Defective STAT signaling by the leptin receptor in diabetic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 13, 1996, Pages 6231-6235

  Ghilardi, Nico ^a   Ziegler, Sandra ^a   Wiestner, Adrian ^a   Stoffel, Ruedi ^a   Heim, Markus H ^b   Skoda, Radek C ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

alternative splicing; janus kinase; obese mutant; obesity; signal transducers and activators of transcription signaling pathway

Indexed keywords

GENE PRODUCT; LEPTIN; PROTEIN;

ANIMAL CELL; ARTICLE; DIABETES MELLITUS; GENE EXPRESSION; HOMOZYGOSITY; HYPOTHALAMUS; MOLECULAR CLONING; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DNA PRIMERS; DNA-BINDING PROTEINS; EXONS; HUMANS; INTRONS; MICE; MICE, INBRED C57BL; MILK PROTEINS; MOLECULAR SEQUENCE DATA; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0030015417     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.13.6231     Document Type: Article

References (40)

1. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. & Friedman, J. M. (1994) Nature (London) 372, 425-432.
2. Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., Kern, P. A. & Friedman, J. M. (1995) Nat. Med. 1, 1155-1161.
3. Frederich, R. C., Hamann, A., Anderson, S., Loellmann, B., Lowell, B. B. & Flier, J. S. (1995) Nat. Med. 1, 1311-1314.
4. Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciumas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L. & Caro, J. F. (1996) N. Engl. J. Med. 334, 292-295.
5. Considine, R. V., Considine, E. L., Williams, C. J., Nyce, M. R., Magosin, S. A., Bauer, T. L., Rosato, E. L., Colberg, J. & Caro, J. F. (1995) J. Clin. Invest. 95, 2986-2988.
6. Coleman, D. L. (1978) Diabetologia 14, 141-148.
7. Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T. & Collins, F. (1995) Science 269, 540-543.
8. Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K. & Friedman, J. M. (1995) Science 269, 543-546.
9. Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R. & Burn, P. (1995) Science 269, 546-549.
10. Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K. J., Smutko, J. S., Mays, G. G., Woolf, E. A., Monroe, C. A. & Tepper, R. I. (1995) Cell 83, 1263-1271.
11. Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., Moore, K, J., Breitbart, R. E., Duyk, G. M., Tepper, R. I. & Morgenstern, J. P. (1996) Cell 84, 491-495.
12. Lee, G.-H., Proenca, R., Montez, J. M., Caroll, K. M., Darvishzadeh, J. G., Lee, J. I. & Friedman, J. M. (1996) Nature (London) 379, 632-635.
13. Bazan, J. F. (1990) Proc. Natl. Acad. Sci. USA 87, 6934-6938.
14. Ihle, J. N. (1995) Nature (London) 377, 591-594.
15. Darnell, J. E., Jr., Kerr, I. M. & Stark, G. R. (1994) Science 264, 1415-1421.
16. Schindler, C, Fu, X. Y., Improta, T., Aebersold, R. & Darnell, J. E., Jr. (1992) Proc. Natl. Acad. Sci. USA 89, 7836-7839.
17. Fu, X. Y., Schindler, C., Improta, T., Aebersold, R. & Darnell, J. E., Jr. (1992) Proc. Natl. Acad. Sci. USA 89, 7840-7843.
18. Zhong, Z., Wen, Z. & Darnell, J. E., Jr. (1994) Proc. Natl. Acad. Sci. USA 91, 4806-4810.
19. Akira, S., Nishio, Y., Inoue, M., Wang, X. J., Wei, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M. & Kishimoto, T. (1994) Cell 77, 63-71.
20. Yamamoto, K., Quelle, F. W., Thierfelder, W. E., Kreider, B. L., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., Silvennoinen, O. & Ihle, J. N. (1994) Mol. Cell. Biol. 14, 4342-4349.
21. Wakao, H., Gouilleux, F. & Groner, B. (1994) EMBO J. 13, 2182-2191.
22. Hou, J., Schindler, U., Henzel, W. J., Ho, T. C., Brasseur, M. & McKnight, S. L. (1994) Science 265, 1701-1706.
23. Ihle, J. N. (1996) Cell 84, 331-334.
24. Krieg, P. A. & Melton, D. A. (1987) Methods Enzymol. 155, 397-415.
25. Chomczynski, P. & Sachi, N. (1987) Anal. Biochem. 162, 156-159.
26. Chinault, A. C., Brennand, J., Konecki, D. S., Nussbaum, R. L. & Caskey, C. T. (1984) Adv. Exp. Med. Biol. 165, 411-415.
27. Seed, B. & Aruffo, A. (1987) Proc. Natl. Acad. Sci. USA 84, 3365-3369.
28. Levy, D. E., Kessler, D. S., Pine, R. & Darnell, J. E., Jr. (1989) Genes Dev. 3, 1362-1371.
29. Wagner, B. J., Hayes, T. E., Hoban, C. J. & Cochran, B. H. (1990) EMBO J. 9, 4477-4484.
30. Schmitt, N. M., Doppler, W., Ball, R. K. & Groner, B. (1991) Mol. Cell. Biol. 11, 3745-3755.
31. Qureshi, S. A., Salditt-Georgieff, M. & Darnell, J. E., Jr. (1995) Proc. Natl. Acad. Sci. USA 92, 3829-3833.
32. Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T. & Kishimoto, T. (1990) Cell 63, 1149-1157.
33. Gearing, D. P., Thut, C. J., VandeBos, T., Gimpel, S. D., Delaney, P. B., King, J., Price, V., Cosman, D. & Beckmann, M. P. (1991) EMBO J. 10, 2839-2848.
34. Reich, N., Evans, B., Levy, D., Fahey, D., Knight, E. J. & Darnell, J. E., Jr. (1987) Proc. Natl. Acad. Sci. USA 84, 6394-6398.
35. Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. E., Jr., & Yancopoulos, G. D. (1995) Science 267, 1349-1353.
36. Montgomery, L. B., Loria, R. M. & Chinchilli, V. M. (1990) Diabetes 39, 675-682.
37. Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., Carver-Moore, K., DuBois, R. N., Clark, R., Aguet, M. & Schreiber, R. D. (1996) Cell 84, 431-442.
38. Durbin, J. E., Hackenmiller, R., Simon, M. C. & Levy, D. E. (1996) Cell 84, 443-450.
39. Hou, X. S., Melnick, M. B. & Perrimon, N. (1996) Cell 84, 411-419.
40. Yan, R., Small, S., Desplan, C., Dearolf, C. R. & Darnell, J. E. (1996) Cell 84, 421-430.