Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus

Journal of Clinical Investigation

Volumn 114, Issue 7, 2004, Pages 917-927

  Kubota, Naoto ^a,b,c,d   Terauchi, Yasuo ^a,b   Tobe, Kazuyuki ^a,b   Yano, Wataru ^a   Suzuki, Ryo ^a,b   Ueki, Kohjiro ^a   Takamoto, Iseki ^a,b   Satoh, Hidemi ^a   Maki, Toshiyuki ^a   Kubota, Tetsuya ^e   Moroi, Masao ^e   Okada Iwabu, Miki ^d   Ezaki, Osamu ^d   Nagai, Ryozo ^a   Ueta, Yoichi ^f   Kadowaki, Takashi ^a,b,d   Noda, Tetsuo ^c,g  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c The Japan Foundation   (Japan)

^d NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^e TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^g TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; LEPTIN; MESSENGER RNA;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CALORIC RESTRICTION; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GLUCOSE INTOLERANCE; HYPOTHALAMUS; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIVER; MALE; MOUSE; MUSCLE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 9644260562     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI21484     Document Type: Article

References (36)

1. Kadowaki, T. 2000. Insights into insulin resistance and type 2 diabetes from knockout mouse models. J. Clin. Invest. 106:459-465.
2. White, M.F. 1998. The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol. Cell. Biochem. 182:3-11.
3. Virkamaki, A., Ueki, K., and Kahn, C.R. 1999. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J. Clin. Invest. 103:931-943.
4. Saltiel, A.R., and Kahn, CR. 2001. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 414:799-806.
5. Nakae, J., Kido, Y., and Accili, D. 2001. Distinct and overlapping functions of insulin and IGF-I receptors. Endocr. Rev. 22:813-835.
6. Shulman, G.I. 2000. Cellular mechanisms of insulin resistance. J. Clin. Invest. 106:171-176.
7. Mauvais-Jarvis, F., Kulkarni, R.N., and Kahn, C.R. 2002. Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin. Endocrinol. (Oxf). 57:1-9.
8. Tamemoto, H., et al. 1994. Insulin and growth retardation in mice lacking insulin receptor substrate-1. Nature. 372:182-186
9. Araki, E., et al. 1994. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 372:186-190.
10. Terauchi, Y., et al. 1997. Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. J. Clin. Invest. 99:861-866.
11. Withers, D.J., et al. 1998. Disruption of IRS2 causes type 2 diabetes in mice. Nature. 391:900-904.
12. Withers, D.J., et al. 1999. Irs2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat. Genet. 23:32-40.
13. Kubota, N., et al. 2000. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes. 49:1880-1889.
14. -/- mouse liver. J. Biol Chem. 276:38337-38340.
15. Terauchi, Y., et al. 2003. Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice. J. Biol. Chem. 278:14284-14290.
16. Kulkarni, R.N., et al. 1999. Tissue-specific knockout of the insulin receptor in pancreatic beta cells cteates an insulin secretory defect similar to that in type 2 diabetes. Cell. 96:329-339.
17. Kulkarni, R.N., et al. 2002. Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat. Genet. 31:111-115.
18. -/- mice. J. Biol. Chem. 279:25039-25049.
19. Cui, Y., et al. 2004. Essential role of STAT3 in body weight and glucose homeostasis. Mol. Cell. Biol. 24:258-269.
20. Bruning, J.C., et al. 2000. Role of brain insulin receptor in control of body weight and reproduction. Science. 289:2122-2125.
21. Kushner, J.A., et al. 2002. Pdx1 restores beta cell function in Irs2 knockout mice. J. Clin. Invest. 109:1193-1201. doi:10.1172/JCI200214439.
22. Suzuki, R., et al. 2003. Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. J. Biol. Chem. 278:43691-43698.
23. Aspinwall, C.A., Lakey, J.R., and Kennedy, R.T. 1999. Insulin-stimulated insulin secretion in single pancreatic β cells. J. Biol. Chem. 274:6360-6365.
24. Kulkarni, R.N., et al. 1999. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin. Invest. 104:R69-R75.
25. Accili, D. 2001. A kinase in the life of the β cell. J. Clin. Invest. 108:1575-1576. doi:10.1172/JCI200114454.
26. Porzio, O., et al. 1999. The Gly972 → Argamino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic β-cells. J. Clin. Invest. 104:357-364.
27. Eto, K., et al. 2002. Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals. Diabetes. 51:87-97.
28. Kulkarni, R.N., et al. 1997. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J. Clin. Infest. 100:2729-2736.
29. Kubota, N., et al. 2002. Disruption of adiponectin causes insulin resistance and neointimal formation. J. Biol. Chem. 277:25863-25866.
30. Taniguchi, M., et al. 1998. Efficient production of Cre-mediated site-directed recombinants through the utilization of the puromycin resistance gene, pac: a transient gene-integration marker for ES cells. Nucleic Acids Res. 26:679-680.
31. Glowinski, J., and Iversen, L.L. 1966. Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J. Neurochem. 13:655-669.
32. Kubota, N., et al. 1999. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell. 4:597-609.
33. Ueta, Y., Levy, A., Chowdrey, H.S., and Lightman, S.L. 1995. S-100 antigen-positive folliculostellate cells are not the source of IL-6 gene expression in human pituitary adenomas. J. Neuroendocrinol. 7:467-474.
34. Ueta, Y., Levy, A., Chowdrey, H.S., and Lightman, S.L. 1995. Hypothalamic nitric oxide synthase gene expression is regulated by thyroid hormones. Endocrinology. 136:4182-4187.
35. Offield, M.F., et al. 1996. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 122:983-995.
36. Ohtsuka, N., Urase, K., Momoi, T., and Nogawa, H. 2001. Induction of bud formation of embryonic mouse tracheal epithelium by fibroblast growth factor plus transferrin in mesenchyme-free culture. Dev. Dyn. 222:263-272.