Loss of Cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity

PLoS ONE

Volumn 3, Issue 2, 2008, Pages

  Lee, Ji Yeon ^a   Muenzberg, Heike ^b   Gavrilova, Oksana ^a   Reed, Jacquelyn A ^c   Berryman, Darlene ^d   Villanueva, Eneida C ^b   Louis, Gwendolyn W ^b   Leinninger, Gina M ^b   Bertuzzi, Stefano ^e   Seeley, Randy J ^c   Robinson, Gertraud W ^a   Myers Jr , Martin G ^b   Hennighausen, Lothar ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d OHIO UNIVERSITY   (United States)

^e NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INSULIN; LEPTIN; STAT5 PROTEIN; STAT5A PROTEIN, MOUSE; STAT5B PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CENTRAL NERVOUS SYSTEM; COLD STRESS; CONTROLLED STUDY; DISEASE SEVERITY; ENERGY BALANCE; FEMALE; FOOD INTAKE; GENE DELETION; GENE LOCUS; GENETIC RECOMBINATION; HOMEOSTASIS; HYPERLEPTINEMIA; HYPERPHAGIA; HYPOPHYSIS; HYPOTHALAMUS; INSULIN RESISTANCE; MALE; MOUSE; MUTANT; NONHUMAN; OBESITY; PROTEIN LOCALIZATION; RAT; RISK REDUCTION; SIGNAL TRANSDUCTION; THERMOREGULATION; ACTIVE TRANSPORT; ANIMAL; CYTOLOGY; ENERGY METABOLISM; METABOLISM; NERVE CELL; PHYSIOLOGY; TRANSGENIC MOUSE;

MUS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CENTRAL NERVOUS SYSTEM; CYTOKINES; ENERGY METABOLISM; FEMALE; HOMEOSTASIS; HYPOTHALAMUS; MALE; MICE; MICE, TRANSGENIC; NEURONS; OBESITY; PITUITARY GLAND; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR;

EID: 45749150715     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001639     Document Type: Article

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