Soluble receptor inhibits leptin transport

Journal of Cellular Physiology

Volumn 214, Issue 2, 2008, Pages 301-305

  Tu, Hong ^a,b   Kastin, Abba J ^a   Hsuchou, Hung ^a   Pan, Weihong ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b SHANGHAI CANCER INSTITUTE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE 123; LEPTIN; LEPTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; ENDOCYTOSIS; FLUORESCENCE; HORMONE BINDING; HORMONE TRANSPORT; HUMAN; HUMAN CELL; INTERNALIZATION; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

MUS;

EID: 37349060346     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21195     Document Type: Article

References (29)

1. Banks WA. 2003. Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations. Curr Pharm Des 9:801-809.
2. Banks W. 2004. The many lives of leptin. Peptides 25:331-338.
3. Banks WA, Ortiz L, Plotkin SR, Kastin AJ. 1991. Human interleukin (IL) 1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism. J Pharmacol Exp Ther 259:988-996.
4. Banks WA, Plotkin SR, Kastin AJ. 1995. Permeability of the blood-brain barrier to soluble cytokine receptors. Neuroimmunomodulation 2:161-165.
5. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. 1996. Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311.
6. Banks WA, Niehoff ML, Martin D, Farrell CL. 2002. Leptin transport across the blood-brain barrier of the Koletsky rat is not mediated by a product of the leptin receptor gene. Brain Res 950:130-136.
7. Bjorbaek C, Elmquist JK, Michl P, Ahima RS, van Bueren A, McCall AL, Flier JS. 1998. Expression of leptin receptor isoforms in rat brain microvessels. Endocrinol 139:3485-3491.
8. Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim CA, Ogawa Y, Liu X, Ware SM, Craigen WJ, Robert JJ, Vinson C, Nakao K, Capeau J, Karsenty G. 2004. Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci USA 101:3263.
9. Gallardo N, Arribas C, Villar M, Ros M, Carrascosa JM, Martinez C, Andres A. 2005. ObRa and ObRe are differentially expressed in adipose tissue in aged food-restricted rats: Effects on circulating soluble leptin receptor levels. Endocrinology 146:4934-4942.
10. Gavrilova O, Barr V, Marcus-Samuels B, Reitman M. 1997. Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. J Biol Chem 272:30546-30551.
11. Hileman SM, Pierroz DD, Masuzaki H, Bjorbaek C, El-Haschimi K, Banks WA, Flier JS. 2002. Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinol 143:775-783.
12. Huang L, Wang Z, Li C. 2001. Modulation of circulating leptin levels by its soluble receptor. J Biol Chem 276:6343-6349.
13. Kastin AJ, Pan W. 2000. Dynamic regulation of leptin entry into brain by the blood-brain barrier. Regul Pept 92:37-43.
14. Kastin AJ, Pan W. 2006. Editorial: Intranasal leptin: Blood-brain barrier bypass (BBBB) for obesity? Endocrinol 147:2086-2087.
15. Kastin AJ, Pan W, Maness LM, Koletsky RJ, Ernsberger P. 1999. Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides 20:1449-1453.
16. Kastin AJ, Akerstrom V, Pan W. 2001. Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: Meaningful controls. Peptides 22:2127-2136.
17. Kokoeva MV, Yin H, Flier JS. 2005. Neurogenesis in the hypothalamus of adult mice: Potential role in energy balance. Science 310:679-683.
18. Mistry A, Romsos D. 2002. Intracerebroventricular leptin administration reduces food intake in pregnant and lactating mice. Exp Biol Med 227:616-619.
19. Pan W, Kastin AJ. 2002. TNFa transport across the blood-brain barrier is abolished in receptor knockout mice. Exp Neurol 174:193-200.
20. Pan W, Banks WA, Kastin AJ. 1997. Permeability of the blood-brain and blood-spinal cord barriers to interferons. J Neuroimmunol 76:105-111.
21. Pan W, Tu H, Kastin AJ. 2006. Differential BBB interactions of three ingestive peptides: Obestatin, ghrelin, and adiponectin. Peptides 27:911-916.
22. Pu S, Dhillon H, Moldawer LL, Kalra PS, Kalra SP. 2000. Neuropeptide Y counteracts the anorectic and weight reducing effects of ciliary neurotropic factor. J Neuroendocrinol 12:827-832.
23. Smith JT, Mark PJ, Waddell BJ. 2005. Developmental increases in plasma leptin binding activity and tissue Ob-Re mRNA expression in the rat. J Endocrinol 184:535-541.
24. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, DeedsJ, Muir C, Sanker S, Moriarty A, Moore KJ, SmutkoJS, Mays GG, Woolf EA, Monroe CA, Tepper RI. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271.
25. Tu H, Kastin AJ, Bjorbaek C, Pan W. 2007a. Urocortin trafficking in cerebral microvessel endothelial cells. J Mol Neurosci 31:171-182.
26. Tu H, Pan W, Feucht L, Kastin AJ. 2007b. Convergent trafficking pattern of leptin after endocytosis mediated by ObRa - ObRd. J Cell Physiol 212:215-222.
27. Uotani S, Bjorbaek C, Tornoe J, Flier JS. 1999. Functional properties of leptin receptor isoforms: Internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes 48:279-286.
28. Yang G, Ge H, Boucher A, Yu X, Li C. 2004. Modulation of direct leptin signalling by soluble leptin receptor. Mol Endocrinol 18:1354-1362.
29. Yu C, Kastin AJ, Pan W. 2007. TNF reduces LIF endocytosis despite increasing NFκB-mediated gp 130 expression. J Cell Physiol (Epub April 18).