Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance

Lancet

Volumn 348, Issue 9021, 1996, Pages 159-161

  Caro, José F ^a,b   Kolaczynski, Jerzy W ^a   Nyce, Mark R ^a   Ohannesian, Joanna P ^a   Opentanova, Irina ^a   Goldman, Warren H ^a   Lynn, Richard B ^a   Zhang, Pei Li ^a   Sinha, Madhur K ^a   Considine, Robert V ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; BODY WEIGHT; CEREBROSPINAL FLUID; CHOROID PLEXUS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOBLOTTING; MALE; OBESITY; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

EID: 0030594830     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)03173-X     Document Type: Article

References (19)

1. 1 Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546-49.
2. 2 Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-46.
3. 3 Pellymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-43.
4. 4 Stephens TW, Basinski M, Bristow PK, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995; 377: 530-32.
5. 5 Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-32.
6. 6 Considine RV, Considine EL, Williams CJ, et al. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 1995; 95: 2986-88.
7. 7 Considine RV, Considine EL, Williams CJ, et al. Mutation screening and identification of a sequence variation in the human ob gene coding region. Biochem Biophys Res Commun 1996; 220: 735-39.
8. 8 Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-95.
9. 9 Lynn RB, Cao GU, Considine RV, Hyde TM, Caro JF. Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice. Biochem Biophys Res Commun 1996; 219: 884.
10. 10 Malik KF, Young WS. Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob),and diabetic (db/db) C57BL/6J mice. Endocrinology 1996; 137: 1497-500.
11. 11 Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263-71.
12. 12 Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996; 17: 305-11.
13. 13 Davson H, Segal MB. Blood-brain-CSF relations in physiology of the CSF and blood-brain barriers. Boca Raton: CRC Press Inc, 1996: 257-302.
14. 14 Considine RV, Considine EL, Williams CJ, Hyde TM, Caro JF. The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 1996; 19: 992-96.
15. 15 Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84: 491-95.
16. 16 Lee G-H, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-35.
17. 17 Chua SC Jr, Chung WK, Wu-Peng S, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996; 271: 994-96.
18. 18 Phillips MS, Liu Q, Hammond HA, et al. Identification of a missense mutation in the leptin receptor (OB-R) associated with the fatty Zucker rat. Nat Genet 1996; 13: 18-19.
19. 19 Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 1996; 2: 589-93.