Identification of SOCS-3 as a potential mediator of central leptin resistance

Molecular Cell

Volumn 1, Issue 4, 1998, Pages 619-625

  Bjørbæk, Christian ^a   Elmquist, Joel K ^a   Frantz, J Daniel ^a   Shoelson, Steven E ^a   Flier, Jeffrey S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE INDUCIBLE SH2 CONTAINING PROTEIN; CYTOKINE INDUCIBLE SH2-CONTAINING PROTEIN; DNA BINDING PROTEIN; IMMEDIATE EARLY PROTEIN; LEPTIN; MESSENGER RNA; PROTEIN; RECOMBINANT PROTEIN; REPRESSOR PROTEIN; SOCS2 PROTEIN, MOUSE; SOCS3 PROTEIN, MOUSE; SUPPRESSOR OF CYTOKINE SIGNALING; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; C57BL MOUSE; CELL STRAIN COS1; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENETICS; HYPOTHALAMUS; IN SITU HYBRIDIZATION; MALE; METABOLISM; MOUSE; MOUSE MUTANT; NERVE CELL; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALS; COS CELLS; DNA-BINDING PROTEINS; GENES, REPORTER; HYPOTHALAMUS; IMMEDIATE-EARLY PROTEINS; IN SITU HYBRIDIZATION; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; NEURONS; OBESITY; PROTEINS; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0032014178     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80062-3     Document Type: Article

References (47)

1. Adams, T.E., Hansen, J.A., Starr, R., Nicola, N.A., Hilton, D.J., and Billestrup, N. (1998). Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J. Biol. Chem. 273, 1285-1287.
2. Ahima, R.S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., and Flier, J.S. (1996). Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252.
3. Argetsinger, L.S., Campbell, G.S., Yang, X., Witthuhn, B.A., Silvennoinen, O., Ihle, J.N., and Carter-Su, C. (1993). Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74, 237-244.
4. Baumann, H., Morella, K.K., White, D.W., Dembski, M., Bailon, P.S., Kim, H., Lai, C.-F., and Tartaglia, L.A. (1996). The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Natl. Acad. Sci. USA 93, 8374-8378.
5. Bjørbæk, C., Uotani, S., da Silva, B., and Flier, J.S. (1997). Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 272, 32686-32695.
6. Boston, B.A., Blaydon, K.M., Varnerin, J., and Cone, R.D. (1997). Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 278, 1641-1644.
7. Brady, L.S., Lynn, A.B., Herkenham, M., and Gottesfeld, Z. (1994). Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain. J. Neurosci. 14, 4951-4964.
8. Bultman, S.J., Michaud, E.J., and Woychik, R.P. (1992). Molecular characterization of the mouse agouti locus. Cell 71, 1195-1204.
9. Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R., and Burn, P. (1995). Recombinant mouse OB protein: evidence for peripheral signal linking adiposity and central neural networks. Science 269, 546-549.
10. Caro, J.F., Kolaczynski, J.W., Nyce, M.R., Ohannesian, J.P., Opentanova, I., Goldman, W.H., Lynn, R.B., Zhang, P.L., Sinha, M.K., and Considine, R.V. (1996). Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348, 159-161.
11. Chan, R.K., Brown, E.R., Ericsson, A., Kovacs, K.J., and Sawchenko, P.E. (1993). A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry. J. Neurosci. 13, 5126-5138.
12. Chen, H., Chatlat, O., Tartaglia, L.A., Woolf, E.A., Weng, X., Ellis, S.J., Lakey, N.D., Culpepper, J., Moore, K.J., Breitbart, R.E., Duyk, G.M., Tepper, R.I., and Morgenstern, J.P. (1996). Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84, 491-495.
13. Cheung, C.C., Clifton, D.K., and Steiner, R.A. (1997). Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138, 4489-4492.
14. Considine, R.V., Sinha, M.K., Heiman, M.L., Kriauciunas, A., Stephens, T.W., Nyce, M.R., Ohannesian, J.P., Marco, C.C., McKee, L.J., Bauer, T.L., and Caro, J.F. (1996). Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334, 292-295.
15. Dickie, M.M. (1969). Mutations at the agouti locus in the mouse. J. Hered. 60, 20-25.
16. Elmquist, J.K., Ahima, R.S., Elias, C.F., Flier, J.S., and Saper, C.B. (1998). Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc. Natl. Acad. Sci. USA 95, 741-746.
17. Elmquist, J.K., Ahima, R.S., Maratos-Flier, E., Flier, J.S., and Saper, C.B. (1997). Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138, 839-842.
18. Endo, T.A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Tanimura, S., Ohtsubo, M., Misawa, H., et al. (1997). A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387, 921-924.
19. Fei, H., Okano, H.J., Li, C., Lee, G.H., Zhao, C., Darnell, R., and Friedman, J.M. (1997). Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. USA 94, 7001-7005.
20. Frederich, R.C., Hamann, A., Anderson, S., Lollmann, B., Lowell, B.B., and Flier, J.S. (1995). Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1, 1311-1314.
21. Ghilardi, N., and Skoda, R.C. (1997). The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol. Endocrinol. 11, 393-399.
22. Ghilardi, N., Ziegler, S., Wiestner, A., Stoffel, R., Heim, M.H., and Skoda, R.C. (1996). Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. USA 93, 6231-6235.
23. Halaas, J.L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D.A., and Friedman, J.M. (1997). Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. USA 94, 8878-8883.
24. Halaas, J.L., Gajiwala, K.S., Maffei, M., Cohen, S.L., Chait, B.T., Rabinowitz, D., Lallone, R.L., Burley, S.K., and Friedman, J.M.(1995). Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546.
25. Kesterson, R.A., Huszar, D., Lynch, C.A., Simerly, R.B., and Cone, R.D. (1997). Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome. Mol. Endocrinol. 11, 630-637.
26. Lee, G.-H., Proenca, R., Montez, J.M., Carroll, K.M., Darvishzadeh, J.G., Lee, J.I., and Friedman, J.M. (1996). Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632-635.
27. Lu, D., Willard, D., Patel, I.R., Kadwell, S., Overton, L., Kost, T., Luther, M., Chen, W., Woychik, R.P., Wilkison, W.O., and Cone, R.D. (1994). Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371, 799-802.
28. Maffei, M., Halaas, J., Ravussin, E., Pratley, R.E., Lee, G.H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., Kern, P.A., and Friedman, J.M. (1995). Leptin levels in human and rodent: measurement of plasma leptin and ob BNA in obese and weight-reduced subjects. Nat. Med. 1, 1155-1161.
29. Masuhara, M., Sakamoto, H., Matsumoto, A., Suzuki, R., Yasukawa, H., Mitsui, K., Wakioka, T., Tanimura, S., Sasaki, A., Misawa, H., Yokouchi, M., Ohtsubo, M., and Yoshimura, A. (1997). Cloning and characterization of novel CIS family genes. Biochem. Biophys. Res. Commun. 239, 439-446.
30. Matsumoto, A., Masuhara, M., Mitsui, K., Yokouchi, M., Ohtsubo, M., Misawa, H., Miyajima, A., and Yoshimura, A. (1997). CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STATS activation. Blood 89, 3148-3154.
31. Miller, M.W., Duhl, D.M., Vrieling, H., Cordes, S.P., Ollmann, M.M., Winkes, B.M., and Barsh, G.S. (1993). Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. 7, 454-467.
32. Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K., et al. (1997). Structure and function of a new STAT-induced STAT inhibitor. Nature 387, 924-929.
33. Ollmann, M.M., Wilson, B.D., Yang, Y.K., Kerns, J.A., Chen, Y., Gantz, I., and Barsh, G.S. (1997). Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135-138.
34. Pelleymounter, M.A., Cullen, M.J., Baker, M.B., Hecht, R., Winters, D., Boone, T., and Collins, F. (1995). Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543.
35. Schwartz, M.W., Baskin, D.G., Bukowski, T.R., Kuijper, J.L., Foster, D., Lasser, G., Prunkard, D.E., Porte, D., Jr., Woods, S.C., Seeley, R.J., and Weigle, D.S. (1996). Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45, 531-535.
36. Schwartz, M.W., Peskind, E., Raskind, M., Boyko, E.J., and Porte, D., Jr. (1996). Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat. Med. 2, 589-593.
37. Seeley, R.J., Yagaloff, K.A., Fisher, S.L., Burn, P., Thiele, T.E., van Dijk, G., Baskin, D.G., and Schwartz, M.W. (1997). Melanocortin receptors in leptin effects. Nature 390, 349.
38. Simmons, D.M., Arriza, J.L., and Swanson, L.W. (1989). A complete protocol for in situ hybridization of messenger RNA's in brain and other tissues with radiolabelled single stranded RNA probes. J. Histotech. 12, 169-181.
39. Starr, R., Willson, T.A., Viney, E.M., Murray, L.J., Rayner, J.R., Jenkins, B.J., Gonda, T.J., Alexander, W.S., Metcalf, D., Nicola, N.A., and Hilton, D.J. (1997). A family of cytokine-inducible inhibitors of signaling. Nature 387, 917-921.
40. Stephens, T.W., Basinski, M., Bristow, P.K., Bue-Valleskey, J.M., Burgett, S.G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H.M., Kriauciunas, A., et al. (1995). The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530-532.
41. Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G.J., Campfield, L.A., Clark, F.T., Deeds, J., et al. (1995). Identification and expression cloning of a leptin receptor. Cell 83, 1263-1271.
42. Thornton, J.E., Cheung, C.C., Clifton, D.K., and Steiner, R.A. (1997). Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138, 5063-5066.
43. Vaisse, C., Halaas, J.L., Horvath, C.M., Darnell, J.E., Jr., Stoffel, M., and Friedman, J.M. (1996). Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. 14, 95-97.
44. Van Dijk, G., Thiele, T.E., Donahey, J.C., Campfield, L.A., Smith, F.J., Burn, P., Bernstein, I.L., Woods, S.C., and Seeley, R.J. (1996). Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain. Am. J. Physiol. 271, R1096-R1100.
45. Yoshimura, A., Ohkubo, T., Kiguchi, T., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Hara, T., and Miyajima, A. (1995). A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14, 2816-2826.
46. Zhang, F., Basinski, M.B., Beals, J.M., Briggs, S.L., Churgay, L.M., Clawson, D.K., DiMarchi, R.D., Furman, T.C., Hale, J.E., Hsiung, H.M., et al. (1997). Crystal structure of the obese protein leptin-E100. Nature 387, 206-209.
47. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J.M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432.