메뉴 건너뛰기




Volumn 26, Issue 1, 2000, Pages 97-102

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR; THYROXINE; UNCLASSIFIED DRUG;

EID: 0033818103     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/79254     Document Type: Article
Times cited : (815)

References (30)
  • 1
    • 0031838353 scopus 로고    scopus 로고
    • Severe early onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude, H. et al. Severe early onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genet. 19, 155-157 (1998).
    • (1998) Nature Genet. , vol.19 , pp. 155-157
    • Krude, H.1
  • 2
    • 0031455342 scopus 로고    scopus 로고
    • Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the quebec family study
    • Chagnon, Y.C. et al. Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the quebec family study. Mol. Med. 3, 663-673 (1997).
    • (1997) Mol. Med. , vol.3 , pp. 663-673
    • Chagnon, Y.C.1
  • 3
    • 0031668219 scopus 로고    scopus 로고
    • A frameshift mutation in MC4R associated with dominantly inherited human obesity
    • Yeo, G.S.H. et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nature Genet. 20, 111-112 (1998).
    • (1998) Nature Genet. , vol.20 , pp. 111-112
    • Yeo, G.S.H.1
  • 4
    • 0031662163 scopus 로고    scopus 로고
    • A frameshift mutation in human MC4R is associated with a dominant form of obesity
    • Vaisse, C., Clement, K., Guy-Grand, B. & Froguel, P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genet. 20, 113-114 (1998).
    • (1998) Nature Genet. , vol.20 , pp. 113-114
    • Vaisse, C.1    Clement, K.2    Guy-Grand, B.3    Froguel, P.4
  • 6
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann, M.M. et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135-138 (1997).
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1
  • 8
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar, D. et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141 (1997).
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1
  • 9
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan, W., Boston, B.A., Kesterson, R.A., Hruby, V.J. & Cone, R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385, 165-168 (1997).
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 10
    • 0028112970 scopus 로고
    • Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
    • Lu, D. et al. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371, 799-802 (1994).
    • (1994) Nature , vol.371 , pp. 799-802
    • Lu, D.1
  • 11
    • 0032900284 scopus 로고    scopus 로고
    • Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
    • Marsh, D.J. et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nature Genet. 21, 119-122 (1999).
    • (1999) Nature Genet. , vol.21 , pp. 119-122
    • Marsh, D.J.1
  • 12
    • 0000304384 scopus 로고    scopus 로고
    • Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
    • in press
    • Chen, A.S. et al. Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res. (in press).
    • Transgenic Res.
    • Chen, A.S.1
  • 13
    • 0027436690 scopus 로고
    • Identification of a receptor for γ melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system
    • Roselli-Rehfuss, L. et al. Identification of a receptor for γ melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc. Natl Acad. Sci. USA 90, 8856-8860 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 8856-8860
    • Roselli-Rehfuss, L.1
  • 14
    • 0015473277 scopus 로고
    • Cellularity of adipose depots in six strains of genetically obese mice
    • Johnson, P.R. & Hirsch, J. Cellularity of adipose depots in six strains of genetically obese mice. J. Lipid Res. 13, 2-11 (1972).
    • (1972) J. Lipid Res. , vol.13 , pp. 2-11
    • Johnson, P.R.1    Hirsch, J.2
  • 16
    • 0014814862 scopus 로고
    • Lipolysis in genetically obese and diabetes-prone mice
    • Yen, T.T., Steinmetz, J. & Wolff, G.L. Lipolysis in genetically obese and diabetes-prone mice. Horm. Metab. Res. 2, 200-203 (1970).
    • (1970) Horm. Metab. Res. , vol.2 , pp. 200-203
    • Yen, T.T.1    Steinmetz, J.2    Wolff, G.L.3
  • 17
    • 0030062529 scopus 로고    scopus 로고
    • Upregulation of adipocyte metabolism by agouti protein: Possible paracrine actions in yellow mouse obesity
    • Jones, B.H. et al. Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity. Am. J. Physiol. 270, E192-E196 (1996).
    • (1996) Am. J. Physiol. , vol.270
    • Jones, B.H.1
  • 19
    • 0342858793 scopus 로고    scopus 로고
    • α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression
    • Fekete, C. et al. α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J. Neurosci. 20, 1550-1558 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 1550-1558
    • Fekete, C.1
  • 20
    • 0034037278 scopus 로고    scopus 로고
    • The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin
    • Kim, M.S. et al. The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J. Clin. Invest. 105, 1005-1011 (2000).
    • (2000) J. Clin. Invest. , vol.105 , pp. 1005-1011
    • Kim, M.S.1
  • 21
    • 0023724613 scopus 로고
    • 1 hybrid mice to the same diets: Glucose tolerance, weight gain, and adipocyte cellularity
    • 1 hybrid mice to the same diets: glucose tolerance, weight gain, and adipocyte cellularity. Int. J. Obes. 12, 305-320 (1988).
    • (1988) Int. J. Obes. , vol.12 , pp. 305-320
    • Frigeri, L.G.1    Wolff, G.L.2    Teguh, C.3
  • 22
    • 0024341408 scopus 로고
    • Effects of MSH on food intake, body weight and coat color of the yellow obese mouse
    • Shimizu, H., Shargill, N.S., Bray, G.A., Yen, T.T. & Geselichen, P.D. Effects of MSH on food intake, body weight and coat color of the yellow obese mouse. Life Sci. 45, 543-552 (1989).
    • (1989) Life Sci. , vol.45 , pp. 543-552
    • Shimizu, H.1    Shargill, N.S.2    Bray, G.A.3    Yen, T.T.4    Geselichen, P.D.5
  • 23
    • 0029154516 scopus 로고
    • Cyclic lactam α-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7, Lys10] α-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors
    • Hruby, V.J. et al. Cyclic lactam α-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7, Lys10] α-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J. Med. Chem. 38, 3454-3461 (1995).
    • (1995) J. Med. Chem. , vol.38 , pp. 3454-3461
    • Hruby, V.J.1
  • 24
    • 0033567543 scopus 로고    scopus 로고
    • Anatomy of an endogenous antagonist: Relationship between agouti-related protein and proopiomelanocortin in brain
    • Bagnol, D. et al. Anatomy of an endogenous antagonist: relationship between agouti-related protein and proopiomelanocortin in brain. J. Neurosci. 19, RC26 (1-7) (1999).
    • (1999) J. Neurosci. , vol.19 , Issue.1-7
    • Bagnol, D.1
  • 25
    • 0027456619 scopus 로고
    • Molecular cloning of a novel melanocortin receptor
    • Gantz, I. et al. Molecular cloning of a novel melanocortin receptor. J. Biol. Chem. 268, 8246-8250 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 8246-8250
    • Gantz, I.1
  • 26
    • 0029848043 scopus 로고    scopus 로고
    • Distribution of cDNA for melanocortin receptor subtypes in human tissues
    • Chhajlani, V. Distribution of cDNA for melanocortin receptor subtypes in human tissues, Biochem. Mol. Biol. Int. 38, 73-80 (1996).
    • (1996) Biochem. Mol. Biol. Int. , vol.38 , pp. 73-80
    • Chhajlani, V.1
  • 27
    • 1842292786 scopus 로고    scopus 로고
    • Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q
    • Lembertas, A.V. et al. Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J. Clin. Invest 100, 1240-1247 (1997).
    • (1997) J. Clin. Invest , vol.100 , pp. 1240-1247
    • Lembertas, A.V.1
  • 28
    • 0032584978 scopus 로고    scopus 로고
    • Evidence of altered hypothalamic proopiomelanocortin/neuropeptide Y mRNA expression in tubby mice
    • Guan, X.-M., Yu, H. & Van der Ploeg, L.H.T. Evidence of altered hypothalamic proopiomelanocortin/neuropeptide Y mRNA expression in tubby mice. Mol. Brain Res. 59, 273-279 (1998).
    • (1998) Mol. Brain Res. , vol.59 , pp. 273-279
    • Guan, X.-M.1    Yu, H.2    Van Der Ploeg, L.H.T.3
  • 30
    • 0034116222 scopus 로고    scopus 로고
    • Human body composition: In vivo methods
    • Ellis, K.J. Human body composition: in vivo methods. Physiol. Rev. 80, 649-680 (2000).
    • (2000) Physiol. Rev. , vol.80 , pp. 649-680
    • Ellis, K.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.