Localization of leptin binding domain in the leptin receptor

Molecular Pharmacology

Volumn 53, Issue 2, 1998, Pages 234-240

  Fong, Tung Ming ^a   Huang, Ruey Ruey C ^a   Tota, Michael R ^a   Mao, Cheri ^a   Smith, Tim ^a   Varnerin, Jeff ^a   Karpitskiy, Vladimir V ^b   Krause, James E ^b,c   Van Der Ploeg, Lex H T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Neurogen Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR RECEPTOR; CYTOKINE RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH HORMONE RECEPTOR; INTERLEUKIN 6 RECEPTOR; LEPTIN; LEPTIN RECEPTOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL LINE; CHO CELL; CONTROLLED STUDY; DELETION MUTANT; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING;

EID: 0031886385     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.53.2.234     Document Type: Article

References (31)

1. Banks WA, Kastin AJ, Huang W, Jaspan JB, and Maness LM (1996) Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311.
2. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF, and Tartaglia LA (1996) The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93:8374-8378.
3. Bazan JF (1990) Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87:6934-6938.
4. Callard C and Gearing A (1994) The Cytokine Facts Book, Academic Press, San Diego.
5. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, and Morgenstern JP (1996) Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495.
6. Chua SC Jr, White DW, Wu-Peng XS, Liu SM, Okada N, Kershaw EE, Chung WK, Power-Kehoe L, Chua M, Tartaglia LA, and Leibel RL (1996) Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 45:1141-1143.
7. Cioffi JA, Shafer AW, Zupancic TJ, Smith-Gbur J, Mikhail A, Platika D, and Snodgrass HR (1996) Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat Med 2:585-589.
8. DeBlasi A, O'Reilly K, and Motulsky HJ (1989) Calculating receptor number from binding experiments using same compound as radioligand and competitor. Trends Pharmacol Sci 10:227-229.
9. Devos R, Guisez Y, Van der Heyden J, White DW, Kalai M, Fountoulakis M, and Plaetinck G (1997) Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. J BM Chem 272:18304-18310.
10. Fukunaga R, Ishizaka-Ikeda E, Pan C-X, Seto Y, and Nagata S (1991) Functional domains of the granulocyte colony-stimulating factor receptor. EMBO J 10:2855-2865.
11. Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, and Skoda RC (1996) Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 93:6231-6235.
12. Glaum SR, Kara M, Bindokas VP, Lee CC, Polonsky KS, Bell GI, and Miller RJ (1996) Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol Pharmacol 50:230-235.
13. Horsten U, Schmitz-Van de Leur H, Mullberg J, Heinrich PC, and Rose-John S (1995) The membrane distal half of gp 130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor. FEBS Lett 360:43-46.
14. Ihle JN (1996) STATs: signal transducers and activators of transcription. Cell 84:331-334.
15. Kim S-H (1994) Frozen dynamic dimer model for transmembrane signaling in bacterial chemotaxis receptors. Protein Sci 3:159-165.
16. Larsen A, Davis T, Curtis BM, Gimpel S, Sims JE, Cosman D, Park L, Sorensen E, March CJ, and Smith CA (1990) Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains. J Exp Med 172:1559-1570.
17. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, and Friedman JM (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature (Lond) 379:632-635.
18. Lin AY, Devaux B, Green A, Sagerstrom C, Elliott JF, and Davis MM (1990) Expression of T cell cell antigen receptor heterodimer in a lipid-linked form. Science (Washington DC) 249:677-679.
19. Livnah O, Stura EA, Johnson DL, Middleton SA, Mulcahy LS, Wrighton NC, Dower WJ, Jolliffe LK, and Wilson IA (1996) Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 Å. Science (Washington DC) 273:464-471.
20. Miyazaki T, Maruyama M, Yamada G, Hatakeyama M, and Taniguchi T (1991) The integrity of the conserved WS motif common to IL-2 and other receptors is essential for ligand binding and signal transduction. EMBO J 10:3191-3197.
21. Patthy L (1990) Homology of a domain of the growth hormone/prolactin receptor family with type 3 modules of fibronectin. Cell 61:13-14.
22. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CT, and Hess JF (1996) Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet 13:18-19.
23. Rosenblum CI, Tota M, Cully D, Smith T, Collum R, Qureshi Q, Hess JF, Phillips MS, Hey PJ, Vongs A, Fong TM, Xu L, Chen HY, Smith RG, Schindler C, and Van der Ploeg LHT (1996) Functional STAT1 and 3 signaling by the leptin receptor (OB-R): reduced expression of the rat fatty leptin receptor in transfected cells. Endocrinology 137:5178-5181.
24. Schindler C and Darnell JE (1995) Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64:621-651.
25. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D Jr, Woods SC, Seeley RJ, and Weigle DS (1996) Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-535.
26. Stahl N and Yancopoulos GD (1993) The alphas, betas, and kinases of cytokine receptor complexes. Cell 74:587-590.
27. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, and Tepper RI (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271.
28. Wells JA and de Vos AM (1996) Hematopoietic receptor complexes. Annu Rev Biochem 65:609-634.
29. White DW, Kuropatwinski KK, Devos R, Baumann H, and Tartaglia LA (1997) Leptin receptor (OB-R) signaling, cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J Biol Chem 272:4065-4071.
30. Woodcock JM, Bagley CJ, Zacharakis B, and Lopez AF (1996) A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all three ligands. J Biol Chem 271:25999-26006.
31. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, and Friedman JM (1994) Positional cloning of the mouse ob gene and its human homolog. Nature (Lond) 372:425-443.