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Volumn 479, Issue 1, 2010, Pages 18-21

A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus

Author keywords

Hypothalamus; Leptin; NT; Phosphodiesterase 3B; POMC

Indexed keywords

CILOSTAMIDE; LEPTIN; MESSENGER RNA; NEUROTENSIN; PHOSPHODIESTERASE 3B; PHOSPHODIESTERASE III; PROOPIOMELANOCORTIN; UNCLASSIFIED DRUG; PDE3B PROTEIN, RAT; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; QUINOLONE DERIVATIVE;

EID: 77953693953     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.05.018     Document Type: Article
Times cited : (13)

References (55)
  • 3
    • 0034640508 scopus 로고    scopus 로고
    • Activation of downstream signals by the long form of the leptin receptor
    • Banks A.S., Davis S.M., Bates S.H., Myers M.G. Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 2000, 275:14563-14572.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14563-14572
    • Banks, A.S.1    Davis, S.M.2    Bates, S.H.3    Myers, M.G.4
  • 8
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjorbaek C., Uotani S., da Silva B., Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 1997, 272:32686-32695.
    • (1997) J. Biol. Chem. , vol.272 , pp. 32686-32695
    • Bjorbaek, C.1    Uotani, S.2    da Silva, B.3    Flier, J.S.4
  • 10
    • 0032772960 scopus 로고    scopus 로고
    • The central melanocortin system and energy homeostasis
    • Cone R.D. The central melanocortin system and energy homeostasis. Trends Endocrinol. Metab. 1999, 10:211-216.
    • (1999) Trends Endocrinol. Metab. , vol.10 , pp. 211-216
    • Cone, R.D.1
  • 12
    • 26844475055 scopus 로고    scopus 로고
    • Anorexigenic hormones leptin, insulin, and alpha-melanocyte-stimulating hormone directly induce neurotensin (NT) gene expression in novel NT-expressing cell models
    • Cui H., Cai F., Belsham D.D. Anorexigenic hormones leptin, insulin, and alpha-melanocyte-stimulating hormone directly induce neurotensin (NT) gene expression in novel NT-expressing cell models. J. Neurosci. 2005, 25:9497-9506.
    • (2005) J. Neurosci. , vol.25 , pp. 9497-9506
    • Cui, H.1    Cai, F.2    Belsham, D.D.3
  • 13
    • 0033931981 scopus 로고    scopus 로고
    • Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
    • El-Haschimi K., Pierroz D.D., Hileman S.M., Bjorbaek C., Flier J.S. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J. Clin. Invest. 2000, 105:1827-1832.
    • (2000) J. Clin. Invest. , vol.105 , pp. 1827-1832
    • El-Haschimi, K.1    Pierroz, D.D.2    Hileman, S.M.3    Bjorbaek, C.4    Flier, J.S.5
  • 16
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 17
    • 1842584949 scopus 로고    scopus 로고
    • Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
    • Gao Q., Wolfgang M.J., Neschen S., Morino K., Horvath T.L., Shulman G.I., Fu X.Y. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:4661-4666.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 4661-4666
    • Gao, Q.1    Wolfgang, M.J.2    Neschen, S.3    Morino, K.4    Horvath, T.L.5    Shulman, G.I.6    Fu, X.Y.7
  • 18
    • 0030956390 scopus 로고    scopus 로고
    • The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
    • Ghilardi N., Skoda R.C. The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol. Endocrinol. 1997, 11:393-399.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 393-399
    • Ghilardi, N.1    Skoda, R.C.2
  • 22
    • 0035313069 scopus 로고    scopus 로고
    • Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation
    • Hubschle T., Thom E., Watson A., Roth J., Klaus S., Meyerhof W. Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J. Neurosci. 2001, 21:2413-2424.
    • (2001) J. Neurosci. , vol.21 , pp. 2413-2424
    • Hubschle, T.1    Thom, E.2    Watson, A.3    Roth, J.4    Klaus, S.5    Meyerhof, W.6
  • 23
    • 0026508835 scopus 로고
    • Multiplex solution hybridization-ribonuclease protection assay for quantification of different ribonucleic acid transcripts from snap-frozen neuroendocrine tissues of individual animals
    • Jakubowski M., Roberts J.L. Multiplex solution hybridization-ribonuclease protection assay for quantification of different ribonucleic acid transcripts from snap-frozen neuroendocrine tissues of individual animals. J. Neuroendocrinol. 1992, 4:79-89.
    • (1992) J. Neuroendocrinol. , vol.4 , pp. 79-89
    • Jakubowski, M.1    Roberts, J.L.2
  • 25
    • 0023878936 scopus 로고
    • The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences
    • Kislauskis E., Bullock B., McNeil S., Dobner P.R. The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences. J. Biol. Chem. 1988, 263:4963-4968.
    • (1988) J. Biol. Chem. , vol.263 , pp. 4963-4968
    • Kislauskis, E.1    Bullock, B.2    McNeil, S.3    Dobner, P.R.4
  • 27
    • 0035145908 scopus 로고    scopus 로고
    • Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene
    • Kowalski T.J., Liu S.M., Leibel R.L., Chua S.C. Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes 2001, 50:425-435.
    • (2001) Diabetes , vol.50 , pp. 425-435
    • Kowalski, T.J.1    Liu, S.M.2    Leibel, R.L.3    Chua, S.C.4
  • 28
    • 0347988175 scopus 로고    scopus 로고
    • Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset
    • Levin B.E., Dunn-Meynell A.A., Banks W.A. Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 286:R143-150.
    • (2004) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.286
    • Levin, B.E.1    Dunn-Meynell, A.A.2    Banks, W.A.3
  • 29
    • 0020666623 scopus 로고
    • Effect of centrally administered neurotensin on multiple feeding paradigms
    • Levine A.S., Kneip J., Grace M., Morley J.E. Effect of centrally administered neurotensin on multiple feeding paradigms. Pharmacol. Biochem. Behav. 1983, 18:19-23.
    • (1983) Pharmacol. Biochem. Behav. , vol.18 , pp. 19-23
    • Levine, A.S.1    Kneip, J.2    Grace, M.3    Morley, J.E.4
  • 30
    • 77953711371 scopus 로고    scopus 로고
    • Evidence showing phosphodiesterase-3B (PDE3B) co-localization in proopiomelanocortin (POMC) and neuropeptide Y (NPY) expressing neurons in the hypothalamus: further insight into leptin signaling
    • Abst# P4-4
    • Litvin D., Sahu M., Koshinaka K., Sahu A. Evidence showing phosphodiesterase-3B (PDE3B) co-localization in proopiomelanocortin (POMC) and neuropeptide Y (NPY) expressing neurons in the hypothalamus: further insight into leptin signaling. Proceedings of the 89th Annual Meeting of the Endocrine Society 2007, Abst# P4-4.
    • (2007) Proceedings of the 89th Annual Meeting of the Endocrine Society
    • Litvin, D.1    Sahu, M.2    Koshinaka, K.3    Sahu, A.4
  • 33
    • 0038747134 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin
    • Munzberg H., Huo L., Nillni E.A., Hollenberg A.N., Bjorbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 2003, 144:2121-2131.
    • (2003) Endocrinology , vol.144 , pp. 2121-2131
    • Munzberg, H.1    Huo, L.2    Nillni, E.A.3    Hollenberg, A.N.4    Bjorbaek, C.5
  • 35
    • 9644252998 scopus 로고    scopus 로고
    • The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice
    • Ohinata K., Shimano T., Yamauchi R., Sakurada S., Yanai K., Yoshikawa M. The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice. Peptides 2004, 25:2135-2138.
    • (2004) Peptides , vol.25 , pp. 2135-2138
    • Ohinata, K.1    Shimano, T.2    Yamauchi, R.3    Sakurada, S.4    Yanai, K.5    Yoshikawa, M.6
  • 36
    • 0042922605 scopus 로고    scopus 로고
    • Leptin signaling in the hypothalamus during chronic central leptin infusion
    • Pal R., Sahu A. Leptin signaling in the hypothalamus during chronic central leptin infusion. Endocrinology 2003, 144:3789-3798.
    • (2003) Endocrinology , vol.144 , pp. 3789-3798
    • Pal, R.1    Sahu, A.2
  • 37
    • 40849124301 scopus 로고    scopus 로고
    • Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons
    • Piper M.L., Unger E.K., Myers M.G., Xu A.W. Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol. Endocrinol. 2008, 22:751-759.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 751-759
    • Piper, M.L.1    Unger, E.K.2    Myers, M.G.3    Xu, A.W.4
  • 38
    • 0031764893 scopus 로고    scopus 로고
    • Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus
    • Sahu A. Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology 1998, 139:795-798.
    • (1998) Endocrinology , vol.139 , pp. 795-798
    • Sahu, A.1
  • 39
    • 0033661026 scopus 로고    scopus 로고
    • Quantification of NPY mRNA by ribonuclease protection assay
    • Sahu A. Quantification of NPY mRNA by ribonuclease protection assay. Methods Mol. Biol. 2000, 153:219-230.
    • (2000) Methods Mol. Biol. , vol.153 , pp. 219-230
    • Sahu, A.1
  • 40
    • 0036798083 scopus 로고    scopus 로고
    • Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide Y neurones
    • Sahu A. Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide Y neurones. J. Neuroendocrinol. 2002, 14:796-804.
    • (2002) J. Neuroendocrinol. , vol.14 , pp. 796-804
    • Sahu, A.1
  • 41
    • 0347320633 scopus 로고    scopus 로고
    • Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance
    • Sahu A. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front. Neuroendocrinol. 2003, 24:225-253.
    • (2003) Front. Neuroendocrinol. , vol.24 , pp. 225-253
    • Sahu, A.1
  • 42
    • 45449097234 scopus 로고    scopus 로고
    • Effects of chronic central leptin infusion on proopiomelanocortin and neurotensin gene expression in the rat hypothalamus
    • Sahu A. Effects of chronic central leptin infusion on proopiomelanocortin and neurotensin gene expression in the rat hypothalamus. Neurosci. Lett. 2008, 440:125-129.
    • (2008) Neurosci. Lett. , vol.440 , pp. 125-129
    • Sahu, A.1
  • 44
    • 27644513401 scopus 로고    scopus 로고
    • Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion
    • Sahu A., Metlakunta A.S. Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion. J. Neuroendocrinol. 2005, 17:720-726.
    • (2005) J. Neuroendocrinol. , vol.17 , pp. 720-726
    • Sahu, A.1    Metlakunta, A.S.2
  • 45
    • 0035847242 scopus 로고    scopus 로고
    • Evidence that neurotensin mediates the central effect of leptin on food intake in rat
    • Sahu A., Carraway R.E., Wang Y.P. Evidence that neurotensin mediates the central effect of leptin on food intake in rat. Brain Res. 2001, 888:343-347.
    • (2001) Brain Res. , vol.888 , pp. 343-347
    • Sahu, A.1    Carraway, R.E.2    Wang, Y.P.3
  • 46
    • 0023405202 scopus 로고
    • Effects of neuropeptide Y, NPY analog (norleucine4-NPY), galanin and neuropeptide K on LH release in ovariectomized (ovx) and ovx estrogen, progesterone-treated rats
    • Sahu A., Crowley W.R., Tatemoto K., Balasubramaniam A., Kalra S.P. Effects of neuropeptide Y, NPY analog (norleucine4-NPY), galanin and neuropeptide K on LH release in ovariectomized (ovx) and ovx estrogen, progesterone-treated rats. Peptides 1987, 8:921-926.
    • (1987) Peptides , vol.8 , pp. 921-926
    • Sahu, A.1    Crowley, W.R.2    Tatemoto, K.3    Balasubramaniam, A.4    Kalra, S.P.5
  • 48
    • 0021061860 scopus 로고
    • Neurotensin: effects of hypothalamic and intravenous injections on eating and drinking in rats
    • Stanley B.G., Hoebel B.G., Leibowitz S.F. Neurotensin: effects of hypothalamic and intravenous injections on eating and drinking in rats. Peptides 1983, 4:493-500.
    • (1983) Peptides , vol.4 , pp. 493-500
    • Stanley, B.G.1    Hoebel, B.G.2    Leibowitz, S.F.3
  • 49
    • 0033051923 scopus 로고    scopus 로고
    • Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques
    • Tang-Christensen M., Havel P.J., Jacobs R.R., Larsen P.J., Cameron J.L. Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques. J. Clin. Endocrinol. Metab. 1999, 84:711-717.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 711-717
    • Tang-Christensen, M.1    Havel, P.J.2    Jacobs, R.R.3    Larsen, P.J.4    Cameron, J.L.5
  • 50
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia L.A. The leptin receptor. J. Biol. Chem. 1997, 272:6093-6096.
    • (1997) J. Biol. Chem. , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 51
    • 0029739826 scopus 로고    scopus 로고
    • Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    • Vaisse C., Halaas J.L., Horvath C.M., Darnell J.E., Stoffel M., Friedman J.M. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. 1996, 14:95-97.
    • (1996) Nat. Genet. , vol.14 , pp. 95-97
    • Vaisse, C.1    Halaas, J.L.2    Horvath, C.M.3    Darnell, J.E.4    Stoffel, M.5    Friedman, J.M.6
  • 52
    • 33845867730 scopus 로고    scopus 로고
    • Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
    • Xu A.W., Ste-Marie L., Kaelin C.B., Barsh G.S. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology 2007, 148:72-80.
    • (2007) Endocrinology , vol.148 , pp. 72-80
    • Xu, A.W.1    Ste-Marie, L.2    Kaelin, C.B.3    Barsh, G.S.4
  • 53
    • 8644268830 scopus 로고    scopus 로고
    • Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
    • Zhang E.E., Chapeau E., Hagihara K., Feng G.S. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:16064-16069.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 16064-16069
    • Zhang, E.E.1    Chapeau, E.2    Hagihara, K.3    Feng, G.S.4
  • 55
    • 0036321620 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding
    • Zhao A.Z., Huan J.N., Gupta S., Pal R., Sahu A. A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat. Neurosci. 2002, 5:727-728.
    • (2002) Nat. Neurosci. , vol.5 , pp. 727-728
    • Zhao, A.Z.1    Huan, J.N.2    Gupta, S.3    Pal, R.4    Sahu, A.5


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