Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors

Journal of Biological Chemistry

Volumn 276, Issue 7, 2001, Pages 4747-4755

  Bjørbæk, Christian ^a   Buchholz, Ryan M ^a   Davis, Sarah M ^b   Bates, Sarah H ^b   Pierroz, Dominique D ^a   Gu, Haihua ^a   Neel, Benjamin G ^a   Myers Jr , Martin G ^b   Flier, Jeffrey S ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYMES; PROTEINS; RNA;

INTRACELLULAR TYROSIN RESIDUES; LEPTIN SIGNALING;

BIOCHEMISTRY;

EARLY GROWTH RESPONSE FACTOR 1; GENE PRODUCT; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; REGULATOR PROTEIN; TYROSINE; UNCLASSIFIED DRUG; CARRIER PROTEIN; CELL SURFACE RECEPTOR; DNA BINDING PROTEIN; EGR1 PROTEIN, MOUSE; IMMEDIATE EARLY PROTEIN; JAK2 PROTEIN, MOUSE; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 3; ONCOPROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; PTPN6 PROTEIN, MOUSE; SIGNAL PEPTIDE; SRC HOMOLOGY 2 (SH2) DOMAIN CONTAINING PHOSPHATASES; SRC HOMOLOGY-2 (SH2) DOMAIN-CONTAINING PHOSPHATASES; STAT3 PROTEIN; STAT3 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; C57BL MOUSE; CHEMISTRY; CHO CELL; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HAMSTER; HYPOTHALAMUS; MALE; METABOLISM; MOUSE; MUTATION; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALIA;

ANIMALS; CARRIER PROTEINS; CHO CELLS; CRICETINAE; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; HYPOTHALAMUS; IMMEDIATE-EARLY PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JANUS KINASE 2; LEPTIN; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MUTATION; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SHP1 PROTEIN TYROSINE PHOSPHATASE; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0000430395     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007439200     Document Type: Article

References (63)

1. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994) Nature 372, 425-432
2. Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., and Collins, F. (1995) Science 269, 540-543
3. Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., and Friedman, J. M. (1995) Science 269, 543-546
4. Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., and Burn, P. (1995) Science 269, 546-549
5. Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., and Flier, J. S. (1996) Nature 382, 250-252
6. Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K. J., Smutko, J. S., Mays, G. G., Woolf, E. A., Monroe, C. A., and Tepper, R. I. (1995) Cell 83, 1263-1271
7. Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., and Friedman, J. M. (1996) Nature 379, 632-635
8. Chen, H., Chatlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., Moore, K. J., Breitbart, R. E., Duyk, G. M., Tepper, R. I., and Morgenstern, J. P. (1996) Cell 84, 491-495
9. Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., Cheetham, C. H., Earley, A. R., Barnett, A. H., Prins, J. B., and O'Rahilly, S. (1997) Nature 387, 903-908
10. Clement, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J. M., Basdevant, A., Bougneres, P., Lebouc, Y., Froguel, P., and Guy-Grand, B. (1998) Nature 392, 398-401
11. Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) Nat. Med. 1, 1155-1161
12. Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., and Flier, J. S. (1998) Mol. Cell 1, 619-625
13. Elmquist, J. K., Ahima, R. S., Maratos-Flier, E., Flier, J. S., and Saper, C. B. (1997) Endocrinology 138, 839-842
14. Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjørbæk, C., Flier, J. S., Saper, C. B., and Elmquist, J. K. (1999) Neuron 23, 775-786
15. Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., MacKellar, W., Rosteck, P. R., Jr., Schoner, B., Smith, D., Tinsley, F. C., Zhang, X.-Y., and Heiman, M. (1995) Nature 377, 530-532
16. Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Jr., Woods, S. C., Seeley, R. J., and Weigle, D. S. (1996) Diabetes 45, 531-535
17. Ollmann, M. M., Wilson, B. D., Yang, Y. K., Kerns, J. A., Chen, Y., Gantz, I., and Barsh, G. S. (1997) Science 278, 135-138
18. Kristensen, P., Judge, M., E., Thim, L., Ribel, U., Christjansen, K. N., Wulff, B. S., Clausen, J. T., Jensen, P. B., Madsen, O. D., Vrang, N., Larsen, P. J., and Hastrup, S. (1998) Nature 393, 72-76
19. Thornton, J. E., Cheung, C. C., Clifton, D. K., and Steiner, R. A. (1997) Endocrinology 138, 5063-5066
20. Cheung, C. C., Clifton, D. K., and Steiner, R. A. (1997) Endocrinology 138, 4489-4492
21. Nillni, E. A., Vaslet, C., Harris, M., Hollenberg, A. N., Bjorbeek, C., and Flier, J. S. (2000) J. Biol. Chem. 275, 36124-36133
22. Ghilardi, N., Ziegler, S., Wiestner, A., Stoffel, R., Heim, M. H., and Skoda, R. C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 6231-6235
23. Bjørbæk, C., Elmquist, J. K., Miehl, P., Ahima, R. S., van Bueren, A., McCall, A. L., and Flier, J. S. (1998) Endocrinology 139, 3485-3491
24. Elmquist, J. K., Bjørbæk, C., Ahima, R. S., Flier, J. S., and Saper, C. B. (1998) J. Comp. Neurol. 395, 535-547
25. Ghilardi, N., and Skoda, R. C. (1997) Mol. Endocrinol. 11, 393-399
26. Bjørbæk, C., Uotani, S., da Silva, B., and Flier, J. S. (1997) J. Biol. Chem. 272, 32686-32695
27. Ihle, J. N. (1995) Nature 377, 591-594
28. Darnell, J. E. (1997) Science 277, 1630-1635
29. Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. E., Jr., and Yancopoulos, G. D. (1995) Science 267, 1349-1353
30. Baumann, H., Morella, K. K., White, D. W., Dembski, M., Bailon, P. S., Kim, H., Lai, C.-F., and Tartaglia, L. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 8374-8378
31. White, D. W., Kuropatwinski, K. K., Devos, R., Baumann, H., and Tartaglia, L. A. (1997) J. Biol. Chem. 272, 4065-4071
32. Carpenter, L. R., Farruggella, T. J., Symes, A., Karow, M. L., Yancopoulos, G. D., and Stahl, N. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6061-6066
33. Banks, A. S., Davis, S. M., Bates, S. H., and Myers, M. G., Jr. (2000) J. Biol. Chem. 275, 14563-14572
34. Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Jr., Stoffel, M., and Friedman, J. M. (1996) Nat. Genet. 14, 95-97
35. Wang, Y., Kuropatwinski, K. K., White, D. W., Hawley, T. S., Hawley, R. G., Tartaglia, L. A., and Baumann, H. (1997) J. Biol. Chem. 272, 16216-16223
36. Berti, L., Kellerer, M., Capp, E., and Haring, H. U. (1997) Diabetologia 40, 606-609
37. Kim, Y. B., Uotani, S., Pierroz, D. D., Flier, J. S., and Kahn, B. B. (2000) Endocrinology 141, 2328-2339
38. Takahashi, Y., Okimura, Y., Mizuno, I., Iida K., Takahashi, T., Kaji, H., Abe, H., and Chihara, K. (1997) J. Biol. Chem. 272, 12897-12900
39. Neel, B. G., and Tonks, N. K. (1997) Curr. Opin. Cell Biol. 9, 193-204
40. Li, C., and Friedman, J. M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 9677-9682
41. Tang, T. L., Freeman, R. M., Jr., O'Reilly, A. M., and Neel, B. G., and Sokol, S. Y. (1995) Cell 80, 473-483
42. Bennett, A. M., Hausdorff, S. F., O'Reilly, A. M., Freeman, R. M., and Neel, B. G. (1996) Mol. Cell. Biol. 16, 1189-1202
43. Shi, Z. Q., Lu, W., and Feng, G. S. (1998) J. Biol. Chem. 273, 4904-4908
44. Gu, H., Pratt, J. C., Burakoff, S. J., and Neel, B. G. (1998) Mol. Cell. 2, 729-740
45. Kim, H., and Baumann, H. (1999) Mol. Cell. Biol. 19, 5326-5338
46. David, M., Zhou, G., Pine, R., Dixon, J. E., and Larner, A. C. (1996) J. Biol. Chem. 271, 15862-15865
47. Ali, S., Chen, Z., Lebrun, J. J., Vogel, W., Kharitonenkov, A., Kelly, P. A., and Ullrich, A. (1996) EMBO J. 15, 135-142
48. You, M., Yu, D. H., and Feng, G. S. (1999) Mol. Cell. Biol. 19, 2416-2424
49. Bjørbæk, C., Lavery, H. J., Bates, S. H., Olson, R. K., Davis, S. M., Flier, J. S., and Myers, M. G., Jr. (2000) J. Biol. Chem. 275, 40649-40657
50. Myers, M. G., Jr., Mendez, R., Shi, P., Pierce, J. H., Rhoads, R., and White, M. F. (1998) J. Biol. Chem. 273, 26908-26914
51. Park, J. A., and Koh, J. Y. (1999) Neurochem. 73, 450-456
52. Hodge, C., Liao, J., Stofega, M., Guan, K., Carter-Su, C., and Schwartz, J. (1998) J. Biol. Chem. 273, 31327-31336
53. Bjørbæk, C., El-Haschimi, K., Frantz, J. D., and Flier, J. S. (1999) J. Biol. Chem. 274, 30059-30065
54. Auernhammer, C. J., Chesnokova, V., Bousquet, C., and Melmed, S. (1998) Mol. Endocrinol. 12, 954-961
55. Bennett, A. M., Tang, T. L., Sugimoto, S., Walsh, C. T., and Neel, B. G. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 7335-7339
56. Li, W., Nishimura, R., Kashishian, A., Batzer, A. G., Kim, W. J., Cooper, J. A., and Schlessinger, J. (1994) Mol. Cell. Biol. 14, 509-517
57. Shi, Z.-Q., Yu, D.-H., Park, M., Marshall, M., and Feng, G.-S. (2000) Mol. Cell. Biol. 20, 1526-1536
58. Fujioka, Y., Matozaki, T., Noguchi, T., Iwamatsu, A., Yamao, T., Takahashi, N., Tsuda, M., Takada, T., and Kasuga, M. (1996) Mol. Cell. Biol. 16, 6887-6899
59. Tsuda, M., Matozaki, T., Fukunaga, K., Fujioka, Y., Imamoto, A., Noguchi, T., Takada, T., Yamao, T., Takeda, H., Ochi, F., Yamamoto, T., and Kasuga, M. (1998) J. Biol. Chem. 273, 13223-13229
60. Oh, E. S., Gu, H., Saxton, T. M., Timms, J. F., Hausdorff, S., Frevert E. U., Kahn, B. B., Pawson, T., Neel, B. G., and Thomas, S. M. (1999) Mol. Cell. Biol. 19, 3205-3215
61. Nicholson, S. E., De Souza, D., Fabri, L. J., Corbin, J., Willson, T. A., Zhang, J. G., Silva, A., Asimakis, M., Farley, A., Nash, A. D., Metcalf, D., Hilton, D. J., Nicola, N. A., and Baca, M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6493-6498
62. Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C., and Schaper, F. (2000) J. Biol. Chem. 275, 12848-12856
63. Murakami, M., Narazaki, M., Hibi, M., Yawata, H., Yasukawa, K., Hamaguchi, M., Taga, T., and Kishimoto, T. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 11349-11353