Antagonism of Central Melanocortin receptors in vitro and in vivo by agouti-related protein

Science

Volumn 278, Issue 5335, 1997, Pages 135-138

  Ollmann, Michael M ^a   Wilson, Brent D ^a   Yang, Ying Kui ^b   Kerns, Julie A ^a   Chen, Yanru ^a   Gantz, Ira ^b   Barsh, Gregory S ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; NEUROPEPTIDE; PIGMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; HYPOTHALAMUS; MOUSE; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; WEIGHT GAIN; WEIGHT REDUCTION;

ADRENAL GLANDS; AMINO ACID SEQUENCE; ANIMALS; FEMALE; HUMANS; HYPOTHALAMUS; MALE; MELANOCYTE-STIMULATING HORMONES; MELANOPHORES; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, OBESE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; OBESITY; ORGANOPHOSPHORUS COMPOUNDS; PROTEINS; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, CORTICOTROPIN; RECEPTORS, PEPTIDE; RECOMBINANT PROTEINS; RNA; SIGNAL TRANSDUCTION; XENOPUS;

AGOUTI; ANIMALIA; MUS MUSCULUS;

EID: 0030764741     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.278.5335.135     Document Type: Article

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40. We thank M. Lerner, J. Rine, T. Gunn, and F. Chehab for advice and reagents. Supported by NIH grants EY07106 and GM07365 to M.M.O., J.A.K., and B.D.W. This work was supported in part by a Veterans Administration Award to I.G. and by grants from the NIH to the University of Michigan (P30DK-34933) and to G.S.B. (DK28506), who is an Associate Investigator of the Howard Hughes Medical Institute.