Induction of endoplasmic reticulum stress-induced β-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide

American Journal of Physiology - Endocrinology and Metabolism

Volumn 293, Issue 6, 2007, Pages

  Huang, Chang Jiang ^a   Haataja, Leena ^a   Gurlo, Tatyana ^b   Butler, Alexandra E ^a   Wu, Xiuju ^a   Soeller, Walter C ^b   Butler, Peter C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Diabetes; Ubiquitinated proteins

Indexed keywords

AMYLOID; CASPASE 12; OLIGOMER; POLYPEPTIDE;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL LOSS; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; TRANSGENIC MOUSE; UBIQUITINATION;

ACTIVATING TRANSCRIPTION FACTOR 4; AMYLOID; ANIMALS; APOPTOSIS; BLOOD GLUCOSE; BODY WEIGHT; CASPASE 12; CELL LINE, TUMOR; CYTOSOL; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MOLECULAR CHAPERONES; NUCLEAR PROTEINS; POLYUBIQUITIN; PROTEINS; RATS; TRANSCRIPTION FACTOR CHOP;

EID: 37149012111     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00318.2007     Document Type: Article

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