Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 47, 2008, Pages 18619-18624

  Jiang, Lei ^a   You, Jia ^a   Yu, Xinxin ^b   Gonzalez, Lety ^b   Yu, Yue ^a   Wang, Qiong ^a   Yang, Guoqing ^b,c   Li, Wenjun ^a   Li, Cai ^b,d   Liu, Yong ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c AGENCY FOR SCIENCE   (Singapore)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Insulin resistance; Knockin; Leptin signaling; Obesity

Indexed keywords

AGOUTI RELATED PROTEIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y; PHENYLALANINE; STAT3 PROTEIN; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENERGY BALANCE; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLYCEMIC CONTROL; HYPERPHAGIA; HYPOTHALAMUS; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERMOGENESIS;

ANIMALS; BODY TEMPERATURE REGULATION; ENERGY METABOLISM; GLUCOSE; HOMEOSTASIS; HYPOTHALAMUS; LEPTIN; MICE; MICE, INBRED C57BL; OBESITY; RECEPTORS, LEPTIN; STAT3 TRANSCRIPTION FACTOR; TYROSINE;

ANIMALIA; MUS;

EID: 57449099877     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804589105     Document Type: Article

References (36)

1. Zhang Y, et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.
2. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549.
3. Cohen P, et al. (2001) Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 108:1113-1121.
4. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395:763-770.
5. Chua SC, Jr, et al. (1996) Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271:994-996.
6. Mantzoros CS, Flier JS (2000) Leptin as a therapeutic agent: Trials and tribulations. J Clin Endocrinol Metab 85:4000-4002.
7. Kloek C, et al. (2002) Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem 277:41547-41555.
8. Bates SH, et al. (2003) STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421:856-859.
9. Bates SH, et al. (2004) LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes 53:3067-3073.
10. Li C, Friedman JM (1999) Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc Natl Acad Sci USA 96:9677-9682.
11. Zhang EE, Chapeau E, Hagihara K, Feng GS (2004) Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci USA 101:16064-16069.
12. Bjorbaek C, et al. (2001) Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem 276:4747-4755.
13. Banks AS, Davis SM, Bates SH, Myers MG, Jr (2000) Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 275:14563-14572.
14. Bjorbaek C, El-Haschimi K, Frantz JD, Flier JS (1999) The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 274:30059-30065.
15. Bjorbaek C, et al. (2000) SOCS3 mediates feedback inhibition of the leptin receptor via Tyr-985. J Biol Chem 275:40649-40657.
16. Bjornholm M, et al. (2007) Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest 117:1354-1360.
17. Niswender KD, et al. (2001) Intracellular signalling: Key enzyme in leptin-induced anorexia. Nature 413:794-795.
18. Gong Y, et al. (2007) The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem 282:31019-31027.
19. Lee GH, et al. (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635.
20. Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ (1997) Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389:374-377.
21. Bates SH, Kulkarni RN, Seifert M, Myers MG, Jr (2005) Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab 1:169-178.
22. Steppan CM, et al. (2001) The hormone resistin links obesity to diabetes. Nature 409:307-312.
23. Breslow MJ, et al. (1999) Effect of leptin deficiency on metabolic rate in ob/ob mice. Am J Physiol 276:E443-E449.
24. Himms-Hagen J (1997) On raising energy expenditure in ob/ob mice. Science 276:1132-1133.
25. Hwa JJ, et al. (1997) Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice. Am J Physiol 272:R1204-R1209.
26. Lowell BB, Spiegelman BM (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404:652-660.
27. Puigserver P, et al. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839.
28. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW (2006) Central nervous system control of food intake and body weight. Nature 443:289-295.
29. Arora S, Anubhuti (2006) Role of neuropeptides in appetite regulation and obesity: A review. Neuropeptides 40:375-401.
30. Morrison CD, Morton GJ, Niswender KD, Gelling RW, Schwartz MW (2005) Leptin inhibits hypothalamic NPY and AgRP gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Am J Physiol 289:E1051-E1057.
31. Morton GJ, et al. (2005) Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab 2:411-420.
32. Ren D, Li M, Duan C, Rui L (2005) Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab 2:95-104.
33. Minokoshi Y, et al. (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415:339-343.
34. Unger RH (2004) The hyperleptinemia of obesity: Regulator of caloric surpluses. Cell 117:145-146.
35. Wang MY, et al. (2008) Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proc Natl Acad Sci USA 105:6139-6144.
36. O'Gorman S, Dagenais NA, Qian M, Marchuk Y (1997) Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci USA 94:14602-14607.