Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through sirt1-mediated deacetylation

Stem Cells

Volumn 32, Issue 1, 2014, Pages 157-165

  Zhang, Zhen Ning ^a   Chung, Sun Ku ^a   Xu, Zheng ^a   Xu, Yang ^a  

^a SECTION OF MOLECULAR BIOLOGY   (United States)

Author keywords

Acetylation; Differentiation; DNA damage response; Human ESCs; P53; Pluripotency

Indexed keywords

LEFT RIGHT DETERMINATION FACTOR; MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 4; OSTEOPONTIN; PROTEIN P53; SIRTUIN 1; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR GATA 6;

ACETYLATION; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; DEACETYLATION; DNA DAMAGE; EMBRYONIC STEM CELL; GENE SILENCING; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; LOXP SITE; PLURIPOTENT STEM CELL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; REGULATORY MECHANISM;

ACETYLATION; DIFFERENTIATION; DNA DAMAGE RESPONSE; HUMAN ESCS; P53; PLURIPOTENCY;

ACETYLATION; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; DNA DAMAGE; EMBRYONIC STEM CELLS; GENE KNOCKOUT TECHNIQUES; HUMANS; OCTAMER TRANSCRIPTION FACTOR-3; PLURIPOTENT STEM CELLS; SIRTUIN 1; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84891823754     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1532     Document Type: Article

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