-
1
-
-
84898017417
-
Huntington disease: natural history, biomarkers and prospects for therapeutics
-
Ross CA, Aylward EH, Wild EJ, et al. Huntington disease: natural history, biomarkers and prospects for therapeutics. Nat Rev Neurol 2014;10:204–216.
-
(2014)
Nat Rev Neurol
, vol.10
, pp. 204-216
-
-
Ross, C.A.1
Aylward, E.H.2
Wild, E.J.3
-
2
-
-
84855563516
-
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
-
Jeong H, Cohen DE, Cui L, et al. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med 2011;18:159–165.
-
(2011)
Nat Med
, vol.18
, pp. 159-165
-
-
Jeong, H.1
Cohen, D.E.2
Cui, L.3
-
3
-
-
84855544817
-
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
-
Jiang M, Wang J, Fu J, et al. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med 2011;18:153–158.
-
(2011)
Nat Med
, vol.18
, pp. 153-158
-
-
Jiang, M.1
Wang, J.2
Fu, J.3
-
4
-
-
84893459319
-
SIRT1 in neurodevelopment and brain senescence
-
Herskovits AZ, Guarente L. SIRT1 in neurodevelopment and brain senescence. Neuron 2014;81:471–483.
-
(2014)
Neuron
, vol.81
, pp. 471-483
-
-
Herskovits, A.Z.1
Guarente, L.2
-
5
-
-
84896739647
-
Small molecule SIRT1 activators for the treatment of aging and age-related diseases
-
Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci 2014;35:146–154.
-
(2014)
Trends Pharmacol Sci
, vol.35
, pp. 146-154
-
-
Hubbard, B.P.1
Sinclair, D.A.2
-
6
-
-
84874721105
-
Evidence for a common mechanism of SIRT1 regulation by allosteric activators
-
Hubbard BP, Gomes AP, Dai H, et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science 2013;339:1216–1219.
-
(2013)
Science
, vol.339
, pp. 1216-1219
-
-
Hubbard, B.P.1
Gomes, A.P.2
Dai, H.3
-
7
-
-
84879613312
-
Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol
-
Lakshminarasimhan M, Curth U, Moniot S, et al. Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol. Biosci Rep 2013;33:395–404.
-
(2013)
Biosci Rep
, vol.33
, pp. 395-404
-
-
Lakshminarasimhan, M.1
Curth, U.2
Moniot, S.3
-
8
-
-
84895925833
-
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
-
Mitchell SJ, Martin-Montalvo A, Mercken EM, et al. The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Rep 2014;6:836–843.
-
(2014)
Cell Rep
, vol.6
, pp. 836-843
-
-
Mitchell, S.J.1
Martin-Montalvo, A.2
Mercken, E.M.3
-
9
-
-
84877994005
-
A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration
-
Graff J, Kahn M, Samiei A, et al. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci 2013;33:8951–8960.
-
(2013)
J Neurosci
, vol.33
, pp. 8951-8960
-
-
Graff, J.1
Kahn, M.2
Samiei, A.3
-
10
-
-
84887936276
-
The identification of the SIRT1 activator SRT2104 as a clinical candidate
-
Ng PY, Bemis JE, Disch JS, et al. The identification of the SIRT1 activator SRT2104 as a clinical candidate. Lett Drug Des Discov 2013;10:793–797.
-
(2013)
Lett Drug Des Discov
, vol.10
, pp. 793-797
-
-
Ng, P.Y.1
Bemis, J.E.2
Disch, J.S.3
-
11
-
-
84871118476
-
Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man
-
Hoffmann E, Wald J, Lavu S, et al. Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man. Br J Clin Pharmacol 2012;75:186–196.
-
(2012)
Br J Clin Pharmacol
, vol.75
, pp. 186-196
-
-
Hoffmann, E.1
Wald, J.2
Lavu, S.3
-
12
-
-
84871431259
-
A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers
-
Libri V, Brown AP, Gambarota G, et al. A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers. PLoS One 2013;7:e51395.
-
(2013)
PLoS One
, vol.7
-
-
Libri, V.1
Brown, A.P.2
Gambarota, G.3
-
13
-
-
0037418339
-
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
-
Duan W, Guo Z, Jiang H, et al. Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci USA 2003;100:2911–2916.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2911-2916
-
-
Duan, W.1
Guo, Z.2
Jiang, H.3
-
14
-
-
84878481329
-
Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease
-
Jiang M, Peng Q, Liu X, et al. Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum Mol Genet 2013;22:2462–2470.
-
(2013)
Hum Mol Genet
, vol.22
, pp. 2462-2470
-
-
Jiang, M.1
Peng, Q.2
Liu, X.3
-
15
-
-
79955466394
-
Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model
-
Cheng Y, Peng Q, Hou Z, et al. Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model. Neuroimage 2011;56:1027–1034.
-
(2011)
Neuroimage
, vol.56
, pp. 1027-1034
-
-
Cheng, Y.1
Peng, Q.2
Hou, Z.3
-
16
-
-
16844375290
-
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
-
Parker JA, Arango M, Abderrahmane S, et al. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat Genet 2005;37:349–350.
-
(2005)
Nat Genet
, vol.37
, pp. 349-350
-
-
Parker, J.A.1
Arango, M.2
Abderrahmane, S.3
-
17
-
-
84899965665
-
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease
-
Smith MR, Syed A, Lukacsovich T, et al. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. Hum Mol Genet 2014;23:2995–3007.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 2995-3007
-
-
Smith, M.R.1
Syed, A.2
Lukacsovich, T.3
-
18
-
-
78649738291
-
SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310
-
Rothgiesser KM, Erener S, Waibel S, et al. SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310. J Cell Sci 2010;123:4251–4258.
-
(2010)
J Cell Sci
, vol.123
, pp. 4251-4258
-
-
Rothgiesser, K.M.1
Erener, S.2
Waibel, S.3
-
19
-
-
77952413052
-
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
-
Luthi-Carter R, Taylor DM, Pallos J, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci USA 2010;107:7927–7932.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 7927-7932
-
-
Luthi-Carter, R.1
Taylor, D.M.2
Pallos, J.3
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