메뉴 건너뛰기




Volumn 100, Issue 2, 2000, Pages 197-207

Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

EID: 0141737573     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81558-5     Document Type: Article
Times cited : (1895)

References (50)
  • 3
    • 17744375347 scopus 로고    scopus 로고
    • Regulation of neuronal and glial proteins by leptin: Implications for brain development
    • Ahima, R.S., Bjorbek, C., Osei, S., and Flier, J.S. (1999). Regulation of neuronal and glial proteins by leptin: Implications for brain development. Endocrinology 140, 2755-2762.
    • (1999) Endocrinology , vol.140 , pp. 2755-2762
    • Ahima, R.S.1    Bjorbek, C.2    Osei, S.3    Flier, J.S.4
  • 4
    • 0033303655 scopus 로고    scopus 로고
    • Rescue of the skeletal phenotype of vitamin D receptor ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses
    • Amling, M., Priemel, M., Holzmann, T., Chapin, K., Rueger, J.M., Baron, R., and Demay, M.B. (1999). Rescue of the skeletal phenotype of vitamin D receptor ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses. Endocrinology 140, 4982-4987.
    • (1999) Endocrinology , vol.140 , pp. 4982-4987
    • Amling, M.1    Priemel, M.2    Holzmann, T.3    Chapin, K.4    Rueger, J.M.5    Baron, R.6    Demay, M.B.7
  • 5
    • 0007525621 scopus 로고
    • Uber die funktion der hypophyse
    • Aschner, B. (1912). Uber die funktion der hypophyse. Pflügers Arch. Physiol. 146, 1-146.
    • (1912) Pflügers Arch. Physiol. , vol.146 , pp. 1-146
    • Aschner, B.1
  • 7
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjorbaek, C., Elmquist, J.K., Frantz, J.D., Shoelson, S.E., and Flier, J.S. (1998). Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell 4, 619-62 5.
    • (1998) Mol. Cell , vol.4 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 9
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab, F., Lim, M., and Lu, R. (1996). Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12, 318-320.
    • (1996) Nat. Genet. , vol.12 , pp. 318-320
    • Chehab, F.1    Lim, M.2    Lu, R.3
  • 10
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
    • Chen, H., Charlat, O., Tartaglia, L.A., Woolf, E.A., Weng, X., Ellis, S.J., Lakey, N.D., Culpepper, J., Moore, K.J., Breitbart, R.E., et al. (1996). Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell 84, 491-49 5.
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3    Woolf, E.A.4    Weng, X.5    Ellis, S.J.6    Lakey, N.D.7    Culpepper, J.8    Moore, K.J.9    Breitbart, R.E.10
  • 11
    • 0030685790 scopus 로고    scopus 로고
    • Fine structure of the murine leptin receptor gene: Splice site suppression is required to form two alternatively spliced transcripts
    • Chua, S.C.J., Koutras, I.K., Han, L., Liu, S.M., Kay, J., Young, S.J., Chung, W.K., and Leibel, R.L. (1997). Fine structure of the murine leptin receptor gene: Splice site suppression is required to form two alternatively spliced transcripts. Genomics 45, 264-270.
    • (1997) Genomics , vol.45 , pp. 264-270
    • Chua, S.C.J.1    Koutras, I.K.2    Han, L.3    Liu, S.M.4    Kay, J.5    Young, S.J.6    Chung, W.K.7    Leibel, R.L.8
  • 12
    • 0027222768 scopus 로고
    • Consensus Development Conference: Prophylaxis and treatment of osteoporosis
    • Consensus Development Conference: Prophylaxis and treatment of osteoporosis (1993). Am. J. Med., pp. 646-650.
    • (1993) Am. J. Med. , pp. 646-650
  • 14
    • 0002627493 scopus 로고    scopus 로고
    • Osteoporosis, R. Marcus, D. Feldman, and J. Kelsey, eds. San Diego, CA: Academic Press
    • Cooper, C., and Melton, L.J., III (1996). Magnitude and Impact of Osteoporosis and Fractures. In Osteoporosis, R. Marcus, D. Feldman, and J. Kelsey, eds. (San Diego, CA: Academic Press), pp. 419-434.
    • (1996) Magnitude and Impact of Osteoporosis and Fractures , pp. 419-434
    • Cooper, C.1    Melton L.J. III2
  • 16
    • 0031054014 scopus 로고    scopus 로고
    • Leptin activates neurons in ventrobasal hypothalamus and brainstem
    • Elmquist, J.K., Ahima, R.S., Maratos-Flier, E., Flier, J.S., and Saper, C.B. (1997). Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138, 839-842.
    • (1997) Endocrinology , vol.138 , pp. 839-842
    • Elmquist, J.K.1    Ahima, R.S.2    Flier, J.S.3    Saper, C.B.4
  • 17
    • 0033082380 scopus 로고    scopus 로고
    • From lesions to leptin: Hypothalamic control of food intake and body weight
    • Elmquist, J.K., Elias, C.F., and Saper, C.B. (1999). From lesions to leptin: Hypothalamic control of food intake and body weight. Neuron 22, 221-23 2.
    • (1999) Neuron , vol.22 , pp. 221-232
    • Elmquist, J.K.1    Elias, C.F.2    Saper, C.B.3
  • 18
    • 0023935232 scopus 로고
    • Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mautre hydroxypyridinium residues
    • Eyre, D.R., Dickson, I.R., and Van Ness, K. (1988). Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mautre hydroxypyridinium residues. Biochemistry 252, 494-500.
    • (1988) Biochemistry , vol.252 , pp. 494-500
    • Eyre, D.R.1    Dickson, I.R.2    Van Ness, K.3
  • 19
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • Erickson, J.C., Hollopeter, G., and Palmiter, R.D. (1996). Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274, 1704-1707.
    • (1996) Science , vol.274 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 20
    • 0027310187 scopus 로고
    • Effects of weight and body mass index on bone mineral density in men and women: The Framingham study
    • Felson, D.T., Zhang, Y., Hannan, M.T., and Anderson, J.J. (1993). Effects of weight and body mass index on bone mineral density in men and women: The Framingham study. J. Bone Miner. Res. 8, 567-573.
    • (1993) J. Bone Miner. Res. , vol.8 , pp. 567-573
    • Felson, D.T.1    Zhang, Y.2    Hannan, M.T.3    Anderson, J.J.4
  • 21
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman, J.M., and Halaas, J.L. (1998). Leptin and the regulation of body weight in mammals. Nature 395, 763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 22
    • 0014451102 scopus 로고
    • Tetracycline-based histological analysis of bone remodeling
    • Frost, H.M. (1969). Tetracycline-based histological analysis of bone remodeling. Calcif. Tissue Res. 3, 211-23 7.
    • (1969) Calcif. Tissue Res. , vol.3 , pp. 211-237
    • Frost, H.M.1
  • 25
    • 0017349397 scopus 로고
    • Laboratory animals exhibiting obesity and diabetes syndromes
    • Herberg, L., and Coleman, D.L. (1977). Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26, 59-99.
    • (1977) Metabolism , vol.26 , pp. 59-99
    • Herberg, L.1    Coleman, D.L.2
  • 27
    • 0017353291 scopus 로고
    • The effect of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity
    • Inoue, S., and Bray, G.A. (1977). The effect of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity. Endocrinology 100,108-114.
    • (1977) Endocrinology , vol.100 , pp. 108-114
    • Inoue, S.1    Bray, G.A.2
  • 28
    • 0033082426 scopus 로고    scopus 로고
    • Feeding and body-weight regulation by hypothalamic neuropeptides-mediation of the actions of leptin
    • Inui, A. (1999). Feeding and body-weight regulation by hypothalamic neuropeptides-mediation of the actions of leptin. Trends Neurosci. 22, 62-67.
    • (1999) Trends Neurosci. , vol.22 , pp. 62-67
    • Inui, A.1
  • 29
    • 0026590269 scopus 로고
    • Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset
    • Kaufman, J.-M., Taelman, P., Vermeulen, A., and Vandeweghe, M. (1992). Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset. J. Clin. Endocrinol. Metab. 74, 118-123.
    • (1992) J. Clin. Endocrinol. Metab. , vol.74 , pp. 118-123
    • Kaufman, J.-M.1    Taelman, P.2    Vermeulen, A.3    Vandeweghe, M.4
  • 32
    • 0029866704 scopus 로고    scopus 로고
    • Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells
    • Levy, J.B., Schindler, C., Raz, R., Levy, D.E., Baron, R., and Horowitz, M.C. (1996). Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells. Endocrinology 137, 1159-116 5.
    • (1996) Endocrinology , vol.137 , pp. 1159-1165
    • Levy, J.B.1    Schindler, C.2    Raz, R.3    Levy, D.E.4    Baron, R.5    Horowitz, M.C.6
  • 35
    • 0025945012 scopus 로고
    • Insulin resistance-mechanisms, syndromes, and implications
    • Moller, D.E., and Flier, J.S. (1991). Insulin resistance-mechanisms, syndromes, and implications. N. Engl. J. Med. 325, 938-948.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 938-948
    • Moller, D.E.1    Flier, J.S.2
  • 36
    • 0031992120 scopus 로고    scopus 로고
    • New method for genotyping the mouse Lep(ob) mutation, using a polymerase chain reaction assay
    • Namae, M., Mori, Y., Yasuda, K., Kadowaki, T., Kanazawa, Y., and Komeda, K. (1998). New method for genotyping the mouse Lep(ob) mutation, using a polymerase chain reaction assay. Lab. Anim. Sci. 48, 103-104.
    • (1998) Lab. Anim. Sci. , vol.48 , pp. 103-104
    • Namae, M.1    Mori, Y.2    Yasuda, K.3    Kadowaki, T.4    Kanazawa, Y.5    Komeda, K.6
  • 37
    • 0023488581 scopus 로고
    • Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
    • Parfitt, A.M., Drezner, M.K., Glorieux, F.H., Kanis, J.A., Malluche, H., Meunier, P.J., Ott, S.M., and Recker, R.R. (1987). Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2, 595-610.
    • (1987) J. Bone Miner. Res. , vol.2 , pp. 595-610
    • Parfitt, A.M.1    Drezner, M.K.2    Glorieux, F.H.3    Kanis, J.A.4    Malluche, H.5    Meunier, P.J.6    Ott, S.M.7    Recker, R.R.8
  • 38
    • 0031765480 scopus 로고    scopus 로고
    • A combination of osteoclast differentiation factor and macrophagecolony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro
    • Quinn, J.M., Elliott, J., Gillespie, M.T., and Martin, T.J. (1998). A combination of osteoclast differentiation factor and macrophagecolony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro. Endocrinology 139, 4424-4427.
    • (1998) Endocrinology , vol.139 , pp. 4424-4427
    • Quinn, J.M.1    Elliott, J.2    Gillespie, M.T.3    Martin, T.J.4
  • 40
    • 0030742358 scopus 로고    scopus 로고
    • Preventing glucocorticoid-induced osteoporosis
    • Reid, I.R. (1997). Preventing glucocorticoid-induced osteoporosis. N. Engl. J. Med. 337, 420-421.
    • (1997) N. Engl. J. Med. , vol.337 , pp. 420-421
    • Reid, I.R.1
  • 41
    • 0031955217 scopus 로고    scopus 로고
    • A unitary model for involutional osteoporosis: Estrogen deficiency causes both Type I and Type II osteoporosis in postmenopausal women and contributes to bone loss in aging men
    • Riggs, B., Khosla, S., and Melton, M.J. (1998). A unitary model for involutional osteoporosis: Estrogen deficiency causes both Type I and Type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J. Bone Miner. Res. 13, 763-773.
    • (1998) J. Bone Miner. Res. , vol.13 , pp. 763-773
    • Riggs, B.1    Khosla, S.2    Melton, M.J.3
  • 42
    • 0022625922 scopus 로고
    • Medical progress: Involutional osteoporosis
    • Riggs, B.L., and Melton, L.J.I. (1986). Medical progress: Involutional osteoporosis. N. Engl. J. Med. 314, 1676-1678.
    • (1986) N. Engl. J. Med. , vol.314 , pp. 1676-1678
    • Riggs, B.L.1    Melton, L.J.I.2
  • 44
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • Spiegelman, B.M., and Flier, J.S. (1996). Adipogenesis and obesity: Rounding out the big picture. Cell 87, 377-389.
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 45
    • 0033304730 scopus 로고    scopus 로고
    • Modulatinof osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
    • Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M.T., and Martin, T.J. (1999). Modulatinof osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 3, 345-357.
    • (1999) Endocr. Rev. , vol.3 , pp. 345-357
    • Suda, T.1    Takahashi, N.2    Udagawa, N.3    Jimi, E.4    Gillespie, M.T.5    Martin, T.J.6
  • 47
    • 0032982438 scopus 로고    scopus 로고
    • Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes
    • Thomas, T., Gori, F., Khosla, S., Jensen, M.D., Burguera, B., and Riggs, B.L. (1999). Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 140, 1630-1638.
    • (1999) Endocrinology , vol.140 , pp. 1630-1638
    • Thomas, T.1    Gori, F.2    Khosla, S.3    Jensen, M.D.4    Burguera, B.5    Riggs, B.L.6
  • 48
    • 0027369098 scopus 로고
    • Vertebral post-menopausal bone loss is reduced in overweight women: A longitudinal study in 155 early postmenopausal women
    • Tremollieres, F.A., Rouilles, J.M., and Ribot, C. (1993). Vertebral post-menopausal bone loss is reduced in overweight women: A longitudinal study in 155 early postmenopausal women. J. Clin. Endocrinol. Metab. 77, 683-68 6.
    • (1993) J. Clin. Endocrinol. Metab. , vol.77 , pp. 683-686
    • Tremollieres, F.A.1    Rouilles, J.M.2    Ribot, C.3
  • 49
    • 0029739826 scopus 로고    scopus 로고
    • Leptin activation of stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    • Vaisse, C., Halaas, J.L., Horvath, C.M., Darnell, J.E.J., Stoffel, M., and Friedman, J.M. (1996). Leptin activation of stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. 14, 95-97.
    • (1996) Nat. Genet. , vol.14 , pp. 95-97
    • Vaisse, C.1    Halaas, J.L.2    Horvath, C.M.3    Darnell, J.E.J.4    Stoffel, M.5    Friedman, J.M.6
  • 50
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J.M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.