Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1

Journal of Cell Science

Volumn 120, Issue 9, 2007, Pages 1681-1688

  Oikawa, Daisuke ^a   Kimata, Yuklo ^a   Kohno, Kenji ^a  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Endplasmic reticulum; Misfolded proteins; Molecular chaperone; Stress response; Unfolded protein response

Indexed keywords

ARGININE; GLUCOSE REGULATED PROTEIN 78; LYSINE; PROTEIN IRE1;

AMINO TERMINAL SEQUENCE; ARTICLE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN SECRETION; SACCHAROMYCES CEREVISIAE;

AMINO ACID SUBSTITUTION; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BINDING SITES; ENDOPLASMIC RETICULUM; HSP70 HEAT-SHOCK PROTEINS; IMMUNOPRECIPITATION; LAC OPERON; MEMBRANE GLYCOPROTEINS; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TUNICAMYCIN;

SACCHAROMYCES CEREVISIAE;

EID: 34249707984     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.002808     Document Type: Article

References (36)

1. Bader, M. W., Sanowar, S., Daley, M. E., Schneider, A. R, Cho, U., Xu, W., Klevit, R. E., Le Moual, H. and Miller, S. I. (2005). Recognition of antimicrobial peptides by a bacterial sensor kinase. Cell 122, 461-472.
2. Bertolotti, A., Zhang, Y, Hendershot, L. M., Harding, H. P. and Ron, D. (2000). Dynamic interaction of BiP and ER strew transducers in the unfolded-protein response. Nat. Cell. Biol. 2, 326-332.
3. Calfon, M., Zeng, H.. Urano, F., Till, J. H., Hubbard, S. R., Harding, H. P., Clark, S. G. and Ron, D. (2002). IRE1 couples endoplasmic reticulurn load to secretory capacity by processing the XBP-1 mRNA. Nature 415, 92-96.
4. Christianson, T. W, Sikorski, R. S., Dante, M., Shero, J. H. and Hieter, P. (1992). Multifunctional yeast high-copy-number shuttle vectors. Gene 110, 119-122.
5. Collart, M. A. and Oliviero, S. (1993). In Current Protocols in Molecular Biology (ed. F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smoth and K. Struhl), pp. 13.12.1-13.122. New York: Greene Publishing Associates.
6. Cox, J. S. and Walter, P. (1996). A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87, 391-404.
7. Cox, J. S.. Shamu, C. E. and Walter, P. (1993). Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73, 1197-1206.
8. Credle, J. J., Finer-Moore, J. S., Papa, F. R., Stroud, R. M. and Walter, P. (2005). On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 102, 18773-18784.
9. Harding, H. P.. Zhang, Y. and Ron, D. (1999). Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397, 271-274.
10. Iwawaki, T., Hosoda, A., Okuda, T., Kamigori, Y., Nomura-Furuwatari, C., Kimata, Y., Tsuru, A. and Kohno, K. (2001). Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER strew. Nat. Cell Biol. 3, 158-164.
11. Kaiser, C., Michaelis, S. and Mitchell, A. (1994). Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
12. Kawahara, T., Yanagi, H., Yura, T. and Mori, K. (1998). Unconventional splicing of HAC1/ERN4 mRNA required for the unfolded protein response. Sequence-specific and non-sequential cleavage of the splice sites. J. Biol. Chem. 273, 1802-1807.
13. Kimata, Y., Khania, Y. I., Shimizu, Y., Abe, H., Farcasanu, I. C., Takeuchi, M., Rose, M. D. and Kohno, K. (2003). Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins. Mol. Biol. Cell 14, 2559-2569.
14. Kimata, Y.. Oikawa, D, Shimizu, Y., Ishiwata-Kimata. Y. and Kohno, K. (2004). A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1. J. Cell Biol. 167, 445456.
15. Kimata, Y., Ishiwata-Kimata, Y., Yamada, S. and Kohno, K. (W06). Yeast unfolded protein response pathway regulates expression of genes for anti-oxidative stress and for cell surface proteins. Genes Cells 11, 56-69.
16. Kohno, K., Normington, K., Sambrook, J., Gething, M. J. and Mori, K. (1993). The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum. Mol. Cell. Biol. 13, 877-890.
17. Liu, C. Y., Wong, H. N., Schauerte, J. A. and Kaufman, R. J. (2002). The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. J. Biol. Chem. 277. 18346-18356.
18. Livnah, O., Johnson, D. L., Stura, E. A., Farrell, F. X., Barbone, F. P., You, Y., Liu, K. D., Goldsmith, M. A., He, W., Krause, C. D. et al. (1998). An antagonist peptide-EPO receptor complex suggests that receptor dimenzation is not sufficient for activation. Nat. Struct. Biol. 5, 993-1004.
19. Livnah, O., Stura, E. A., Middleton, S. A., Johnson, D. L., Jolliffe, L. K. and Wilson, I. A. (1999). Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 283, 987-990.
20. Mori, K., Sant, A., Kohno, K., Normington, K., Gething, M. J. and Sambrook, J. F. (1992). A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins. EMBO J. 11, 2583-2593.
21. Mori, K., Ma, W., Gething, M. J. and Sambrook, J. (1993). A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell 74, 743-756.
22. Mori, K., Kawahara, T., Yoshida, H., Yanagi, H. and Yura, T. (1996). Signalling from endoplasmic reticulum, to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway. Genes Cells 1, 803-817.
23. Oikawa, D, Kimatat Y., Takeuchi, M. and Kohno, K. (2005). An essential dimerforming subregion of the endoplasmic reticulum stress sensor Ire1. Biochem. J. 391, 135-142.
24. Okamura, K., Kimata, Y., Higashio, H., Tsuru, A. and Kohno, K. (2000). Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast. Biochem. Biophys. Res. Commun. 279, 445-450.
25. Papa, F. R., Zhang, C., Shokat, K. and Walter, P. (2003). Bypassing a kinase activity with an ATP-competitive drug. Science 302, 1533-1537.
26. Remy, I. Wilson, I. A. and Michnick, S. W. (1999). Erythropoietin receptor activation by a ligand-induced conformation change. Science 283, 990-993.
27. Shamu, C. E. and Walter, P. (1996). Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J. 15, 3028-3039.
28. Sidrauski, C. and Walter, P. (1997).The trasmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90, 1031-1039.
29. Sikorski, R. S. and Hieter, P. (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
30. Takeuchi, M., Kimata, Y., Hirata, A., Oka, M. and Kohno, K. (2006). Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding. J. Biochem. (Tokyo) 139, 597-605.
31. Tirasophon, W., Welihinda, A. A. and Kaufman, R. J. (1998). A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12. 1812-1824.
32. Travers, K. J., Patil, C. K., Wodicka, L., Lockhart, D. J., Weissman, J. S. and Walter, P. (2000). Functional and genomic, analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101, 249-258.
33. Wang, X. Z., Harding, H. P., Zhang, Y., Jolicoeur, E. M., Kuroda, M. and Ron, D. (1998). Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17, 5708-5717.
34. Yoshida, H., Haze, K., Yanagi H., Yura, T. and Mori, K. (1998). Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J. Biol. Chem. 273, 33741-337490
35. Yoshida, H., Matsui, T., Yamamoto, A., Okada, T. and Mori, K. (2001). XBPI mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881-891.
36. Zhou, J., Lia, C. Y., Back, S. H., Clark, R. L., Peisach, D., Xu, Z. and Kaufman, R. J. (2006). The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc. Natl. Acad. Sci. USA 103, 14343-14348.