Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Lou, Phing How ^a   Yang, Guoqing ^a   Huang, Lu ^b   Cui, Yunxia ^b   Pourbahrami, Tiffany ^b   Radda, George K ^a   Li, Cai ^b,d   Han, Weiping ^a,c  

^a AGENCY FOR SCIENCE   (Singapore)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN RECEPTOR; LIPID; SERUM AMYLOID P; SOLUBLE LEPTIN RECEPTOR; UNCLASSIFIED DRUG; ISOPROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BASAL METABOLIC RATE; BODY FAT; CALORIMETRY; CONTROLLED STUDY; ENERGY EXPENDITURE; FOOD INTAKE; GEL FILTRATION CHROMATOGRAPHY; GENE OVEREXPRESSION; HOMEOSTASIS; LIPID OXIDATION; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN FUNCTION; TRANSGENIC MOUSE; WEIGHT GAIN; WEIGHT REDUCTION; WESTERN BLOTTING; WILD TYPE; ANIMAL; BODY WEIGHT; C57BL MOUSE; ENERGY METABOLISM; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY;

MUS; MUS MUSCULUS;

ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; ENERGY METABOLISM; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN ISOFORMS; RECEPTORS, LEPTIN;

EID: 77955458427     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011669     Document Type: Article

References (38)

1. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549.
2. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, et al. (1995) Weightreducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546.
3. Friedman JM (2002) The function of leptin in nutrition, weight, and physiology. Nutr Rev 60: S1-14; discussion S68-84, 85-17.
4. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.
5. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, et al. (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387: 903-908.
6. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395: 763-770.
7. Chehab FF, Lim ME, Lu R (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 12: 318-320.
8. Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, et al. (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 341: 879-884.
9. Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, et al. (2004) Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci U S A 101: 4531-4536.
10. Myers MG, Cowley MA, Munzberg H (2008) Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 70: 537-556.
11. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271.
12. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, et al. (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635.
13. Ge H, Huang L, Pourbahrami T, Li C (2002) Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem 277: 45898-45903.
14. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, et al. (1996) Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84: 491-495.
15. Tu H, Pan W, Feucht L, Kastin AJ (2007) Convergent trafficking pattern of leptin after endocytosis mediated by ObRa-ObRd. J Cell Physiol 212: 215-222.
16. Hileman SM, Pierroz DD, Masuzaki H, Bjorbaek C, El-Haschimi K, et al. (2002) Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 143: 775-783.
17. Tu H, Kastin AJ, Hsuchou H, Pan W (2008) Soluble receptor inhibits leptin transport. J Cell Physiol 214: 301-305.
18. Liu C, Liu XJ, Barry G, Ling N, Maki RA, et al. (1997) Expression and characterization of a putative high affinity human soluble leptin receptor. Endocrinology 138: 3548-3554.
19. Chan JL, Bluher S, Yiannakouris N, Suchard MA, Kratzsch J, et al. (2002) Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes 51: 2105-2112.
20. Ogier V, Ziegler O, Mejean L, Nicolas JP, Stricker-Krongrad A (2002) Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans. Int J Obes Relat Metab Disord 26: 496-503.
21. Shimizu H, Shimomura K, Negishi M, Masunaga M, Uehara Y, et al. (2002) Circulating concentrations of soluble leptin receptor: influence of menstrual cycle and diet therapy. Nutrition 18: 309-312.
22. Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, et al. (2007) High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem 282: 23672-23678.
23. Sinha MK, Opentanova I, Ohannesian JP, Kolaczynski JW, Heiman ML, et al. (1996) Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. J Clin Invest 98: 1277-1282.
24. Huang L, Wang Z, Li C (2001) Modulation of circulating leptin levels by its soluble receptor. J Biol Chem 276: 6343-6349.
25. Yoshimoto T, Wang CR, Yoneto T, Waki S, Sunaga S, et al. (1998) Reduced T helper 1 responses in IL-12 p40 transgenic mice. J Immunol 160: 588-594.
26. Gustavsson N, Lao Y, Maximov A, Chuang JC, Kostromina E, et al. (2008) Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc Natl Acad Sci U S A 105: 3992-3997.
27. Matsuda J, Suzuki M, Nozaki C, Shinya N, Tashiro K, et al. (1998) Transgenic mouse expressing a full-length hepatitis C virus cDNA. Jpn J Cancer Res 89: 150-158.
28. Zhao X, Araki K, Miyazaki J, Yamamura K (1992) Developmental and liverspecific expression directed by the serum amyloid P component promoter in transgenic mice. J Biochem 111: 736-738.
29. Li C, Ioffe E, Fidahusein N, Connolly E, Friedman JM (1998) Absence of soluble leptin receptor in plasma from dbPas/dbPas and other db/db mice. J Biol Chem 273: 10078-10082.
30. Maamra M, Bidlingmaier M, Postel-Vinay MC, Wu Z, Strasburger CJ, et al. (2001) Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology 142: 4389-4393.
31. Harper JA, Stuart JA, Jekabsons MB, Roussel D, Brindle KM, et al. (2002) Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria. Biochem J 361: 49-56.
32. Stuart JA, Harper JA, Brindle KM, Jekabsons MB, Brand MD (2001) Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria. J Biol Chem 276: 18633-18639.
33. Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, et al. (1997) Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci U S A 94: 8878-8883.
34. Scarpace PJ, Matheny M (1998) Leptin induction of UCP1 gene expression is dependent on sympathetic innervation. Am J Physiol 275: E259-264.
35. Doring H, Schwarzer K, Nuesslein-Hildesheim B, Schmidt I (1998) Leptin selectively increases energy expenditure of food-restricted lean mice. Int J Obes Relat Metab Disord 22: 83-88.
36. Gavrilova O, Barr V, Marcus-Samuels B, Reitman M (1997) Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. J Biol Chem 272: 30546-30551.
37. Lewandowski K, Horn R, O'Callaghan CJ, Dunlop D, Medley GF, et al. (1999) Free leptin, bound leptin, and soluble leptin receptor in normal and diabetic pregnancies. J Clin Endocrinol Metab 84: 300-306.
38. Brabant G, Horn R, von zur Muhlen A, Mayr B, Wurster U, et al. (2000) Free and protein bound leptin are distinct and independently controlled factors in energy regulation. Diabetologia 43: 438-442.