Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner

Journal of Biological Chemistry

Volumn 282, Issue 14, 2007, Pages 10164-10171

  Silva, Aristóbolo M ^a,e   Wang, Die ^a,b   Komar, Anton A ^c   Castilho, Beatriz A ^d   Williams, Bryan R G ^a,b,f  

^a LERNER RESEARCH INSTITUTE   (United States)

^b MONASH UNIVERSITY   (Australia)

^c CLEVELAND STATE UNIVERSITY   (United States)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^e FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^f MONASH MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; DRUG PRODUCTS; ENZYME ACTIVITY; GENES; PHOSPHORYLATION; SYNTHESIS (CHEMICAL);

CELLULAR EFFECTS; ENDOPLASMIC RETICULUM KINASE (PERK); PROTEIN SYNTHESIS INHIBITION; SALICYLIC ACID;

ENZYME INHIBITION;

ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; PROTEIN KINASE R; SALICYLIC ACID DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; DDIT3 PROTEIN, HUMAN; ERN2 PROTEIN, HUMAN; INITIATION FACTOR 2; MEMBRANE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PERK KINASE; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EXPOSURE; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FIBROBLAST; GENE DELETION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; RNA TRANSLATION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL LINE; ENZYMOLOGY; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN SYNTHESIS;

EUKARYOTA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CELL LINE; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; EUKARYOTIC INITIATION FACTOR-2; FIBROBLASTS; HUMANS; MEMBRANE PROTEINS; MICE; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION FACTOR CHOP;

EID: 34249857603     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609996200     Document Type: Article

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