메뉴 건너뛰기




Volumn 118, Issue 1, 2008, Pages 316-332

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B100; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; INTRALIPID; MESSENGER RNA; OLEIC ACID; TRIACYLGLYCEROL; TUNICAMYCIN; VERY LOW DENSITY LIPOPROTEIN; X BOX BINDING PROTEIN 1;

EID: 38149136598     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI32752     Document Type: Article
Times cited : (317)

References (75)
  • 1
    • 0036437307 scopus 로고    scopus 로고
    • Transcriptional and translational control in the mammalian unfolded protein response
    • Harding, H.P., Calfon, M., Urano, F., Novoa, I., and Ron, D. 2002. Transcriptional and translational control in the mammalian unfolded protein response. Annu. Rev. Cell. Dev. Biol. 18:575-599.
    • (2002) Annu. Rev. Cell. Dev. Biol , vol.18 , pp. 575-599
    • Harding, H.P.1    Calfon, M.2    Urano, F.3    Novoa, I.4    Ron, D.5
  • 2
    • 0036086064 scopus 로고    scopus 로고
    • The unfolded protein response in nutrient sensing and differentiation
    • Kaufman, R.J., et al. 2002. The unfolded protein response in nutrient sensing and differentiation. Nat. Rev. Mol. Cell Biol. 3:411-421.
    • (2002) Nat. Rev. Mol. Cell Biol , vol.3 , pp. 411-421
    • Kaufman, R.J.1
  • 3
    • 0034716887 scopus 로고    scopus 로고
    • Tripartite management of unfolded proteins in the endoplasmic reticulum
    • Mori, K. 2000. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell. 101:451-454.
    • (2000) Cell , vol.101 , pp. 451-454
    • Mori, K.1
  • 4
    • 0033590451 scopus 로고    scopus 로고
    • Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    • Harding, H.P., Zhang, Y., and Ron, D. 1999. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature. 397:271-274.
    • (1999) Nature , vol.397 , pp. 271-274
    • Harding, H.P.1    Zhang, Y.2    Ron, D.3
  • 5
    • 0033634654 scopus 로고    scopus 로고
    • Regulated translation initiation controls stress-induced gene expression in mammalian cells
    • Harding, H., et al. 2000. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell. 6:1099-1108.
    • (2000) Mol. Cell , vol.6 , pp. 1099-1108
    • Harding, H.1
  • 6
    • 33749492425 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress signaling in disease
    • Marciniak, S.J., and Ron, D. 2006. Endoplasmic reticulum stress signaling in disease. Physiol. Rev. 86:1133-1149.
    • (2006) Physiol. Rev , vol.86 , pp. 1133-1149
    • Marciniak, S.J.1    Ron, D.2
  • 8
    • 0033329864 scopus 로고    scopus 로고
    • Liver pathology and the metabolic syndrome X in severe obesity
    • Marceau, P., et al. 1999. Liver pathology and the metabolic syndrome X in severe obesity. J. Clin. Endocrinol. Metab. 84:1513-1517.
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , pp. 1513-1517
    • Marceau, P.1
  • 9
    • 18244385511 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association
    • Pagano, G., et al. 2002. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology. 35:367-372.
    • (2002) Hepatology , vol.35 , pp. 367-372
    • Pagano, G.1
  • 10
    • 33845490856 scopus 로고    scopus 로고
    • Review: The role of insulin resistance in nonalcoholic fatty liver disease
    • Utzschneider, K.M., and Kahn, S.E. 2006. Review: the role of insulin resistance in nonalcoholic fatty liver disease. J. Clin. Endocrinol. Metab. 91:4753-4761.
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 11
    • 4644279733 scopus 로고    scopus 로고
    • Increasing prevalence of the metabolic syndrome among U.S. adults
    • Ford, E.S., Giles, W.H., and Mokdad, A.H. 2004. Increasing prevalence of the metabolic syndrome among U.S. adults. Diabetes Care. 27:2444-2449.
    • (2004) Diabetes Care , vol.27 , pp. 2444-2449
    • Ford, E.S.1    Giles, W.H.2    Mokdad, A.H.3
  • 12
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning, J.D., et al. 2004. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 40:1387-1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1
  • 13
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan, U., et al. 2004. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 306:457-461.
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1
  • 14
    • 19944430402 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
    • Nakatani, Y., et al. 2005. Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J. Biol. Chem. 280:847-851.
    • (2005) J. Biol. Chem , vol.280 , pp. 847-851
    • Nakatani, Y.1
  • 15
    • 18244370762 scopus 로고    scopus 로고
    • Inflammation, stress, and diabetes
    • Wellen, K.E., and Hotamisligil, G.S. 2005. Inflammation, stress, and diabetes. J. Clin. Invest. 115:1111-1119.
    • (2005) J. Clin. Invest , vol.115 , pp. 1111-1119
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 16
    • 8544244943 scopus 로고    scopus 로고
    • Modulation of the JNK pathway in liver affects insulin resistance status
    • Nakatani, Y., et al. 2004. Modulation of the JNK pathway in liver affects insulin resistance status. J. Biol. Chem. 279:45803-45809.
    • (2004) J. Biol. Chem , vol.279 , pp. 45803-45809
    • Nakatani, Y.1
  • 17
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • Malhi, H., Bronk, S.F., Werneburg, N.W., and Gores, G.J. 2006. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J. Biol. Chem. 281:12093-12101.
    • (2006) J. Biol. Chem , vol.281 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3    Gores, G.J.4
  • 18
    • 0037124084 scopus 로고    scopus 로고
    • Complexity in the secretory pathway: The assembly and secretion of apolipoprotein B-containing lipoproteins
    • Fisher, E.A., and Ginsberg, H.N. 2002. Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins. J. Biol. Chem. 277:17377-17380.
    • (2002) J. Biol. Chem , vol.277 , pp. 17377-17380
    • Fisher, E.A.1    Ginsberg, H.N.2
  • 19
    • 0032927776 scopus 로고    scopus 로고
    • Apolipoprotein B in the rough endoplasmic reticulum: Translation, translocation and the initiation of lipoprotein assembly
    • Shelness, G.S., Ingram, M.F., Huang, X.F., and DeLozier, J.A. 1999. Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assembly. J. Nutr. 129:456S- 462S.
    • (1999) J. Nutr , vol.129
    • Shelness, G.S.1    Ingram, M.F.2    Huang, X.F.3    DeLozier, J.A.4
  • 20
    • 0030725291 scopus 로고    scopus 로고
    • Intracellular degradation of newly synthesized apolipoprotein B
    • Yao, Z., Tran, K., and McLeod, R.S. 1997. Intracellular degradation of newly synthesized apolipoprotein B. J. Lipid Res. 38:1937-1953.
    • (1997) J. Lipid Res , vol.38 , pp. 1937-1953
    • Yao, Z.1    Tran, K.2    McLeod, R.S.3
  • 21
    • 0015981773 scopus 로고
    • Homocystinuria due to cystathionine synthase deficiency: Enzymatic and ultrastructural studies
    • Gaull, G., Sturman, J.A., and Schaffner, F. 1974. Homocystinuria due to cystathionine synthase deficiency: enzymatic and ultrastructural studies. J. Pediatr. 84:381-390.
    • (1974) J. Pediatr , vol.84 , pp. 381-390
    • Gaull, G.1    Sturman, J.A.2    Schaffner, F.3
  • 22
    • 33644649625 scopus 로고    scopus 로고
    • Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease
    • Gulsen, M., et al. 2005. Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease. J. Gastroenterol. Hepatol. 20:1448-1455.
    • (2005) J. Gastroenterol. Hepatol , vol.20 , pp. 1448-1455
    • Gulsen, M.1
  • 23
    • 0035014266 scopus 로고    scopus 로고
    • Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways
    • Werstuck, G.H., et al. 2001. Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J. Clin. Invest. 107:1263-1273.
    • (2001) J. Clin. Invest , vol.107 , pp. 1263-1273
    • Werstuck, G.H.1
  • 24
    • 0031443539 scopus 로고    scopus 로고
    • Conformational changes in apolipoprotein B modulate intracellular assembly and degradation of apoB-containing lipoprotein particles in HepG2 cells
    • Macri, J., and Adeli, K. 1997. Conformational changes in apolipoprotein B modulate intracellular assembly and degradation of apoB-containing lipoprotein particles in HepG2 cells. Arterioscler. Thromb. Vasc. Biol. 17:2982-2994.
    • (1997) Arterioscler. Thromb. Vasc. Biol , vol.17 , pp. 2982-2994
    • Macri, J.1    Adeli, K.2
  • 25
    • 0029993847 scopus 로고    scopus 로고
    • Apolipoprotein B-100 destined for lipoprotein assembly and intracellular degradation undergoes efficient translocation across the endoplasmic reticulum membrane
    • Ingram, M.F., and Shelness, G.S. 1996. Apolipoprotein B-100 destined for lipoprotein assembly and intracellular degradation undergoes efficient translocation across the endoplasmic reticulum membrane. J. Lipid Res. 37:2202-2214.
    • (1996) J. Lipid Res , vol.37 , pp. 2202-2214
    • Ingram, M.F.1    Shelness, G.S.2
  • 26
    • 14644405001 scopus 로고    scopus 로고
    • Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation
    • Qiu, W., et al. 2005. Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation. Arterioscler. Thromb. Vasc. Biol. 25:571-577.
    • (2005) Arterioscler. Thromb. Vasc. Biol , vol.25 , pp. 571-577
    • Qiu, W.1
  • 27
    • 0031054643 scopus 로고    scopus 로고
    • Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins
    • Morris, J.A., Dorner, A.J., Edwards, C.A., Hendershot, L.M., and Kaufman, R.J. 1997. Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins. J. Biol. Chem. 272:4327-4334.
    • (1997) J. Biol. Chem , vol.272 , pp. 4327-4334
    • Morris, J.A.1    Dorner, A.J.2    Edwards, C.A.3    Hendershot, L.M.4    Kaufman, R.J.5
  • 28
    • 0037011917 scopus 로고    scopus 로고
    • IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    • Calfon, M., et al. 2002. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature. 415:92-96.
    • (2002) Nature , vol.415 , pp. 92-96
    • Calfon, M.1
  • 29
    • 0035966269 scopus 로고    scopus 로고
    • XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
    • Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., and Mori, K. 2001. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell. 107:881-891.
    • (2001) Cell , vol.107 , pp. 881-891
    • Yoshida, H.1    Matsui, T.2    Yamamoto, A.3    Okada, T.4    Mori, K.5
  • 30
    • 0030860899 scopus 로고    scopus 로고
    • The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70
    • Fisher, E.A., et al. 1997. The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J. Biol. Chem. 272:20427-20434.
    • (1997) J. Biol. Chem , vol.272 , pp. 20427-20434
    • Fisher, E.A.1
  • 31
    • 0035958917 scopus 로고    scopus 로고
    • The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways
    • Fisher, E.A., et al. 2001. The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways. J. Biol. Chem. 276:27855-27863.
    • (2001) J. Biol. Chem , vol.276 , pp. 27855-27863
    • Fisher, E.A.1
  • 32
    • 85047692761 scopus 로고    scopus 로고
    • Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
    • Pan, M., et al. 2004. Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. J. Clin. Invest. 113:1277-1287.
    • (2004) J. Clin. Invest , vol.113 , pp. 1277-1287
    • Pan, M.1
  • 33
    • 24344495336 scopus 로고    scopus 로고
    • Sodium 4-phenylbutyrate protects against ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis
    • Vilatoba, M., et al. 2005. Sodium 4-phenylbutyrate protects against ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. Surgery. 138:342-351.
    • (2005) Surgery , vol.138 , pp. 342-351
    • Vilatoba, M.1
  • 34
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • Ozcan, U., et al. 2006. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 313:1137-1140.
    • (2006) Science , vol.313 , pp. 1137-1140
    • Ozcan, U.1
  • 35
    • 2442477510 scopus 로고    scopus 로고
    • Regulation of hepatic apolipoprotein B-lipoprotein assembly and secretion by the availability of fatty acids 1: Differential effects of delivering fatty acids via albumin or remnant-like emulsion particles
    • Zhang, Y.-L., et al. 2004. Regulation of hepatic apolipoprotein B-lipoprotein assembly and secretion by the availability of fatty acids 1: differential effects of delivering fatty acids via albumin or remnant-like emulsion particles. J. Biol. Chem. 279:19362-19374.
    • (2004) J. Biol. Chem , vol.279 , pp. 19362-19374
    • Zhang, Y.-L.1
  • 36
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven, G.M. 1988. Role of insulin resistance in human disease. Diabetes. 37:1595-1607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 37
    • 1842443960 scopus 로고    scopus 로고
    • Mechanisms of metabolic dyslipidemia in insulin resistant states: Deregulation of hepatic and intestinal lipoprotein secretion
    • Avramoglu, R.K., Qiu, W., and Adeli, K. 2003. Mechanisms of metabolic dyslipidemia in insulin resistant states: deregulation of hepatic and intestinal lipoprotein secretion. Front. Biosci. 8:d464-d476.
    • (2003) Front. Biosci , vol.8
    • Avramoglu, R.K.1    Qiu, W.2    Adeli, K.3
  • 38
    • 19944366619 scopus 로고    scopus 로고
    • Regulation of plasma triglycerides in insulin resistance and diabetes
    • Ginsberg, H.N., Zhang, Y.L., and Hernandez-Ono, A. 2005. Regulation of plasma triglycerides in insulin resistance and diabetes. Arch. Med. Res. 36:232-240.
    • (2005) Arch. Med. Res , vol.36 , pp. 232-240
    • Ginsberg, H.N.1    Zhang, Y.L.2    Hernandez-Ono, A.3
  • 39
    • 0033209998 scopus 로고    scopus 로고
    • Fatty acid regulation of very low density lipoprotein (VLDL) production
    • Lewis, G.F. 1999. Fatty acid regulation of very low density lipoprotein (VLDL) production. Curr. Opin. Lipidol. 10:475-477.
    • (1999) Curr. Opin. Lipidol , vol.10 , pp. 475-477
    • Lewis, G.F.1
  • 40
    • 14644397903 scopus 로고    scopus 로고
    • The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes
    • Ozawa, K., et al. 2005. The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes. 54:657-663.
    • (2005) Diabetes , vol.54 , pp. 657-663
    • Ozawa, K.1
  • 41
    • 33846013601 scopus 로고    scopus 로고
    • Sterol-regulated degradation of insig-1 mediated by the membrane-bound ubiquitin ligase gp78
    • Lee, J.N., Song, B., DeBose-Boyd, R.A., and Ye, J. 2006. Sterol-regulated degradation of insig-1 mediated by the membrane-bound ubiquitin ligase gp78. J. Biol. Chem. 281:39308-39315.
    • (2006) J. Biol. Chem , vol.281 , pp. 39308-39315
    • Lee, J.N.1    Song, B.2    DeBose-Boyd, R.A.3    Ye, J.4
  • 42
    • 0028115062 scopus 로고
    • Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion
    • Sparks, J.D., and Sparks, C.E. 1994. Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion. Biochim. Biophys. Acta. 1215:9-32.
    • (1994) Biochim. Biophys. Acta , vol.1215 , pp. 9-32
    • Sparks, J.D.1    Sparks, C.E.2
  • 43
    • 0027299436 scopus 로고
    • Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals
    • Lewis, G.F., Uffelman, K.D., Szeto, L.W., and Steiner, G. 1993. Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals. Diabetes. 42:833-842.
    • (1993) Diabetes , vol.42 , pp. 833-842
    • Lewis, G.F.1    Uffelman, K.D.2    Szeto, L.W.3    Steiner, G.4
  • 44
    • 16944367066 scopus 로고    scopus 로고
    • Metabolic basis of hypotriglyceridemic effects of insulin in normal men
    • Malmstrom, R., et al. 1997. Metabolic basis of hypotriglyceridemic effects of insulin in normal men. Arterioscler. Thromb. Vasc. Biol. 17:1454-1464.
    • (1997) Arterioscler. Thromb. Vasc. Biol , vol.17 , pp. 1454-1464
    • Malmstrom, R.1
  • 45
    • 0028888899 scopus 로고
    • VLDL output by hepatocytes from obese Zucker rats is resistant to the inhibitory effect of insulin
    • Bourgeois, C.S., Wiggins, D., Hems, R., and Gibbons, G.F. 1995. VLDL output by hepatocytes from obese Zucker rats is resistant to the inhibitory effect of insulin. Am. J. Physiol. 269:E208-E215.
    • (1995) Am. J. Physiol , vol.269
    • Bourgeois, C.S.1    Wiggins, D.2    Hems, R.3    Gibbons, G.F.4
  • 46
    • 0034708682 scopus 로고    scopus 로고
    • Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular apoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model
    • Taghibiglou, C., et al. 2000. Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular apoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model. J. Biol. Chem. 275:8416-8425.
    • (2000) J. Biol. Chem , vol.275 , pp. 8416-8425
    • Taghibiglou, C.1
  • 47
    • 0030986959 scopus 로고    scopus 로고
    • Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM
    • Malmstrom, R., et al. 1997. Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM. Diabetologia. 40:454-462.
    • (1997) Diabetologia , vol.40 , pp. 454-462
    • Malmstrom, R.1
  • 48
    • 33745116619 scopus 로고    scopus 로고
    • Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1pancreatic β-Cell Apoptosis
    • Karaskov, E., et al. 2006. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1pancreatic β-Cell Apoptosis. Endocrinology. 147:3398-3407.
    • (2006) Endocrinology , vol.147 , pp. 3398-3407
    • Karaskov, E.1
  • 49
    • 33947510911 scopus 로고    scopus 로고
    • Selective inhibition of EIF2α dephosphorylation potentiates fatty acid-induced ER stress and causes pancreatic β-cell dysfunction and apoptosis
    • Cnop, M., et al. 2007. Selective inhibition of EIF2α dephosphorylation potentiates fatty acid-induced ER stress and causes pancreatic β-cell dysfunction and apoptosis. J. Biol. Chem. 282:3989-3997.
    • (2007) J. Biol. Chem , vol.282 , pp. 3989-3997
    • Cnop, M.1
  • 50
    • 26244456414 scopus 로고    scopus 로고
    • ER stress and SREBP-1 activation are implicated in {beta}-cell glucolipotoxicity
    • Wang, H., Kouri, G., and Wollheim, C.B. 2005. ER stress and SREBP-1 activation are implicated in {beta}-cell glucolipotoxicity. J. Cell Sci. 118:3905-3915.
    • (2005) J. Cell Sci , vol.118 , pp. 3905-3915
    • Wang, H.1    Kouri, G.2    Wollheim, C.B.3
  • 51
    • 31944439780 scopus 로고    scopus 로고
    • A critical role for eukaryotic elongation faction 1A-1 in lipotoxic cell death
    • Borradaile, N.M., et al. 2006. A critical role for eukaryotic elongation faction 1A-1 in lipotoxic cell death. Mol. Biol. Cell. 17:770-778.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 770-778
    • Borradaile, N.M.1
  • 52
    • 33745828301 scopus 로고    scopus 로고
    • Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
    • Wei, Y., Wang, D., Topczewski, F., and Pagliassotti, M.J. 2006. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am. J. Physiol. Endocrinol. Metab. 291:E275-E281.
    • (2006) Am. J. Physiol. Endocrinol. Metab , vol.291
    • Wei, Y.1    Wang, D.2    Topczewski, F.3    Pagliassotti, M.J.4
  • 53
    • 30944451788 scopus 로고    scopus 로고
    • Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
    • Wang, D., Wei, Y., and Pagliassotti, M.J. 2006. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology. 147:943-951.
    • (2006) Endocrinology , vol.147 , pp. 943-951
    • Wang, D.1    Wei, Y.2    Pagliassotti, M.J.3
  • 54
    • 0142042348 scopus 로고    scopus 로고
    • Blocking microsomal triglyceride protein interferes with apoB secretion without causing retention or stress in the ER
    • Liao, W., Hui, T.Y., Young, S.G., and Davis, R.A. 2003. Blocking microsomal triglyceride protein interferes with apoB secretion without causing retention or stress in the ER. J. Lipid Res. 44:978-985.
    • (2003) J. Lipid Res , vol.44 , pp. 978-985
    • Liao, W.1    Hui, T.Y.2    Young, S.G.3    Davis, R.A.4
  • 55
    • 0025727192 scopus 로고    scopus 로고
    • Dixon, J.L., Furukawa, S., and Ginsberg, H.N. 1991. Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B. J. Biol. Chem. 266:5080-5086.
    • Dixon, J.L., Furukawa, S., and Ginsberg, H.N. 1991. Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B. J. Biol. Chem. 266:5080-5086.
  • 56
    • 0027504998 scopus 로고
    • Proteolysis and lipid facilitated translocation are distinct but competitive processes which regulate secretion of apolipoprotein B in HepG2 cells
    • Sakata, N., Wu, X., Dixon, J.L., and Ginsberg, H.N. 1993. Proteolysis and lipid facilitated translocation are distinct but competitive processes which regulate secretion of apolipoprotein B in HepG2 cells. J. Biol. Chem. 268:22967-22970.
    • (1993) J. Biol. Chem , vol.268 , pp. 22967-22970
    • Sakata, N.1    Wu, X.2    Dixon, J.L.3    Ginsberg, H.N.4
  • 57
    • 0034443707 scopus 로고    scopus 로고
    • Intracellular assembly of VLDL. Two major steps in separate cell compartments
    • Olofsson, S.-O., Stillemark-Billton, P., and Asp, L. 2000. Intracellular assembly of VLDL. Two major steps in separate cell compartments. Trends Cardiovasc. Med. 10:338-345.
    • (2000) Trends Cardiovasc. Med , vol.10 , pp. 338-345
    • Olofsson, S.-O.1    Stillemark-Billton, P.2    Asp, L.3
  • 58
    • 0035958947 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein binding and lipid transfer activities are independent of each other, but both are required for secretion of apoB lipoproteins from liver cells
    • Liang, J.-S., and Ginsberg, H.N. 2001. Microsomal triglyceride transfer protein binding and lipid transfer activities are independent of each other, but both are required for secretion of apoB lipoproteins from liver cells. J. Biol. Chem. 276:28606-28612.
    • (2001) J. Biol. Chem , vol.276 , pp. 28606-28612
    • Liang, J.-S.1    Ginsberg, H.N.2
  • 59
    • 0031565656 scopus 로고    scopus 로고
    • Effects of fatty acids on apolipoprotein B secretion by McArdle PH-7777 rat hepatoma cells
    • Sparks, J.D., et al. 1997. Effects of fatty acids on apolipoprotein B secretion by McArdle PH-7777 rat hepatoma cells. Biochim. Biophys. Acta. 1347:51-61.
    • (1997) Biochim. Biophys. Acta , vol.1347 , pp. 51-61
    • Sparks, J.D.1
  • 60
    • 0032544634 scopus 로고    scopus 로고
    • Regulated co-translational ubiquitination of apoliprotein B100. A new paradigm for proteasomal degradation of a secretory protein
    • Zhou, M., Fisher, E.A., and Ginsberg, H.N. 1998. Regulated co-translational ubiquitination of apoliprotein B100. A new paradigm for proteasomal degradation of a secretory protein. J. Biol. Chem. 273:24649-24653.
    • (1998) J. Biol. Chem , vol.273 , pp. 24649-24653
    • Zhou, M.1    Fisher, E.A.2    Ginsberg, H.N.3
  • 61
    • 0034282732 scopus 로고    scopus 로고
    • Pan, M., Liang, J.S., Fisher, E.A., and Ginsberg, H.N. 2000. Inhibition of translocation of nascent apolipoprotein B across the endoplasmic reticulum membrane is associated with selective inhibition of the synthesis of apolipoprotein B. J. Biol. Chem. 275:27399-27405.
    • Pan, M., Liang, J.S., Fisher, E.A., and Ginsberg, H.N. 2000. Inhibition of translocation of nascent apolipoprotein B across the endoplasmic reticulum membrane is associated with selective inhibition of the synthesis of apolipoprotein B. J. Biol. Chem. 275:27399-27405.
  • 62
    • 33747144535 scopus 로고    scopus 로고
    • Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins
    • Qiu, W., Avramoglu, R.K., Rutledge, A.C., Tsai, J., and Adeli, K. 2006. Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins. J. Lipid Res. 47:1749-1761.
    • (2006) J. Lipid Res , vol.47 , pp. 1749-1761
    • Qiu, W.1    Avramoglu, R.K.2    Rutledge, A.C.3    Tsai, J.4    Adeli, K.5
  • 63
    • 33747175431 scopus 로고    scopus 로고
    • Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload
    • Oyadomari, S., et al. 2006. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell. 126:727-739.
    • (2006) Cell , vol.126 , pp. 727-739
    • Oyadomari, S.1
  • 64
    • 34250737299 scopus 로고    scopus 로고
    • Transient arrest in proteasomal degradation during inhibition of translation in the unfolded protein response
    • Shenkman, M., Tolchinsky, S., Kondratyev, M., and Lederkremer, G.Z. 2007. Transient arrest in proteasomal degradation during inhibition of translation in the unfolded protein response. Biochem. J. 404:509-516.
    • (2007) Biochem. J , vol.404 , pp. 509-516
    • Shenkman, M.1    Tolchinsky, S.2    Kondratyev, M.3    Lederkremer, G.Z.4
  • 65
    • 0346727128 scopus 로고    scopus 로고
    • Therapeutic approaches to protein-misfolding diseases
    • Cohen, F.E., and Kelly, J.W. 2003. Therapeutic approaches to protein-misfolding diseases. Nature. 426:905-909.
    • (2003) Nature , vol.426 , pp. 905-909
    • Cohen, F.E.1    Kelly, J.W.2
  • 66
    • 0030809817 scopus 로고    scopus 로고
    • In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR
    • Rubenstein, R.C., Egan, M.E., and Zeitlin, P.L. 1997. In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR. J. Clin. Invest. 100:2457-2465.
    • (1997) J. Clin. Invest , vol.100 , pp. 2457-2465
    • Rubenstein, R.C.1    Egan, M.E.2    Zeitlin, P.L.3
  • 67
    • 0034652248 scopus 로고    scopus 로고
    • Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency
    • Burrows, J.A., Willis, L.K., and Perlmutter, D.H. 2000. Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: a potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency. Proc. Natl. Acad. Sci. U. S. A. 97:1796-1801.
    • (2000) Proc. Natl. Acad. Sci. U. S. A , vol.97 , pp. 1796-1801
    • Burrows, J.A.1    Willis, L.K.2    Perlmutter, D.H.3
  • 68
    • 0034798513 scopus 로고    scopus 로고
    • Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy
    • McGuinness, M.C., Zhang, H.P., and Smith, K.D. 2001. Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy. Mol. Genet. Metab. 74:256-263.
    • (2001) Mol. Genet. Metab , vol.74 , pp. 256-263
    • McGuinness, M.C.1    Zhang, H.P.2    Smith, K.D.3
  • 69
    • 33644827082 scopus 로고    scopus 로고
    • Overproduction of large VLDL particles is driven by increased liver fat content in man
    • Adiels, M., et al. 2006. Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia. 49:755-765.
    • (2006) Diabetologia , vol.49 , pp. 755-765
    • Adiels, M.1
  • 70
    • 0002552045 scopus 로고
    • A method for chronic intravenous drug administration in the rat
    • S. Ehrenpreis and A. Neidle, editors. Marcel Dekker. New York, New York, USA
    • Smith, S.G., and Davis, W.M. 1974. A method for chronic intravenous drug administration in the rat. In Methods in narcotics research. S. Ehrenpreis and A. Neidle, editors. Marcel Dekker. New York, New York, USA. 3-32.
    • (1974) Methods in narcotics research , pp. 3-32
    • Smith, S.G.1    Davis, W.M.2
  • 72
    • 0035824678 scopus 로고    scopus 로고
    • Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B-lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity and insulin resistance
    • Siri, P., et al. 2001. Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B-lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity and insulin resistance. J. Biol. Chem. 276:46064-46072.
    • (2001) J. Biol. Chem , vol.276 , pp. 46064-46072
    • Siri, P.1
  • 73
    • 0013825330 scopus 로고
    • Factors affecting lipoprotein metabolism
    • Scanu, A.M. 1965. Factors affecting lipoprotein metabolism. Adv. Lipid Res. 3:63-138.
    • (1965) Adv. Lipid Res , vol.3 , pp. 63-138
    • Scanu, A.M.1
  • 74
    • 0014088255 scopus 로고
    • The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions
    • Otway, S. 1967. The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions. J. Physiol. 190:321-332.
    • (1967) J. Physiol , vol.190 , pp. 321-332
    • Otway, S.1
  • 75
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch, J., and Lees, M. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 224:497-509.
    • (1957) J. Biol. Chem , vol.224 , pp. 497-509
    • Folch, J.1    Lees, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.