Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells

Endocrinology

Volumn 141, Issue 6, 2000, Pages 1955-1961

  Hileman, Stanley M ^a   Tornøe, Jens ^a   Flier, Jeffrey S ^a   Bjørbæk, Christian ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; IODINE 125; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; BLOOD BRAIN BARRIER; BODY WEIGHT; BRAIN BLOOD VESSEL; CELL STRAIN; CELL SURFACE; CONTROLLED STUDY; HORMONE BINDING; HORMONE TRANSPORT; NEUROENDOCRINOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOACTIVITY; TRANSCYTOSIS;

EID: 17744388106     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.141.6.7450     Document Type: Article

References (45)

1. Positional cloning of the mouse obese gene and its human homologue
2. Weight-reducing effects of the plasma protein encoded by the obese gene
3. Recombinant mouse OB protein: Evidence for peripheral signal linking adiposity and central neural networks
4. Role of leptin in the neuroendocrine response to fasting
5. Congenital leptin deficiency is associated with severe early-onset obesity in humans
6. Abnormal splicing of the leptin receptor in diabetic mice
7. Identification and expression cloning of a leptin receptor, OB-R
8. Localizaton of leptin receptor mRNA expression in mouse brain
9. Distributions of leptin receptor mRNA isoforms in the rat brain
10. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
11. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
12. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin
13. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
14. Serum immunoreactive-leptin concentrations in normal-weight and obese humans
15. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
16. Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
17. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
18. Diet-induced obese mice develop peripheral, but not central, resistance to leptin
19. Leptin enters the brain by a saturable system independent of insulin
20. Human blood-brain barrier leptin receptor
21. Expression of leptin receptor isoforms in rat brain microvessels
22. Apical membrane aminopeptidase appears at site of cell-cell contact in cultured kidney epithelial cells
23. Transepithelial transport in cell culture
24. Demonstration of protein asymmetries in the plasma membrane of cultured renal (MDCK) epithelial cells by lactoperoxidase-mediated iodination
25. Experimental modulation of occluding junctions in a cultured transporting epithelium
26. Divergent signaling capacities of the long and short isoforms of the leptin receptor
27. Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells
28. Phosphorylation of the polymeric immunoglobulin receptor is required for its efficient transcytosis
29. Gsα stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase A
30. Polarized monolayers formed by epithelial cells on a permeable and translucent support
31. Development of cell surface polarity in the epithelial Madin-Darby canine kidney (MDCK) cell line
32. Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family
33. Apical and basolateral endocytosis in Madin-Darby canine kidney (MDCK) cells grown on nitrocellulose filters
34. Polarized expression of GABA transporters in Madin-Darby canine kidney cells and cultured hippocampal neurons
35. Vesicular stomatitis virus infects and matures only through the basolateral surface of the polarized epithelial cell line, MDCK
36. Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture
37. Functional properties of leptin receptor isoforms: Internalization and degradation of leptin and ligand-induced receptor downregulation
38. Kinetics of insulin receptor internalization and recycling in adipocytes
39. Comparative studies on insulin-like growth factor II and insulin processing by vascular endothelial cells
40. Mechanism of leptin removal from the circulation by the kidney
41. Regional leptin kinetics in humans
42. The relationship of tissue localization, distribution, and turnover to feeding after intraperitoneal 125I-leptin administration 6to ob/ob and db/db mice
43. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
44. Insulin degradation by Madin-Darby canine kidney cells expressing the insulin receptor