Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons

Cell Metabolism

Volumn 9, Issue 6, 2009, Pages 537-547

  Huo, Lihong ^a   Gamber, Kevin ^a   Greeley, Sarah ^a   Silva, Jose ^a   Huntoon, Nicholas ^a   Leng, Xing Hong ^b   Bjørbæk, Christian ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

HUMDISEASE; MOLNEURO

Indexed keywords

LEPTIN RECEPTOR; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FOOD INTAKE; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; INSULIN SENSITIVITY; LOCOMOTION; MALE; MORBID OBESITY; MOUSE; NONHUMAN; PANCREAS ISLET; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WEIGHT REDUCTION;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; EATING; LEPTIN; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; NEURONS; PRO-OPIOMELANOCORTIN; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION;

MUS;

EID: 66049133685     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2009.05.003     Document Type: Article

References (60)

1. Baetens D., Stefan Y., Ravazzola M., Malaisse-Lagae F., Coleman D.L., and Orci L. Alteration of islet cell populations in spontaneously diabetic mice. Diabetes 27 (1978) 1-7
2. Balthasar N., Coppari R., McMinn J., Liu S.M., Lee C.E., Tang V., Kenny C.D., McGovern R.A., Chua Jr. S.C., Elmquist J.K., and Lowell B.B. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42 (2004) 983-991
3. Brito M.N., Brito N.A., Baro D.J., Song C.K., and Bartness T.J. Differential activation of the sympathetic innervation of adipose tissues by melanocortin receptor stimulation. Endocrinology 148 (2007) 5339-5347
4. Chen H., Charlat O., Tartaglia L.A., Woolf E.A., Weng X., Ellis S.J., Lakey N.D., Culpepper J., Moore K.J., Breitbart R.E., et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84 (1996) 491-495
5. Coleman D.L. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14 (1978) 141-148
6. Cone R.D. Anatomy and regulation of the central melanocortin system. Nat. Neurosci. 8 (2005) 571-578
7. Coppari R., Ichinose M., Lee C.E., Pullen A.E., Kenny C.D., McGovern R.A., Tang V., Liu S.M., Ludwig T., Chua Jr. S.C., et al. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab. 1 (2005) 63-72
8. Cowley M.A., Smart J.L., Rubinstein M., Cerdan M.G., Diano S., Horvath T.L., Cone R.D., and Low M.J. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411 (2001) 480-484
9. Cusin I., Zakrzewska K.E., Boss O., Muzzin P., Giacobino J.P., Ricquier D., Jeanrenaud B., and Rohner-Jeanrenaud F. Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins. Diabetes 47 (1998) 1014-1019
10. Dhillon H., Zigman J.M., Ye C., Lee C.E., McGovern R.A., Tang V., Kenny C.D., Christiansen L.M., White R.D., Edelstein E.A., et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49 (2006) 191-203
11. Ellacott K.L., Halatchev I.G., and Cone R.D. Characterization of leptin-responsive neurons in the caudal brainstem. Endocrinology 147 (2006) 3190-3195
12. Elmquist J.K., Bjorbaek C., Ahima R.S., Flier J.S., and Saper C.B. Distributions of leptin receptor mRNA isoforms in the rat brain. J. Comp. Neurol. 395 (1998) 535-547
13. Fan W., Dinulescu D.M., Butler A.A., Zhou J., Marks D.L., and Cone R.D. The central melanocortin system can directly regulate serum insulin levels. Endocrinology 141 (2000) 3072-3079
14. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
15. Gamber K.M., Macarthur H., and Westfall T.C. Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus. Neuropharmacology 49 (2005) 646-652
16. Guo L., Munzberg H., Stuart R.C., Nillni E.A., and Bjorbaek C. N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin. Proc. Natl. Acad. Sci. USA 101 (2004) 11797-11802
17. Haque M.S., Minokoshi Y., Hamai M., Iwai M., Horiuchi M., and Shimazu T. Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats. Diabetes 48 (1999) 1706-1712
18. Heijboer A.C., van den Hoek A.M., Pijl H., Voshol P.J., Havekes L.M., Romijn J.A., and Corssmit E.P. Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice. Diabetologia 48 (2005) 1621-1626
19. Hespel P., Vergauwen L., Vandenberghe K., and Richter E.A. Significance of insulin for glucose metabolism in skeletal muscle during contractions. Diabetes 45 (1996) S99-S104
20. Huo L., Grill H.J., and Bjorbaek C. Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus. Diabetes 55 (2006) 567-573
21. Huszar D., Lynch C.A., Fairchild-Huntress V., Dunmore J.H., Fang Q., Berkemeier L.R., Gu W., Kesterson R.A., Boston B.A., Cone R.D., et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88 (1997) 131-141
22. Hwa J.J., Fawzi A.B., Graziano M.P., Ghibaudi L., Williams P., Van Heek M., Davis H., Rudinski M., Sybertz E., and Strader C.D. Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice. Am. J. Physiol. 272 (1997) R1204-R1209
23. Imai J., Katagiri H., Yamada T., Ishigaki Y., Suzuki T., Kudo H., Uno K., Hasegawa Y., Gao J., Kaneko K., et al. Regulation of pancreatic beta cell mass by neuronal signals from the liver. Science 322 (2008) 1250-1254
24. Kamohara S., Burcelin R., Halaas J.L., Friedman J.M., and Charron M.J. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389 (1997) 374-377
25. Karaca M., Magnan C., and Kargar C. Functional pancreatic beta-cell mass: Involvement in type 2 diabetes and therapeutic intervention. Diabetes Metab 35 (2009) 77-84
26. Lee G.H., Proenca R., Montez J.M., Carroll K.M., Darvishzadeh J.G., Lee J.I., and Friedman J.M. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379 (1996) 632-635
27. Leiter E.H., Coleman D.L., Ingram D.K., and Reynolds M.A. Influence of dietary carbohydrate on the induction of diabetes in C57BL/KsJ-db/db diabetes mice. J. Nutr. 113 (1983) 184-195
28. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Morgan P.J., and Trayhurn P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J. Neuroendocrinol. 8 (1996) 733-735
29. Mesaros A., Koralov S.B., Rother E., Wunderlich F.T., Ernst M.B., Barsh G.S., Rajewsky K., and Bruning J.C. Activation of Stat3 Signaling in AgRP Neurons Promotes Locomotor Activity. Cell Metab. 7 (2008) 236-248
30. Minokoshi Y., Haque M.S., and Shimazu T. Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats. Diabetes 48 (1999) 287-291
31. Morton G.J., Niswender K.D., Rhodes C.J., Myers Jr. M.G., Blevins J.E., Baskin D.G., and Schwartz M.W. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology 144 (2003) 2016-2024
32. Munzberg H., Huo L., Nillni E.A., Hollenberg A.N., and Bjorbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 144 (2003) 2121-2131
33. Munzberg H., Flier J.S., and Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145 (2004) 4880-4889
34. Musi N., and Goodyear L.J. AMP-activated protein kinase and muscle glucose uptake. Acta Physiol. Scand. 178 (2003) 337-345
35. Obici S., Feng Z., Tan J., Liu L., Karkanias G., and Rossetti L. Central melanocortin receptors regulate insulin action. J. Clin. Invest. 108 (2001) 1079-1085
36. Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I., and Barsh G.S. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278 (1997) 135-138
37. Oral E.A., Simha V., Ruiz E., Andewelt A., Premkumar A., Snell P., Wagner A.J., DePaoli A.M., Reitman M.L., Taylor S.I., et al. Leptin-replacement therapy for lipodystrophy. N. Engl. J. Med. 346 (2002) 570-578
38. Palkovits M., and Eskay R.L. Distribution and possible origin of beta-endorphin and ACTH in discrete brainstem nuclei of rats. Neuropeptides 9 (1987) 123-137
39. Parton L.E., Ye C.P., Coppari R., Enriori P.J., Choi B., Zhang C.Y., Xu C., Vianna C.R., Balthasar N., Lee C.E., et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449 (2007) 228-232
40. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., and Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269 (1995) 540-543
41. Petersen K.F., Oral E.A., Dufour S., Befroy D., Ariyan C., Yu C., Cline G.W., DePaoli A.M., Taylor S.I., Gorden P., and Shulman G.I. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J. Clin. Invest. 109 (2002) 1345-1350
42. Pocai A., Morgan K., Buettner C., Gutierrez-Juarez R., Obici S., and Rossetti L. Central leptin acutely reverses diet-induced hepatic insulin resistance. Diabetes 54 (2005) 3182-3189
43. Qiu J., Bosch M.A., Tobias S.C., Grandy D.K., Scanlan T.S., Ronnekleiv O.K., and Kelly M.J. Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C. J. Neurosci. 23 (2003) 9529-9540
44. Rahmouni K., Haynes W.G., Morgan D.A., and Mark A.L. Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J. Neurosci. 23 (2003) 5998-6004
45. Ryder J.W., Gilbert M., and Zierath J.R. Skeletal muscle and insulin sensitivity: pathophysiological alterations. Front. Biosci. 6 (2001) D154-D163
46. Satoh N., Ogawa Y., Katsuura G., Hayase M., Tsuji T., Imagawa K., Yoshimasa Y., Nishi S., Hosoda K., and Nakao K. The arcuate nucleus as a primary site of satiety effect of leptin in rats. Neurosci. Lett. 224 (1997) 149-152
47. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
48. Shi H., Strader A.D., Sorrell J.E., Chambers J.B., Woods S.C., and Seeley R.J. Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis. Am. J. Physiol. Endocrinol. Metab. 294 (2008) E630-E639
49. Shimomura I., Hammer R.E., Ikemoto S., Brown M.S., and Goldstein J.L. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401 (1999) 73-76
50. Ste Marie L., Miura G.I., Marsh D.J., Yagaloff K., and Palmiter R.D. A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc. Natl. Acad. Sci. USA 97 (2000) 12339-12344
51. Tanaka T., Masuzaki H., Yasue S., Ebihara K., Shiuchi T., Ishii T., Arai N., Hirata M., Yamamoto H., Hayashi T., et al. Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet. Cell Metab. 5 (2007) 395-402
52. Tang-Christensen M., Vrang N., Ortmann S., Bidlingmaier M., Horvath T.L., and Tschop M. Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology 145 (2004) 4645-4652
53. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 83 (1995) 1263-1271
54. Thornton J.E., Cheung C.C., Clifton D.K., and Steiner R.A. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138 (1997) 5063-5066
55. Tsien J.Z., Chen D.F., Gerber D., Tom C., Mercer E.H., Anderson D.J., Mayford M., Kandel E.R., and Tonegawa S. Subregion- and cell type-restricted gene knockout in mouse brain. Cell 87 (1996) 1317-1326
56. van de Wall E., Leshan R., Xu A.W., Balthasar N., Coppari R., Liu S.M., Jo Y.H., Mackenzie R.G., Allison D.B., Dun N.J., et al. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149 (2007) 1773-1785
57. van den Hoek A.M., Teusink B., Voshol P.J., Havekes L.M., Romijn J.A., and Pijl H. Leptin deficiency per se dictates body composition and insulin action in ob/ob mice. J. Neuroendocrinol. 20 (2008) 120-127
58. van den Top M., Lee K., Whyment A.D., Blanks A.M., and Spanswick D. Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat. Neurosci. 7 (2004) 493-494
59. Wortley K.E., Anderson K.D., Yasenchak J., Murphy A., Valenzuela D., Diano S., Yancopoulos G.D., Wiegand S.J., and Sleeman M.W. Agouti-related protein-deficient mice display an age-related lean phenotype. Cell Metab. 2 (2005) 421-427
60. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432