Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

Nature Medicine

Volumn 10, Issue 7, 2004, Pages 739-743

  Mori, Hiroyuki ^a   Hanada, Reiko ^b   Hanada, Toshikatsu ^a   Aki, Daisuke ^a   Mashima, Ryuichi ^a   Nishinakamura, Hitomi ^a   Torisu, Takehiro ^a   Chien, Kenneth R ^c   Yasukawa, Hideo ^b   Yoshimura, Akihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KURUME UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; LEPTIN; PROOPIOMELANOCORTIN; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET; ENERGY; FEMALE; FOOD INTAKE; HOMEOSTASIS; HORMONE SENSITIVITY; HYPOTHALAMUS; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; KNOCKOUT MOUSE; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SOCS3 DEFICIENCY; WEIGHT REDUCTION; WILD TYPE;

ANIMALS; BRAIN CHEMISTRY; DIETARY FATS; DNA-BINDING PROTEINS; EATING; FEMALE; INSULIN RESISTANCE; LEPTIN; MALE; MICE; OBESITY; PHOSPHORYLATION; REPRESSOR PROTEINS; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; WEIGHT LOSS;

ANIMALIA; RODENTIA;

EID: 3142723983     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1071     Document Type: Article

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