Fat storage in adipocytes requires inactivation of leptin's paracrine activity: Implications for treatment of human obesity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 50, 2005, Pages 18011-18016

  Wang, May Yun ^a   Orci, Lelio ^c   Ravazzola, Mariella ^c   Unger, Roger H ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

AMP activated protein kinase; Autocrine paracrine action; Diet induced obesity; Hyperleptinemia; Lepr b

Indexed keywords

FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BODY FAT; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; CELL HYPERPLASIA; CELL SIZE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY ACID OXIDATION; HYPERLEPTINEMIA; HYPERTROPHY; IMMUNOBLOTTING; LIPID DIET; LIPID STORAGE; MALE; MOUSE; NONHUMAN; OBESITY; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WHITE ADIPOSE TISSUE;

ADENYLATE KINASE; ADIPOCYTES; ANIMALS; CARRIER PROTEINS; DIETARY FATS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; ION CHANNELS; LEPTIN; LIPID METABOLISM; MALE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, TRANSGENIC; MITOCHONDRIAL PROTEINS; OBESITY; PARACRINE COMMUNICATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TIME FACTORS; TRANS-ACTIVATORS; TRANSGENES;

ANIMALIA; MUS MUSCULUS;

EID: 29144510014     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509001102     Document Type: Article

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