Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line

Molecular and Cellular Endocrinology

Volumn 195, Issue 1-2, 2002, Pages 109-118

  Kaszubska, Wiweka ^a   Falls, H Douglas ^a   Schaefer, Verlyn G ^a   Haasch, Deanna ^a   Frost, Leigh ^a   Hessler, Paul ^a   Kroeger, Paul E ^a   White, David W ^b   Jirousek, Michael R ^a   Trevillyan, James M ^a  

^a ABBOTT LABORATORIES   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

GT1 7 cell line; JAK2; Leptin; Protein tyrosine phosphatase 1B; SOCS3; STAT3

Indexed keywords

JANUS KINASE; LEPTIN; LEPTIN RECEPTOR; LUCIFERASE; MESSENGER RNA; PROTEIN; PROTEIN C FOS; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; DNA BINDING PROTEIN; JAK2 PROTEIN, HUMAN; JAK2 PROTEIN, MOUSE; JANUS KINASE 2; ONCOPROTEIN; PROTEIN TYROSINE KINASE; STAT3 PROTEIN, HUMAN; STAT3 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HYPOTHALAMUS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; CELL LINE; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; HYPOTHALAMUS; JANUS KINASE 2; LEPTIN; MICE; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFECTION;

EID: 0037201559     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(02)00178-8     Document Type: Article

References (37)

1. Aoki N., Matsuda T. A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b. J. Biol. Chem. 275:2000;39718-39726.
2. Banks A.S., Davis S.M., Bates S.H., Myers M.G. Jr. Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 275:2000;14563-14572.
3. Baumann H., Morella K.K., White D.W., Dembski M., Bailon P.S., Kim H., Lai C.F., Tartaglia L.A. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Natl. Acad. Sci. USA. 93:1996;8374-8378.
4. Bjorbaek C., Uotani S., da Silva B., Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 272:1997;32686-32695.
5. Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell. 1:1998;619-625.
6. Bjorbaek C., El-Haschimi K., Frantz J.D., Flier J.S. The role of SOCS-3 in leptin signaling and leptin resistance. J. Biol. Chem. 274:1999;30059-30065.
7. Bjorbaek C., Lavery H.J., Bates S.H., Olson R.K., Davis S.M., Flier J.S., Myers M.G. Jr. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275:2000;40649-40657.
8. Bjorbaek C., Buchholz R.M., Davis S.M., Bates S.H., Pierroz D.D., Gu H., Neel B.G., Myers M.G. Jr, Flier J.S. Divergent roles of SHP-2 in ERK activation by leptin receptors. J. Biol. Chem. 276:2001;4747-4755.
9. Carpenter L.R., Farruggella T.J., Symes A., Karow M.L., Yancopoulos G.D., Stahl N. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor. Proc. Natl. Acad. Sci. USA. 95:1998;6061-6066.
10. Carpenter L.R., Yancopoulos G.D., Stahl N. General mechanisms of cytokine receptor signaling. Adv. Protein Chem. 52:1998;109-140.
11. El-Haschimi K., Pierroz D.D., Hileman S.M., Bjorbaek C., Flier J.S. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J. Clin. Invest. 105:2000;1827-1832.
12. Elmquist J.K. Anatomic basis of leptin action in the hypothalamus. Frontiers Horm. Res. 26:2000;21-41.
13. Emilsson V., Arch J.R., de Groot R.P., Lister C.A., Cawthorne M.A. Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues. FEBS Lett. 455:1999;170-174.
14. Eyckerman S., Broekaert D., Verhee A., Vandekerckhove J., Tavernier J. Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor. FEBS Lett. 486:2000;33-37.
15. Friedman J.M. Obesity in the new millennium. Nature. 404:2000;632-634.
16. Ghilardi N., Ziegler S., Wiestner A., Stoffel R., Heim M.H., Skoda R.C. Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. USA. 93:1996;6231-6235.
17. Haj F.G., Verveer P.J., Squire A., Neel B.G., Bastiaens P.I.H. Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum. Science. 295:2002;1708-1711.
18. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., Friedman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:1995;543-546.
19. Heim M.H. The JAK-STAT pathway: cytokine signalling from the receptor to the nucleus. J. Recept. Signal Transd. Res. 19:1999;75-120.
20. Heymsfield S.B., Greenberg A.S., Fujioka K., Dixon R.M., Kushner R., Hunt T., Lubina J.A., Patane J., Self B., Hunt P., McCamish M. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. J. Am. Med. Assoc. 282:1999;1568-1575.
21. Houseknecht K.L., Baile C.A., Matteri R.L., Spurlock M.E. The biology of leptin: a review. J. Anim. Sci. 76:1998;1405-1420.
22. Kaszubska W., Zhang H., Patterson R.L., Suhar T.S., Uchic M.E., Dickinson R.W., Schaefer V.G., Haasch D., Janis R.S., DeVries P.J., Okasinski G.F., Meuth J.L. Expression, purification, and characterization of human recombinant thrombopoietin in Chinese hamster ovary cells. Protein Exp. Purif. 18:2000;213-220.
23. Kopelman P.G. Obesity as a medical problem. Nature. 404:2000;635-643.
24. Li C., Friedman J.M. Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc. Natl. Acad. Sci. USA. 96:1999;9677-9682.
25. Mellon P.L., Windle J.J., Goldsmith P.C., Padula C.A., Roberts J.L., Weiner R.I. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron. 5:1990;1-10.
26. Myers M.P., Andersen J.N., Cheng A., Tremblay M.L., Horvath C.M., Parisien J.P., Salmeen A., Barford D., Tonks N.K. TYK2 and JAK2 are substrates of protein tyrosine phosphatase 1B. J. Biol. Chem. 276:2001;47771-47774.
27. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:1995;540-543.
28. Rentsch J., Levens N., Chiesi M. Recombinant ob-gene product reduces food intake in fasted mice. Biochem. Biophys. Res. Commun. 214:1995;131-136.
29. Saleem A., Andersen J.N., Myers M.P., Tonks N.K., Barford D. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein-tyrosine phosphatase 1B. Mol. Cell. 6:2000;1401-1412.
30. Schwartz M.W., Woods S.C., Porte D. Jr, Seeley R.J., Baskin D.G. Central nervous system control of food intake. Nature. 404:2000;661-671.
31. Spiegelman B.M., Flier J.S. Obesity and the regulation of energy balance. Cell. 104:2001;531-543.
32. Tao J., Malbon C.C., Wang H.Y. Insulin stimulates tyrosine phosphorylation and inactivation of protein-tyrosine phosphatase 1B in vivo. J. Biol. Chem. 276:2001;29520-29525.
33. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J. Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1995;1263-1271.
34. Vaisse C., Halaas J.L., Horvath C.M., Darnell J.E. Jr, Stoffel M., Friedman J.M. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. 14:1996;95-97.
35. White D.W., Wang D.W., Chua S.C. Jr, Morgenstern J.P., Leibel R.L., Baumann H., Tartaglia L.A. Constitutive and impaired signaling of leptin receptors containing the Gln→Pro extracellular domain fatty mutation. Proc. Natl. Acad. Sci. USA. 94:1997;10657-10662.
36. Woods A.J., Stock M.J. Leptin activation in hypothalamus. Nature. 381:1996;745.
37. Zabolotny J.M., Bence-Hanulec K.K., Stricker-Krongrad A., Pierroz D.D., Mozell R., Haj F.G., Wang Y.P., Minokoshi Y., Kim Y.B., Flier J.S., Neel B.G., Kahn B.B. Mice lacking protein tyrosine phosphatase 1B have increased leptin sensitivity. Diabetes. 50:2001;A58.