Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways

Journal of Biological Chemistry

Volumn 283, Issue 42, 2008, Pages 28066-28073

  Jiang, Lin ^a   Li, Zhiqin ^a   Rui, Liangyou ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL REACTIONS; PHOSPHORYLATION;

AUTOPHOSPHORYLATES; BODY WEIGHTS; DOMINANT NEGATIVES; JANUS KINASES; LEPTIN RECEPTORS; LEPTIN SIGNALING; OVEREXPRESSION; PHARMACOLOGICAL INHIBITORS; SIGNALING COMPLEXES; SIGNALING PATHWAYS; SRC FAMILIES; STIMULATED PHOSPHORYLATIONS; TYROSINE KINASES; TYROSINE PHOSPHORYLATIONS;

HORMONES;

JANUS KINASE 2; LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE FYN; STAT3 PROTEIN; TYROSINE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; CELL SURVIVAL; GENES, DOMINANT; JANUS KINASE 2; LEPTIN; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; NEURONS; PHOSPHORYLATION; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; STAT3 TRANSCRIPTION FACTOR; TYROSINE;

EID: 57649137956     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805545200     Document Type: Article

References (45)

1. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994) Nature 372, 425-432
2. Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., Moore, K. J., Breitbart, R. E., Duyk, G. M., Tepper, R. I., and Morgenstern, J. P. (1996) Cell 84, 491-495
3. Chua, S. C., Jr., Chung, W. K., Wu-Peng, X. S., Zhang, Y., Liu, S. M., Tartaglia, L., and Leibel, R. L. (1996) Science 271, 994-996
4. Lee, G. H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., and Friedman, J. M. (1996) Nature 379, 632-635
5. Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Jr., Stoffel, M., and Friedman, J. M. (1996) Nat. Genet. 14, 95-97
6. Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K. J., Smutko, J. S., Mays, G. G., Wool, E. A., Monroe, C. A., and Tepper, R. I. (1995) Cell 83, 1263-1271
7. Clement, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J. M., Basdevant, A., Bougneres, P., Lebouc, Y., Froguel, P., and Guy-Grand, B. (1998) Nature 392, 398-401
8. Cohen, P., Zhao, C., Cai, X., Montez, J. M., Rohani, S. C., Feinstein, P., Mombaerts, P., and Friedman, J. M. (2001) J. Clin. 108, 1113-1121
9. de Luca, C., Kowalski, T. J., Zhang, Y., Elmquist, J. K., Lee, C., Kilimann, M. W., Ludwig, T., Liu, S. M., and Chua, S. C. (2005) J. Clin. Investig. 115, 3484-3493
10. Cohen, P., Yang, G., Yu, X., Soukas, A. A., Wolfish, C. S., Friedman, J. M., and Li, C. (2005) J. Biol. Chem. 280, 10034-10039
11. Minokoshi, Y., Kim, Y. B., Peroni, O. D., Fryer, L. G., Muller, C., Carling, D., and Kahn, B. B. (2002) Nature 415, 339-343
12. Park, B. H., Wang, M. Y., Lee, Y., Yu, X., Ravazzola, M., Orci, L., and Unger, R. H. (2006) J. Biol. Chem. 281, 40283-40291
13. Bjorbaek, C., and Kahn, B. B. (2004) Recent Prog. Horm. Res. 59, 305-331
14. Lord, G. M., Matarese, G., Howard, J. K., Baker, R. J., Bloom, S. R., and Lechler, R. I. (1998) Nature 394, 897-901
15. Anderwald, C., Muller, G., Koca, G., Furnsinn, C., Waldhausl, W., and Roden, M. (2002) Mol. Endocrinol. 16, 1612-1628
16. Morioka, T., Asilmaz, E., Hu, J., Dishinger, J. F., Kurpad, A. J., Elias, C. F., Li, H., Elmquist, J. K., Kennedy, R. T., and Kulkarni, R. N. (2007) J. Clin. Investig. 117, 2860-2868
17. Schwartz, M. W., and Porte, D., Jr. (2005) Science 307, 375-379
18. Ren, D., Li, M., Duan, C., and Rui, L. (2005) Cell Metabolism 2, 95-104
19. Flier, J. S. (2004) Cell 116, 337-350
20. Friedman, J. M. (2003) Science 299, 856-858
21. Friedman, J. M., and Halaas, J. L. (1998) Nature 395, 763-770
22. Herrington, J., Smit, L. S., Schwartz, J., and Carter-Su, C. (2000) Oncogene 19, 2585-2597
23. Banks, A. S., Davis, S. M., Bates, S. H., and Myers, M. G., Jr. (2000) J. Biol. Chem. 275, 14563-14572
24. Bjorbaek, C., Uotani, S., da Silva, B., and Flier, J. S. (1997) J. Biol. Chem. 272, 32686-32695
25. Bjorbak, C., El-Haschimi, K., Frantz, J. D., and Flier, J. S. (1999) J. Biol. Chem. 274, 30059-30065
26. Kurzer, J. H., Argetsinger, L. S., Zhou, Y. J., Kouadio, J. L., O'Shea, J. J., and Carter-Su, C. (2004) Mol. Cell. Biol. 24, 4557-4570
27. Ren, D., Zhou, Y., Morris, D., Li, M., Li, Z., and Rui, L. (2007) J. Clin. Investig. 117, 397-406
28. Bates, S. H., Stearns, W. H., Dundon, T. A., Schubert, M., Tso, A. W., Wang, Y., Banks, A. S., Lavery, H. J., Haq, A. K., Maratos-Flier, E., Neel, B. G., Schwartz, M. W., and Myers, M. G., Jr. (2003) Nature 421, 856-859
29. Cui, Y., Huang, L., Elefteriou, F., Yang, G., Shelton, J. M., Giles, J. E., Oz, O. K., Pourbahrami, T., Lu, C. Y., Richardson, J. A., Karsenty, G., and Li, C. (2004) Mol. Cell. Biol. 24, 258-269
30. Gao, Q., Wolfgang, M. J., Neschen, S., Morino, K., Horvath, T. L., Shulman, G. I., and Fu, X. Y. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 4661-4666
31. Burfoot, M. S., Rogers, N. C., Watling, D., Smith, J. M., Pons, S., Paonessaw, G., Pellegrini, S., White, M. F., and Kerr, I. M. (1997) J. Biol. Chem. 272, 24183-24190
32. Kohlhuber, F., Rogers, N. C., Watling, D., Feng, J., Guschin, D., Briscoe, J., Witthuhn, B. A., Kotenko, S. V., Pestka, S., Stark, G. R., Ihle, J. N., and Kerr, I. M. (1997) Mol. Cell. Biol. 17, 695-706
33. Li, Z., Zhou, Y., Carter-Su, C., Myers, M. G., Jr., and Rui, L. (2007) Mol. Endocrinol. 21, 2270-2281
34. Parganas, E., Wang, D., Stravopodis, D., Topham, D. J., Marine, J. C., Teglund, S., Vanin, E. F., Bodner, S., Colamonici, O. R., van Deursen, J. M., Grosveld, G., and Ihle, J. N. (1998) Cell 93, 385-395
35. Duan, C., Li, M., and Rui, L. (2004) J. Biol. Chem. 279, 43684-43691
36. Yu, C. L., Meyer, D. J., Campbell, G. S., Larner, A. C., Carter-Su, C., Schwartz, J., and Jove, R. (1995) Science 269, 81-83
37. Bjorbak, C., Lavery, H. J., Bates, S. H., Olson, R. K., Davis, S. M., Flier, J. S., and Myers, M. G., Jr. (2000) J. Biol. Chem. 275, 40649-40657
38. Li, C., and Friedman, J. M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 9677-9682
39. Zhang, E. E., Chapeau, E., Hagihara, K., and Feng, G.-S. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 16064-16069
40. Bjornholm, M., Munzberg, H., Leshan, R. L., Villanueva, E. C., Bates, S. H., Louis, G. W., Jones, J. C., Ishida-Takahashi, R., Bjorbaek, C., and Myers, M. G., Jr. (2007) J. Clin. Investig. 117, 1354-1360
41. Roskoski, R., Jr. (2004) Biochem. Biophys. Res. Commun. 324, 1155-1164
42. Montecucco, F., Bianchi, G., Gnerre, P., Bertolotto, M., Dallegri, F., and Ottonello, L. (2006) Ann. N. Y. Acad. Sci. 1069, 463-471
43. Beltowski, J., Wojcicka, G., Trzeciak, J., and Marciniak, A. (2006) Peptides 27, 3234-3244
44. Feng, J., Witthuhn, B. A., Matsuda, T., Kohlhuber, F., Kerr, I. M., and Ihle, J. N. (1997) Mol. Cell. Biol. 17, 2497-2501
45. Ungureanu, D., Saharinen, P., Junttila, I., Hilton, D. J., and Silvennoinen, O. (2002) Mol. Cell. Biol. 22, 3316-3326