Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway

PLoS ONE

Volumn 4, Issue 7, 2009, Pages

  Zhang, Hui H ^a   Huang, Jingxiang ^a   Düvel, Katrin ^a   Boback, Bernard ^a   Wu, Shulin ^b   Squillance, Rachel M ^c   Wu, Chin Lee ^b   Manning, Brendan D ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; TRIACYLGLYCEROL; TUBERIN; MTORC1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANGIOMYOLIPOMA; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST CULTURE; HORMONAL REGULATION; HORMONE ACTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; KIDNEY TUMOR; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; TUBEROUS SCLEROSIS; ANIMAL; CELL DIVISION; CYTOLOGY; DRUG EFFECT; GENE SILENCING; GENETICS; IMMUNOHISTOCHEMISTRY; PHOSPHORYLATION; PHYSIOLOGY; WESTERN BLOTTING;

MAMMALIA;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; BLOTTING, WESTERN; CELL DIVISION; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; MICE; PHOSPHORYLATION; PPAR GAMMA; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 67650523945     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006189     Document Type: Article

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