Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

Neuron

Volumn 42, Issue 6, 2004, Pages 983-991

  Balthasar, Nina ^a   Coppari, Roberto ^a   McMinn, Julie ^b   Liu, Shun M ^b   Lee, Charlotte E ^a   Tang, Vinsee ^a   Kenny, Christopher D ^a   McGovern, Robert A ^a   Chua Jr , Streamson C ^b   Elmquist, Joel K ^a   Lowell, Bradford B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; LEPTIN RECEPTOR; NEUROPEPTIDE; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; GENE DELETION; HOMEOSTASIS; HYPOTHALAMUS; MALE; MOUSE; NERVE CELL; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

AGE FACTORS; ALPHA-MSH; ANIMALS; BODY COMPOSITION; BODY WEIGHT; EATING; FEMALE; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HOMEOSTASIS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LEPTIN; LUMINESCENT PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; NEUROPEPTIDES; OXYGEN CONSUMPTION; PRO-OPIOMELANOCORTIN; RECEPTORS, CELL SURFACE; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX FACTORS; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTION FACTORS;

EID: 2942733252     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2004.06.004     Document Type: Article

References (55)

1. Ahima R.S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E., Flier J.S. Role of leptin in the neuroendocrine response to fasting. Nature. 382:1996;250-252
2. Albarado D.C., McClaine J., Stephens J.M., Mynatt R.L., Ye J., Bannon A.W., Richards W.G., Butler A.A. Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice. Endocrinology. 145:2004;243-252
3. Bates S.H., Stearns W.H., Dundon T.A., Schubert M., Tso A.W., Wang Y., Banks A.S., Lavery H.J., Haq A.K., Maratos-Flier E., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature. 421:2003;856-859
4. Bergen H.T., Mizuno T.M., Taylor J., Mobbs C.V. Hyperphagia and weight gain after gold-thioglucose. relation to hypothalamic neuropeptide Y and proopiomelanocortin Endocrinology. 139:1998;4483-4488
5. Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell. 1:1998;619-625
6. Boston B.A., Blaydon K.M., Varnerin J., Cone R.D. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science. 278:1997;1641-1644
7. Bronstein D.M., Schafer M.K., Watson S.J., Akil H. Evidence that beta-endorphin is synthesized in cells in the nucleus tractus solitarius. detection of POMC mRNA Brain Res. 587:1992;269-275
8. Butler A.A., Marks D.L., Fan W., Kuhn C.M., Bartolome M., Cone R.D. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat. Neurosci. 4:2001;605-611
9. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein. evidence for a peripheral signal linking adiposity and central neural networks Science. 269:1995;546-549
10. Catzeflis C., Pierroz D.D., Rohner-Jeanrenaud F., Rivier J.E., Sizonenko P.C., Aubert M.L. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats. Endocrinology. 132:1993;224-234
11. Challis B.G., Coll A.P., Yeo G.S., Pinnock S.B., Dickson S.L., Thresher R.R., Dixon J., Zahn D., Rochford J.J., White A., et al. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY3-36. Proc. Natl. Acad. Sci. USA. 101:2004;4695-4700
12. Chen H., Charlat O., Tartaglia L.A., Woolf E.A., Weng X., Ellis S.J., Lakey N.D., Culpepper J., Moore K.J., Breitbart R.E., et al. Evidence that the diabetes gene encodes the leptin receptor. identification of a mutation in the leptin receptor gene in db/db mice Cell. 84:1996;491-495
13. Chen A.S., Marsh D.J., Trumbauer M.E., Frazier E.G., Guan X.M., Yu H., Rosenblum C.I., Vongs A., Feng Y., Cao L., et al. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat. Genet. 26:2000;97-102
14. Chua S.C. Jr., Chung W.K., Wu-Peng X.S., Zhang Y., Liu S.M., Tartaglia L., Leibel R.L. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 271:1996;994-996
15. Cohen P., Zhao C., Cai X., Montez J.M., Rohani S.C., Feinstein P., Mombaerts P., Friedman J.M. Selective deletion of leptin receptor in neurons leads to obesity. J. Clin. Invest. 108:2001;1113-1121
16. Coleman D.L. Obese and diabetes. two mutant genes causing diabetes-obesity syndromes in mice Diabetologia. 14:1978;141-148
17. Coleman D.L. Diabetes-obesity syndromes in mice. Diabetes. 31:1982;1-6
18. Collin M., Backberg M., Ovesjo M.L., Fisone G., Edwards R.H., Fujiyama F., Meister B. Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight. Eur. J. Neurosci. 18:2003;1265-1278
19. Cowley M.A., Smart J.L., Rubinstein M., Cerdan M.G., Diano S., Horvath T.L., Cone R.D., Low M.J. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 411:2001;480-484
20. Cowley M.A., Cone R.D., Enriori P., Louiselle I., Williams S.M., Evans A.E. Electrophysiological actions of peripheral hormones on melanocortin neurons. Ann. N Y Acad. Sci. 994:2003;175-186
21. Ducy P., Amling M., Takeda S., Priemel M., Schilling A.F., Beil F.T., Shen J., Vinson C., Rueger J.M., Karsenty G. Leptin inhibits bone formation through a hypothalamic relay. a central control of bone mass Cell. 100:2000;197-207
22. Elias C.F., Lee C., Kelly J., Aschkenasi C., Ahima R.S., Couceyro P.R., Kuhar M.J., Saper C.B., Elmquist J.K. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron. 21:1998;1375-1385. a
23. Elias C.F., Saper C.B., Maratos-Flier E., Tritos N.A., Lee C., Kelly J., Tatro J.B., Hoffman G.E., Ollmann M.M., Barsh G.S., et al. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J. Comp. Neurol. 402:1998;442-459. b
24. Elias C.F., Aschkenasi C., Lee C., Kelly J., Ahima R.S., Bjorbaek C., Flier J.S., Saper C.B., Elmquist J.K. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. 23:1999;775-786
25. Elmquist J.K., Bjorbaek C., Ahima R.S., Flier J.S., Saper C.B. Distributions of leptin receptor mRNA isoforms in the rat brain. J. Comp. Neurol. 395:1998;535-547
26. Elmquist J.K., Elias C.F., Saper C.B. From lesions to leptin. hypothalamic control of food intake and body weight Neuron. 22:1999;221-232
27. Erickson J.C., Hollopeter G., Palmiter R.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science. 274:1996;1704-1707
28. Grill H.J., Schwartz M.W., Kaplan J.M., Foxhall J.S., Breininger J., Baskin D.G. Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology. 143:2002;239-246
29. Hogan B.L.H., Constantini F., Lacy E. Manipulating the Mouse Embryo. 1986;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
30. Hohmann J.G., Teal T.H., Clifton D.K., Davis J., Hruby V.J., Han G., Steiner R.A. Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278:2000;R50-R59
31. Huszar D., Lynch C.A., Fairchild-Huntress V., Dunmore J.H., Fang Q., Berkemeier L.R., Gu W., Kesterson R.A., Boston B.A., Cone R.D., et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 88:1997;131-141
32. Kowalski T.J., Liu S.M., Leibel R.L., Chua S.C. Jr. Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes. 50:2001;425-435
33. Lee G.H., Proenca R., Montez J.M., Carroll K.M., Darvishzadeh J.G., Lee J.I., Friedman J.M. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 379:1996;632-635
34. Lee E.C., Yu D., Martinez de Velasco J., Tessarollo L., Swing D.A., Court D.L., Jenkins N.A., Copeland N.G. A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics. 73:2001;56-65
35. Liu H., Kishi T., Roseberry A.G., Cai X., Lee C.E., Montez J.M., Friedman J.M., Elmquist J.K. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J. Neurosci. 23:2003;7143-7154
36. Marsh D.J., Hollopeter G., Huszar D., Laufer R., Yagaloff K.A., Fisher S.L., Burn P., Palmiter R.D. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat. Genet. 21:1999;119-122
37. Meister B., Ceccatelli S., Hokfelt T., Anden N.E., Anden M., Theodorsson E. Neurotransmitters, neuropeptides and binding sites in the rat mediobasal hypothalamus. effects of monosodium glutamate (MSG) lesions Exp. Brain Res. 76:1989;343-368
38. Michaud E.J., Bultman S.J., Klebig M.L., van Vugt M.J., Stubbs L.J., Russell L.B., Woychik R.P. A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. Proc. Natl. Acad. Sci. USA. 91:1994;2562-2566
39. Mizuno T.M., Kleopoulos S.P., Bergen H.T., Roberts J.L., Priest C.A., Mobbs C.V. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin. Diabetes. 47:1998;294-297
40. Novak A., Guo C., Yang W., Nagy A., Lobe C.G. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis. 28:2000;147-155
41. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:1995;540-543
42. Richter W.O., Schwandt P. Lipolytic potency of proopiomelanocorticotropin peptides in vitro. Neuropeptides. 9:1987;59-74
43. Roseberry A.G., Liu H., Jackson A.C., Cai X., Friedman J.M. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron. 41:2004;711-722
44. Schwartz M.W., Baskin D.G., Bukowski T.R., Kuijper J.L., Foster D., Lasser G., Prunkard D.E., Porte D. Jr., Woods S.C., Seeley R.J., Weigle D.S. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 45:1996;531-535
45. Schwartz M.W., Seeley R.J., Woods S.C., Weigle D.S., Campfield L.A., Burn P., Baskin D.G. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes. 46:1997;2119-2123
46. Schwartz M.W., Woods S.C., Seeley R.J., Barsh G.S., Baskin D.G., Leibel R.L. Is the energy homeostasis system inherently biased toward weight gain? Diabetes. 52:2003;232-238
47. Seeley R.J., Yagaloff K.A., Fisher S.L., Burn P., Thiele T.E., van Dijk G., Baskin D.G., Schwartz M.W. Melanocortin receptors in leptin effects. Nature. 390:1997;349
48. Spiegelman B.M., Flier J.S. Obesity and the regulation of energy balance. Cell. 104:2001;531-543
49. Stephens T.W., Basinski M., Bristow P.K., Bue-Valleskey J.M., Burgett S.G., Craft L., Hale J., Hoffmann J., Hsiung H.M., Kriauciunas A., et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:1995;530-532
50. Takeda S., Elefteriou F., Levasseur R., Liu X., Zhao L., Parker K.L., Armstrong D., Ducy P., Karsenty G. Leptin regulates bone formation via the sympathetic nervous system. Cell. 111:2002;305-317
51. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., et al. Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1995;1263-1271
52. Thornton J.E., Cheung C.C., Clifton D.K., Steiner R.A. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology. 138:1997;5063-5066
53. Yaswen L., Diehl N., Brennan M.B., Hochgeschwender U. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat. Med. 5:1999;1066-1070
54. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432
55. Zigman J.M., Elmquist J.K. Minireview. From anorexia to obesity-the yin and yang of body weight control Endocrinology. 144:2003;3749-3756