Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance

Endocrinology

Volumn 146, Issue 3, 2005, Pages 1473-1481

  Khamzina, Leila ^a   Veilleux, Alain ^a   Bergeron, Sébastien ^a   Marette, André ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; SERINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TYPE; CONTROLLED STUDY; DIETARY INTAKE; ENZYME ANALYSIS; FAT INTAKE; IN VITRO STUDY; INHIBITION KINETICS; INSULIN RESISTANCE; LIVER; MALE; NONHUMAN; NUTRIENT; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TIME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FOOD DEPRIVATION; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MUSCLE, SKELETAL; MUSCLES; OBESITY; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SERINE; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 14244256097     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0921     Document Type: Article

References (39)

1. Schmelzle T, Hall MN 2000 TOR, a central controller of cell growth. Cell 103:253-262
2. Raught B, Gingras AC, Sonenberg N 2001 The target of rapamycin (TOR) proteins. Proc Natl Acad Sci USA 98:7037-7044
3. Rohde J, Heitman J, Cardenas ME 2001 The TOR kinases link nutrient sensing to cell growth. J Biol Chem 276:9583-9586
4. Brunn GJ, Fadden P, Haystead TAJ, Lawrence Jr JC 1997 The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. J Biol Chem 272:32547-32550
5. Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM 1998 RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci USA 95:1432-1437
6. Hara K, Yonezawa K, Kozlowski MT, Sugimoto T, Andrabi K, Weng QP, Kasuga M, Nishimoto I, Avruch J 1997 Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem 272:26457-26463
7. Isotani S, Hara K, Tokunaga C, Inoue H, Avruch J, Yonezawa K 1999 Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase α in vitro. J Biol Chem 274:34493-34498
8. Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR 1999 Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 344:427-431
9. Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT 2000 A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 60:3504-3513
10. Scott PH, Brunn GJ, Kohn AD, Roth RA, Lawrence Jr JC 1998 Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc Natl Acad Sci USA 95:7772-7777
11. Shamji AF, Nghiem P, Schreiber SL 2003 Integration of growth factor and nutrient signaling: implications for cancer biology. Mol Cell 12:271-280
12. Tremblay F, Marette A 2001 Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276:38052-38060
13. Berg CE, Lavan BE, Rondinone CM 2002 Rapamycin partially prevents insulin resistance induced by chronic insulin treatment. Biochem Biophys Res Commun 293:1021-1027
14. Haruta T, Uno T, Kawahara J, Takano A, Egawa K, Sharma PM, Olef sky JM, Kobayashi M 2000 A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol 14:783-794
15. Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB 2001 A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci USA 98:4640-4645
16. Takano A, Usui I, Haruta T, Kawahara J, Uno T, Iwata M, Kobayashi M 2001 Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol Cell Biol 21:5050-5062
17. Qiao LY, Goldberg JL, Russell JC, Sun XJ 1999 Identification of enhanced serine kinase activity in insulin resistance. J Biol Chem 274:10625-10632
18. Qiao LY, Zhande R, Jetton TL, Zhou G, Sun XJ 2002 In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents. J Biol Chem 277:26530-26539
19. Zick Y 2003 Role of Ser/Thr kinases in the uncoupling of insulin signaling. Int J Obes Relat Metab Disord 27(Suppl 3):S56-S60
20. Lavigne C, Tremblay F, Asselin G, Jacques H, Marette A 2001 Prevention of skeletal muscle insulin resistance by dietary cod protein in high fat-fed rats. Am J Physiol 281:E62-E71
21. Gual P, Gremeaux T, Gonzalez T, Le Marchand-Brustel Y, Tanti JF 2003 MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. Diabetologia 46:1532-1542
22. 632 in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells. Endocrinology 142:2833-2840
23. Mothe I, Van Obberghen E 1996 Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. J Biol Chem 271:11222-11227
24. Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB 3rd, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ 2001 Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292:1728-1731
25. Peak M, Rochford JJ, Borthwick AC, Yeaman SJ, Agius L 1998 Signalling pathways involved in the stimulation of glycogen synthesis by insulin in rat hepatocytes. Diabetologia 41:16-25
26. Mothe-Satney I, Gautier N, Hinault C, Lawrence Jr JC, Van Obberghen E 2004 In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids. J Biol Chem 279: 42628-42637
27. 2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. J Biol Chem 277:17657-17662
28. Felig P, Wahren J, Hendler R, Brundin T 1974 Splanchnic glucose and amino acid metabolism in obesity. J Clin Invest 53:582-590
29. Bouzakri K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, Laville M, Le Marchand-Brustel Y, Tanti JF, Vidal H 2003 Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes. Diabetes 52:1319-1325
30. Carbon CJ, White MF, Rondinone CM 2004 Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem Biophys Res Commun 316:533-539
31. Li J, DeFea K, Roth RA 1999 Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway. J Biol Chem 274:9351-9356
32. Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Dowries CP, Lamb RF 2004 The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 166:213-223
33. rsk, and p70 S6 kinase in skeletal muscle of normal and insulin-resistant mice. Implications for the regulation of glycogen synthase. J Biol Chem 270:29928-29935
34. Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G 2004 Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431:200-205
35. Davies SP, Reddy H, Caivano M, Cohen P 2000 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105
36. 307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 277:1531-1537
37. Gao Z, Zuberi A, Quon MJ, Dong Z, Ye J 2003 Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J Biol Chem 278:24944-24950
38. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS 2002 A central role for JNK in obesity and insulin resistance. Nature 420:333-336
39. Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE 2001 Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of inhibitor κB kinase β. Science 293:1673-1677