메뉴 건너뛰기




Volumn 4, Issue 5, 2004, Pages 371-379

The weight of leptin in immunity

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; CYTOKINE; INTERLEUKIN 1; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 2442618838     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1350     Document Type: Review
Times cited : (759)

References (89)
  • 1
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman, J. M. & Halaas, J. L. Leptin and the regulation of body weight in mammals. Nature 395, 763-770 (1998).
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 2
    • 0036533493 scopus 로고    scopus 로고
    • Balancing susceptibility to infection and autoimmunity: A role for leptin?
    • Matarese, G. et al. Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol. 23, 192-187 (2002).
    • (2002) Trends Immunol. , vol.23 , pp. 192-187
    • Matarese, G.1
  • 3
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab, F., Lim, M. & Lu, R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet. 12, 318-320 (1998).
    • (1998) Nature Genet. , vol.12 , pp. 318-320
    • Chehab, F.1    Lim, M.2    Lu, R.3
  • 4
    • 0030250892 scopus 로고    scopus 로고
    • A role for leptin and its cognate receptor in hematopolesis
    • Bennett B. D. et al. A role for leptin and its cognate receptor in hematopolesis. Curr. Biol. 6, 1170-1180 (1996).
    • (1996) Curr. Biol. , vol.6 , pp. 1170-1180
    • Bennett, B.D.1
  • 5
    • 0032508682 scopus 로고    scopus 로고
    • Biological action of leptin as an angiogenic factor
    • Sierra-Honigmann, M. R. et al. Biological action of leptin as an angiogenic factor. Science 281, 1683-1686 (1998).
    • (1998) Science , vol.281 , pp. 1683-1686
    • Sierra-Honigmann, M.R.1
  • 6
    • 0035973147 scopus 로고    scopus 로고
    • Potential role of leptin in angiogenesis: Leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro
    • Park, H. Y. et al. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp. Mol. Med. 33, 95-102 (2001).
    • (2001) Exp. Mol. Med. , vol.33 , pp. 95-102
    • Park, H.Y.1
  • 7
    • 0141737573 scopus 로고    scopus 로고
    • Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
    • Ducy, P. et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100, 197-201 (2000).
    • (2000) Cell , vol.100 , pp. 197-201
    • Ducy, P.1
  • 8
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • + T-cell responses and is involved in starvation-induced immunosuppression.
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1
  • 9
    • 0038723695 scopus 로고    scopus 로고
    • Role of leptin as an immunomodulator of blood mononuclear cells: Mechanisms of action
    • Sanchez-Margalet, V. et al. Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin. Exp. Immunol. 133, 11-19 (2003).
    • (2003) Clin. Exp. Immunol. , vol.133 , pp. 11-19
    • Sanchez-Margalet, V.1
  • 10
    • 0032905515 scopus 로고    scopus 로고
    • Regulation of the hypothelamis-pituitary-adrenal axis by cytokines: Actions and mechanisms of action
    • Tumbull, A. V. & Rivier, C. L. Regulation of the hypothelamis-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiol. Rev. 79 1-71 (1999).
    • (1999) Physiol. Rev. , vol.79 , pp. 1-71
    • Tumbull, A.V.1    Rivier, C.L.2
  • 11
    • 0036889766 scopus 로고    scopus 로고
    • Cytokines and neuro-Immune-endocrine interactions: A role for the hypothalamic-pituitary-adrenal revolving axes
    • Haddad, J. J. et al. Cytokines and neuro-immune-endocrine interactions: a role for the hypothalamic-pituitary-adrenal revolving axes. J. Neuroimmunol. 133, 1-19 (2002).
    • (2002) J. Neuroimmunol. , vol.133 , pp. 1-19
    • Haddad, J.J.1
  • 12
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994). This study reports the cloning of the gene encoding leptin in mice and humans.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1
  • 13
    • 0037338955 scopus 로고    scopus 로고
    • Endotoxin stimulates leptin in the human and nonhuman primate
    • Landman, R. E. et al. Endotoxin stimulates leptin in the human and nonhuman primate. J. Clin. Endocrinol. Metab. 88, 1285-1291 (2003).
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 1285-1291
    • Landman, R.E.1
  • 14
    • 0029863684 scopus 로고    scopus 로고
    • Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. A role for leptin in the anorexia of infection
    • Grunfeld, C. et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. A role for leptin in the anorexia of infection. J. Clin. Invest. 97, 2152-2180 (1996).
    • (1996) J. Clin. Invest. , vol.97 , pp. 2152-2180
    • Grunfeld, C.1
  • 15
    • 17344384196 scopus 로고    scopus 로고
    • Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia
    • Sarraf, P. et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J. Exp. Med. 185, 171-180 (1997).
    • (1997) J. Exp. Med. , vol.185 , pp. 171-180
    • Sarraf, P.1
  • 16
    • 0033782028 scopus 로고    scopus 로고
    • Leptin in the regulation of immunity, inflammation, and hematopoieses
    • Fantuzzi, G. & Faggioni, R. Leptin in the regulation of immunity, inflammation, and hematopoieses. J. Leukoc. Biol. 68, 437-446 (2000).
    • (2000) J. Leukoc. Biol. , vol.68 , pp. 437-446
    • Fantuzzi, G.1    Faggioni, R.2
  • 17
    • 0142248881 scopus 로고    scopus 로고
    • Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression
    • Bullo, M., Garcia-Lorda, P., Megias, I. & Salas-Salvado, J. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obes. Res. 11, 525-531 (2003).
    • (2003) Obes. Res. , vol.11 , pp. 525-531
    • Bullo, M.1    Garcia-Lorda, P.2    Megias, I.3    Salas-Salvado, J.4
  • 18
    • 0032866142 scopus 로고    scopus 로고
    • Relationship of plasma leptin to plasma cytokines and human survivalin sepsis and septic shock
    • Amalich, F. et al. Relationship of plasma leptin to plasma cytokines and human survivalin sepsis and septic shock. J. Infect. Dis. 180, 908-911 (1999).
    • (1999) J. Infect. Dis. , vol.180 , pp. 908-911
    • Amalich, F.1
  • 20
    • 0031657189 scopus 로고    scopus 로고
    • Circulating leptin levels during acute experimental endotoxiemia and antiinflammatory therapy in humans
    • Bornstein, S. R., Preas, H. L., Chrousos, G. P. & Suffredini, A. F. Circulating leptin levels during acute experimental endotoxiemia and antiinflammatory therapy in humans. J. Infect. Dis. 178, 887-890 (1998).
    • (1998) J. Infect. Dis. , vol.178 , pp. 887-890
    • Bornstein, S.R.1    Preas, H.L.2    Chrousos, G.P.3    Suffredini, A.F.4
  • 21
    • 0348143310 scopus 로고    scopus 로고
    • Serum leptin levels and their relationship to tumor necrosis factor-α and interleukin- 6 in neonatal sepsis
    • Koc, E. et al. Serum leptin levels and their relationship to tumor necrosis factor-α and interleukin-6 in neonatal sepsis. J. Pediatr. Endocrinol. Metab. 16, 1283-1287 (2003).
    • (2003) J. Pediatr. Endocrinol. Metab. , vol.16 , pp. 1283-1287
    • Koc, E.1
  • 22
    • 0031024791 scopus 로고    scopus 로고
    • Serum leptin concentrations in human immunodeficiency virus-infected men with low adiposity
    • Yarasheski, K. E. et al. Serum leptin concentrations in human immunodeficiency virus-infected men with low adiposity. Metabolism 46, 303-305 (1997).
    • (1997) Metabolism , vol.46 , pp. 303-305
    • Yarasheski, K.E.1
  • 23
    • 0037171456 scopus 로고    scopus 로고
    • Effects of pro-inflammatory cytokines and chemokines on leptin production in human edipose tissue in vitro
    • Bruun, J. M. et al. Effects of pro-inflammatory cytokines and chemokines on leptin production in human edipose tissue in vitro. Mol. Cell. Endocrinol. 190, 91-99 (2002).
    • (2002) Mol. Cell. Endocrinol. , vol.190 , pp. 91-99
    • Bruun, J.M.1
  • 24
    • 0035946468 scopus 로고    scopus 로고
    • Chemokines control fat accumulation and leptin secretion by cultured human adipocytes
    • Gerhardt, C. C. et al. Chemokines control fat accumulation and leptin secretion by cultured human adipocytes. Mol. Cell. Endocrinol. 175, 81-92 (2001).
    • (2001) Mol. Cell. Endocrinol. , vol.175 , pp. 81-92
    • Gerhardt, C.C.1
  • 25
    • 0030977992 scopus 로고    scopus 로고
    • Crystal structure of the obese protein leptin-E100
    • Zhang, F. et al. Crystal structure of the obese protein leptin-E100. Nature 387, 206-208 (1997). This paper describes the crystal structure of leptin.
    • (1997) Nature , vol.387 , pp. 206-208
    • Zhang, F.1
  • 26
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, Ob-R
    • Tartaglia, L. A. et al. Identification and expression cloning of a leptin receptor, Ob-R. Cell 83, 1263-1270 (1995). This study reports the cloning of the gene encoding the leptin receptor.
    • (1995) Cell , vol.83 , pp. 1263-1270
    • Tartaglia, L.A.1
  • 27
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia, L. A. The leptin receptor. J. Biol. Chem. 272, 6093-6100 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 6093-6100
    • Tartaglia, L.A.1
  • 28
    • 0034640508 scopus 로고    scopus 로고
    • Activation of downstream signals by the long form of the leptin receptor
    • Banks, A. S., Davis, S. M., Bates, S. H. & Myers, M. G. Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 275, 14563-14572 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 14563-14572
    • Banks, A.S.1    Davis, S.M.2    Bates, S.H.3    Myers, M.G.4
  • 29
    • 0000430395 scopus 로고    scopus 로고
    • Divergent roles of SHP-2 in ERK activation by leptin receptors
    • Bjorbaek, C. et al. Divergent roles of SHP-2 in ERK activation by leptin receptors. J. Biol. Chem. 276, 4747-4755 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 4747-4755
    • Bjorbaek, C.1
  • 30
    • 0036000280 scopus 로고    scopus 로고
    • Leptin signaling
    • Sweeney, G. Leptin signaling. Cell Signal. 14, 655-663 (2002).
    • (2002) Cell Signal. , vol.14 , pp. 655-663
    • Sweeney, G.1
  • 31
    • 0037090316 scopus 로고    scopus 로고
    • Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia
    • Mancuso, P. et al. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J. Immunol. 166, 4018-4024 (2002).
    • (2002) J. Immunol. , vol.166 , pp. 4018-4024
    • Mancuso, P.1
  • 32
    • 0035887941 scopus 로고    scopus 로고
    • High-dose leptin activates human leukocytes via receptor expression on monocytes
    • Zarkesh-Esfahani, H. et al. High-dose leptin activates human leukocytes via receptor expression on monocytes. J. Immunol. 167, 4593-4599 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 4593-4599
    • Zarkesh-Esfahani, H.1
  • 33
    • 0345688661 scopus 로고    scopus 로고
    • Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanism
    • Dixit, V. D., Melenz, M., Taub, D. D. & Parvizi, N. Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanism. Endocrinology 144, 5595-5603 (2003).
    • (2003) Endocrinology , vol.144 , pp. 5595-5603
    • Dixit, V.D.1    Melenz, M.2    Taub, D.D.3    Parvizi, N.4
  • 34
    • 0035109175 scopus 로고    scopus 로고
    • Leptin: A potential regulator of polymorphonuclear neutrophil bactericidal action?
    • Caldefie-Chezet, F., Poulin, A., Tridon, A., Sion, B. & Vasson, M. P. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action? J. Leukoc. Biol. 69, 414-418 (2001).
    • (2001) J. Leukoc. Biol. , vol.69 , pp. 414-418
    • Caldefie-Chezet, F.1    Poulin, A.2    Tridon, A.3    Sion, B.4    Vasson, M.P.5
  • 35
    • 0043198155 scopus 로고    scopus 로고
    • Leptin regulates functional capacities of polymorphonuclear neutrophils
    • Caldefie-Chezet, F., Poulin, A. & Vasson, M. P. Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radic. Res. 37, 809-814 (2003).
    • (2003) Free Radic. Res. , vol.37 , pp. 809-814
    • Caldefie-Chezet, F.1    Poulin, A.2    Vasson, M.P.3
  • 36
    • 1642525689 scopus 로고    scopus 로고
    • Leptin indirectly activates human neutrophils via induction of TNF-α
    • Zarkesh-Esfahani, H. et al. Leptin indirectly activates human neutrophils via induction of TNF-α. J. Immunol. 172, 1809-1814 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 1809-1814
    • Zarkesh-Esfahani, H.1
  • 37
    • 0036181471 scopus 로고    scopus 로고
    • Leptin deficiency, not obesity, protects mice from Con A-Induced hepatitis
    • Siegmund, B., Lear-Kaul, K. C., Faggioni, R. & Fantuzzi, G. Leptin deficiency, not obesity, protects mice from Con A-Induced hepatitis. Eur. J. Immunol. 32, 552-560 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 552-560
    • Siegmund, B.1    Lear-Kaul, K.C.2    Faggioni, R.3    Fantuzzi, G.4
  • 38
    • 0037427522 scopus 로고    scopus 로고
    • Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines
    • Zhao, Y., Sun, R., You, L., Gao, C., & Tian, Z. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem. Biophys Res. Commun. 300, 247-252 (2003).
    • (2003) Biochem. Biophys Res. Commun. , vol.300 , pp. 247-252
    • Zhao, Y.1    Sun, R.2    You, L.3    Gao, C.4    Tian, Z.5
  • 39
    • 0036431034 scopus 로고    scopus 로고
    • Impaired natural killer (NK) cell activity in leptin receptor deficient mice: Leptin as a critical regulator in NK cell development and activation
    • Tian, Z., Sun, R., Wei, H. & Gao, B. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem. Biophys Res. Commun. 298, 297-302 (2002).
    • (2002) Biochem. Biophys Res. Commun. , vol.298 , pp. 297-302
    • Tian, Z.1    Sun, R.2    Wei, H.3    Gao, B.4
  • 40
    • 0032741972 scopus 로고    scopus 로고
    • Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
    • Howard, J. K. et al. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J. Clin. Invest. 104, 1051-1059 (1999). The first study of the effects of leptin on thymic cellularity and function.
    • (1999) J. Clin. Invest. , vol.104 , pp. 1051-1059
    • Howard, J.K.1
  • 41
  • 42
    • 0036737730 scopus 로고    scopus 로고
    • Peripheral but not central leptin prevents the immunosuppression associated with hypoleptinaemia in rats
    • Zhang, Y. et al. Peripheral but not central leptin prevents the immunosuppression associated with hypoleptinaemia in rats. J. Endocrinol. 174, 455-461 (2002).
    • (2002) J. Endocrinol. , vol.174 , pp. 455-461
    • Zhang, Y.1
  • 43
    • 0036069699 scopus 로고    scopus 로고
    • The CD28 signaling pathway regulates glucose metabolism
    • Frauwirth, K. A. et al. The CD28 signaling pathway regulates glucose metabolism. Immunity. 16, 769-777 (2002).
    • (2002) Immunity , vol.16 , pp. 769-777
    • Frauwirth, K.A.1
  • 44
    • 0036831818 scopus 로고    scopus 로고
    • Lymphocide: Cytokines and the control of lymphoid homeostasis
    • Khaled, A. R. & Durum, S. K. Lymphocide: cytokines and the control of lymphoid homeostasis. Nature Rev. Immunol. 2, 817-830 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 817-830
    • Khaled, A.R.1    Durum, S.K.2
  • 45
    • 0032701466 scopus 로고    scopus 로고
    • Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2
    • Berti, L., & Gammeltoft, S. Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2. Mol. Cell. Endocrinol. 157, 121-130 (1999).
    • (1999) Mol. Cell. Endocrinol. , vol.157 , pp. 121-130
    • Berti, L.1    Gammeltoft, S.2
  • 46
    • 0036243107 scopus 로고    scopus 로고
    • Leptin inhibits stress-induced apoptosis of T lymphocytes
    • Fujita, Y. et al. Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin. Exp. Immunol. 126, 21-26 (2002).
    • (2002) Clin. Exp. Immunol. , vol.126 , pp. 21-26
    • Fujita, Y.1
  • 47
    • 0032482988 scopus 로고    scopus 로고
    • Protection against lipoapoptosis of β-cells through leptin-dependent maintenance of Bcl-2 expression
    • Shimabukuro, M., Wang, M. Y., Zhou, Y. T., Newgard, C. B. & Unger, R. H. Protection against lipoapoptosis of β-cells through leptin-dependent maintenance of Bcl-2 expression. Proc. Natl Acad. Sci. USA 95, 9558-9561 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9558-9561
    • Shimabukuro, M.1    Wang, M.Y.2    Zhou, Y.T.3    Newgard, C.B.4    Unger, R.H.5
  • 48
    • 0036947629 scopus 로고    scopus 로고
    • Human leptin promotes survival of human circulating blood monocytes prone to apoptosis by activation of p42/44 MAPK pathway
    • Najib, S. & Sanchez-Margalet, W. Human leptin promotes survival of human circulating blood monocytes prone to apoptosis by activation of p42/44 MAPK pathway. Cell. Immunol. 220, 143-149 (2002).
    • (2002) Cell. Immunol. , vol.220 , pp. 143-149
    • Najib, S.1    Sanchez-Margalet, W.2
  • 49
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • + T-cell function and cytokine abnormalities that can be reversed by leptin replacement.
    • (2002) J. Clin. Invest. , vol.110 , pp. 1093-1103
    • Farooqi, I.S.1
  • 50
    • 0034058378 scopus 로고    scopus 로고
    • Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor α and IL-1B
    • Faggioni, R. et al. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor α and IL-1B. Proc. Natl. Acad. Sci. USA 97, 2367-2372 (2000). This study (together with references 37, 51-53, 56 and 59) shows that leptin-deficient ob/ob mice are resistant to the induction of autoimmunity.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2367-2372
    • Faggioni, R.1
  • 51
    • 0037080196 scopus 로고    scopus 로고
    • Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis
    • Busso, N. et al. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J. Immunol. 188, 875-882 (2002).
    • (2002) J. Immunol. , vol.188 , pp. 875-882
    • Busso, N.1
  • 52
    • 0035873418 scopus 로고    scopus 로고
    • Requirement for leptin in the induction and progression of autoimmune encephalomyelitis
    • Matarese G. et al. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J. Immunol. 166, 5909-5916 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 5909-5916
    • Matarese, G.1
  • 53
    • 0037241113 scopus 로고    scopus 로고
    • Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses
    • Sanne, V. et al. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J. Clin. Invest. 111, 241-250 (2003). The first report showing that T helper 1 cells can produce leptin and can be found in inflammatory lesions in experimental autoimmune encephalomyelitis.
    • (2003) J. Clin. Invest. , vol.111 , pp. 241-250
    • Sanne, V.1
  • 54
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock, C. et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nature Med. 8, 500-508 (2002).
    • (2002) Nature Med. , vol.8 , pp. 500-508
    • Lock, C.1
  • 55
    • 0038797814 scopus 로고    scopus 로고
    • Leptin as marker of multiple sclerosis activity in patients treated with interferon-β
    • Batocchi, A. P. et al. Leptin as marker of multiple sclerosis activity in patients treated with interferon-β. J. Neuroimmunol. 139, 150-154 (2003).
    • (2003) J. Neuroimmunol. , vol.139 , pp. 150-154
    • Batocchi, A.P.1
  • 56
    • 0036080142 scopus 로고    scopus 로고
    • Leptin: A pivotal mediator of intestinal inflammation in mice
    • Siegmund, B., Lehr, H. A. & Fantuzzi, G. Leptin: a pivotal mediator of intestinal inflammation in mice. Gatroenterology 122, 2011-2025 (2002).
    • (2002) Gatroenterology , vol.122 , pp. 2011-2025
    • Siegmund, B.1    Lehr, H.A.2    Fantuzzi, G.3
  • 57
    • 0037008676 scopus 로고    scopus 로고
    • Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE
    • Buyse, M., Sitaraman, S. V., Liu, X., Bado, A. & Merlin, D. Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE. J. Biol. Chem. 277, 28182-28190 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 28182-28190
    • Buyse, M.1    Sitaraman, S.V.2    Liu, X.3    Bado, A.4    Merlin, D.5
  • 58
    • 0035191858 scopus 로고    scopus 로고
    • PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine
    • Buyse, M. et al. PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine. J. Clin. Invest. 108, 1483-1494 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 1483-1494
    • Buyse, M.1
  • 59
    • 1542379725 scopus 로고    scopus 로고
    • Leptin-deficient mice are protected from accelerated nephrotoxic nephritis
    • Tarzi, R. M., Cook, T. H., Jackson, I., Pusey, C. D. & Lord, G. M. Leptin-deficient mice are protected from accelerated nephrotoxic nephritis. Am. J. Pathol. 164, 385-390 (2004).
    • (2004) Am. J. Pathol. , vol.164 , pp. 385-390
    • Tarzi, R.M.1    Cook, T.H.2    Jackson, I.3    Pusey, C.D.4    Lord, G.M.5
  • 60
    • 0036312494 scopus 로고    scopus 로고
    • Leptin accelerates autoimmune diabetes in female NOD mice
    • Matarese, G. et al. Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes 51, 1356-1361 (2002).
    • (2002) Diabetes , vol.51 , pp. 1356-1361
    • Matarese, G.1
  • 61
    • 0141954186 scopus 로고    scopus 로고
    • Anti-TNF-α antibody normalizes serum leptin in IL-2 deficiant mice
    • Gastke, L. M. Oz, H. S., Frederich, R. C. & McClain, C. J. Anti-TNF-α antibody normalizes serum leptin in IL-2 deficiant mice. J. Am. Coll. Nutr. 22, 415-420 (2003).
    • (2003) J. Am. Coll. Nutr. , vol.22 , pp. 415-420
    • Gastke, L.M.1    Oz, H.S.2    Frederich, R.C.3    McClain, C.J.4
  • 62
    • 0034998907 scopus 로고    scopus 로고
    • Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males
    • Matarese, G. et al. Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males. Eur. J. Immunol. 31, 1324-1332 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1324-1332
    • Matarese, G.1
  • 63
    • 0033304576 scopus 로고    scopus 로고
    • Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicates new targets for leptin action, greater central than peripheral resistance to the effect of leptin, and spontaneous correction of leptin-mediated defects
    • Ozata, M., Ozdemir, I. C. & Licinio, J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicates new targets for leptin action, greater central than peripheral resistance to the effect of leptin, and spontaneous correction of leptin-mediated defects. J. Clin. Endocrinol. Metab. 84, 3686-3690 (1998).
    • (1998) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3686-3690
    • Ozata, M.1    Ozdemir, I.C.2    Licinio, J.3
  • 64
    • 17744384711 scopus 로고    scopus 로고
    • Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis
    • Matarese, G. et al. Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis. J. Clin. Endocrinol. Metab. 85, 2483-2487 (2000).
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 2483-2487
    • Matarese, G.1
  • 65
    • 0033636915 scopus 로고    scopus 로고
    • Serum leptin levels in patients with nonalcoholic steatohepatitis
    • Uygun, A. et al. Serum leptin levels in patients with nonalcoholic steatohepatitis. Am. J. Gastroenterol. 95, 3584-3589 (2000).
    • (2000) Am. J. Gastroenterol. , vol.95 , pp. 3584-3589
    • Uygun, A.1
  • 66
    • 0032852782 scopus 로고    scopus 로고
    • Plasma leptin is related to pro-inflammatory status and dietary intake in patients with chronic obstructive pulmonary disease
    • Schols, A. M. et al. Plasma leptin is related to pro-inflammatory status and dietary intake in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 160, 1220-1226 (1999).
    • (1999) Am. J. Respir. Crit. Care Med. , vol.160 , pp. 1220-1226
    • Schols, A.M.1
  • 68
    • 0034042923 scopus 로고    scopus 로고
    • Increases in serum leptin during peritoneal dialysis are associated with inflammation and a decrease in lean body mass
    • Stenvinkel, P. et al. Increases in serum leptin during peritoneal dialysis are associated with inflammation and a decrease in lean body mass. J. Am. Soc. Nephrol. 11, 1303-1309 (2000).
    • (2000) J. Am. Soc. Nephrol. , vol.11 , pp. 1303-1309
    • Stenvinkel, P.1
  • 69
    • 0036379507 scopus 로고    scopus 로고
    • Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity
    • Evereklioglu, C. et al. Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity. Br. J. Dermatol. 147, 331-336 (2002).
    • (2002) Br. J. Dermatol. , vol.147 , pp. 331-336
    • Evereklioglu, C.1
  • 70
    • 0033829574 scopus 로고    scopus 로고
    • Thyroid hormones influence serum leptin levels in patients with Grave's diseas during suppression of β-adrenergic receptors
    • Sera, N. et al. Thyroid hormones influence serum leptin levels in patients with Grave's diseas during suppression of β-adrenergic receptors. Thyroid 10, 641-646 (2000).
    • (2000) Thyroid , vol.10 , pp. 641-646
    • Sera, N.1
  • 71
    • 1042276557 scopus 로고    scopus 로고
    • High leptin levels in women developing post-partum thyroiditis
    • Mazziotti, G. et al. High leptin levels in women developing post-partum thyroiditis. Clin. Endocrinol. 60, 208-213 (2004)
    • (2004) Clin. Endocrinol. , vol.60 , pp. 208-213
    • Mazziotti, G.1
  • 72
    • 0035044335 scopus 로고    scopus 로고
    • Elevated leptin levels are associated with excess gains in fat mass in girls, but not in boys, with type 1 diabetes: Longitudinal study during adolescence
    • Ahmed, M. L. et al. Elevated leptin levels are associated with excess gains in fat mass in girls, but not in boys, with type 1 diabetes: longitudinal study during adolescence. J. Clin. Endocrinol. Metab. 85, 1188-1193 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.85 , pp. 1188-1193
    • Ahmed, M.L.1
  • 73
    • 0141762514 scopus 로고    scopus 로고
    • Leptin consumption in the inflamed joints of patients with rheumatoid arthritis
    • Bokarewa, M., Bokarew, D., Hultgren, O. & Tarkowski, A. Leptin consumption in the inflamed joints of patients with rheumatoid arthritis. Ann. Rheum. Dis. 62, 952-956 (2003).
    • (2003) Ann. Rheum. Dis. , vol.62 , pp. 952-956
    • Bokarewa, M.1    Bokarew, D.2    Hultgren, O.3    Tarkowski, A.4
  • 74
    • 0033002314 scopus 로고    scopus 로고
    • Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis
    • Anders, H. J., Rihl, M., Heufelder, A. Loch, O. & Schattenkirchner, M. Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis. Metabolism 48, 745-748 (1999).
    • (1999) Metabolism , vol.48 , pp. 745-748
    • Anders, H.J.1    Rihl, M.2    Heufelder, A.3    Loch, O.4    Schattenkirchner, M.5
  • 75
    • 0347364706 scopus 로고    scopus 로고
    • Does leptin play a role in the pathogenesis of human nonalcoholic steatohepatitis?
    • Chalasani, N. et al. Does leptin play a role in the pathogenesis of human nonalcoholic steatohepatitis? Am. J. Gastroenterol. 96, 2771-2776 (2003).
    • (2003) Am. J. Gastroenterol. , vol.96 , pp. 2771-2776
    • Chalasani, N.1
  • 76
    • 0032960162 scopus 로고    scopus 로고
    • Circulating leptin in patients with chronic obstructive pulmonary disease
    • Takabatake, N. et al. Circulating leptin in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 159, 1215-1219 (1999).
    • (1999) Am. J. Respir. Crit. Care Med. , vol.159 , pp. 1215-1219
    • Takabatake, N.1
  • 77
    • 0031897150 scopus 로고    scopus 로고
    • Serum leptin in children and young adults with inflammatory bowel disease
    • Hoppin, A. G. et al. Serum leptin in children and young adults with inflammatory bowel disease. J. Pedaitr. Gastroenterol. Nutr. 25, 500-505 (1998).
    • (1998) J. Pedaitr. Gastroenterol. Nutr. , vol.25 , pp. 500-505
    • Hoppin, A.G.1
  • 78
    • 0032880663 scopus 로고    scopus 로고
    • + lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation
    • + lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation. Clin. Rheumatol. 18, 394-401 (1999).
    • (1999) Clin. Rheumatol. , vol.18 , pp. 394-401
    • Fraser, D.A.1    Thoen, J.2    Reseland, J.E.3    Forre, O.4    Kjeldsen-Kragh, J.5
  • 79
    • 0025944458 scopus 로고
    • Controlled trial of fasting and one year vegetarian diet in rheumatoid arthritis
    • Kjeldsen-Kragh, J. et al. Controlled trial of fasting and one year vegetarian diet in rheumatoid arthritis. Lancet 338, 899-902 (1991).
    • (1991) Lancet , vol.338 , pp. 899-902
    • Kjeldsen-Kragh, J.1
  • 80
    • 0034748832 scopus 로고    scopus 로고
    • Nutrition and diet in the clinical management of multiple sclerosis
    • Payne, A. Nutrition and diet in the clinical management of multiple sclerosis. J. Hum. Nutr. Diet. 14, 349-357 (2001).
    • (2001) J. Hum. Nutr. Diet. , vol.14 , pp. 349-357
    • Payne, A.1
  • 81
    • 0020385380 scopus 로고
    • Nutritional factors and autoimmunity. III. Zinc deprivation versus restricted food intake in MRL/1 mice - The distincton between interacting dietary influences
    • Beach, R. S., Gershwin, M. E. & Hurley, L. S. Nutritional factors and autoimmunity. III. Zinc deprivation versus restricted food intake in MRL/1 mice - the distincton between interacting dietary influences. J. Immunol. 129, 2686-2692 (1982).
    • (1982) J. Immunol. , vol.129 , pp. 2686-2692
    • Beach, R.S.1    Gershwin, M.E.2    Hurley, L.S.3
  • 82
    • 0022524518 scopus 로고
    • Calories versus protein in onset of renal disease in NZB × NZW mice
    • Johnson, B. C., Gajjar, A., Kubo, C. & Good, R. A. Calories versus protein in onset of renal disease in NZB × NZW mice. Proc. Natl Acad. Sci. USA 83, 5659-5662 (1986).
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5659-5662
    • Johnson, B.C.1    Gajjar, A.2    Kubo, C.3    Good, R.A.4
  • 84
    • 0029150507 scopus 로고
    • Effects of calorie restriction of transforming growth factor-β1 and proinflammatory cytokines in murine Sjogren's syndrome
    • Chandrasekar, B. et al. Effects of calorie restriction of transforming growth factor-β1 and proinflammatory cytokines in murine Sjogren's syndrome. Clin. Immunol. Immunopathol. 76, 291-296 (1995).
    • (1995) Clin. Immunol. Immunopathol. , vol.76 , pp. 291-296
    • Chandrasekar, B.1
  • 85
    • 0037244039 scopus 로고    scopus 로고
    • The intricate interplay among body weight, stress, and the immune response to friend or foe
    • Steinman, L., Conlon, P., Maki R. & Foster, A. The intricate interplay among body weight, stress, and the immune response to friend or foe. J. Clin. Invest. 111, 183-185 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 183-185
    • Steinman, L.1    Conlon, P.2    Maki, R.3    Foster, A.4
  • 86
    • 0037422034 scopus 로고    scopus 로고
    • Fast and feel good?
    • Kuchroo, V. K. & Nicholson, L. B. Fast and feel good? Nature 422, 27-28 (2003).
    • (2003) Nature , vol.422 , pp. 27-28
    • Kuchroo, V.K.1    Nicholson, L.B.2
  • 87
    • 0035885876 scopus 로고    scopus 로고
    • Human leptin activates P13K and MAPK pathways in human peripheral blood mononuclear cells: Possible role of Sam68
    • Martin-Romero, C. & Sanchez-Margalet, V. Human leptin activates PI3K and MAPK pathways in human peripheral blood mononuclear cells: possible role of Sam68. Cell. Immunol. 212, 83-91 (2001).
    • (2001) Cell. Immunol. , vol.212 , pp. 83-91
    • Martin-Romero, C.1    Sanchez-Margalet, V.2
  • 88
    • 0035838266 scopus 로고    scopus 로고
    • Human leptin signaling in human peripheral blood mononuclear cells: Activation of the JAK-STAT pathway
    • Sanchez-Margalet, V. & Marin-Romero, C. Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell. Immunol. 211, 30-36 (2001).
    • (2001) Cell. Immunol. , vol.211 , pp. 30-36
    • Sanchez-Margalet, V.1    Marin-Romero, C.2
  • 89
    • 0034452029 scopus 로고    scopus 로고
    • Leptin signaling in human peripheral blood mononuclear cells, on of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase
    • Van den Brink, G. R. et al. Leptin signaling in human peripheral blood mononuclear cells, on of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase. Mol. Cell. Biol. Res. Commun. 4, 144-150 (2000).
    • (2000) Mol. Cell. Biol. Res. Commun. , vol.4 , pp. 144-150
    • Van Den Brink, G.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.