issue.5335 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.-K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 49
    • 27744457512 scopus 로고    scopus 로고
    • Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting
    • DOI 10.1038/nn1550, PII N1550
    • S. M. Sternson, G. M. G. Shepherd & J. M. Friedman: Topographic mapping of VMH [rarr] arcuate nucleus microcircuits and their reorganization by fasting. Nat Neurosci, 8, 1356-1363 (2005) (Pubitemid 41630424)
    • (2005) Nature Neuroscience , vol.8 , Issue.10 , pp. 1356-1363
    • Sternson, S.M.1    Shepherd, G.M.G.2    Friedman, J.M.3
  • 52
    • 38749135486 scopus 로고    scopus 로고
    • Hypothalamic Neural Projections Are Permanently Disrupted in Diet-Induced Obese Rats
    • DOI 10.1016/j.cmet.2007.12.001, PII S1550413107003749
    • S. G. Bouret, J. N. Gorski, C. M. Patterson, S. Chen, B. E. Levin & R. B. Simerly: Hypothalamic Neural Projections Are Permanently Disrupted in Diet-Induced Obese Rats. Cell Metab, 7, 179-185 (2008) (Pubitemid 351181005)
    • (2008) Cell Metabolism , vol.7 , Issue.2 , pp. 179-185
    • Bouret, S.G.1    Gorski, J.N.2    Patterson, C.M.3    Chen, S.4    Levin, B.E.5    Simerly, R.B.6
  • 53
    • 0030965884 scopus 로고    scopus 로고
    • Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
    • V. Emilsson, Y. L. Liu, M. A. Cawthorne, N. M. Morton & M. Davenport: Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes, 46, 313-316 (1997) (Pubitemid 27272267)
    • (1997) Diabetes , vol.46 , Issue.2 , pp. 313-316
    • Emilsson, V.1    Liu, Y.-L.2    Cawthorne, M.A.3    Morton, N.M.4    Davenport, M.5
  • 55
    • 0033580938 scopus 로고    scopus 로고
    • Novel form of lipolysis induced by leptin
    • M. Y. Wang, Y. Lee & R. H. Unger: Novel form of lipolysis induced by leptin. J Biol Chem, 274, 17541-17544 (1999)
    • (1999) J Biol Chem , vol.274 , pp. 17541-17544
    • Wang, M.Y.1    Lee, Y.2    Unger, R.H.3
  • 56
    • 70149108302 scopus 로고    scopus 로고
    • Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway
    • L. Jiang, Q. Wang, Y. Yu, F. Zhao, P. Huang, R. Zeng, R. Z. Qi, W. Li & Y. Liu: Leptin Contributes to the Adaptive Responses of Mice to High-Fat Diet Intake through Suppressing the Lipogenic Pathway. Plos One, 4, e6884 (2009)
    • (2009) Plos One , vol.4
    • Jiang, L.1    Wang, Q.2    Yu, Y.3    Zhao, F.4    Huang, P.5    Zeng, R.6    Qi, R.Z.7    Li, W.8    Liu, Y.9
  • 58
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • DOI 10.1038/415339a
    • Y. Minokoshi, Y. B. Kim, O. D. Peroni, L. G. D. Fryer, C. Muller, D. Carling & B. B. Kahn: Leptin stimulates fattyacid oxidation by activating AMP-activated protein kinase. Nature, 415, 339-343 (2002) (Pubitemid 34087557)
    • (2002) Nature , vol.415 , Issue.6869 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.-B.2    Peroni, O.D.3    Fryer, L.G.D.4    Muller, C.5    Carling, D.6    Kahn, B.B.7
  • 61
    • 2542444292 scopus 로고    scopus 로고
    • Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity
    • DOI 10.1074/jbc.M401546200
    • W. Huang, N. Dedousis, B. A. Bhatt & R. M. O'Doherty: Impaired activation of phosphatidylinositol 3- kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. J Biol Chem, 279, 21695-21700 (2004) (Pubitemid 38679354)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.21 , pp. 21695-21700
    • Huang, W.1    Dedousis, N.2    Bhatt, B.A.3    O'Doherty, R.M.4
  • 62
    • 34547126211 scopus 로고    scopus 로고
    • Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities
    • DOI 10.1210/en.2007-0261
    • K. Y. Guo, J. E. McMinn, T. Ludwig, Y. H. Yu, G. Q. Yang, L. Chen, D. Loh, C. Li, S. Chua & Y. Y. Zhang: Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities. Endocrinology, 148, 3987-3997 (2007) (Pubitemid 47105835)
    • (2007) Endocrinology , vol.148 , Issue.8 , pp. 3987-3997
    • Guo, K.1    McMinn, J.E.2    Ludwig, T.3    Yu, Y.-H.4    Yang, G.5    Chen, L.6    Loh, D.7    Li, C.8    Chua Jr., S.9    Zhang, Y.10
  • 64
    • 0034628016 scopus 로고    scopus 로고
    • Human leptin enhances activation and proliferation of human circulating T lymphocytes
    • DOI 10.1006/cimm.1999.1594
    • C. Martín-Romero, J. Santos-Alvarez, R. Goberna & V. Sánchez-Margalet: Human Leptin Enhances Activation and Proliferation of Human Circulating T Lymphocytes. Cell Immunol, 199, 15-24 (2000) (Pubitemid 30118591)
    • (2000) Cellular Immunology , vol.199 , Issue.1 , pp. 15-24
    • Martin-Romero, C.1    Santos-Alvarez, J.2    Goberna, R.3    Sanchez-Margalet, V.4
  • 66
    • 33847312289 scopus 로고    scopus 로고
    • A Key Role of Leptin in the Control of Regulatory T Cell Proliferation
    • DOI 10.1016/j.immuni.2007.01.011, PII S1074761307001410
    • V. de Rosa, C. Procaccini, G. Calì, G. Pirozzi, S. Fontana, S. Zappacosta, A. La Cava & G. Matarese: A Key Role of Leptin in the Control of Regulatory T Cell Proliferation. Immunity, 26, 241-255 (2007) (Pubitemid 46329441)
    • (2007) Immunity , vol.26 , Issue.2 , pp. 241-255
    • De Rosa, V.1    Procaccini, C.2    Cali, G.3    Pirozzi, G.4    Fontana, S.5    Zappacosta, S.6    La Cava, A.7    Matarese, G.8
  • 67
    • 13444267906 scopus 로고    scopus 로고
    • Leptin, immune responses and autoimmune disease. Perspectives on the use of leptin antagonists
    • DOI 10.2174/1381612053382070
    • F. Peelman, H. Iserentant, S. Eyckerman, L. Zabeau & J. Tavernier: Leptin, immune responses and autoimmune disease. Perspectives on the use of leptin antagonists. Curr Pharm Des, 11, 539-548 (2005) (Pubitemid 40207761)
    • (2005) Current Pharmaceutical Design , vol.11 , Issue.4 , pp. 539-548
    • Peelman, F.1    Iserentant, H.2    Eyckerman, S.3    Zabeau, L.4    Tavernier, J.5
  • 68
    • 0036533493 scopus 로고    scopus 로고
    • Balancing susceptibility to infection and autoimmunity: A role for leptin?
    • DOI 10.1016/S1471-4906(02)02188-9, PII S1471490602021889
    • G. Matarese, A. La Cava, V. Sanna, G. M. Lord, R. I. Lechler, S. Fontana & S. Zappacosta: Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol, 23, 182-187 (2002) (Pubitemid 34260933)
    • (2002) Trends in Immunology , vol.23 , Issue.4 , pp. 182-187
    • Matarese, G.1    La Cava, A.2    Sanna, V.3    Lord, G.M.4    Lechler, R.I.5    Fontana, S.6    Zappacosta, S.7
  • 69
    • 2442618838 scopus 로고    scopus 로고
    • The weight of leptin in immunity
    • A. La Cava & G. Matarese: The weight of leptin in immunity. Nat Rev Immunol, 4, 371-379 (2004) (Pubitemid 38649279)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.5 , pp. 371-379
    • La Cava, A.1    Matarese, G.2
  • 71
    • 0037080196 scopus 로고    scopus 로고
    • Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis
    • N. Busso, A. So, V. Chobaz-Peclat, C. Morard, E. Martinez-Soria, D. Talabot-Ayer & C. Gabay: Leptin Signaling Deficiency Impairs Humoral and Cellular Immune Responses and Attenuates Experimental Arthritis. J Immunol, 168, 875-882 (2002) (Pubitemid 34049591)
    • (2002) Journal of Immunology , vol.168 , Issue.2 , pp. 875-882
    • Busso, N.1    So, A.2    Chobaz-Peclat, V.3    Morard, C.4    Martinez-Soria, E.5    Talabot-Ayer, D.6    Gabay, C.7
  • 73
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • DOI 10.1074/jbc.272.51.32686
    • C. Bjorbaek, S. Uotani, B. da Silva & J. S. Flier: Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem, 272, 32686-32695 (1997) (Pubitemid 28011961)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.51 , pp. 32686-32695
    • Bjorbaek, C.1    Uotani, S.2    Da Silva, B.3    Flier, J.S.4
  • 76
    • 0036219070 scopus 로고    scopus 로고
    • Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers
    • DOI 10.1210/me.16.4.859
    • G. Bahrenberg, I. Behrmann, A. Barthel, P. Hekerman, P. C. Heinrich, H. G. Joost & W. Becker: Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. Mol Endocrinol, 16, 859-872 (2002) (Pubitemid 34297753)
    • (2002) Molecular Endocrinology , vol.16 , Issue.4 , pp. 859-872
    • Bahrenberg, G.1    Behrmann, I.2    Barthel, A.3    Hekerman, P.4    Heinrich, P.C.5    Joost, H.-G.6    Becker, W.7
  • 77
    • 0036168190 scopus 로고    scopus 로고
    • Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity
    • DOI 10.1210/en.143.3.775
    • S. M. Hileman, D. D. Pierroz, H. Masuzaki, C. Bjorbaek, K. El-Haschimi, W. A. Banks & J. S. Flier: Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology, 143, 775-783 (2002) (Pubitemid 34164025)
    • (2002) Endocrinology , vol.143 , Issue.3 , pp. 775-783
    • Hileman, S.M.1    Pierroz, D.D.2    Masuzaki, H.3    Bjorbk, C.4    El-Haschimi, K.5    Banks, W.A.6    Flier, J.S.7
  • 78
    • 17744388106 scopus 로고    scopus 로고
    • Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells
    • DOI 10.1210/en.141.6.1955
    • S. M. Hileman, J. Tornoe, J. S. Flier & C. Bjorbaek: Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells. Endocrinology, 141, 1955-1961 (2000) (Pubitemid 32274343)
    • (2000) Endocrinology , vol.141 , Issue.6 , pp. 1955-1961
    • Hileman, S.M.1    Tornoe, J.2    Flier, J.S.3    Bjorbaek, C.4
  • 79
    • 0033008075 scopus 로고    scopus 로고
    • Functional properties of leptin receptor isoforms: Internalization and degradation of leptin and ligand-induced receptor downregulation
    • DOI 10.2337/diabetes.48.2.279
    • S. Uotani, C. Bjorbaek, J. Tornoe & J. S. Flier: Functional properties of leptin receptor isoforms internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes, 48, 279-286 (1999) (Pubitemid 29061099)
    • (1999) Diabetes , vol.48 , Issue.2 , pp. 279-286
    • Uotani, S.1    Bjorbaek, C.2    Tornoe, J.3    Flier, J.S.4
  • 80
    • 0034801977 scopus 로고    scopus 로고
    • Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors
    • DOI 10.1210/en.142.10.4389
    • M. Maamra, M. Bidlingmaier, M. C. Postel-Vinay, Z. Wu, C. J. Strasburger & R. J. Ross: Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology, 142, 4389-93 (2001) (Pubitemid 32907068)
    • (2001) Endocrinology , vol.142 , Issue.10 , pp. 4389-4393
    • Maamra, M.1    Bidlingmaier, M.2    Postel-Vinay, M.-C.3    Wu, Z.4    Strasburger, C.J.5    Ross, R.J.M.6
  • 81
    • 0037195916 scopus 로고    scopus 로고
    • Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo
    • DOI 10.1074/jbc.M205825200
    • H. F. Ge, L. Huang, T. Pourbahrami & C. Li: Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem, 277, 45898-45903 (2002) (Pubitemid 35417571)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.48 , pp. 45898-45903
    • Ge, H.1    Huang, L.2    Pourbahrami, T.3    Li, C.4
  • 82
    • 79952811396 scopus 로고    scopus 로고
    • RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding
    • in press
    • J. Wauman, L. de Ceuninck, N. Vanderroost, S. Lievens & J. Tavernier: RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding. J Cell Sci, in press, (2010)
    • (2010) J Cell Sci
    • Wauman, J.1    De Ceuninck, L.2    Vanderroost, N.3    Lievens, S.4    Tavernier, J.5
  • 85
    • 77955458427 scopus 로고    scopus 로고
    • Reduced body weight and increased energy expenditure in transgenic mice over- expressing soluble leptin receptor
    • P.-H. Lou, G. Yang, L. Huang, Y. Cui, T. Pourbahrami, G. K. Radda, C. Li & W. Han: Reduced Body Weight and Increased Energy Expenditure in Transgenic Mice Over- Expressing Soluble Leptin Receptor. Plos One, 5, e11669 (2010)
    • (2010) Plos One , vol.5
    • Lou, P.-H.1    Yang, G.2    Huang, L.3    Cui, Y.4    Pourbahrami, T.5    Radda, G.K.6    Li, C.7    Han, W.8
  • 86
    • 2542450776 scopus 로고    scopus 로고
    • Modulation of direct leptin signaling by soluble leptin receptor
    • DOI 10.1210/me.2004-0027
    • G. Q. Yang, H. F. Ge, A. Boucher, X. X. Yu & C. Li: Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol, 18, 1354-1362 (2004) (Pubitemid 38692175)
    • (2004) Molecular Endocrinology , vol.18 , Issue.6 , pp. 1354-1362
    • Yang, G.1    Ge, H.2    Boucher, A.3    Yu, X.4    Li, C.5
  • 87
  • 88
    • 69549088269 scopus 로고    scopus 로고
    • The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo
    • J. J. Zhang & P. J. Scarpace: The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo. Br J Pharmacol, 158, 475-482 (2009)
    • (2009) Br J Pharmacol , vol.158 , pp. 475-482
    • Zhang, J.J.1    Scarpace, P.J.2
  • 89
    • 0030956390 scopus 로고    scopus 로고
    • The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
    • DOI 10.1210/me.11.4.393
    • N. Ghilardi & R. C. Skoda: The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol, 11, 393-399 (1997) (Pubitemid 27147006)
    • (1997) Molecular Endocrinology , vol.11 , Issue.4 , pp. 393-399
    • Ghilardi, N.1    Skoda, R.C.2
  • 90
    • 0030793449 scopus 로고    scopus 로고
    • Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding
    • DOI 10.1074/jbc.272.29.18304
    • R. Devos, Y. Guisez, J. VanderHeyden, D. W. White, M. Kalai, M. Fountoulakis & G. Plaetinck: Ligandindependent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. J Biol Chem, 272, 18304-18310 (1997) (Pubitemid 27306421)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.29 , pp. 18304-18310
    • Devos, R.1    Guisez, Y.2    Van Der Heyden, J.3    White, D.W.4    Kalai, M.5    Fountoulakis, M.6    Plaetinck, G.7
  • 91
    • 0033135272 scopus 로고    scopus 로고
    • Evidence for ligand-independent homo-oligomerization of leptin receptor (OB-R) isoforms: A proposed mechanism permitting productive long-form signaling in the presence of excess short-form expression
    • DOI 10.1002/(SICI)1097-4644(19990501) 73:2<278::AID-JCB13>3.0.CO;2- W
    • D. W. White & L. A. Tartaglia: Evidence for ligandindependent homo-oligomerization of leptin receptor (OBR) isoforms: A proposed mechanism permitting productive long-form signaling in the presence of excess short-form expression. J Cell Biochem, 73, 278-288 (1999) (Pubitemid 29160194)
    • (1999) Journal of Cellular Biochemistry , vol.73 , Issue.2 , pp. 278-288
    • White, D.W.1    Tartaglia, L.A.2
  • 93
    • 0038374250 scopus 로고    scopus 로고
    • Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers
    • DOI 10.1074/jbc.M302002200
    • C. Couturier & R. Jockers: Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers. J Biol Chem, 278, 26604-26611 (2003) (Pubitemid 36876805)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.29 , pp. 26604-26611
    • Couturier, C.1    Jockers, R.2
  • 94
    • 77952956961 scopus 로고    scopus 로고
    • Evidence for leptin receptor isoforms heteromerization at the cell surface
    • J. Bacart, A. Leloire, A. Levoye, P. Froguel, R. Jockers & C. Couturier: Evidence for leptin receptor isoforms heteromerization at the cell surface. FEBS Lett, 584, 2213-2217 (2010)
    • (2010) FEBS Lett , vol.584 , pp. 2213-2217
    • Bacart, J.1    Leloire, A.2    Levoye, A.3    Froguel, P.4    Jockers, R.5    Couturier, C.6
  • 95
    • 33744959239 scopus 로고    scopus 로고
    • Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin leptin receptor complex
    • DOI 10.1074/jbc.M512622200
    • F. Peelman, H. Iserentant, A. S. de Smet, J. Vandekerckhove, L. Zabeau & J. Tavernier: Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin:leptin receptor complex. J Biol Chem, 281, 15496-15504 (2006) (Pubitemid 43855142)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.22 , pp. 15496-15504
    • Peelman, F.1    Iserentant, H.2    De Smet, A.-S.3    Vandekerckhove, J.4    Zabeau, L.5    Tavernier, J.6
  • 98
    • 0034640508 scopus 로고    scopus 로고
    • Activation of downstream signals by the long form of the leptin receptor
    • DOI 10.1074/jbc.275.19.14563
    • A. S. Banks, S. M. Davis, S. H. Bates & M. G. Myers: Activation of downstream signals by the long form of the leptin receptor. J Biol Chem, 275, 14563-14572 (2000) (Pubitemid 30339746)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.19 , pp. 14563-14572
    • Banks, A.S.1    Davis, S.M.2    Bates, S.H.3    Myers Jr., M.G.4
  • 99
    • 0031040793 scopus 로고    scopus 로고
    • Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization
    • DOI 10.1074/jbc.272.7.4065
    • D. W. White, K. K. Kuropatwinski, R. Devos, H. Baumann & L. A. Tartaglia: Leptin receptor (OB-R) signaling - Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J Biol Chem, 272, 4065-4071 (1997) (Pubitemid 27078469)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.7 , pp. 4065-4071
    • White, D.W.1    Kuropatwinski, K.K.2    Devos, R.3    Baumann, H.4    Tartaglia, L.A.5
  • 100
    • 11444250092 scopus 로고    scopus 로고
    • Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines
    • DOI 10.1111/j.1432-1033.2004.04391.x
    • P. Hekerman, J. Zeidler, S. Bamberg-Lemper, H. Knobelspies, D. Lavens, J. Tavernier, H. G. Joost & W. Becker: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. Febs J, 272, 109-119 (2005) (Pubitemid 40083071)
    • (2005) FEBS Journal , vol.272 , Issue.1 , pp. 109-119
    • Hekerman, P.1    Zeidler, J.2    Bamberg-Lemper, S.3    Knobelspies, H.4    Lavens, D.5    Tavernier, J.6    Joost, H.-G.7    Becker, W.8
  • 101
    • 57449099877 scopus 로고    scopus 로고
    • Tyrosinedependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis
    • L. Jiang, J. You, X. X. Yu, L. Gonzalez, Y. Yu, Q. Wang, G. Q. Yang, W. J. Li, C. Li & Y. Liu: Tyrosinedependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc Natl Acad Sci USA, 105, 18619-18624 (2008)
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 18619-18624
    • Jiang, L.1    You, J.2    Yu, X.X.3    Gonzalez, L.4    Yu, Y.5    Wang, Q.6    Yang, G.Q.7    Li, W.J.8    Li, C.9    Liu, Y.10
  • 103
    • 57649137956 scopus 로고    scopus 로고
    • Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways
    • L. Jiang, Z. Q. Li & L. Y. Rui: Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways. J Biol Chem, 283, 28066-28073 (2008)
    • (2008) J Biol Chem , vol.283 , pp. 28066-28073
    • Jiang, L.1    Li, Z.Q.2    Rui, L.Y.3
  • 104
    • 0028931604 scopus 로고
    • Choice of stats and other substrates specified by modular tyrosine-based motifs in cytokine receptors
    • N. Stahl, T. J. Farruggella, T. G. Boulton, Z. Zhong, J. E. Darnell & G. D. Yancopoulos: Choice of Stats and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors. Science, 267, 1349-1353 (1995)
    • (1995) Science , vol.267 , pp. 1349-1353
    • Stahl, N.1    Farruggella, T.J.2    Boulton, T.G.3    Zhong, Z.4    Darnell, J.E.5    Yancopoulos, G.D.6
  • 105
    • 0029739826 scopus 로고    scopus 로고
    • Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    • DOI 10.1038/ng0996-95
    • C. Vaisse, J. L. Halaas, C. M. Horvath, J. E. Darnell, M. Stoffel & J. M. Friedman: Leptin activation of Stat3 in the hypothalamus of wildtype and ob/ob mice but not db/db mice. Nat Genet, 14, 95-97 (1996) (Pubitemid 26301554)
    • (1996) Nature Genetics , vol.14 , Issue.1 , pp. 95-97
    • Vaisse, C.1    Halaas, J.L.2    Horvath, C.M.3    Dernell Jr., J.E.4    Stoffel, M.5    Friedman, J.M.6
  • 106
    • 0034657231 scopus 로고    scopus 로고
    • Identification and expression analysis of leptin-regulated immediate early response and late target genes
    • DOI 10.1042/0264-6021:3480055
    • W. Waelput, A. Verhee, D. Broekaert, S. Eyckerman, J. Vandekerckhove, J. H. Beattie & J. Tavernier: Identification and expression analysis of leptin-regulated immediate early response and late target genes. Biochem J, 348 Pt 1, 55-61 (2000) (Pubitemid 30312130)
    • (2000) Biochemical Journal , vol.348 , Issue.1 , pp. 55-61
    • Waelput, W.1    Verhee, A.2    Broekaert, D.3    Eyckerman, S.4    Vandekerckhove, J.5    Beattie, J.H.6    Tavernier, J.7
  • 107
    • 0037453270 scopus 로고    scopus 로고
    • Determination of leptin signaling pathways in human and murine keratinocytes
    • DOI 10.1016/S0006-291X(03)00480-7
    • I. Goren, J. Pfeilschifter & S. Frank: Determination of leptin signaling pathways in human and murine keratinocytes. Biochem. Biophys. Res. Commun, 303, 1080-1085 (2003) (Pubitemid 36390255)
    • (2003) Biochemical and Biophysical Research Communications , vol.303 , Issue.4 , pp. 1080-1085
    • Goren, I.1    Pfeilschifter, J.2    Frank, S.3
  • 108
    • 0029117304 scopus 로고
    • Maximal activation of transcription by STAT1 and STAT3 requires both tyrosine and serine phosporylation
    • Z. L. Wen, Z. Zhong & J. E. Darnell: Maximal activation of transcription by STAT1 and STAT3 requires both tyrosine and serine phosporylation. Cell, 82, 241-250 (1995)
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.L.1    Zhong, Z.2    Darnell, J.E.3
  • 109
    • 0347624595 scopus 로고    scopus 로고
    • Essential Role of STAT3 in Postnatal Survival and Growth Revealed by Mice Lacking STAT3 Serine 727 Phosphorylation
    • DOI 10.1128/MCB.24.1.407-419.2004
    • Y. H. Shen, K. Schlessinger, X. J. Zhu, E. Meffre, F. Quimby, D. E. Levy & J. E. Darnell: Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylatione. Mol Cell Biol, 24, 407-419 (2004) (Pubitemid 38010065)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.1 , pp. 407-419
    • Shen, Y.1    Schlessinger, K.2    Zhu, X.3    Meffre, E.4    Quimby, F.5    Levy, D.E.6    Darnell Jr., J.E.7
  • 110
    • 0028942656 scopus 로고
    • Requirement of serine phosphorylation for formation of STAT-promoter complexes
    • X. K. Zhang, J. Blenis, H. C. Li, C. Schindler & S. Chenkiang: Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science, 267, 1990-1994 (1995)
    • (1995) Science , vol.267 , pp. 1990-1994
    • Zhang, X.K.1    Blenis, J.2    Li, H.C.3    Schindler, C.4    Chenkiang, S.5
  • 111
    • 52049122570 scopus 로고    scopus 로고
    • C-Jun NH2- terminal kinase mediates leptin-stimulated androgenindependent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt
    • T. Miyazaki, J. D. Bub & Y. Iwamoto: c-Jun NH2- terminal kinase mediates leptin-stimulated androgenindependent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt. Biochim. Biophys. Acta, 1782, 593-604 (2008)
    • (2008) Biochim. Biophys. Acta , vol.1782 , pp. 593-604
    • Miyazaki, T.1    Bub, J.D.2    Iwamoto, Y.3
  • 112
    • 0037096988 scopus 로고    scopus 로고
    • 727 phosphorylation and DNA binding
    • DOI 10.1042/BJ20020295
    • L. O'Rourke & P. R. Shepherd: Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages: role in regulating STAT3 Ser(727) phosphorylation and DNA binding. Biochemical J, 364, 875-879 (2002) (Pubitemid 34680866)
    • (2002) Biochemical Journal , vol.364 , Issue.3 , pp. 875-879
    • O'Rourke, L.1    Shepherd, P.R.2
  • 113
    • 77958471611 scopus 로고    scopus 로고
    • Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation
    • H. Iwasaki, J. C. Kovacic, M. Olive, J. K. Beers, T. Yoshimoto, M. F. Crook, L. H. Tonelli & E. G. Nabel: Disruption of Protein Arginine N-Methyltransferase 2 Regulates Leptin Signaling and Produces Leanness In Vivo Through Loss of STAT3 Methylation. Circ Res, 107, 992-1001 (2010)
    • (2010) Circ Res , vol.107 , pp. 992-1001
    • Iwasaki, H.1    Kovacic, J.C.2    Olive, M.3    Beers, J.K.4    Yoshimoto, T.5    Crook, M.F.6    Tonelli, L.H.7    Nabel, E.G.8
  • 114
    • 12244251445 scopus 로고    scopus 로고
    • Stat3 dimerization regulated by reversible acetylation of a single lysine residue
    • DOI 10.1126/science.1105166
    • Z.-l. Yuan, Y.-j. Guan, D. Chatterjee & Y. E. Chin: Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue. Science, 307, 269-273 (2005) (Pubitemid 40116244)
    • (2005) Science , vol.307 , Issue.5707 , pp. 269-273
    • Yuan, Z.-L.1    Guan, Y.-J.2    Chatterjee, D.3    Chin, Y.E.4
  • 118
    • 9444264702 scopus 로고    scopus 로고
    • LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin
    • DOI 10.2337/diabetes.53.12.3067
    • S. H. Bates, T. A. Dundon, M. Seifert, M. Carlson, E. Maratos-Filer & M. G. Myers: LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes, 53, 3067-3073 (2004) (Pubitemid 39564480)
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3067-3073
    • Bates, S.H.1    Dundon, T.A.2    Seifert, M.3    Carlson, M.4    Maratos-Flier, E.5    Myers Jr., M.G.6
  • 119
    • 33745362866 scopus 로고    scopus 로고
    • Critical role of STAT3 in leptin's metabolic actions
    • DOI 10.1016/j.cmet.2006.04.014, PII S1550413106001549
    • C. Buettner, A. Pocai, E. D. Muse, A. M. Etgen, M. G. Myers Jr & L. Rossetti: Critical role of STAT3 in leptin's metabolic actions. Cell Metab, 4, 49-60 (2006) (Pubitemid 43942253)
    • (2006) Cell Metabolism , vol.4 , Issue.1 , pp. 49-60
    • Buettner, C.1    Pocai, A.2    Muse, E.D.3    Etgen, A.M.4    Myers Jr., M.G.5    Rossetti, L.6
  • 120
    • 0038747134 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription 3 in regulation of hypothalamic Proopiomelanocortin gene expression by leptin
    • DOI 10.1210/en.2002-221037
    • H. Munzberg, L. H. Huo, E. A. Nillni, A. N. Hollenberg & C. Bjorbaek: Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology, 144, 2121-2131 (2003) (Pubitemid 36543352)
    • (2003) Endocrinology , vol.144 , Issue.5 , pp. 2121-2131
    • Munzberg, H.1    Huo, L.2    Nillni, E.A.3    Hollenberg, A.N.4    Bjorbaek, C.5
  • 121
    • 33845867730 scopus 로고    scopus 로고
    • Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased Pomc expression, mild obesity, and defects in compensatory refeeding
    • DOI 10.1210/en.2006-1119
    • A. W. Xu, L. Ste-Marie, C. B. Kaelin & G. S. Barsh: Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased Pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology, 148, 72-80 (2007) (Pubitemid 46021439)
    • (2007) Endocrinology , vol.148 , Issue.1 , pp. 72-80
    • Xu, A.W.1    Ste-Marie, L.2    Kaelin, C.B.3    Barsh, G.S.4
  • 122
    • 46349110307 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis
    • DOI 10.1210/en.2007-0945
    • L. Gong, F. Yao, K. Hockman, H. H. Heng, G. J. Morton, K. Takeda, S. Akira, M. J. Low, M. Rubinstein & R. G. MacKenzie: Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Endocrinology, 149, 3346-3354 (2008) (Pubitemid 351919579)
    • (2008) Endocrinology , vol.149 , Issue.7 , pp. 3346-3354
    • Gong, L.1    Yao, F.2    Hockman, K.3    Heng, H.H.4    Morton, G.J.5    Takeda, K.6    Akira, S.7    Low, M.J.8    Rubinstein, M.9    MacKenzie, R.G.10
  • 123
    • 33749350398 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription (Stat) binding sites but not Stat3 are required for fasting-induced transcription of Agouti-related protein messenger ribonucleic acid
    • DOI 10.1210/me.2006-0107
    • C. B. Kaelin, L. J. Gong, A. W. Xu, F. Y. Yao, K. Hockman, G. J. Morton, M. W. Schwartz, G. S. Barsh & R. G. MacKenzie: Signal transducer and activator of transcription (Stat) binding sites but not Stat3 are required for fasting-induced transcription of Agouti-related protein messenger ribonucleic acid. Mol Endocrinol, 20, 2591-2602 (2006) (Pubitemid 44496426)
    • (2006) Molecular Endocrinology , vol.20 , Issue.10 , pp. 2591-2602
    • Kaelin, C.B.1    Gong, L.2    Xu, A.W.3    Yao, F.4    Hockman, K.5    Morton, G.J.6    Schwartz, M.W.7    Barsh, G.S.8    MacKenzie, R.G.9
  • 125
    • 2042506366 scopus 로고    scopus 로고
    • Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo
    • DOI 10.1210/en.2003-1312
    • F. Guo, K. Bakal, Y. Minokoshi & A. N. Hollenberg: Leptin Signaling Targets the Thyrotropin-Releasing Hormone Gene Promoter in Vivo. Endocrinology, 145, 2221-2227 (2004) (Pubitemid 38535051)
    • (2004) Endocrinology , vol.145 , Issue.5 , pp. 2221-2227
    • Guo, F.1    Bakal, K.2    Minokoshi, Y.3    Hollenberg, A.N.4
  • 126
    • 11144358404 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin
    • DOI 10.1210/en.2003-1242
    • L. H. Huo, H. Munzberg, E. A. Nillni & C. Bjorbaek: Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin. Endocrinology, 145, 2516-2523 (2004) (Pubitemid 38535079)
    • (2004) Endocrinology , vol.145 , Issue.5 , pp. 2516-2523
    • Huo, L.1    Munzberg, H.2    Nillni, E.A.3    Bjorbaek, C.4
  • 129
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • C. Bjorbaek, J. K. Elmquist, J. D. Frantz, S. E. Shoelson & J. S. Flier: Identification of SOCS-3 as a potential mediator of central leptin resistance. Molecular Cell, 1, 619-625 (1998) (Pubitemid 128374698)
    • (1998) Molecular Cell , vol.1 , Issue.4 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 130
    • 40849124301 scopus 로고    scopus 로고
    • Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons
    • DOI 10.1210/me.2007-0389
    • M. L. Piper, E. K. Unger, M. G. Myers & A. W. Xu: Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol, 22, 751-759 (2008) (Pubitemid 351397800)
    • (2008) Molecular Endocrinology , vol.22 , Issue.3 , pp. 751-759
    • Piper, M.L.1    Unger, E.K.2    Myers Jr., M.G.3    Xu, A.W.4
  • 134
    • 34247102713 scopus 로고    scopus 로고
    • Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration
    • DOI 10.1016/j.neulet.2007.02.074, PII S0304394007002431
    • J. Mutze, J. Roth, R. Gerstberger & T. Hubschle: Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration. Neurosci Lett, 417, 286-291 (2007) (Pubitemid 46589788)
    • (2007) Neuroscience Letters , vol.417 , Issue.3 , pp. 286-291
    • Mutze, J.1    Roth, J.2    Gerstberger, R.3    Hubschle, T.4
  • 135
    • 33646570845 scopus 로고    scopus 로고
    • Analysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategy
    • DOI 10.1016/j.febslet.2006.04.094, PII S001457930600576X
    • T. Montoye, J. Piessevaux, D. Lavens, J. Wauman, D. Catteeuw, J. Vandekerckhove, I. Lemmens & J. Tavernier: Analysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategy. FEBS Lett, 580, 3301-7 (2006) (Pubitemid 43729669)
    • (2006) FEBS Letters , vol.580 , Issue.13 , pp. 3301-3307
    • Montoye, T.1    Piessevaux, J.2    Lavens, D.3    Wauman, J.4    Catteeuw, D.5    Vandekerckhove, J.6    Lemmens, I.7    Tavernier, J.8
  • 139
    • 0033578334 scopus 로고    scopus 로고
    • Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction
    • DOI 10.1073/pnas.96.17.9677
    • C. Li & J. M. Friedman: Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc Natl Acad Sci U S A, 96, 9677-82 (1999) (Pubitemid 29398791)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.17 , pp. 9677-9682
    • Li, C.1    Friedman, J.M.2
  • 140
    • 62749109421 scopus 로고    scopus 로고
    • Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin
    • K. Rahmouni, C. D. Sigmund, W. G. Haynes & A. L. Mark: Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes, 58, 536-42 (2009)
    • (2009) Diabetes , vol.58 , pp. 536-542
    • Rahmouni, K.1    Sigmund, C.D.2    Haynes, W.G.3    Mark, A.L.4
  • 143
    • 0033180532 scopus 로고    scopus 로고
    • Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
    • DOI 10.1016/S0896-6273(01)80035-0
    • C. F. Elias, C. Aschkenasi, C. Lee, J. Kelly, R. S. Ahima, C. Bjorbaek, J. S. Flier, C. B. Saper & J. K. Elmquist: Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron, 23, 775-786 (1999) (Pubitemid 29411566)
    • (1999) Neuron , vol.23 , Issue.4 , pp. 775-786
    • Elias, C.F.1    Aschkenasi, C.2    Lee, C.3    Kelly, J.4    Ahima, R.S.5    Bjorbaek, C.6    Flier, J.S.7    Saper, C.B.8    Elmquist, J.K.9
  • 144
    • 33845672095 scopus 로고    scopus 로고
    • Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1
    • H. Cui, F. Cai & D. D. Belsham: Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1. FASEB J., 20, 2654-2656 (2006)
    • (2006) FASEB J. , vol.20 , pp. 2654-2656
    • Cui, H.1    Cai, F.2    Belsham, D.D.3
  • 147
    • 77949415378 scopus 로고    scopus 로고
    • Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance
    • J. You, Y. Yu, L. Jiang, W. Li, X. Yu, L. Gonzalez, G. Yang, Z. Ke, W. Li, C. Li & Y. Liu: Signaling through Tyr985 of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance. Mol. Cell. Biol., 30, 1650-1659 (2010)
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 1650-1659
    • You, J.1    Yu, Y.2    Jiang, L.3    Li, W.4    Yu, X.5    Gonzalez, L.6    Yang, G.7    Ke, Z.8    Li, W.9    Li, C.10    Liu, Y.11
  • 150
    • 49049114337 scopus 로고    scopus 로고
    • The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
    • D. Cota, E. K. Matter, S. C. Woods & R. J. Seeley: The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci, 28, 7202-7208 (2008)
    • (2008) J Neurosci , vol.28 , pp. 7202-7208
    • Cota, D.1    Matter, E.K.2    Woods, S.C.3    Seeley, R.J.4
  • 152
    • 41649087434 scopus 로고    scopus 로고
    • Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways
    • DOI 10.1210/me.2007-0414
    • J. Wauman, A. S. de Smet, D. Catteeuw, D. Belsham & J. Tavernier: Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways. Mol Endocrinol, 22, 965-977 (2008) (Pubitemid 351482831)
    • (2008) Molecular Endocrinology , vol.22 , Issue.4 , pp. 965-977
    • Wauman, J.1    De Smet, A.-S.2    Dominiek Catteeuw, D.B.3    Tavernier, J.4
  • 153
    • 6344243617 scopus 로고    scopus 로고
    • SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
    • C. J. Duan, M. H. Li & L. Y. Rui: SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. J Biol Chem, 279, 43684-43691 (2004)
    • (2004) J Biol Chem , vol.279 , pp. 43684-43691
    • Duan, C.J.1    Li, M.H.2    Rui, L.Y.3
  • 154
    • 0030828823 scopus 로고    scopus 로고
    • 12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
    • DOI 10.1007/s001250050832
    • M. Kellerer, M. Koch, E. Metzinger, J. Mushack, E. Capp & H. U. Haring: Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia, 40, 1358-1362 (1997) (Pubitemid 27469678)
    • (1997) Diabetologia , vol.40 , Issue.11 , pp. 1358-1362
    • Kellerer, M.1    Koch, M.2    Metzinger, E.3    Mushack, J.4    Capp, E.5    Haring, H.U.6
  • 155
    • 34548370733 scopus 로고    scopus 로고
    • 813 phosphorylation-dependent and -independent mechanisms
    • DOI 10.1210/me.2007-0111
    • Z. Q. Li, Y. J. Zhou, C. Carter-Su, M. G. Myers & L. Rui: SH2B1 enhances leptin signaling by both janus kinase 2 Tyr(813) phosphorylation- dependent and -independent mechanisms. Mol Endocrinol, 21, 2270-2281 (2007) (Pubitemid 47347387)
    • (2007) Molecular Endocrinology , vol.21 , Issue.9 , pp. 2270-2281
    • Li, Z.1    Zhou, Y.2    Carter-Su, C.3    Myers Jr., M.G.4    Rui, L.5
  • 156
    • 25144523930 scopus 로고    scopus 로고
    • Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
    • D. C. Ren, M. H. Li, C. J. Duan & L. Y. Rui: Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab, 2, 95-104 (2005)
    • (2005) Cell Metab , vol.2 , pp. 95-104
    • Ren, D.C.1    Li, M.H.2    Duan, C.J.3    Rui, L.Y.4
  • 157
    • 33846822094 scopus 로고    scopus 로고
    • Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
    • DOI 10.1172/JCI29417
    • D. C. Ren, Y. J. Zhou, D. Morris, M. H. Li, Z. Q. Li & L. Y. Rui: Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest, 117, 397-406 (2007) (Pubitemid 46203968)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.2 , pp. 397-406
    • Ren, D.1    Zhou, Y.2    Morris, D.3    Li, M.4    Li, Z.5    Rui, L.6
  • 160
    • 63649158684 scopus 로고    scopus 로고
    • FoxO1 inhibits leptin regulation of proopiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
    • G. Yang, C. Y. Lim, C. Li, X. Xiao, G. K. Radda, X. Cao & W. Han: FoxO1 inhibits leptin regulation of proopiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1. J Biol Chem, 284, 3719-27 (2009)
    • (2009) J Biol Chem , vol.284 , pp. 3719-3727
    • Yang, G.1    Lim, C.Y.2    Li, C.3    Xiao, X.4    Radda, G.K.5    Cao, X.6    Han, W.7
  • 161
    • 33745747676 scopus 로고    scopus 로고
    • A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells
    • DOI 10.1038/sj.emboj.7601118, PII 7601118
    • K. Ning, L. C. Miller, H. A. Laidlaw, L. A. Burgess, N. M. Perera, C. P. Downes, N. R. Leslie & M. L. J. Ashford: A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic [beta]- cells. EMBO J, 25, 2377-2387 (2006) (Pubitemid 44012221)
    • (2006) EMBO Journal , vol.25 , Issue.11 , pp. 2377-2387
    • Ning, K.1    Miller, L.C.2    Laidlaw, H.A.3    Burgess, L.A.4    Perera, N.M.5    Downes, C.P.6    Leslie, N.R.7    Ashford, M.L.J.8
  • 162
    • 66149101629 scopus 로고    scopus 로고
    • Leptindependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels
    • K. Ning, L. C. Miller, H. A. Laidlaw, K. R. Watterson, J. Gallagher, C. Sutherland & M. L. J. Ashford: Leptindependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels. J Biol Chem, 284, 9331-9340 (2009)
    • (2009) J Biol Chem , vol.284 , pp. 9331-9340
    • Ning, K.1    Miller, L.C.2    Laidlaw, H.A.3    Watterson, K.R.4    Gallagher, J.5    Sutherland, C.6    Ashford, M.L.J.7
  • 163
    • 0036321620 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase-phosphodiesterase 3b-cyclic AMP pathway in hypothalamic action of leptin on feeding
    • DOI 10.1038/nn885
    • A. Z. Zhao, J. N. Huan, S. Gupta, R. Pal & A. Sahu: A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat Neurosci, 5, 727-8 (2002) (Pubitemid 34827588)
    • (2002) Nature Neuroscience , vol.5 , Issue.8 , pp. 727-728
    • Zhao, A.Z.1    Huan, J.-N.2    Gupta, S.3    Pal, R.4    Sahu, A.5
  • 164
    • 77953693953 scopus 로고    scopus 로고
    • A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus
    • A. Sahu: A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus. Neurosci Lett, 479, 18-21 (2010)
    • (2010) Neurosci Lett , vol.479 , pp. 18-21
    • Sahu, A.1
  • 168
    • 9644260563 scopus 로고    scopus 로고
    • Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes
    • DOI 10.1172/JCI200422217
    • X. Lin, A. Taguchi, S. Park, J. A. Kushner, F. Li, Y. Li & M. F. White: Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest, 114, 908-16 (2004) (Pubitemid 39578718)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.7 , pp. 908-916
    • Lin, X.1    Taguchi, A.2    Park, S.3    Kushner, J.A.4    Li, F.5    Li, Y.6    White, M.F.7
  • 172
    • 34249829624 scopus 로고    scopus 로고
    • Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway
    • DOI 10.1210/en.2006-1240
    • D. Kohno, M. Nakata, F. Maekawa, K. Fujiwara, Y. Maejima, M. Kuramochi, T. Shimazaki, H. Okano, T. Onaka & T. Yada: Leptin Suppresses Ghrelin-Induced Activation of Neuropeptide Y Neurons in the Arcuate Nucleus via Phosphatidylinositol 3-Kinase- and Phosphodiesterase 3-Mediated Pathway. Endocrinology, 148, 2251-2263 (2007) (Pubitemid 46997030)
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2251-2263
    • Kohno, D.1    Nakata, M.2    Maekawa, F.3    Fujiwara, K.4    Maejima, Y.5    Kuramochi, M.6    Shimazaki, T.7    Okano, H.8    Onaka, T.9    Yada, T.10
  • 173
    • 12944261926 scopus 로고    scopus 로고
    • Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation
    • S. Mirshamsi, H. Laidlaw, K. Ning, E. Anderson, L. Burgess, A. Gray, C. Sutherland & M. Ashford: Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. BMC Neurosci, 5, 54 (2004)
    • (2004) BMC Neurosci , vol.5 , pp. 54
    • Mirshamsi, S.1    Laidlaw, H.2    Ning, K.3    Anderson, E.4    Burgess, L.5    Gray, A.6    Sutherland, C.7    Ashford, M.8
  • 174
    • 0034681407 scopus 로고    scopus 로고
    • Essential role of phosphoinositide 3-kinase in leptin-induced K(ATP) channel activation in the rat CRI-G1 insulinoma cell line
    • DOI 10.1074/jbc.275.7.4660
    • J. Harvey, N. G. McKay, K. S. Walker, J. Van der Kaay, C. P. Downes & M. L. J. Ashford: Essential Role of Phosphoinositide 3-Kinase in Leptin-inducedK ATP Channel Activation in the Rat CRI-G1 Insulinoma Cell Line. J Biol Chem, 275, 4660-4669 (2000) (Pubitemid 30108852)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.7 , pp. 4660-4669
    • Harvey, J.1    McKay, N.G.2    Walker, K.S.3    Van Der Kaay, J.4    Downes, C.P.5    Ashford, M.L.J.6
  • 175
    • 40849083773 scopus 로고    scopus 로고
    • Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice
    • DOI 10.1210/en.2007-1307
    • A. S. Metlakunta, M. Sahu & A. Sahu: Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice. Endocrinology, 149, 1121-8 (2008) (Pubitemid 351397951)
    • (2008) Endocrinology , vol.149 , Issue.3 , pp. 1121-1128
    • Metlakunta, A.S.1    Sahu, M.2    Sahu, A.3
  • 179
    • 41549108590 scopus 로고    scopus 로고
    • PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response
    • DOI 10.1016/j.cmet.2008.01.006, PII S1550413108000077
    • B. F. Belgardt, A. Husch, E. Rother, M. B. Ernst, F. T. Wunderlich, B. Hampel, T. Klockener, D. Alessi, P. Kloppenburg & J. C. Bruning: PDK1 deficiency in POMCExpressing cells reveals FOXO1-dependent and - independent pathways in control of energy homeostasis and stress response. Cell Metab, 7, 291-301 (2008) (Pubitemid 351467391)
    • (2008) Cell Metabolism , vol.7 , Issue.4 , pp. 291-301
    • Belgardt, B.F.1    Husch, A.2    Rother, E.3    Ernst, M.B.4    Wunderlich, F.T.5    Hampel, B.6    Klockener, T.7    Alessi, D.8    Kloppenburg, P.9    Bruning, J.C.10
  • 181
    • 0034457883 scopus 로고    scopus 로고
    • In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
    • DOI 10.1210/en.141.7.2328
    • Y.-B. Kim, S. Uotani, D. D. Pierroz, J. S. Flier & B. B. Kahn: In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin. Endocrinology, 141, 2328-2339 (2000) (Pubitemid 32269051)
    • (2000) Endocrinology , vol.141 , Issue.7 , pp. 2328-2339
    • Kim, Y.-B.1    Uotani, S.2    Pierroz, D.D.3    Flier, J.S.4    Kahn, B.B.5
  • 182
    • 0037288941 scopus 로고    scopus 로고
    • Insulin and leptin revisited: Adiposity signals with overlapping physiological and intracellular signaling capabilities
    • DOI 10.1016/S0091-3022(02)00105-X
    • K. D. Niswender & M. W. Schwartz: Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Frontiers in Neuroendocrinology, 24, 1-10 (2003) (Pubitemid 36263453)
    • (2003) Frontiers in Neuroendocrinology , vol.24 , Issue.1 , pp. 1-10
    • Niswender, K.D.1    Schwartz, M.W.2
  • 184
    • 30044447631 scopus 로고    scopus 로고
    • Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
    • G. J. Morton, R. W. Gelling, K. D. Niswender, C. D. Morrison, C. J. Rhodes & M. W. Schwartz: Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab, 2, 411-420 (2005)
    • (2005) Cell Metab , vol.2 , pp. 411-420
    • Morton, G.J.1    Gelling, R.W.2    Niswender, K.D.3    Morrison, C.D.4    Rhodes, C.J.5    Schwartz, M.W.6
  • 185
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
    • B. B. Kahn, T. Alquier, D. Carling & D. G. Hardie: AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab, 1, 15-25 (2005) (Pubitemid 43960587)
    • (2005) Cell Metabolism , vol.1 , Issue.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 187
    • 33750333938 scopus 로고    scopus 로고
    • Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway
    • DOI 10.1016/j.bbrc.2006.10.015, PII S0006291X06022480
    • S. Uotani, T. Abe & Y. Yamaguchi: Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2- dependent pathway. Biochem. Biophys. Res. Commun, 351, 171-175 (2006) (Pubitemid 44635422)
    • (2006) Biochemical and Biophysical Research Communications , vol.351 , Issue.1 , pp. 171-175
    • Uotani, S.1    Abe, T.2    Yamaguchi, Y.3
  • 194
    • 56449115916 scopus 로고    scopus 로고
    • Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis
    • C. Blouet, H. Ono & G. J. Schwartz: Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis. Cell Metab, 8, 459-467 (2008)
    • (2008) Cell Metab , vol.8 , pp. 459-467
    • Blouet, C.1    Ono, H.2    Schwartz, G.J.3
  • 195
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • DOI 10.1038/ncb839
    • K. Inoki, Y. Li, T. Q. Zhu, J. Wu & K. L. Guan: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol, 4, 648-657 (2002) (Pubitemid 34993700)
    • (2002) Nature Cell Biology , vol.4 , Issue.9 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.-L.5
  • 196
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
    • DOI 10.1016/S0092-8674(03)00929-2
    • K. Inoki, T. Q. Zhu & K. L. Guan: TSC2 mediates cellular energy response to control cell growth and survival. Cell, 115, 577-590 (2003) (Pubitemid 37506046)
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.-L.3
  • 198
    • 78049518304 scopus 로고    scopus 로고
    • Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition
    • S. K. Chun & Y.-H. Jo: Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition. J Neurophysiol 104, 2321-2328 (2010)
    • (2010) J Neurophysiol , vol.104 , pp. 2321-2328
    • Chun, S.K.1    Jo, Y.-H.2
  • 199
    • 3142546889 scopus 로고    scopus 로고
    • Low levels of expression of leptin receptor at the cell surface result from constitutive endocytosis and intracellular retention in the biosynthetic pathway
    • DOI 10.1074/jbc.M400508200
    • S. Belouzard, D. Delcroix & Y. Rouille: Low levels of expression of leptin receptor at the cell surface result from constitutive endocytosis and intracellular retention in the biosynthetic pathway. J Biol Chem, 279, 28499-28508 (2004) (Pubitemid 38900132)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.27 , pp. 28499-28508
    • Belouzard, S.1    Delcroix, D.2    Rouille, Y.3
  • 200
    • 0033597897 scopus 로고    scopus 로고
    • Subcellular localization and internalization of the four human leptin receptor isoforms
    • V. A. Barr, K. Lane & S. I. Taylor: Subcellular localization and internalization of the four human leptin receptor isoforms. J Biol Chem, 274, 21416-21424 (1999)
    • (1999) J Biol Chem , vol.274 , pp. 21416-21424
    • Barr, V.A.1    Lane, K.2    Taylor, S.I.3
  • 202
    • 33644864967 scopus 로고    scopus 로고
    • Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis
    • DOI 10.1038/sj.emboj.7600989, PII 7600989
    • S. Belouzard & Y. Rouille: Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis. Embo J, 25, 932-942 (2006) (Pubitemid 43372108)
    • (2006) EMBO Journal , vol.25 , Issue.5 , pp. 932-942
    • Belouzard, S.1    Rouille, Y.2
  • 204
  • 207
    • 64149130937 scopus 로고    scopus 로고
    • Leptin resistance: A predisposing factor for diet-induced obesity
    • P. J. Scarpace & Y. Zhang: Leptin resistance: a predisposing factor for diet-induced obesity. Am J Physiol Regul Integr Comp Physiol, 296, R493-500 (2009)
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296
    • Scarpace, P.J.1    Zhang, Y.2
  • 208
    • 15444366416 scopus 로고    scopus 로고
    • 1138 of the leptin receptor and suppressor of cytokine signaling 3
    • DOI 10.1210/me.2004-0353
    • S. L. Dunn, M. Bjornholm, S. H. Bates, Z. B. Chen, M. Seifert & M. G. Myers: Feedback inhibition of leptin receptor/Jak2 signaling via Tyr(1138) of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol, 19, 925-938 (2005) (Pubitemid 40397057)
    • (2005) Molecular Endocrinology , vol.19 , Issue.4 , pp. 925-938
    • Dunn, S.L.1    Bjornholm, M.2    Bates, S.H.3    Chen, Z.4    Seifert, M.5    Myers Jr., M.G.6
  • 209
    • 0034548763 scopus 로고    scopus 로고
    • Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor
    • S. Eyckerman, D. Broekaert, A. Verhee, J. Vandekerckhove & J. Tavernier: Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor. FEBS Lett, 486, 33-7 (2000)
    • (2000) FEBS Lett , vol.486 , pp. 33-37
    • Eyckerman, S.1    Broekaert, D.2    Verhee, A.3    Vandekerckhove, J.4    Tavernier, J.5
  • 210
    • 0033569730 scopus 로고    scopus 로고
    • The role of SOCS-3 in leptin signaling and leptin resistance
    • C. Bjorbaek, K. El-Haschimi, J. D. Frantz & J. S. Flier: The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem, 274, 30059-30065 (1999)
    • (1999) J Biol Chem , vol.274 , pp. 30059-30065
    • Bjorbaek, C.1    El-Haschimi, K.2    Frantz, J.D.3    Flier, J.S.4
  • 211
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • DOI 10.1210/en.2004-0726
    • H. Munzberg, J. S. Flier & C. Bjorbaek: Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology, 145, 4880-4889 (2004) (Pubitemid 39551104)
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 213
    • 3142782772 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
    • DOI 10.1038/nm1072
    • J. K. Howard, B. J. Cave, L. J. Oksanen, I. Tzameli, C. Bjorbaek & J. S. Flier: Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med, 10, 734-738 (2004) (Pubitemid 38937639)
    • (2004) Nature Medicine , vol.10 , Issue.7 , pp. 734-738
    • Howard, J.K.1    Cave, B.J.2    Oksanen, L.J.3    Tzameli, I.4    Bjoorbaek, C.5    Flier, J.S.6
  • 214
    • 33746537247 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
    • DOI 10.1016/j.cmet.2006.06.010, PII S1550413106002427
    • P. Kievit, J. K. Howard, M. K. Badman, N. Balthasar, R. Coppari, H. Mori, C. E. Lee, J. K. Elmquist, A. Yoshimura & J. S. Flier: Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab, 4, 123-132 (2006) (Pubitemid 44138722)
    • (2006) Cell Metabolism , vol.4 , Issue.2 , pp. 123-132
    • Kievit, P.1    Howard, J.K.2    Badman, M.K.3    Balthasar, N.4    Coppari, R.5    Mori, H.6    Lee, C.E.7    Elmquist, J.K.8    Yoshimura, A.9    Flier, J.S.10
  • 215
    • 77951194676 scopus 로고    scopus 로고
    • Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis
    • A. S. Reed, E. K. Unger, L. E. Olofsson, M. L. Piper, M. G. Myers & A. W. Xu: Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis. Diabetes, 59, 894-906 (2010)
    • (2010) Diabetes , vol.59 , pp. 894-906
    • Reed, A.S.1    Unger, E.K.2    Olofsson, L.E.3    Piper, M.L.4    Myers, M.G.5    Xu, A.W.6
  • 223
    • 33845882537 scopus 로고    scopus 로고
    • Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age
    • DOI 10.1210/en.2006-0672
    • C. D. Morrison, C. L. White, Z. Wang, S.-Y. Lee, D. S. Lawrence, W. T. Cefalu, Z.-Y. Zhang & T. W. Gettys: Increased Hypothalamic Protein Tyrosine Phosphatase 1B Contributes to Leptin Resistance with Age. Endocrinology, 148, 433-440 (2007) (Pubitemid 46021475)
    • (2007) Endocrinology , vol.148 , Issue.1 , pp. 433-440
    • Morrison, C.D.1    White, C.L.2    Wang, Z.3    Lee, S.-Y.4    Lawrence, D.S.5    Cefalu, W.T.6    Zhang, Z.-Y.7    Gettys, T.W.8
  • 224
    • 60849120123 scopus 로고    scopus 로고
    • HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms
    • C. L. White, A. Whittington, M. J. Barnes, Z. Wang, G. A. Bray & C. D. Morrison: HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. Am J Physiol Endocrinol Metab, 296, E291-299 (2009)
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • White, C.L.1    Whittington, A.2    Barnes, M.J.3    Wang, Z.4    Bray, G.A.5    Morrison, C.D.6
  • 225
    • 47249148827 scopus 로고    scopus 로고
    • Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammation in Vivo
    • J. M. Zabolotny, Y.-B. Kim, L. A. Welsh, E. E. Kershaw, B. G. Neel & B. B. Kahn: Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammation in Vivo. J Biol Chem, 283, 14230-14241 (2008)
    • (2008) J Biol Chem , vol.283 , pp. 14230-14241
    • Zabolotny, J.M.1    Kim, Y.-B.2    Welsh, L.A.3    Kershaw, E.E.4    Neel, B.G.5    Kahn, B.B.6
  • 228
    • 0029881125 scopus 로고    scopus 로고
    • Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
    • DOI 10.1038/nm0596-589
    • M. W. Schwartz, E. Peskind, M. Raskind, E. J. Boyko & D. Porte: Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans. Nat Med, 2, 589-593 (1996) (Pubitemid 26151520)
    • (1996) Nature Medicine , vol.2 , Issue.5 , pp. 589-593
    • Schwartz, M.W.1    Peskind, E.2    Raskind, M.3    Boyko, E.J.4    Porte Jr., D.5
  • 229
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • DOI 10.1016/0196-9781(96)00025-3
    • W. A. Banks, A. J. Kastin, W. T. Huang, J. B. Jaspan & L. M. Maness: Leptin enters the brain by a saturable system independent of insulin. Peptides, 17, 305-311 (1996) (Pubitemid 26124406)
    • (1996) Peptides , vol.17 , Issue.2 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.3    Jaspan, J.B.4    Maness, L.M.5
  • 230
    • 0033395851 scopus 로고    scopus 로고
    • Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor
    • DOI 10.1016/S0196-9781(99)00156-4, PII S0196978199001564
    • A. J. Kastin, W. H. Pan, L. M. Maness, R. J. Koletsky & P. Ernsberger: Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides, 20, 1449-1453 (1999) (Pubitemid 30069891)
    • (1999) Peptides , vol.20 , Issue.12 , pp. 1449-1453
    • Kastin, A.J.1    Pan, W.2    Maness, L.M.3    Koletsky, R.J.4    Ernsberger, P.5
  • 231
    • 30444460361 scopus 로고    scopus 로고
    • Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors
    • DOI 10.1002/glia.20239
    • O. Cheunsuang & R. Morris: Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide YY1 receptors. Glia, 52, 228-233 (2005) (Pubitemid 43076153)
    • (2005) GLIA , vol.52 , Issue.3 , pp. 228-233
    • Cheunsuang, O.1    Morris, R.2
  • 232
    • 35549009434 scopus 로고    scopus 로고
    • Differential accessibility of circulating leptin to individual hypothalamic sites
    • DOI 10.1210/en.2007-0655
    • M. Faouzi, R. Leshan, M. Bjornholm, T. Hennessey, J. Jones & H. Munzberg: Differential accessibility of circulating leptin to individual hypothalamic sites. Endocrinology, 148, 5414-5423 (2007) (Pubitemid 350012627)
    • (2007) Endocrinology , vol.148 , Issue.11 , pp. 5414-5423
    • Faouzi, M.1    Leshan, R.2    Bjornholm, M.3    Hennessey, T.4    Jones, J.5    Munzberg, H.6
  • 233
    • 33750043782 scopus 로고    scopus 로고
    • Development of leptin antagonists and their potential use in experimental biology and medicine
    • DOI 10.1016/j.tem.2006.09.006, PII S1043276006001780
    • A. Gertler: Development of leptin antagonists and their potential use in experimental biology and medicine. Trends Endocrinol Metab, 17, 372-378 (2006) (Pubitemid 44584733)
    • (2006) Trends in Endocrinology and Metabolism , vol.17 , Issue.9 , pp. 372-378
    • Gertler, A.1
  • 234
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • DOI 10.1038/nrm2199, PII NRM2199
    • D. Ron & P. Walter: Signal integration in the endoplasmic reticulum unfolded protein response. Nat Res Mol Cell Biol, 8, 519-529 (2007) (Pubitemid 46985379)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 237
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKK[beta]/NF-[kappa]B and ER stress link overnutrition to energy imbalance and obesity
    • X. Zhang, G. Zhang, H. Zhang, M. Karin, H. Bai & D. Cai: Hypothalamic IKK[beta]/NF-[kappa]B and ER Stress Link Overnutrition to Energy Imbalance and Obesity. Cell, 135, 61-73 (2008)
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 240
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • DOI 10.1210/en.2004-1520
    • C. T. de Souza, E. P. Araujo, S. Bordin, R. Ashimine, R. L. Zollner, A. C. Boschero, M. J. A. Saad & L. A. Velloso: Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus. Endocrinology, 146, 4192-4199 (2005) (Pubitemid 41324012)
    • (2005) Endocrinology , vol.146 , Issue.10 , pp. 4192-4199
    • De Souza, C.T.1    Araujo, E.P.2    Bordin, S.3    Ashimine, R.4    Zollner, R.L.5    Boschero, A.C.6    Saad, M.J.A.7    Velloso, L.A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.