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Volumn 10, Issue 7, 2004, Pages 734-738

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

EID: 3142782772     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1072     Document Type: Article
Times cited : (398)

References (29)
  • 2
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman, J.M. & Halaas, J.L. Leptin and the regulation of body weight in mammals. Nature 395, 763-770 (1998).
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 3
    • 0032014178 scopus 로고    scopus 로고
    • Identification of Socs3 as a potential mediator of central leptin resistance
    • Bjøbæk, C., Elmquist, J.K., Frantz, J.D., Shoelson, S.E. & Flier, J.S. Identification of Socs3 as a potential mediator of central leptin resistance. Mol. Cell 4, 619-625 (1998).
    • (1998) Mol. Cell , vol.4 , pp. 619-625
    • Bjøbæk, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 4
    • 0033569730 scopus 로고    scopus 로고
    • The role of Socs3 in leptin signaling and leptin resistance
    • Bjøbæk, C., El-Haschimi, K., Frantz, J.D. & Flier, J.S. The role of Socs3 in leptin signaling and leptin resistance. J. Biol. Chem. 274, 30059-30065 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 30059-30065
    • Bjøbæk, C.1    El-Haschimi, K.2    Frantz, J.D.3    Flier, J.S.4
  • 5
    • 0001421697 scopus 로고    scopus 로고
    • SOCS-3 mediates feedback inhibition of the leptin receptor via Tyr 985
    • Bjøbæk, C. et al. SOCS-3 mediates feedback inhibition of the leptin receptor via Tyr 985. J. Biol. Chem. 275, 40649-40657 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 40649-40657
    • Bjøbæk, C.1
  • 6
    • 0033520389 scopus 로고    scopus 로고
    • Socs3 is essential in the regulation of fetal liver erythropoiesis
    • Marine, J.C. et al. Socs3 is essential in the regulation of fetal liver erythropoiesis. Cell 98, 617-627 (1999).
    • (1999) Cell , vol.98 , pp. 617-627
    • Marine, J.C.1
  • 7
    • 0034801684 scopus 로고    scopus 로고
    • SOCS proteins: Negative regulators of cytokine signaling
    • Krebs, D.L. & Hilton, D.J. SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19, 378-387 (2001).
    • (2001) Stem Cells , vol.19 , pp. 378-387
    • Krebs, D.L.1    Hilton, D.J.2
  • 8
    • 0034548763 scopus 로고    scopus 로고
    • Identification of the Y985 and Y1077 motifs as Socs3 recruitment sites in the murine leptin receptor
    • Eyckerman, S., Broekaert, D., Verhee, A., Vandekerckhove, J. & Tavernier, J. Identification of the Y985 and Y1077 motifs as Socs3 recruitment sites in the murine leptin receptor. FEBS Lett. 486, 33-37 (2000).
    • (2000) FEBS Lett. , vol.486 , pp. 33-37
    • Eyckerman, S.1    Broekaert, D.2    Verhee, A.3    Vandekerckhove, J.4    Tavernier, J.5
  • 9
    • 0030737953 scopus 로고    scopus 로고
    • Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
    • Halaas J.L. et al. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. USA. 94, 8878-8883 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA. , vol.94 , pp. 8878-8883
    • Halaas, J.L.1
  • 10
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • Frederich, R.C. et al. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1, 1311-1314 (1995).
    • (1995) Nat. Med. , vol.1 , pp. 1311-1314
    • Frederich, R.C.1
  • 12
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia, L.A. The leptin receptor. J. Biol. Chem. 272, 6093-6096 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 13
    • 0036323306 scopus 로고    scopus 로고
    • Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance
    • Scarpace, P.J. et al. Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Endocrinology 143, 3026-3035 (2002).
    • (2002) Endocrinology , vol.143 , pp. 3026-3035
    • Scarpace, P.J.1
  • 14
    • 0034107525 scopus 로고    scopus 로고
    • Development of high fat diet-induced obesity and leptin resistance in C57BL/6J mice
    • Lin, S., Thomas, T.C., Storlien, L.H. & Huang, X.F. Development of high fat diet-induced obesity and leptin resistance in C57BL/6J mice. Int. J. Obes. Relat. Metab. Disord. 24, 639-646 (2000).
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , pp. 639-646
    • Lin, S.1    Thomas, T.C.2    Storlien, L.H.3    Huang, X.F.4
  • 15
    • 0033931981 scopus 로고    scopus 로고
    • Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
    • El-Haschimi, K., Pierroz, D.D., Hileman, S.M., Bjøbæk, C. & Flier, J.S. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J. Clin. Invest. 105, 1827-1832 (2000).
    • (2000) J. Clin. Invest. , vol.105 , pp. 1827-1832
    • El-Haschimi, K.1    Pierroz, D.D.2    Hileman, S.M.3    Bjøbæk, C.4    Flier, J.S.5
  • 16
    • 0034649219 scopus 로고    scopus 로고
    • Leptin resistance of adipocytes in obesity: Role of suppressors of cytokine signaling
    • Wang Z. et al. Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Biochem. Biophys. Res. Commun. 277, 20-26 (2000).
    • (2000) Biochem. Biophys. Res. Commun. , vol.277 , pp. 20-26
    • Wang, Z.1
  • 17
    • 0034717062 scopus 로고    scopus 로고
    • Socs3 is an insulin-induced negative regulator of insulin signaling
    • Emanuelli, B et al. Socs3 is an insulin-induced negative regulator of insulin signaling. J. Biol. Chem. 275, 15985-15991 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 15985-15991
    • Emanuelli, B.1
  • 18
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Bruning, J.C. et al. Role of brain insulin receptor in control of body weight and reproduction. Science 289, 2122-2125 (2000).
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1
  • 20
    • 0031440266 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    • Spanswick, D., Smith, M.A., Groppi, V.E., Logan, S.D. & Ashford M.J.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390, 521-525 (1997).
    • (1997) Nature , vol.390 , pp. 521-525
    • Spanswick, D.1    Smith, M.A.2    Groppi, V.E.3    Logan, S.D.4    Ashford, M.J.L.5
  • 21
    • 0034457883 scopus 로고    scopus 로고
    • In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
    • Kim, Y.B, Uotani, S., Pierroz, D.D., Flier, J.S. & Kahn, B.B. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141, 2328-2339 (2000).
    • (2000) Endocrinology , vol.141 , pp. 2328-2339
    • Kim, Y.B.1    Uotani, S.2    Pierroz, D.D.3    Flier, J.S.4    Kahn, B.B.5
  • 22
    • 4544256147 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 is a physiologic regulator of adipocyte insulin signaling
    • in the press
    • Shi, H., Tzameli, I., Bjøbæk, C.B. & Flier, J.S. Suppressor of cytokine signaling-3 is a physiologic regulator of adipocyte insulin signaling. J. Biol. Chem. (in the press).
    • J. Biol. Chem.
    • Shi, H.1    Tzameli, I.2    Bjøbæk, C.B.3    Flier, J.S.4
  • 23
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
    • Heymsfield, S.B. et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. J. Am. Med. Assoc. 282, 1568-1575 (1999).
    • (1999) J. Am. Med. Assoc. , vol.282 , pp. 1568-1575
    • Heymsfield, S.B.1
  • 24
    • 0030594830 scopus 로고    scopus 로고
    • Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
    • Caro, J.F. et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348, 159-161 (1996).
    • (1996) Lancet , vol.348 , pp. 159-161
    • Caro, J.F.1
  • 25
    • 0033525870 scopus 로고    scopus 로고
    • Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    • Elchebly, M. et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283, 1544-1548 (1999).
    • (1999) Science , vol.283 , pp. 1544-1548
    • Elchebly, M.1
  • 26
    • 0033942614 scopus 로고    scopus 로고
    • Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
    • Klaman, L.D. et al. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol. Cell Biol. 20, 5479-5489 (2000).
    • (2000) Mol. Cell Biol. , vol.20 , pp. 5479-5489
    • Klaman, L.D.1
  • 27
    • 18344379861 scopus 로고    scopus 로고
    • PTP1B regulates leptin signal transduction in vivo
    • Zabolotny, J.M. et al. PTP1B regulates leptin signal transduction in vivo. Dev. Cell 2, 489-495 (2002).
    • (2002) Dev. Cell , vol.2 , pp. 489-495
    • Zabolotny, J.M.1
  • 28
    • 0036228770 scopus 로고    scopus 로고
    • Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
    • Cheng, A. et al. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev. Cell 2, 497-503 (2002).
    • (2002) Dev. Cell , vol.2 , pp. 497-503
    • Cheng, A.1
  • 29
    • 0022345789 scopus 로고
    • Effect of dietary fat content on the incidence of obesity among ad libitum fed mice
    • Salmon, D.M. & Flatt, J.P. Effect of dietary fat content on the incidence of obesity among ad libitum fed mice. Int. J. Obes. 9, 443-449 (1985).
    • (1985) Int. J. Obes. , vol.9 , pp. 443-449
    • Salmon, D.M.1    Flatt, J.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.