Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration

Neuroscience Letters

Volumn 417, Issue 3, 2007, Pages 286-291

  Mütze, Jörg ^a   Roth, Joachim ^a   Gerstberger, Rüdiger ^a   Hübschle, Thomas ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Hypothalamus; Leptin target cells; Signal transducer and activator of transcription 5 (STAT5); Transcription factors

Indexed keywords

RECOMBINANT LEPTIN; SODIUM CHLORIDE; STAT5 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; ASTROCYTE; CELL NUCLEUS; CELL TYPE; CONTROLLED STUDY; DRUG MECHANISM; HYPOTHALAMUS; MALE; MAMMILLARY BODY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; SUPRAOPTIC NUCLEUS; VENTRAL PREMAMMILLARY NUCLEUS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APPETITE REGULATION; ARCUATE NUCLEUS; ASTROCYTES; BODY WEIGHT; CELL NUCLEUS; HYPOTHALAMUS; INJECTIONS, INTRAPERITONEAL; LEPTIN; MALE; NEURONS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; SUPRAOPTIC NUCLEUS;

EID: 34247102713     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.02.074     Document Type: Article

References (21)

1. Carvalheira J.B.C., Ribeiro E.B., Folli F., Velloso L.A., and Saad M.J.A. Interaction between leptin and insulin signaling pathways differentially affects JAK-STATR and PI3-kinase-mediated signaling in rat liver. Biol. Chem. 384 (2003) 151-159
2. Elmquist J.K., Bjorbaek C., Ahima R.S., Flier J.S., and Saper C.B. Expression of leptin receptor mRNA isoforms in the rat brain. J. Comp. Neurol. 395 (1998) 535-547
3. Fei H., Okana H.J., Li C., Lee G.H., Zhao C., Darnell R., and Friedman J.M. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. USA 94 (1997) 7001-7005
4. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
5. Hakansson M.L., Brown H., Ghilardi N., Skoda R.C., and Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 18 (1998) 559-572
6. Hosoi T., Kawagishi T., Okuma Y., Tanaka J., and Nomura Y. Brain stem is a direct target for leptin's action in the central nervous system. Endocrinology 143 (2002) 3498-3504
7. Hübschle T., Thom E., Watson A., Roth J., Klaus S., and Meyerhof W. Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J. Neurosci. 21 (2001) 2413-2424
8. Inoue W., Poole S., Bristow A.F., and Luheshi G.N. Leptin induces cyclooxygenase-2 via an interaction with interleukin-1β in the rat brain. Eur. J. Neurosci. 24 (2006) 2233-2245
9. Lerant A., Kanyicska B., and Freeman M.E. Nuclear translocation of STAT5 and increased expression of Fos related antigens (FRAs) in hypothalamic dopaminergic neurons after prolactin administration. Brain Res. 904 (2001) 259-269
10. McCowen K.C., Chow J.C., and Smith R.J. Leptin signaling in the hypothalamus of normal rats in vivo. Endocrinology 139 (1998) 4442-4447
11. Morton N.M., Emilsson V., Liu L., and Cawthorne M.A. Leptin action in intestinal cells. J. Biol. Chem. 273 (1998) 26194-26201
12. Mütze J., Roth J., Gerstberger R., Matsumura K., and Hübschle T. Immunohistochemical evidence of functional leptin receptor expression in neuronal and endothelial cells of the rat brain. Neurosci. Lett. 394 (2006) 105-110
13. O'Connor J.C., Satpathy A., Hartman M.E., Horvath E.M., Kelley K.W., Dantzer R., Johnson R.W., and Freund G.G. IL-1β-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes. J. Immunol. 174 (2005) 4991-4997
14. Rehn M., Hübschle T., and Diener M. TNF-α hyperpolarizes membrane potential and potentiates the response to nicotinergic receptor stimulation in cultured rat myenteris neurones. Acta Physiol. Scand. 181 (2004) 13-22
15. Rizk N.M., Stammsen D., Preibisch G., and Eckel J. Leptin and tumor necrosis factor-a induce the tyrosine phosphorylation of signal transducer and activator of transcription proteins in the hypothalamus of normal rats in vivo. Endocrinology 142 (2001) 3027-3032
16. Rummel C., Hübschle T., Gerstberger R., and Roth J. Nuclear translocation of the transcription factor STAT3 in the guinea pig brain during systemic or localized inflammation. J. Physiol. 557 2 (2004) 671-687
17. Rummel C., Voss T., Matsumura K., Korte S., Gerstberger R., Roth J., and Hübschle T. Nuclear STAT3 translocation in guinea pig and rat brain endothelium during systemic challenge with lipopolysaccharide and interleukin-6. J. Comp. Neurol. 491 (2005) 1-14
18. Sahu A. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front. Neuroendocrinol. 24 (2004) 225-253
19. Steiner A.A., Dogan M.D., Ivanov A.I., Patel S., Rudaya A.Y., Jennings D.H., Orchinik M., Pace T.W.W., O'Connor K.A., Watkins L.R., and Romanovsky A.A. A new function of the leptin receptor: mediation of the recovery from lipopolysaccharide-induced hypothermia. FASEB J. 18 (2004) 1949-1951
20. Vaisse C., Halaas J.L., Horvath C.M., Darnell Jr. J.E., Soffel M., and Friedman J.M. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice. Nat. Genet. 14 (1996) 95-97
21. Yamamoto S., Morimoto I., Kai K., Arao T., Fujihira T., Morita E., Kannan H., and Eto S. Centrally administered murine leptin stimulates plasma arginine-vasopressin secretion and increases the level of mRNA expression in the supraoptic nucleus of conscious rats. Neuroendocrinology 70 (1999) 207-212