HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

American Journal of Physiology - Endocrinology and Metabolism

Volumn 296, Issue 2, 2009, Pages

  White, Christy L ^a   Whittington, Amy ^a   Barnes, Maria J ^a   Wang, Zhong ^a   Bray, George A ^a   Morrison, Christopher D ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Food intake; High fat diet; Protein tyrosine phosphatase 1B

Indexed keywords

LEPTIN; MESSENGER RNA; PROTEIN TYROSINE PHOSPHATASE 1B; PTPN1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HORMONE RESISTANCE; HORMONE SENSITIVITY; HYPERLEPTINEMIA; HYPOTHALAMUS; LIPID DIET; LOW FAT DIET; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; TISSUE LEVEL; ANIMAL; ATHEROGENIC DIET; C57BL MOUSE; DRUG EFFECT; DRUG RESISTANCE; FAT INTAKE; GENE EXPRESSION REGULATION; GENETICS; LONG EVANS RAT; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION;

ANIMALS; DIET, ATHEROGENIC; DIETARY FATS; DRUG RESISTANCE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPOTHALAMUS; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; RATS, LONG-EVANS; SIGNAL TRANSDUCTION;

EID: 60849120123     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90513.2008     Document Type: Article

References (43)

1. Banks AS, Davis SM, Bates SH, Myers MG Jr. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 275: 14563-14572, 2000.
2. Banks WA, Farrell CL. Impaired transport of leptin across the bloodbrain barrier in obesity is acquired and reversible. Am J Physiol Endocrinol Metab 285: E10-E15, 2003.
3. Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12: 917-924, 2006. (Pubitemid 44175143)
4. Berthoud HR, Morrison C. The brain, appetite, obesity. Annu Rev Psychol 59: 55-92, 2008.
5. Bjorbaek C, El-Haschimi K, Frantz JD, Flier JS. The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 274: 30059-30065, 1999. (Pubitemid 29483389)
6. Bjorbak C, Lavery HJ, Bates SH, Olson RK, Davis SM, Flier JS, Myers MG Jr. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem 275: 40649-40657, 2000.
7. Callero MA, Perez GM, Vittori DC, Pregi N, Nesse AB. Modulation of protein tyrosine phosphatase 1B by erythropoietin in UT-7 cell line. Cell Physiol Biochem 20: 319-328, 2007. (Pubitemid 47340595)
8. Chen H, Wertheimer SJ, Lin CH, Katz SL, Amrein KE, Burn P, Quon MJ. Protein-tyrosine phosphatases PTP1B and syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. J Biol Chem 272: 8026-8031, 1997. (Pubitemid 27137368)
9. Cheng A, Uetani N, Simoncic PD, Chaubey VP, Lee-Loy A, McGlade CJ, Kennedy BP, Tremblay ML. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell 2: 497-503, 2002. (Pubitemid 34436577)
10. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive- leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292-295, 1996. (Pubitemid 26033933)
11. Dadke S, Chernoff J. Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. Biochem J 364: 377-383, 2002. (Pubitemid 34620797)
12. Dadke S, Kusari A, Kusari J. Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor. Mol Cell Biochem 221: 147-154, 2001. (Pubitemid 33640571)
13. Dadke SS, Li HC, Kusari AB, Begum N, Kusari J. Elevated expression and activity of protein-tyrosine phosphatase 1B in skeletal muscle of insulin-resistant type II diabetic Goto-Kakizaki rats. Biochem Biophys Res Commun 274: 583-589, 2000. (Pubitemid 30663664)
14. Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, Neel BG. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol 27: 7727-7734, 2007. (Pubitemid 350033677)
15. Egawa K, Maegawa H, Shimizu S, Morino K, Nishio Y, Bryer-Ash M, Cheung AT, Kolls JK, Kikkawa R, Kashiwagi A. Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells. J Biol Chem 276: 10207-10211, 2001. (Pubitemid 37391930)
16. Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283: 1544-1548, 1999. (Pubitemid 129503737)
17. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23: 775-786, 1999. (Pubitemid 29411566)
18. Enriori PJ, Evans AE, Sinnayah P, Jobst EE, Tonelli-Lemos L, Billes SK, Glavas MM, Grayson BE, Perello M, Nillni EA, Grove KL, Cowley MA. Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab 5: 181-194, 2007. (Pubitemid 46317303)
19. Kaszubska W, Falls HD, Schaefer VG, Haasch D, Frost L, Hessler P, Kroeger PE, White DW, Jirousek MR, Trevillyan JM. Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line. Mol Cell Endocrinol 195: 109-118, 2002. (Pubitemid 35287166)
20. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 20: 5479-5489, 2000. (Pubitemid 30482885)
21. Lam NT, Lewis JT, Cheung AT, Luk CT, Tse J, Wang J, Bryer-Ash M, Kolls JK, Kieffer TJ. Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression. Mol Endocrinol 18: 1333-1345, 2004. (Pubitemid 38692173)
22. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, and et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1: 1155-1161, 1995.
23. Morrison CD. Leptin resistance and the response to positive energy balance. Physiol Behav 94: 660-663, 2008.
24. Morrison CD, Morton GJ, Niswender KD, Gelling RW, Schwartz MW. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Am J Physiol Endocrinol Metab 289: E1051-E1057, 2005.
25. Morrison CD, White CL, Wang Z, Lee SY, Lawrence DS, Cefalu WT, Zhang ZY, Gettys TW. Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age. Endocrinology 148: 433-440, 2007. (Pubitemid 46021475)
26. Morrison CD, Xi X, White CL, Ye J, Martin RJ. Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism. Am J Physiol Endocrinol Metab 293: E165-E171, 2007.
27. Myers MG, Cowley MA, Munzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 70: 537-656, 2007.
28. Myers MP, Andersen JN, Cheng A, Tremblay ML, Horvath CM, Parisien JP, Salmeen A, Barford D, Tonks NK. TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem 276: 47771-47774, 2001. (Pubitemid 37370669)
29. Pal R, Sahu A. Leptin signaling in the hypothalamus during chronic central leptin infusion. Endocrinology 144: 3789-3798, 2003. (Pubitemid 37088731)
30. Picardi PK, Calegari VC, Prada Pde O, Moraes JC, Araujo E, Marcondes MC, Ueno M, Carvalheira JB, Velloso LA, Saad MJ. Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology 149: 3870-3880, 2008.
31. Ravichandran LV, Chen H, Li Y, Quon MJ. Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor. Mol Endocrinol 15: 1768-1780, 2001. (Pubitemid 32939307)
32. Ropelle ER, Pauli JR, Prada PO, de Souza CT, Picardi PK, Faria MC, Cintra DE, Fernandes MF, Flores MB, Velloso LA, Saad MJ, Carvalheira JB. Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation. J Physiol 577: 997-1007, 2006.
33. Salmeen A, Andersen JN, Myers MP, Tonks NK, Barford D. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol Cell 6: 1401-1412, 2000. (Pubitemid 32045932)
34. Scarpace PJ, Matheny M, Zhang Y, Shek EW, Prima V, Zolotukhin S, Tumer N. Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Endocrinology 143: 3026-3035, 2002.
35. Scarpace PJ, Zhang Y. Elevated leptin: consequence or cause of obesity? Front Biosci 12: 3531-3544, 2007.
36. Seely BL, Staubs PA, Reichart DR, Berhanu P, Milarski KL, Saltiel AR, Kusari J, Olefsky JM. Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes 45: 1379-1385, 1996. (Pubitemid 26332902)
37. Taghibiglou C, Rashid-Kolvear F, Van Iderstine SC, Le-Tien H, Fantus IG, Lewis GF, Adeli K. Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance. J Biol Chem 277: 793-803, 2002.
38. Tao J, Malbon CC, Wang HY. Insulin stimulates tyrosine phosphorylation and inactivation of protein-tyrosine phosphatase 1B in vivo. J Biol Chem 276: 29520-29525, 2001. (Pubitemid 37452049)
39. Wu Y, Ouyang JP, Wu K, Wang SS, Wen CY, Xia ZY. Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats. Br J Pharmacol 146: 234-243, 2005. (Pubitemid 43079963)
40. Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj F, Wang Y, Minokoshi Y, Kim YB, Elmquist JK, Tartaglia LA, Kahn BB, Neel BG. PTP1B regulates leptin signal transduction in vivo. Dev Cell 2: 489-495, 2002. (Pubitemid 34436576)
41. Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, Neel BG, Kahn BB. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. J Biol Chem 279: 24844-24851, 2004.
42. Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem 283: 14230-14241, 2008.
43. Zhang J, Matheny MK, Tumer N, Mitchell MK, Scarpace PJ. Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent. Am J Physiol Regul Integr Comp Physiol 292: R868-R874, 2007. (Pubitemid 46207742)