Stat3 dimerization regulated by reversible acetylation of a single lysine residue

Science

Volumn 307, Issue 5707, 2005, Pages 269-273

  Yuan, Zheng Long ^a   Guan, Ying Jie ^a   Chatterjee, Devasis ^a   Chin, Y Eugene ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; DIMERS; DNA; ENZYMES; GENES; SUBSTITUTION REACTIONS; TRANSDUCERS; TUMORS;

CYTOKINE TREATMENT; REVERSIBLE ACETYLATION; SIGNAL TRANSDUCERS; SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION (STAT);

DIMERIZATION;

CYTOKINE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE 1; LYSINE; ONCOSTATIN M; PROTEIN P300; STAT3 PROTEIN;

ENZYME;

ACETYLATION; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; DIMERIZATION; DNA BINDING; HUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

ACETYLATION; ACETYLTRANSFERASES; ARGININE; BCL-X PROTEIN; CELL CYCLE; CELL LINE, TUMOR; CELL NUCLEUS; CYCLIN D1; CYTOKINES; CYTOPLASM; DIMERIZATION; DNA; DNA-BINDING PROTEINS; HELA CELLS; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HUMANS; INTERFERON-ALPHA; LYSINE; MUTATION; NUCLEAR PROTEINS; ONCOSTATIN M; PEPTIDES; PHOSPHORYLATION; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

EID: 12244251445     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1105166     Document Type: Article

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29. We are grateful to Y. Shi for discussions. We thank J. Singer and J. Padbury for their comments on the manuscript. HA-p300, HA-CBP, and HA-PCAF constructs were provided by T. P. Yao and H. Lu. Flag-Hdac1, Flag-Hdac2, and Flag-Hdac3 constructs were provided by T. Seto. Purified p300 HAT and HA-CBP proteins were provided by P. A. Cole and T. P. Yao, respectively. This work was supported by NIH RO1 grant to Y.E.C. D.C. was supported by a grant from the TJ Martell Foundation and a Lifespan Developmental Award.