-
1
-
-
33749319625
-
Obesity epidemic in need of answers
-
Ahima RS. Obesity epidemic in need of answers. Gastroenterology. 2006;131(4):991.
-
(2006)
Gastroenterology
, vol.131
, Issue.4
, pp. 991
-
-
Ahima, R.S.1
-
2
-
-
66649112489
-
Minireview: Molecular targets for obesity therapy in the brain
-
Obici S. Minireview: molecular targets for obesity therapy in the brain. Endocrinology. 2009; 150(6):2512-2517.
-
(2009)
Endocrinology
, vol.150
, Issue.6
, pp. 2512-2517
-
-
Obici, S.1
-
3
-
-
31044451656
-
Neuro-hormonal control of food intake: Basic mechanisms and clinical implications
-
Konturek PC, et al. Neuro-hormonal control of food intake: basic mechanisms and clinical implications. J Physiol Pharmacol. 2005;56(suppl 6):5-25.
-
(2005)
J Physiol Pharmacol
, vol.56
, Issue.SUPPL. 6
, pp. 5-25
-
-
Konturek, P.C.1
-
4
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ. Baskin, DG. Central nervous system control of food intake. Nature. 2000;404(6778):661-671.
-
(2000)
Nature
, vol.404
, Issue.6778
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte Jr, D.3
Seeley, R.J.4
Baskin, D.G.5
-
5
-
-
0033436355
-
Insulin and leptin: Dual adiposity signals to the brain for the regulation of food intake and body weight
-
Baskin DG, et al. Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Res. 1999;848(1-2):114-123.
-
(1999)
Brain Res
, vol.848
, Issue.1-2
, pp. 114-123
-
-
Baskin, D.G.1
-
6
-
-
1642349297
-
Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice
-
Bouret SG, Draper SJ, Simerly RB. Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J Neurosci. 2004;24(11):2797-2805.
-
(2004)
J Neurosci
, vol.24
, Issue.11
, pp. 2797-2805
-
-
Bouret, S.G.1
Draper, S.J.2
Simerly, R.B.3
-
7
-
-
0033180532
-
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
-
Elias CF, et al. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. 1999;23(4):775-786.
-
(1999)
Neuron
, vol.23
, Issue.4
, pp. 775-786
-
-
Elias, C.F.1
-
8
-
-
0032130554
-
Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
-
Hahn TM, Breininger JF, Baskin DG, Schwartz MW. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci. 1998; 1(4):271-272.
-
(1998)
Nat Neurosci
, vol.1
, Issue.4
, pp. 271-272
-
-
Hahn, T.M.1
Breininger, J.F.2
Baskin, D.G.3
Schwartz, M.W.4
-
9
-
-
2942631413
-
Proopiomelanocortin and energy balance: Insights from human and murine genetics
-
Coll AP, Farooqi IS, Challis BG, Yeo GS, O'Rahilly S. Proopiomelanocortin and energy balance: insights from human and murine genetics. J Clin Endocrinol Metab. 2004;89(6):2557-2562.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, Issue.6
, pp. 2557-2562
-
-
Coll, A.P.1
Farooqi, I.S.2
Challis, B.G.3
Yeo, G.S.4
O'Rahilly, S.5
-
10
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
Cowley MA, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001;411(6836):480-484.
-
(2001)
Nature
, vol.411
, Issue.6836
, pp. 480-484
-
-
Cowley, M.A.1
-
12
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998; 395(6704):763-770.
-
(1998)
Nature
, vol.395
, Issue.6704
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
13
-
-
0034520485
-
Editorial: Leptin as a therapeutic agent - trials and tribulations
-
Mantzoros CS, Flier JS. Editorial: leptin as a therapeutic agent - trials and tribulations. J Clin Endocrinol Metab. 2000;85(11):4000-4002.
-
(2000)
J Clin Endocrinol Metab
, vol.85
, Issue.11
, pp. 4000-4002
-
-
Mantzoros, C.S.1
Flier, J.S.2
-
14
-
-
34347235476
-
Elevated leptin: Consequence or cause of obesity?
-
Scarpace PJ, Zhang Y. Elevated leptin: consequence or cause of obesity? Front Biosci. 2007;12:3531-3544.
-
(2007)
Front Biosci
, vol.12
, pp. 3531-3544
-
-
Scarpace, P.J.1
Zhang, Y.2
-
15
-
-
17844401180
-
Molecular and anatomical determinants of central leptin resistance
-
Munzberg H, Myers MG Jr. Molecular and anatomical determinants of central leptin resistance. Nat Neurosci. 2005;8(5):566-570.
-
(2005)
Nat Neurosci
, vol.8
, Issue.5
, pp. 566-570
-
-
Munzberg, H.1
Myers Jr., M.G.2
-
16
-
-
18344379861
-
PTP1B regulates leptin signal transduction in vivo
-
Zabolotny JM, et al. PTP1B regulates leptin signal transduction in vivo. Dev Cell. 2002;2(4):489-495.
-
(2002)
Dev Cell
, vol.2
, Issue.4
, pp. 489-495
-
-
Zabolotny, J.M.1
-
17
-
-
0036228770
-
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
-
Cheng A, et al. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell. 2002;2(4):497-503.
-
(2002)
Dev Cell
, vol.2
, Issue.4
, pp. 497-503
-
-
Cheng, A.1
-
18
-
-
0035930501
-
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
-
Myers MP, et al. TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem. 2001; 276(51):47771-47774.
-
(2001)
J Biol Chem
, vol.276
, Issue.51
, pp. 47771-47774
-
-
Myers, M.P.1
-
19
-
-
33746810001
-
Neuronal PTP1B regulates body weight, adiposity and leptin action
-
Bence KK, et al. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med. 2006; 12(8):917-924.
-
(2006)
Nat Med
, vol.12
, Issue.8
, pp. 917-924
-
-
Bence, K.K.1
-
20
-
-
35648930917
-
Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B
-
Delibegovic M, et al. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol. 2007; 27(21):7727-7734.
-
(2007)
Mol Cell Biol
, vol.27
, Issue.21
, pp. 7727-7734
-
-
Delibegovic, M.1
-
21
-
-
62749115187
-
Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress
-
Delibegovic M, et al. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes. 2009; 58(3):590-599.
-
(2009)
Diabetes
, vol.58
, Issue.3
, pp. 590-599
-
-
Delibegovic, M.1
-
22
-
-
34247362854
-
PTP1B as a drug target: Recent developments in PTP1B inhibitor discovery
-
Zhang S, Zhang ZY. PTP1B as a drug target: recent developments in PTP1B inhibitor discovery. Drug Discov Today. 2007;12(9-10):373-381.
-
(2007)
Drug Discov Today
, vol.12
, Issue.9-10
, pp. 373-381
-
-
Zhang, S.1
Zhang, Z.Y.2
-
23
-
-
0038771965
-
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
-
Neel BG, Gu H, Pao L. The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci. 2003;28(6):284-293.
-
(2003)
Trends Biochem Sci
, vol.28
, Issue.6
, pp. 284-293
-
-
Neel, B.G.1
Gu, H.2
Pao, L.3
-
24
-
-
33144480723
-
-
Feng GS. Shp2 as a therapeutic target for leptin resistance and obesity. Expert Opin Ther Targets. 2006;10(1):135-142.
-
Feng GS. Shp2 as a therapeutic target for leptin resistance and obesity. Expert Opin Ther Targets. 2006;10(1):135-142.
-
-
-
-
25
-
-
0000430395
-
Divergent roles of SHP-2 in ERK activation by leptin receptors
-
Bjorbaek C, et al. Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem. 2001; 276(7):4747-4755.
-
(2001)
J Biol Chem
, vol.276
, Issue.7
, pp. 4747-4755
-
-
Bjorbaek, C.1
-
26
-
-
0034640508
-
Activation of downstream signals by the long form of the leptin receptor
-
Banks AS, Davis SM, Bates SH, Myers MG Jr. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem. 2000; 275(19):14563-14572.
-
(2000)
J Biol Chem
, vol.275
, Issue.19
, pp. 14563-14572
-
-
Banks, A.S.1
Davis, S.M.2
Bates, S.H.3
Myers Jr., M.G.4
-
27
-
-
8644268830
-
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
-
Zhang EE, Chapeau E, Hagihara K, Feng GS. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci U S A. 2004;101(45):16064-16069.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.45
, pp. 16064-16069
-
-
Zhang, E.E.1
Chapeau, E.2
Hagihara, K.3
Feng, G.S.4
-
28
-
-
43449123047
-
Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase
-
Krajewska M, et al. Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol. 2008;172(5):1312- 1324.
-
(2008)
Am J Pathol
, vol.172
, Issue.5
, pp. 1312-1324
-
-
Krajewska, M.1
-
29
-
-
34548604499
-
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
-
Parton LE, et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature. 2007;449(7159):228-232.
-
(2007)
Nature
, vol.449
, Issue.7159
, pp. 228-232
-
-
Parton, L.E.1
-
30
-
-
40949123295
-
Insights from the genetics of severe childhood obesity
-
Farooqi S. Insights from the genetics of severe childhood obesity. Horm Res. 2007;68(Suppl 5):5-7.
-
(2007)
Horm Res
, vol.68
, Issue.SUPPL. 5
, pp. 5-7
-
-
Farooqi, S.1
-
31
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
Balthasar N, et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 2004;42(6):983-991.
-
(2004)
Neuron
, vol.42
, Issue.6
, pp. 983-991
-
-
Balthasar, N.1
-
32
-
-
41549111593
-
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
-
van de Wall E, et al. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology. 2008;149(4):1773-1785.
-
(2008)
Endocrinology
, vol.149
, Issue.4
, pp. 1773-1785
-
-
van de Wall, E.1
-
33
-
-
40449132293
-
Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis
-
Shi H, Strader AD, Sorrell JE, Chambers JB, Woods SC, Seeley RJ. Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis. Am J Physiol Endocrinol Metab. 2008; 294(3):E630-E639.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
, Issue.3
-
-
Shi, H.1
Strader, A.D.2
Sorrell, J.E.3
Chambers, J.B.4
Woods, S.C.5
Seeley, R.J.6
-
34
-
-
66049133685
-
Leptin-dependent control of glucose balance and locomotor activity by POMC neurons
-
Huo L, et al. Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metab. 2009;9(6):537-547.
-
(2009)
Cell Metab
, vol.9
, Issue.6
, pp. 537-547
-
-
Huo, L.1
-
35
-
-
33746537247
-
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
-
Kievit P, et al. Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab. 2006;4(2):123-132.
-
(2006)
Cell Metab
, vol.4
, Issue.2
, pp. 123-132
-
-
Kievit, P.1
-
36
-
-
33749577870
-
SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth
-
Fornaro M, et al. SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J Cell Biol. 2006;175(1):87-97.
-
(2006)
J Cell Biol
, vol.175
, Issue.1
, pp. 87-97
-
-
Fornaro, M.1
-
37
-
-
4344607526
-
Endocrine regulation of energy metabolism: Review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin
-
Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem. 2004;50(9):1511-1525.
-
(2004)
Clin Chem
, vol.50
, Issue.9
, pp. 1511-1525
-
-
Meier, U.1
Gressner, A.M.2
-
38
-
-
1942534687
-
Adiponectin and its role in the obesity-induced insulin resistance and related complications
-
Haluzik M, Parizkova J, Haluzik MM. Adiponectin and its role in the obesity-induced insulin resistance and related complications. Physiol Res. 2004;53(2):123-129.
-
(2004)
Physiol Res
, vol.53
, Issue.2
, pp. 123-129
-
-
Haluzik, M.1
Parizkova, J.2
Haluzik, M.M.3
-
39
-
-
0035663963
-
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
-
Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest. 2001;108(12):1875-1881.
-
(2001)
J Clin Invest
, vol.108
, Issue.12
, pp. 1875-1881
-
-
Combs, T.P.1
Berg, A.H.2
Obici, S.3
Scherer, P.E.4
Rossetti, L.5
-
40
-
-
34248393099
-
High-fat diets: Modeling the metabolic disorders of human obesity in rodents
-
Buettner R, Scholmerich J, Bollheimer LC. High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring). 2007; 15(4):798-808.
-
(2007)
Obesity (Silver Spring)
, vol.15
, Issue.4
, pp. 798-808
-
-
Buettner, R.1
Scholmerich, J.2
Bollheimer, L.C.3
-
41
-
-
11144357287
-
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
-
Asilmaz E, et al. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J Clin Invest. 2004;113(3):414-424.
-
(2004)
J Clin Invest
, vol.113
, Issue.3
, pp. 414-424
-
-
Asilmaz, E.1
-
42
-
-
0032527071
-
Distributions of leptin receptor mRNA isoforms in the rat brain
-
Elmquist JK, Bjorbaek C, Ahima RS, Flier JS, Saper CB. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol. 1998; 395(4):535-547.
-
(1998)
J Comp Neurol
, vol.395
, Issue.4
, pp. 535-547
-
-
Elmquist, J.K.1
Bjorbaek, C.2
Ahima, R.S.3
Flier, J.S.4
Saper, C.B.5
-
43
-
-
0038076280
-
Distribution, function, and properties of leptin receptors in the brain
-
Funahashi H, Yada T, Suzuki R, Shioda S. Distribution, function, and properties of leptin receptors in the brain. Int Rev Cytol. 2003;224:1-27.
-
(2003)
Int Rev Cytol
, vol.224
, pp. 1-27
-
-
Funahashi, H.1
Yada, T.2
Suzuki, R.3
Shioda, S.4
-
44
-
-
58749086043
-
The geometry of leptin action in the brain: More complicated than a simple ARC
-
Myers MG Jr, Munzberg H, Leinninger GM, Leshan RL. The geometry of leptin action in the brain: more complicated than a simple ARC. Cell Metab. 2009;9(2):117-123.
-
(2009)
Cell Metab
, vol.9
, Issue.2
, pp. 117-123
-
-
Myers Jr, M.G.1
Munzberg, H.2
Leinninger, G.M.3
Leshan, R.L.4
-
45
-
-
0036000280
-
Leptin signalling
-
Sweeney G. Leptin signalling. Cell Signal. 2002; 14(8):655-663.
-
(2002)
Cell Signal
, vol.14
, Issue.8
, pp. 655-663
-
-
Sweeney, G.1
-
46
-
-
2342439732
-
Leptin signaling in the central nervous system and the periphery
-
Bjorbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res. 2004;59:305-331.
-
(2004)
Recent Prog Horm Res
, vol.59
, pp. 305-331
-
-
Bjorbaek, C.1
Kahn, B.B.2
-
50
-
-
47249148827
-
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
-
Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem. 2008;283(21):14230-14241.
-
(2008)
J Biol Chem
, vol.283
, Issue.21
, pp. 14230-14241
-
-
Zabolotny, J.M.1
Kim, Y.B.2
Welsh, L.A.3
Kershaw, E.E.4
Neel, B.G.5
Kahn, B.B.6
-
51
-
-
60849120123
-
HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms
-
White CL, Whittington A, Barnes MJ, Wang Z, Bray GA, Morrison CD. HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. Am J Physiol Endocrinol Metab. 2009;296(2):E291-E299.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
, Issue.2
-
-
White, C.L.1
Whittington, A.2
Barnes, M.J.3
Wang, Z.4
Bray, G.A.5
Morrison, C.D.6
-
52
-
-
0033673994
-
Modulation of insulin signaling by protein tyrosine phosphatases
-
Elchebly M, Cheng A, Tremblay ML. Modulation of insulin signaling by protein tyrosine phosphatases. J Mol Med. 2000;78(9):473-482.
-
(2000)
J Mol Med
, vol.78
, Issue.9
, pp. 473-482
-
-
Elchebly, M.1
Cheng, A.2
Tremblay, M.L.3
-
53
-
-
15044343929
-
Cytoplasmic protein tyrosine phosphatases, regulation and function: The roles of PTP1B and TC-PTP
-
Bourdeau A, Dube N, Tremblay ML. Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP. Curr Opin Cell Biol. 2005;17(2):203-209.
-
(2005)
Curr Opin Cell Biol
, vol.17
, Issue.2
, pp. 203-209
-
-
Bourdeau, A.1
Dube, N.2
Tremblay, M.L.3
-
54
-
-
0034789909
-
Central melanocortin receptors regulate insulin action
-
Obici S, Feng Z, Tan J, Liu L, Karkanias G, Rossetti L. Central melanocortin receptors regulate insulin action. J Clin Invest. 2001;108(7):1079-1085.
-
(2001)
J Clin Invest
, vol.108
, Issue.7
, pp. 1079-1085
-
-
Obici, S.1
Feng, Z.2
Tan, J.3
Liu, L.4
Karkanias, G.5
Rossetti, L.6
-
55
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med. 2002;8(12):1376-1382.
-
(2002)
Nat Med
, vol.8
, Issue.12
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
56
-
-
45749158925
-
Central insulin action regulates peripheral glucose and fat metabolism in mice
-
Koch L, et al. Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest. 2008;118(6):2132-2147.
-
(2008)
J Clin Invest
, vol.118
, Issue.6
, pp. 2132-2147
-
-
Koch, L.1
-
57
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
Bruning JC, et al. Role of brain insulin receptor in control of body weight and reproduction. Science. 2000;289(5487):2122-2125.
-
(2000)
Science
, vol.289
, Issue.5487
, pp. 2122-2125
-
-
Bruning, J.C.1
-
59
-
-
33745838578
-
Central insulin action in energy and glucose homeostasis
-
Plum L, Belgardt BF, Bruning JC. Central insulin action in energy and glucose homeostasis. J Clin Invest. 2006;116(7):1761-1766.
-
(2006)
J Clin Invest
, vol.116
, Issue.7
, pp. 1761-1766
-
-
Plum, L.1
Belgardt, B.F.2
Bruning, J.C.3
-
60
-
-
0037109670
-
The catabolic action of insulin in the brain is mediated by melanocortins
-
Benoit SC, et al. The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci. 2002;22(20):9048-9052.
-
(2002)
J Neurosci
, vol.22
, Issue.20
, pp. 9048-9052
-
-
Benoit, S.C.1
-
61
-
-
0037315042
-
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia
-
Niswender KD, et al. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes. 2003;52(2):227-231.
-
(2003)
Diabetes
, vol.52
, Issue.2
, pp. 227-231
-
-
Niswender, K.D.1
-
62
-
-
16844369740
-
PI3K integrates the action of insulin and leptin on hypothalamic neurons
-
Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS. PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest. 2005;115(4):951-958.
-
(2005)
J Clin Invest
, vol.115
, Issue.4
, pp. 951-958
-
-
Xu, A.W.1
Kaelin, C.B.2
Takeda, K.3
Akira, S.4
Schwartz, M.W.5
Barsh, G.S.6
-
63
-
-
33745819212
-
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
-
Plum L, et al. Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest. 2006; 116(7):1886-1901.
-
(2006)
J Clin Invest
, vol.116
, Issue.7
, pp. 1886-1901
-
-
Plum, L.1
-
64
-
-
34249651956
-
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
-
Konner AC, et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab. 2007;5(6):438-449.
-
(2007)
Cell Metab
, vol.5
, Issue.6
, pp. 438-449
-
-
Konner, A.C.1
-
65
-
-
20144389727
-
The role of insulin receptor substrate 2 in hypothalamic and beta cell function
-
Choudhury AI, et al. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest. 2005;115(4):940-950.
-
(2005)
J Clin Invest
, vol.115
, Issue.4
, pp. 940-950
-
-
Choudhury, A.I.1
-
66
-
-
0032168152
-
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
-
Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J. 1998;334(pt 2):297-314.
-
(1998)
Biochem J
, vol.334
, Issue.PART 2
, pp. 297-314
-
-
Heinrich, P.C.1
Behrmann, I.2
Muller-Newen, G.3
Schaper, F.4
Graeve, L.5
-
67
-
-
33746075210
-
gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor
-
Janoschek R, et al. gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Proc Natl Acad Sci U S A. 2006;103(28):10707-10712.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.28
, pp. 10707-10712
-
-
Janoschek, R.1
-
68
-
-
1842536210
-
Trophic action of leptin on hypothalamic neurons that regulate feeding
-
Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science. 2004;304(5667):108- 110.
-
(2004)
Science
, vol.304
, Issue.5667
, pp. 108-110
-
-
Bouret, S.G.1
Draper, S.J.2
Simerly, R.B.3
-
69
-
-
30044439528
-
Developmental programming of the hypothalamus: A matter of fat
-
Horvath TL, Bruning JC. Developmental programming of the hypothalamus: a matter of fat. Nat Med. 2006;12(1):52-53.
-
(2006)
Nat Med
, vol.12
, Issue.1
, pp. 52-53
-
-
Horvath, T.L.1
Bruning, J.C.2
-
70
-
-
34447547515
-
Development of leptin-sensitive circuits
-
Bouret SG, Simerly RB. Development of leptin-sensitive circuits. J Neuroendocrinol. 2007;19(8):575-582.
-
(2007)
J Neuroendocrinol
, vol.19
, Issue.8
, pp. 575-582
-
-
Bouret, S.G.1
Simerly, R.B.2
-
71
-
-
38749135486
-
Hypothalamic neural projections are permanently disrupted in diet-induced obese rats
-
Bouret SG, Gorski JN, Patterson CM, Chen S, Levin BE, Simerly RB. Hypothalamic neural projections are permanently disrupted in diet-induced obese rats. Cell Metab. 2008;7(2):179-185.
-
(2008)
Cell Metab
, vol.7
, Issue.2
, pp. 179-185
-
-
Bouret, S.G.1
Gorski, J.N.2
Patterson, C.M.3
Chen, S.4
Levin, B.E.5
Simerly, R.B.6
-
72
-
-
34248227278
-
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function
-
Bjornholm M, et al. Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest. 2007;117(5):1354- 1360.
-
(2007)
J Clin Invest
, vol.117
, Issue.5
, pp. 1354-1360
-
-
Bjornholm, M.1
-
73
-
-
0030953448
-
Protein tyrosine phosphatases in signal transduction
-
Neel BG, Tonks NK. Protein tyrosine phosphatases in signal transduction. Curr Opin Cell Biol. 1997; 9(2):193-204.
-
(1997)
Curr Opin Cell Biol
, vol.9
, Issue.2
, pp. 193-204
-
-
Neel, B.G.1
Tonks, N.K.2
-
74
-
-
0033604644
-
-
Feng GS. Shp-2 tyrosine phosphatase: signaling one cell or many. Exp Cell Res. 1999;253(1):47-54.
-
Feng GS. Shp-2 tyrosine phosphatase: signaling one cell or many. Exp Cell Res. 1999;253(1):47-54.
-
-
-
-
75
-
-
0033580431
-
The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism
-
Walter AO, Peng ZY, Cartwright CA. The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism. Oncogene. 1999; 18(11):1911-1920.
-
(1999)
Oncogene
, vol.18
, Issue.11
, pp. 1911-1920
-
-
Walter, A.O.1
Peng, Z.Y.2
Cartwright, C.A.3
-
76
-
-
0024040966
-
c-src gene product in developing rat brain is enriched in nerve growth cone membranes
-
Maness PF, Aubry M, Shores CG, Frame L, Pfenninger KH. c-src gene product in developing rat brain is enriched in nerve growth cone membranes. Proc Natl Acad Sci U S A. 1988;85(14):5001-5005.
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, Issue.14
, pp. 5001-5005
-
-
Maness, P.F.1
Aubry, M.2
Shores, C.G.3
Frame, L.4
Pfenninger, K.H.5
-
77
-
-
0027282452
-
Tyrosine phosphorylation in early embryonic growth cones
-
Bixby JL, Jhabvala P. Tyrosine phosphorylation in early embryonic growth cones. J Neurosci. 1993; 13(8):3421-3432.
-
(1993)
J Neurosci
, vol.13
, Issue.8
, pp. 3421-3432
-
-
Bixby, J.L.1
Jhabvala, P.2
-
78
-
-
0031596087
-
p59fyn and pp60c-src modulate axonal guidance in the developing mouse olfactory pathway
-
Morse WR, Whitesides JG 3rd, LaMantia AS, Maness PF. p59fyn and pp60c-src modulate axonal guidance in the developing mouse olfactory pathway. J Neurobiol. 1998;36(1):53-63.
-
(1998)
J Neurobiol
, vol.36
, Issue.1
, pp. 53-63
-
-
Morse, W.R.1
Whitesides 3rd, J.G.2
LaMantia, A.S.3
Maness, P.F.4
-
79
-
-
0034671913
-
Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
-
Besset V, Scott RP, Ibanez CF. Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase. J Biol Chem. 2000;275(50):39159-39166.
-
(2000)
J Biol Chem
, vol.275
, Issue.50
, pp. 39159-39166
-
-
Besset, V.1
Scott, R.P.2
Ibanez, C.F.3
-
80
-
-
0141785493
-
The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants
-
D'Alessio A, et al. The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants. Endocrinology. 2003;144(10):4298- 4305.
-
(2003)
Endocrinology
, vol.144
, Issue.10
, pp. 4298-4305
-
-
D'Alessio, A.1
-
81
-
-
0034764503
-
RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons
-
Enomoto H, et al. RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons. Development. 2001; 128(20):3963-3974.
-
(2001)
Development
, vol.128
, Issue.20
, pp. 3963-3974
-
-
Enomoto, H.1
-
82
-
-
0036932947
-
SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons
-
Chen B, Hammonds-Odie L, Perron J, Masters BA, Bixby JL. SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons. Dev Biol. 2002;252(2):170-187.
-
(2002)
Dev Biol
, vol.252
, Issue.2
, pp. 170-187
-
-
Chen, B.1
Hammonds-Odie, L.2
Perron, J.3
Masters, B.A.4
Bixby, J.L.5
-
83
-
-
61449129183
-
From observation to experimentation: Leptin action in the mediobasal hypothalamus
-
Williams KW, Scott MM, Elmquist JK. From observation to experimentation: leptin action in the mediobasal hypothalamus. Am J Clin Nutr. 2009; 89(3):985S-990S.
-
(2009)
Am J Clin Nutr
, vol.89
, Issue.3
-
-
Williams, K.W.1
Scott, M.M.2
Elmquist, J.K.3
-
84
-
-
33845911799
-
Distributed neural control of energy balance: Contributions from hindbrain and hypothalamus
-
Grill HJ. Distributed neural control of energy balance: contributions from hindbrain and hypothalamus. Obesity (Silver Spring). 2006;14(Suppl 5):216S-221S.
-
(2006)
Obesity (Silver Spring)
, vol.14
, Issue.SUPPL. 5
-
-
Grill, H.J.1
-
85
-
-
33646780203
-
Minireview: The brain as a molecular target for diabetic therapy
-
Prodi E, Obici S. Minireview: the brain as a molecular target for diabetic therapy. Endocrinology. 2006; 147(6):2664-2669.
-
(2006)
Endocrinology
, vol.147
, Issue.6
, pp. 2664-2669
-
-
Prodi, E.1
Obici, S.2
-
86
-
-
33744729005
-
Hypothalamic pathogenesis of type 2 diabetes
-
Koshiyama H, Hamamoto Y, Honjo S, Wada Y, Lkeda H. Hypothalamic pathogenesis of type 2 diabetes. Med Hypotheses. 2006;67(2):307-310.
-
(2006)
Med Hypotheses
, vol.67
, Issue.2
, pp. 307-310
-
-
Koshiyama, H.1
Hamamoto, Y.2
Honjo, S.3
Wada, Y.4
Lkeda, H.5
-
87
-
-
16244383657
-
A brain-liver circuit regulates glucose homeostasis
-
Pocai A, Obici S, Schwartz GJ, Rossetti L. A brain-liver circuit regulates glucose homeostasis. Cell Metab. 2005;1(1):53-61.
-
(2005)
Cell Metab
, vol.1
, Issue.1
, pp. 53-61
-
-
Pocai, A.1
Obici, S.2
Schwartz, G.J.3
Rossetti, L.4
-
88
-
-
44949163013
-
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
-
Buettner C, et al. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med. 2008;14(6):667-675.
-
(2008)
Nat Med
, vol.14
, Issue.6
, pp. 667-675
-
-
Buettner, C.1
-
89
-
-
17844389670
-
The hypothalamic arcuate nucleus: A key site for mediating leptin's effects on glucose homeostasis and locomotor activity
-
Coppari R, et al. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab. 2005; 1(1):63-72.
-
(2005)
Cell Metab
, vol.1
, Issue.1
, pp. 63-72
-
-
Coppari, R.1
-
90
-
-
30044447631
-
Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
-
Morton GJ, et al. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab. 2005; 2(6):411-420.
-
(2005)
Cell Metab
, vol.2
, Issue.6
, pp. 411-420
-
-
Morton, G.J.1
-
91
-
-
33745142241
-
Characterization of leptin-responsive neurons in the caudal brainstem
-
Ellacott KL, Halatchev IG, Cone RD. Characterization of leptin-responsive neurons in the caudal brainstem. Endocrinology. 2006;147(7):3190-3195.
-
(2006)
Endocrinology
, vol.147
, Issue.7
, pp. 3190-3195
-
-
Ellacott, K.L.1
Halatchev, I.G.2
Cone, R.D.3
-
92
-
-
0026702956
-
Evidence that beta-endorphin is synthesized in cells in the nucleus tractus solitarius: Detection of POMC mRNA
-
Bronstein DM, Schafer MK, Watson SJ, Akil H. Evidence that beta-endorphin is synthesized in cells in the nucleus tractus solitarius: detection of POMC mRNA. Brain Res. 1992;587(2):269-275.
-
(1992)
Brain Res
, vol.587
, Issue.2
, pp. 269-275
-
-
Bronstein, D.M.1
Schafer, M.K.2
Watson, S.J.3
Akil, H.4
-
93
-
-
0023103395
-
Distribution and possible origin of beta-endorphin and ACTH in discrete brainstem nuclei of rats
-
Palkovits M, Eskay RL. Distribution and possible origin of beta-endorphin and ACTH in discrete brainstem nuclei of rats. Neuropeptides. 1987; 9(2):123-137.
-
(1987)
Neuropeptides
, vol.9
, Issue.2
, pp. 123-137
-
-
Palkovits, M.1
Eskay, R.L.2
-
94
-
-
0242300570
-
Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice
-
Mizuno TM, Kelley KA, Pasinetti GM, Roberts JL, Mobbs CV. Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. Diabetes. 2003; 52(11):2675-2683.
-
(2003)
Diabetes
, vol.52
, Issue.11
, pp. 2675-2683
-
-
Mizuno, T.M.1
Kelley, K.A.2
Pasinetti, G.M.3
Roberts, J.L.4
Mobbs, C.V.5
-
95
-
-
59049098636
-
Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity
-
Flowers MT, Ntambi JM. Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity. Biochim Biophys Acta. 2009;1791(2):85-91.
-
(2009)
Biochim Biophys Acta
, vol.1791
, Issue.2
, pp. 85-91
-
-
Flowers, M.T.1
Ntambi, J.M.2
-
96
-
-
0037067570
-
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
-
Cohen P, et al. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science. 2002; 297(5579):240-243.
-
(2002)
Science
, vol.297
, Issue.5579
, pp. 240-243
-
-
Cohen, P.1
-
97
-
-
20444484914
-
The role of stearoyl-CoA desaturase in the control of metabolism
-
Dobrzyn A, Ntambi JM. The role of stearoyl-CoA desaturase in the control of metabolism. Prostaglandins Leukot Essent Fatty Acids. 2005;73(1):35-41.
-
(2005)
Prostaglandins Leukot Essent Fatty Acids
, vol.73
, Issue.1
, pp. 35-41
-
-
Dobrzyn, A.1
Ntambi, J.M.2
-
98
-
-
0037143752
-
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
-
Ntambi JM, et al. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A. 2002;99(17):11482- 11486.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.17
, pp. 11482-11486
-
-
Ntambi, J.M.1
-
99
-
-
3242720242
-
Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity
-
Zhang J, et al. Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity. Proc Natl Acad Sci U S A. 2004; 101(29):10703-10708.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.29
, pp. 10703-10708
-
-
Zhang, J.1
-
100
-
-
35748972366
-
Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/ macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulinresistant subjects
-
Westerbacka J, et al. Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/ macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulinresistant subjects. Diabetes. 2007;56(11):2759-2765.
-
(2007)
Diabetes
, vol.56
, Issue.11
, pp. 2759-2765
-
-
Westerbacka, J.1
-
101
-
-
0033942614
-
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
-
Klaman LD, et al. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol. 2000;20(15):5479-5489.
-
(2000)
Mol Cell Biol
, vol.20
, Issue.15
, pp. 5479-5489
-
-
Klaman, L.D.1
-
102
-
-
0034488835
-
Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cremediated excision
-
Novak A, Guo C, Yang W, Nagy A, Lobe CG. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cremediated excision. Genesis. 2000;28(3-4):147-155.
-
(2000)
Genesis
, vol.28
, Issue.3-4
, pp. 147-155
-
-
Novak, A.1
Guo, C.2
Yang, W.3
Nagy, A.4
Lobe, C.G.5
-
103
-
-
0041624549
-
Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter
-
Liu H, et al. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci. 2003; 23(18):7143-7154.
-
(2003)
J Neurosci
, vol.23
, Issue.18
, pp. 7143-7154
-
-
Liu, H.1
-
105
-
-
0016309270
-
Selection for growth rate, feed efficiency and body composition in mice
-
Sutherland TM, Biondini PE, Ward GM. Selection for growth rate, feed efficiency and body composition in mice. Genetics. 1974;78(1):525-540.
-
(1974)
Genetics
, vol.78
, Issue.1
, pp. 525-540
-
-
Sutherland, T.M.1
Biondini, P.E.2
Ward, G.M.3
-
106
-
-
0037324750
-
Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production
-
Fisher SJ, Kahn CR. Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production. J Clin Invest. 2003;111(4):463-468.
-
(2003)
J Clin Invest
, vol.111
, Issue.4
, pp. 463-468
-
-
Fisher, S.J.1
Kahn, C.R.2
-
107
-
-
36349031265
-
Central resistin induces hepatic insulin resistance via neuropeptide Y
-
Singhal NS, Lazar MA, Ahima RS. Central resistin induces hepatic insulin resistance via neuropeptide Y. J Neurosci. 2007;27(47):12924-12932.
-
(2007)
J Neurosci
, vol.27
, Issue.47
, pp. 12924-12932
-
-
Singhal, N.S.1
Lazar, M.A.2
Ahima, R.S.3
-
108
-
-
4143090543
-
N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin
-
Guo L, Munzberg H, Stuart RC, Nillni EA, Bjorbaek C. N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin. Proc Natl Acad Sci U S A. 2004;101(32):11797-11802.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.32
, pp. 11797-11802
-
-
Guo, L.1
Munzberg, H.2
Stuart, R.C.3
Nillni, E.A.4
Bjorbaek, C.5
-
109
-
-
23944487985
-
Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus
-
Gamber KM, Macarthur H, Westfall TC. Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus. Neuropharmacology. 2005; 49(5):646-652.
-
(2005)
Neuropharmacology
, vol.49
, Issue.5
, pp. 646-652
-
-
Gamber, K.M.1
Macarthur, H.2
Westfall, T.C.3
|