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Volumn 1, Issue 12, 2014, Pages 1047-1052

Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVATOR; SIRTUIN 1; SRT2104; UNCLASSIFIED DRUG;

EID: 84938685650     PISSN: None     EISSN: 23289503     Source Type: Journal    
DOI: 10.1002/acn3.135     Document Type: Article
Times cited : (46)

References (19)
  • 1
    • 84898017417 scopus 로고    scopus 로고
    • Huntington disease: natural history, biomarkers and prospects for therapeutics
    • Ross CA, Aylward EH, Wild EJ, et al. Huntington disease: natural history, biomarkers and prospects for therapeutics. Nat Rev Neurol 2014;10:204–216.
    • (2014) Nat Rev Neurol , vol.10 , pp. 204-216
    • Ross, C.A.1    Aylward, E.H.2    Wild, E.J.3
  • 2
    • 84855563516 scopus 로고    scopus 로고
    • Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
    • Jeong H, Cohen DE, Cui L, et al. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med 2011;18:159–165.
    • (2011) Nat Med , vol.18 , pp. 159-165
    • Jeong, H.1    Cohen, D.E.2    Cui, L.3
  • 3
    • 84855544817 scopus 로고    scopus 로고
    • Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
    • Jiang M, Wang J, Fu J, et al. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med 2011;18:153–158.
    • (2011) Nat Med , vol.18 , pp. 153-158
    • Jiang, M.1    Wang, J.2    Fu, J.3
  • 4
    • 84893459319 scopus 로고    scopus 로고
    • SIRT1 in neurodevelopment and brain senescence
    • Herskovits AZ, Guarente L. SIRT1 in neurodevelopment and brain senescence. Neuron 2014;81:471–483.
    • (2014) Neuron , vol.81 , pp. 471-483
    • Herskovits, A.Z.1    Guarente, L.2
  • 5
    • 84896739647 scopus 로고    scopus 로고
    • Small molecule SIRT1 activators for the treatment of aging and age-related diseases
    • Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci 2014;35:146–154.
    • (2014) Trends Pharmacol Sci , vol.35 , pp. 146-154
    • Hubbard, B.P.1    Sinclair, D.A.2
  • 6
    • 84874721105 scopus 로고    scopus 로고
    • Evidence for a common mechanism of SIRT1 regulation by allosteric activators
    • Hubbard BP, Gomes AP, Dai H, et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science 2013;339:1216–1219.
    • (2013) Science , vol.339 , pp. 1216-1219
    • Hubbard, B.P.1    Gomes, A.P.2    Dai, H.3
  • 7
    • 84879613312 scopus 로고    scopus 로고
    • Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol
    • Lakshminarasimhan M, Curth U, Moniot S, et al. Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol. Biosci Rep 2013;33:395–404.
    • (2013) Biosci Rep , vol.33 , pp. 395-404
    • Lakshminarasimhan, M.1    Curth, U.2    Moniot, S.3
  • 8
    • 84895925833 scopus 로고    scopus 로고
    • The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
    • Mitchell SJ, Martin-Montalvo A, Mercken EM, et al. The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Rep 2014;6:836–843.
    • (2014) Cell Rep , vol.6 , pp. 836-843
    • Mitchell, S.J.1    Martin-Montalvo, A.2    Mercken, E.M.3
  • 9
    • 84877994005 scopus 로고    scopus 로고
    • A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration
    • Graff J, Kahn M, Samiei A, et al. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci 2013;33:8951–8960.
    • (2013) J Neurosci , vol.33 , pp. 8951-8960
    • Graff, J.1    Kahn, M.2    Samiei, A.3
  • 10
    • 84887936276 scopus 로고    scopus 로고
    • The identification of the SIRT1 activator SRT2104 as a clinical candidate
    • Ng PY, Bemis JE, Disch JS, et al. The identification of the SIRT1 activator SRT2104 as a clinical candidate. Lett Drug Des Discov 2013;10:793–797.
    • (2013) Lett Drug Des Discov , vol.10 , pp. 793-797
    • Ng, P.Y.1    Bemis, J.E.2    Disch, J.S.3
  • 11
    • 84871118476 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man
    • Hoffmann E, Wald J, Lavu S, et al. Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man. Br J Clin Pharmacol 2012;75:186–196.
    • (2012) Br J Clin Pharmacol , vol.75 , pp. 186-196
    • Hoffmann, E.1    Wald, J.2    Lavu, S.3
  • 12
    • 84871431259 scopus 로고    scopus 로고
    • A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers
    • Libri V, Brown AP, Gambarota G, et al. A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers. PLoS One 2013;7:e51395.
    • (2013) PLoS One , vol.7
    • Libri, V.1    Brown, A.P.2    Gambarota, G.3
  • 13
    • 0037418339 scopus 로고    scopus 로고
    • Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
    • Duan W, Guo Z, Jiang H, et al. Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci USA 2003;100:2911–2916.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2911-2916
    • Duan, W.1    Guo, Z.2    Jiang, H.3
  • 14
    • 84878481329 scopus 로고    scopus 로고
    • Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease
    • Jiang M, Peng Q, Liu X, et al. Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum Mol Genet 2013;22:2462–2470.
    • (2013) Hum Mol Genet , vol.22 , pp. 2462-2470
    • Jiang, M.1    Peng, Q.2    Liu, X.3
  • 15
    • 79955466394 scopus 로고    scopus 로고
    • Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model
    • Cheng Y, Peng Q, Hou Z, et al. Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model. Neuroimage 2011;56:1027–1034.
    • (2011) Neuroimage , vol.56 , pp. 1027-1034
    • Cheng, Y.1    Peng, Q.2    Hou, Z.3
  • 16
    • 16844375290 scopus 로고    scopus 로고
    • Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
    • Parker JA, Arango M, Abderrahmane S, et al. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat Genet 2005;37:349–350.
    • (2005) Nat Genet , vol.37 , pp. 349-350
    • Parker, J.A.1    Arango, M.2    Abderrahmane, S.3
  • 17
    • 84899965665 scopus 로고    scopus 로고
    • A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease
    • Smith MR, Syed A, Lukacsovich T, et al. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. Hum Mol Genet 2014;23:2995–3007.
    • (2014) Hum Mol Genet , vol.23 , pp. 2995-3007
    • Smith, M.R.1    Syed, A.2    Lukacsovich, T.3
  • 18
    • 78649738291 scopus 로고    scopus 로고
    • SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310
    • Rothgiesser KM, Erener S, Waibel S, et al. SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310. J Cell Sci 2010;123:4251–4258.
    • (2010) J Cell Sci , vol.123 , pp. 4251-4258
    • Rothgiesser, K.M.1    Erener, S.2    Waibel, S.3
  • 19
    • 77952413052 scopus 로고    scopus 로고
    • SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
    • Luthi-Carter R, Taylor DM, Pallos J, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci USA 2010;107:7927–7932.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7927-7932
    • Luthi-Carter, R.1    Taylor, D.M.2    Pallos, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.