-
2
-
-
0345168238
-
The role of leptin receptor signalling in feeding and neuroendocrine function
-
Bates SH, Myers MG (2003) The role of leptin receptor signalling in feeding and neuroendocrine function. Trends Endocrinol Metab 14: 447-452
-
(2003)
Trends Endocrinol Metab
, vol.14
, pp. 447-452
-
-
Bates, S.H.1
Myers, M.G.2
-
3
-
-
0030055540
-
Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells
-
Batty IH, Downes CP (1996) Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells. Biochem J 317: 347-351
-
(1996)
Biochem J
, vol.317
, pp. 347-351
-
-
Batty, I.H.1
Downes, C.P.2
-
4
-
-
0347717868
-
Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders
-
Belsham DD, Cai F, Cui H, Smukler SR, Salapatek AF, Shkreta L (2004) Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders. Endocrinology 145: 393-400
-
(2004)
Endocrinology
, vol.145
, pp. 393-400
-
-
Belsham, D.D.1
Cai, F.2
Cui, H.3
Smukler, S.R.4
Salapatek, A.F.5
Shkreta, L.6
-
5
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
Cowley MA, Smart JL, Rubinstein M, Cerdán MG, Diano S, Horvath TL, Cone RD, Low MJ (2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411: 480-484
-
(2001)
Nature
, vol.411
, pp. 480-484
-
-
Cowley, M.A.1
Smart, J.L.2
Rubinstein, M.3
Cerdán, M.G.4
Diano, S.5
Horvath, T.L.6
Cone, R.D.7
Low, M.J.8
-
6
-
-
20144389727
-
The role of insulin receptor substrate 2 in hypothalamic and β cell function
-
Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, MacColl G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford MLJ, Withers DJ (2005) The role of insulin receptor substrate 2 in hypothalamic and β cell function. J Clin Invest 115: 940-950
-
(2005)
J Clin Invest
, vol.115
, pp. 940-950
-
-
Choudhury, A.I.1
Heffron, H.2
Smith, M.A.3
Al-Qassab, H.4
Xu, A.W.5
Selman, C.6
Simmgen, M.7
Clements, M.8
Claret, M.9
MacColl, G.10
Bedford, D.C.11
Hisadome, K.12
Diakonov, I.13
Moosajee, V.14
Bell, J.D.15
Speakman, J.R.16
Batterham, R.L.17
Barsh, G.S.18
Ashford, M.L.J.19
Withers, D.J.20
more..
-
7
-
-
10744232925
-
Essential role of STAT3 in body weight and glucose homeostasis
-
Cui Y, Huang L, Elefteriou F, Yang G, Shelton JM, Giles JE, Oz OK, Pourbahrami T, Lu CYH, Richardson JA, Karsenty G, Li C (2004) Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol 24: 258-269
-
(2004)
Mol Cell Biol
, vol.24
, pp. 258-269
-
-
Cui, Y.1
Huang, L.2
Elefteriou, F.3
Yang, G.4
Shelton, J.M.5
Giles, J.E.6
Oz, O.K.7
Pourbahrami, T.8
Lu, C.Y.H.9
Richardson, J.A.10
Karsenty, G.11
Li, C.12
-
8
-
-
0038272084
-
Membrane binding and activation mechanisms of PTEN
-
Das S, Dixon JE, Cho W (2003) Membrane binding and activation mechanisms of PTEN. Proc Natl Acad Sci USA 100: 7491-7496
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7491-7496
-
-
Das, S.1
Dixon, J.E.2
Cho, W.3
-
9
-
-
3643119742
-
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells
-
Furnari FB, Huang HJ, Cavenee WK (1998) The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res 58: 5002-5008
-
(1998)
Cancer Res
, vol.58
, pp. 5002-5008
-
-
Furnari, F.B.1
Huang, H.J.2
Cavenee, W.K.3
-
10
-
-
0033845529
-
ATP) channels in rat CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton
-
ATP) channels in rat CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton. J Physiol 527: 95-107
-
(2000)
J Physiol
, vol.527
, pp. 95-107
-
-
Harvey, J.1
Hardy, S.C.2
Irving, A.I.3
Ashford, M.L.J.4
-
12
-
-
0030729888
-
Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1
-
Harvey J, McKenna F, Herson PS, Spanswick D, Ashford MLJ (1997) Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J Physiol 504: 527-535
-
(1997)
J Physiol
, vol.504
, pp. 527-535
-
-
Harvey, J.1
McKenna, F.2
Herson, P.S.3
Spanswick, D.4
Ashford, M.L.J.5
-
13
-
-
0030948734
-
Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells
-
Keiffer TJ, Heller RS, Leech CA, Holz GG, Habener JF (1997) Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes 46: 1087-1093
-
(1997)
Diabetes
, vol.46
, pp. 1087-1093
-
-
Keiffer, T.J.1
Heller, R.S.2
Leech, C.A.3
Holz, G.G.4
Habener, J.F.5
-
14
-
-
0035878707
-
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions
-
Leslie NR, Bennett D, Gray A, Pass I, Hoang-Xuan K, Downes CP (2001) Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions. Biochem J 357: 427-435
-
(2001)
Biochem J
, vol.357
, pp. 427-435
-
-
Leslie, N.R.1
Bennett, D.2
Gray, A.3
Pass, I.4
Hoang-Xuan, K.5
Downes, C.P.6
-
15
-
-
4344684649
-
PTEN function: How normal cells control it and tumour cells lose it
-
Leslie NR, Downes CP (2004) PTEN function: how normal cells control it and tumour cells lose it. Biochem J 382: 1-11
-
(2004)
Biochem J
, vol.382
, pp. 1-11
-
-
Leslie, N.R.1
Downes, C.P.2
-
16
-
-
0034654298
-
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: Differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase
-
Leslie NR, Gray A, Pass I, Orchiston EA, Downes CP (2000) Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase. Biochem J 346: 827-833
-
(2000)
Biochem J
, vol.346
, pp. 827-833
-
-
Leslie, N.R.1
Gray, A.2
Pass, I.3
Orchiston, E.A.4
Downes, C.P.5
-
18
-
-
0037174166
-
Direct identification of PTEN phosphorylation sites
-
Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG (2002) Direct identification of PTEN phosphorylation sites. Febs Lett 528: 145-153
-
(2002)
Febs Lett
, vol.528
, pp. 145-153
-
-
Miller, S.J.1
Lou, D.Y.2
Seldin, D.C.3
Lane, W.S.4
Neel, B.G.5
-
19
-
-
12944261926
-
ATP channel activation
-
ATP channel activation. BMC Neurosci 5: 54
-
(2004)
BMC Neurosci
, vol.5
, pp. 54
-
-
Mirshamsi, S.1
Laidlaw, H.A.2
Ning, K.3
Anderson, E.4
Burgess, L.A.5
Gray, A.6
Sutherland, C.7
Ashford, M.L.J.8
-
20
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor suppressor function
-
Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK (1998) The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl Acad Sci USA 95: 13513-13518
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
Van Der Kaay, J.4
Stolarov, J.P.5
Hemmings, B.A.6
Wigler, M.H.7
Downes, C.P.8
Tonks, N.K.9
-
21
-
-
11144356390
-
Dual neuroprotective signalling mediated by down-regulating two distinct phosphatase activities of PTEN
-
Ning K, Pei L, Liao M, Liu B, Zhang Y, Jiang W, Mielke JG, Li L, Chen Y, El-Hayek YH, Fehlings MG, Zhang X, Liu F, Eubanks J, Wan Q (2004) Dual neuroprotective signalling mediated by down-regulating two distinct phosphatase activities of PTEN. J Neurosci 24: 4052-4060
-
(2004)
J Neurosci
, vol.24
, pp. 4052-4060
-
-
Ning, K.1
Pei, L.2
Liao, M.3
Liu, B.4
Zhang, Y.5
Jiang, W.6
Mielke, J.G.7
Li, L.8
Chen, Y.9
El-Hayek, Y.H.10
Fehlings, M.G.11
Zhang, X.12
Liu, F.13
Eubanks, J.14
Wan, Q.15
-
22
-
-
4544306391
-
Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis
-
Niswender KD, Baskin DG, Schwartz MW (2004) Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends Endocrinol Metab 15: 362-369
-
(2004)
Trends Endocrinol Metab
, vol.15
, pp. 362-369
-
-
Niswender, K.D.1
Baskin, D.G.2
Schwartz, M.W.3
-
23
-
-
0035950093
-
Intracellular signaling. Key enzyme in leptin-induced anorexia
-
Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers Jr MG, Schwartz MW (2001) Intracellular signaling. Key enzyme in leptin-induced anorexia. Nature 413: 794-795
-
(2001)
Nature
, vol.413
, pp. 794-795
-
-
Niswender, K.D.1
Morton, G.J.2
Stearns, W.H.3
Rhodes, C.J.4
Myers Jr., M.G.5
Schwartz, M.W.6
-
24
-
-
0037315042
-
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia
-
Niswender KD, Morrison CD, Clegg DJ, Olson R, Baskin DG, Myers Jr MG, Seeley RJ, Schwartz MW (2003) Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 52: 227-231
-
(2003)
Diabetes
, vol.52
, pp. 227-231
-
-
Niswender, K.D.1
Morrison, C.D.2
Clegg, D.J.3
Olson, R.4
Baskin, D.G.5
Myers Jr., M.G.6
Seeley, R.J.7
Schwartz, M.W.8
-
25
-
-
0037288941
-
Insulin and leptin revisited: Adiposity signals with overlapping physiological and intracellular signalling capabilities
-
Niswender KD, Schwartz MW (2003) Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signalling capabilities. Front Neuroendocrinol 24: 1-10
-
(2003)
Front Neuroendocrinol
, vol.24
, pp. 1-10
-
-
Niswender, K.D.1
Schwartz, M.W.2
-
26
-
-
3843114402
-
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: A novel powerful and selective inhibitor of protein kinase CK2
-
Pagano MA, Meggio F, Ruzzene M, Andrzejewska M, Kazimierczuk Z, Pinna LA (2004) 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2. Biochem Biophys Res Commun 321: 1040-1044
-
(2004)
Biochem Biophys Res Commun
, vol.321
, pp. 1040-1044
-
-
Pagano, M.A.1
Meggio, F.2
Ruzzene, M.3
Andrzejewska, M.4
Kazimierczuk, Z.5
Pinna, L.A.6
-
27
-
-
1242284600
-
Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
-
Rafatopolou M, Etienne-Manneville S, Self A, Nicholls S, Hall A (2004) Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303: 1179-1181
-
(2004)
Science
, vol.303
, pp. 1179-1181
-
-
Rafatopolou, M.1
Etienne-Manneville, S.2
Self, A.3
Nicholls, S.4
Hall, A.5
-
28
-
-
0347320633
-
Leptin signalling in the hypothalamus: Emphasis on energy homeostasis and leptin resistance
-
Sahu A (2004) Leptin signalling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front Neuroendocrinol 24: 225-253
-
(2004)
Front Neuroendocrinol
, vol.24
, pp. 225-253
-
-
Sahu, A.1
-
29
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404: 661-671
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte Jr., D.3
Seeley, R.J.4
Baskin, D.G.5
-
30
-
-
0031440266
-
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
-
Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford MLJ (1997) Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390: 521-525
-
(1997)
Nature
, vol.390
, pp. 521-525
-
-
Spanswick, D.1
Smith, M.A.2
Groppi, V.E.3
Logan, S.D.4
Ashford, M.L.J.5
-
31
-
-
0033944152
-
Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
-
Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford MLJ (2000) Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 3: 757-758
-
(2000)
Nat Neurosci
, vol.3
, pp. 757-758
-
-
Spanswick, D.1
Smith, M.A.2
Mirshamsi, S.3
Routh, V.H.4
Ashford, M.L.J.5
-
32
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
-
Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM (1998) Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280: 1614-1617
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
Aota, S.4
Parsons, R.5
Yamada, K.M.6
-
33
-
-
0035847102
-
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteosome-mediated degradation
-
Torres J, Pulido R (2001) The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteosome-mediated degradation. J Biol Chem 276: 993-998
-
(2001)
J Biol Chem
, vol.276
, pp. 993-998
-
-
Torres, J.1
Pulido, R.2
-
34
-
-
2142758640
-
Orexigen-sensitive NPY/AgRP pacemaker neuons in the hypothalamic arcuate nucleus
-
Van Den Top M, Lee K, Whyment AD, Blanks AM, Spanswick D (2004) Orexigen-sensitive NPY/AgRP pacemaker neuons in the hypothalamic arcuate nucleus. Nat Neurosci 7: 493-494
-
(2004)
Nat Neurosci
, vol.7
, pp. 493-494
-
-
Van Den Top, M.1
Lee, K.2
Whyment, A.D.3
Blanks, A.M.4
Spanswick, D.5
-
35
-
-
0035966127
-
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
-
Vasquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N, Sellars WR (2001) Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem 276: 48627-48630
-
(2001)
J Biol Chem
, vol.276
, pp. 48627-48630
-
-
Vasquez, F.1
Grossman, S.R.2
Takahashi, Y.3
Rokas, M.V.4
Nakamura, N.5
Sellars, W.R.6
-
36
-
-
16844369740
-
PI 3-kinase integrates the action of insulin and leptin on hypothalamic neurons
-
Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS (2005) PI 3-kinase integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest 115: 951-958
-
(2005)
J Clin Invest
, vol.115
, pp. 951-958
-
-
Xu, A.W.1
Kaelin, C.B.2
Takeda, K.3
Akira, S.4
Schwartz, M.W.5
Barsh, G.S.6
-
37
-
-
0036321620
-
A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding
-
Zhao AZ, Huan JN, Gupta S, Pal R, Sahu A (2002) A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat Neurosci 5: 727-728
-
(2002)
Nat Neurosci
, vol.5
, pp. 727-728
-
-
Zhao, A.Z.1
Huan, J.N.2
Gupta, S.3
Pal, R.4
Sahu, A.5
|