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Volumn 118, Issue 4, 2008, Pages 1458-1467

Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PROOPIOMELANOCORTIN;

EID: 41849134729     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI32357     Document Type: Article
Times cited : (191)

References (46)
  • 1
    • 0024472754 scopus 로고
    • The cardinal manifestations of Bardet-Biedl syndrome, a form of Laurence-Moon-Biedl syndrome
    • Green, J.S., et al. 1989. The cardinal manifestations of Bardet-Biedl syndrome, a form of Laurence-Moon-Biedl syndrome. N. Engl. J. Med. 321:1002-1009.
    • (1989) N. Engl. J. Med , vol.321 , pp. 1002-1009
    • Green, J.S.1
  • 2
    • 33749054088 scopus 로고    scopus 로고
    • Bardet-Biedl syndrome: An emerging pathomechanism of intracellular transport
    • Blacque, O.E., and Leroux, M.R. 2006. Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport. Cell. Mol. Life Sci. 63:2145-2161.
    • (2006) Cell. Mol. Life Sci , vol.63 , pp. 2145-2161
    • Blacque, O.E.1    Leroux, M.R.2
  • 3
    • 0023789504 scopus 로고
    • The spectrum of renal disease in Laurence-Moon-Biedl syndrome
    • Harnett, J.D., et al. 1988. The spectrum of renal disease in Laurence-Moon-Biedl syndrome. N. Engl. J. Med. 319:615-618.
    • (1988) N. Engl. J. Med , vol.319 , pp. 615-618
    • Harnett, J.D.1
  • 4
    • 0027963165 scopus 로고
    • Cardiac abnormalities in the Bardet-Biedl syndrome: Echocardiographic studies of 22 patients
    • Elbedour, K., Zucker, N., Zalzstein, E., Barki, Y., and Carmi, R. 1994. Cardiac abnormalities in the Bardet-Biedl syndrome: echocardiographic studies of 22 patients. Am. J. Med. Genet. 52:164-169.
    • (1994) Am. J. Med. Genet , vol.52 , pp. 164-169
    • Elbedour, K.1    Zucker, N.2    Zalzstein, E.3    Barki, Y.4    Carmi, R.5
  • 5
    • 33748994054 scopus 로고    scopus 로고
    • Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians
    • Benzinou, M., et al. 2006. Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians. Diabetes. 55:2876-2882.
    • (2006) Diabetes , vol.55 , pp. 2876-2882
    • Benzinou, M.1
  • 6
    • 0036699538 scopus 로고    scopus 로고
    • Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome
    • Mykytyn, K., et al. 2002. Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome. Nat. Genet. 31:435-438.
    • (2002) Nat. Genet , vol.31 , pp. 435-438
    • Mykytyn, K.1
  • 7
    • 0035311942 scopus 로고    scopus 로고
    • Positional cloning of a novel gene on chromosome 16q causing Bardet-Biedl syndrome (BBS2)
    • Nishimura, D.Y., et al. 2001. Positional cloning of a novel gene on chromosome 16q causing Bardet-Biedl syndrome (BBS2). Hum. Mol. Genet. 10:865-874.
    • (2001) Hum. Mol. Genet , vol.10 , pp. 865-874
    • Nishimura, D.Y.1
  • 8
    • 4143115620 scopus 로고    scopus 로고
    • Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)
    • Chiang, A.P., et al. 2004. Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3). Am. J. Hum. Genet. 75:475-484.
    • (2004) Am. J. Hum. Genet , vol.75 , pp. 475-484
    • Chiang, A.P.1
  • 9
    • 0034967274 scopus 로고    scopus 로고
    • Identification of the gene that, when mutated, causes the human obesity syndrome BBS4
    • Mykytyn, K., et al. 2001. Identification of the gene that, when mutated, causes the human obesity syndrome BBS4. Nat. Genet. 28:188-191.
    • (2001) Nat. Genet , vol.28 , pp. 188-191
    • Mykytyn, K.1
  • 10
    • 2342501364 scopus 로고    scopus 로고
    • Comparative and basal genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene
    • Li, J.B., et al. 2004. Comparative and basal genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell. 117:541-552.
    • (2004) Cell , vol.117 , pp. 541-552
    • Li, J.B.1
  • 11
    • 0033812186 scopus 로고    scopus 로고
    • Mutations in MKKS cause Bardet-Biedl syndrome
    • Slavotinek, A.M., et al. 2000. Mutations in MKKS cause Bardet-Biedl syndrome. Nat. Genet. 26:15-16.
    • (2000) Nat. Genet , vol.26 , pp. 15-16
    • Slavotinek, A.M.1
  • 12
    • 0037371508 scopus 로고    scopus 로고
    • Identification of a novel Bardet-Biedl syndrome protein, BBS7, that shares structural features with BBS1 and BBS2
    • Badano, J.L., et al. 2003. Identification of a novel Bardet-Biedl syndrome protein, BBS7, that shares structural features with BBS1 and BBS2. Am. J. Hum. Genet. 72:650-658.
    • (2003) Am. J. Hum. Genet , vol.72 , pp. 650-658
    • Badano, J.L.1
  • 13
    • 0142104970 scopus 로고    scopus 로고
    • Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome
    • Ansley, S.J., et al. 2003. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature. 425:628-633.
    • (2003) Nature , vol.425 , pp. 628-633
    • Ansley, S.J.1
  • 14
    • 28144460266 scopus 로고    scopus 로고
    • Comparative genomics and gene expression analysis identifies BBS9, a new Bardet-Biedl syndrome gene
    • Nishimura, D.Y., et al. 2005. Comparative genomics and gene expression analysis identifies BBS9, a new Bardet-Biedl syndrome gene. Am. J. Hum. Genet. 77:1021-1033.
    • (2005) Am. J. Hum. Genet , vol.77 , pp. 1021-1033
    • Nishimura, D.Y.1
  • 15
    • 33646354641 scopus 로고    scopus 로고
    • BBS10 encodes a vertebrate-specific chaperonin-like protein and is a major BBS locus
    • Stoetzel, C., et al. 2006. BBS10 encodes a vertebrate-specific chaperonin-like protein and is a major BBS locus. Nat. Genet. 38:521-524.
    • (2006) Nat. Genet , vol.38 , pp. 521-524
    • Stoetzel, C.1
  • 16
    • 33646562887 scopus 로고    scopus 로고
    • Homozygosity mapping with SNP arrays identifies TRIM32 an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11)
    • Chiang, A.P., et al. 2006. Homozygosity mapping with SNP arrays identifies TRIM32 an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). Proc. Natl. Acad. Sci. U. S. A. 103:6287-6292.
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 6287-6292
    • Chiang, A.P.1
  • 17
    • 33845995129 scopus 로고    scopus 로고
    • Identification of a novel BBS gene (BBS12) highlights the major role of a vertebrate-specific branch of chaperonin-related proteins in Bardet-Biedl syndrome
    • Stoetzel, C., et al. 2007. Identification of a novel BBS gene (BBS12) highlights the major role of a vertebrate-specific branch of chaperonin-related proteins in Bardet-Biedl syndrome. Am. J. Hum. Genet. 80:1-11.
    • (2007) Am. J. Hum. Genet , vol.80 , pp. 1-11
    • Stoetzel, C.1
  • 18
    • 0142104970 scopus 로고    scopus 로고
    • Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome
    • Ansley, S.J., et al. 2003. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature. 425:628-633.
    • (2003) Nature , vol.425 , pp. 628-633
    • Ansley, S.J.1
  • 20
    • 4143115620 scopus 로고    scopus 로고
    • Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)
    • Chiang, A.P., et al. 2004. Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3). Am. J. Hum. Genet. 75:475-584.
    • (2004) Am. J. Hum. Genet , vol.75 , pp. 475-584
    • Chiang, A.P.1
  • 21
    • 9344261783 scopus 로고    scopus 로고
    • Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin
    • Nishimura, D.Y., et al. 2004. Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin. Proc. Natl. Acad. Sci. U. S. A. 101:16588-16593.
    • (2004) Proc. Natl. Acad. Sci. U. S. A , vol.101 , pp. 16588-16593
    • Nishimura, D.Y.1
  • 22
    • 2942625562 scopus 로고    scopus 로고
    • Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly
    • Mykytyn, K., et al. 2004. Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly. Proc. Natl. Acad. Sci. U. S. A. 101:8664-8669.
    • (2004) Proc. Natl. Acad. Sci. U. S. A , vol.101 , pp. 8664-8669
    • Mykytyn, K.1
  • 23
    • 20944445215 scopus 로고    scopus 로고
    • Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome
    • Fath, M.A., et al. 2005. Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome. Hum. Mol. Genet. 14:1109-1118.
    • (2005) Hum. Mol. Genet , vol.14 , pp. 1109-1118
    • Fath, M.A.1
  • 24
    • 27144460671 scopus 로고    scopus 로고
    • Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates
    • Ross, A.J., et al. 2005. Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat. Genet. 37:1135-1140.
    • (2005) Nat. Genet , vol.37 , pp. 1135-1140
    • Ross, A.J.1
  • 25
  • 26
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman, J.M., and Halaas, J.L. 1998. Leptin and the regulation of body weight in mammals. Nature. 395:763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 27
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • Banks, W.A., Kastin, A.J., Huang, W., Jaspan, J.B., and Maness, L.M. 1996. Leptin enters the brain by a saturable system independent of insulin. Peptides. 17:305-311.
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.3    Jaspan, J.B.4    Maness, L.M.5
  • 29
    • 12344277552 scopus 로고    scopus 로고
    • Diabetes, obesity, and the brain
    • Schwartz, M.W., and Porte, D., Jr. 2005. Diabetes, obesity, and the brain. Science. 307:375-379.
    • (2005) Science , vol.307 , pp. 375-379
    • Schwartz, M.W.1    Porte Jr., D.2
  • 30
    • 11244349747 scopus 로고    scopus 로고
    • Obesity-associated hypertension: New insights into mechanisms
    • Rahmouni, K., Correia, M.L., Haynes, W.G., and Mark, A.L. 2005. Obesity-associated hypertension: new insights into mechanisms. Hypertension. 45:9-14.
    • (2005) Hypertension , vol.45 , pp. 9-14
    • Rahmouni, K.1    Correia, M.L.2    Haynes, W.G.3    Mark, A.L.4
  • 31
    • 0036066483 scopus 로고    scopus 로고
    • The concept of selective leptin resistance: Evidence from agouti yellow obese mice
    • Correia, M.L., et al. 2002. The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes. 51:439-442.
    • (2002) Diabetes , vol.51 , pp. 439-442
    • Correia, M.L.1
  • 32
    • 21344432100 scopus 로고    scopus 로고
    • Role of selective leptin resistance in diet-induced obesity hypertension
    • Rahmouni, K., Morgan, D.A., Morgan, G.M., Mark, A.L., and Haynes, W.G. 2005. Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes. 54:2012-2018.
    • (2005) Diabetes , vol.54 , pp. 2012-2018
    • Rahmouni, K.1    Morgan, D.A.2    Morgan, G.M.3    Mark, A.L.4    Haynes, W.G.5
  • 33
    • 0842324779 scopus 로고    scopus 로고
    • Obesity wars: Molecular progress confronts an expanding epidemic
    • Flier, J.S. 2004. Obesity wars: molecular progress confronts an expanding epidemic. Cell. 116:337-350.
    • (2004) Cell , vol.116 , pp. 337-350
    • Flier, J.S.1
  • 34
    • 19944431708 scopus 로고    scopus 로고
    • Clinical and genetic epidemiology of Bardet-Biedl syndrome in Newfoundland: A 22-year prospective, population-based, cohort study
    • Moore, S.J., et al. 2005. Clinical and genetic epidemiology of Bardet-Biedl syndrome in Newfoundland: a 22-year prospective, population-based, cohort study. Am. J. Med. Genet. A. 132:352-360.
    • (2005) Am. J. Med. Genet. A , vol.132 , pp. 352-360
    • Moore, S.J.1
  • 35
    • 0242408534 scopus 로고    scopus 로고
    • Energy metabolism in Bardet-Biedl syndrome
    • Grace, C., et al. 2003. Energy metabolism in Bardet-Biedl syndrome. Int. J. Obes. Relat. Metab. Disord. 27:1319-1324.
    • (2003) Int. J. Obes. Relat. Metab. Disord , vol.27 , pp. 1319-1324
    • Grace, C.1
  • 36
    • 33750275270 scopus 로고    scopus 로고
    • Insulin resistance and obesity in a mouse model of systemic lupus erythematosus
    • Ryan, M.J., McLemore, G.R., Jr. and Hendrix, S.T. 2006. Insulin resistance and obesity in a mouse model of systemic lupus erythematosus. Hypertension. 48:988-993.
    • (2006) Hypertension , vol.48 , pp. 988-993
    • Ryan, M.J.1    McLemore Jr., G.R.2    Hendrix, S.T.3
  • 37
    • 7044229277 scopus 로고    scopus 로고
    • Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway
    • Hanada, R., et al. 2004. Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat. Med. 10:1067-1073.
    • (2004) Nat. Med , vol.10 , pp. 1067-1073
    • Hanada, R.1
  • 38
    • 0041921143 scopus 로고    scopus 로고
    • Leptin-target neurones of the rat hypothalamus express somatostatin receptors
    • Stepanyan, Z., et al. 2003. Leptin-target neurones of the rat hypothalamus express somatostatin receptors. J. Neuroendocrinol. 15:822-830.
    • (2003) J. Neuroendocrinol , vol.15 , pp. 822-830
    • Stepanyan, Z.1
  • 39
    • 33846064322 scopus 로고    scopus 로고
    • Leptin and its receptors are present in the rat olfactory mucosa and modulated by the nutritional status
    • Baly, C., et al. 2007. Leptin and its receptors are present in the rat olfactory mucosa and modulated by the nutritional status. Brain Res. 1129:130-141.
    • (2007) Brain Res , vol.1129 , pp. 130-141
    • Baly, C.1
  • 40
    • 33144456230 scopus 로고    scopus 로고
    • Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer's vesicle cilia function
    • Yen, H.J., et al. 2006. Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer's vesicle cilia function. Hum. Mol. Genet. 15:667-677.
    • (2006) Hum. Mol. Genet , vol.15 , pp. 667-677
    • Yen, H.J.1
  • 41
    • 0038149085 scopus 로고    scopus 로고
    • Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
    • Rahmouni, K., Haynes, W.G., Morgan, D.A., and Mark, A.L. 2003. Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J. Neurosci. 23:5998-6004.
    • (2003) J. Neurosci , vol.23 , pp. 5998-6004
    • Rahmouni, K.1    Haynes, W.G.2    Morgan, D.A.3    Mark, A.L.4
  • 42
    • 0031015981 scopus 로고    scopus 로고
    • Neural control of renal function
    • DiBona, G.F., and Kopp, U.C. 1997. Neural control of renal function. Physiol. Rev. 77:75-197.
    • (1997) Physiol. Rev , vol.77 , pp. 75-197
    • DiBona, G.F.1    Kopp, U.C.2
  • 43
    • 0141566812 scopus 로고    scopus 로고
    • High fat feeding is associated with increased blood pressure, sympathetic nerve activity and hypothalamic mu opioid receptors
    • Barnes, M.J., et al. 2003. High fat feeding is associated with increased blood pressure, sympathetic nerve activity and hypothalamic mu opioid receptors. Brain Res. Bull. 61:511-519.
    • (2003) Brain Res. Bull , vol.61 , pp. 511-519
    • Barnes, M.J.1
  • 44
    • 0028920105 scopus 로고
    • Renal denervation attenuates the sodium retention and hypertension associated with obesity
    • Kassab, S., et al. 1995. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension. 25:893-897.
    • (1995) Hypertension , vol.25 , pp. 893-897
    • Kassab, S.1
  • 45
    • 34250012834 scopus 로고    scopus 로고
    • A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
    • Nachury, M.V., et al. 2007. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell. 129:1201-1213.
    • (2007) Cell , vol.129 , pp. 1201-1213
    • Nachury, M.V.1
  • 46
    • 33750703971 scopus 로고    scopus 로고
    • Calcific aortic valve stenosis in old hypercholesterolemic mice
    • Weiss, R.M., Ohashi, M., Miller, J.D., Young, S.G., and Heistad, D.D. 2006. Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation. 114:2065-2069.
    • (2006) Circulation , vol.114 , pp. 2065-2069
    • Weiss, R.M.1    Ohashi, M.2    Miller, J.D.3    Young, S.G.4    Heistad, D.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.