-
1
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum H. A. and Guarente, L. (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
2
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina, B. and Helfand, S. L. (2004) Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101, 15998-16003.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
3
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., et al. (2004) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase, Science 305, 390-392.
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
-
4
-
-
80053168829
-
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
-
Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., et al. (2011) Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila, Nature, 477, 482-485.
-
(2011)
Nature
, vol.477
, pp. 482-485
-
-
Burnett, C.1
Valentini, S.2
Cabreiro, F.3
Goss, M.4
Somogyvári, M.5
-
5
-
-
0034705129
-
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
-
Landry, J., Sutton, A., Tafrov, S. T., Heller, R. C., Stebbins, J., et al. (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl. Acad. Sci. USA 97, 5807-5811.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5807-5811
-
-
Landry, J.1
Sutton, A.2
Tafrov, S.T.3
Heller, R.C.4
Stebbins, J.5
-
6
-
-
35748957521
-
Recent advances in the medicinal chemistry of histone deacetylase inhibitors
-
Brittain, W. H. and Ottow, E. (2007) Recent advances in the medicinal chemistry of histone deacetylase inhibitors. Ann. Rep. Med. Chem. 42, 337-348.
-
(2007)
Ann. Rep. Med. Chem.
, vol.42
, pp. 337-348
-
-
Brittain, W.H.1
Ottow, E.2
-
7
-
-
34249083199
-
Sirtuins in mammals: insights into their biological function
-
Michan, S. and Sinclair, D. (2007) Sirtuins in mammals: insights into their biological function. Biochem. J. 404, 1-13.
-
(2007)
Biochem. J.
, vol.404
, pp. 1-13
-
-
Michan, S.1
Sinclair, D.2
-
8
-
-
0035913903
-
hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri, H., Dessain, S. K., Ng Eaton, E., Imai, S. I., Frye, R. A., et al. (2001) hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159.
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
Imai, S.I.4
Frye, R.A.5
-
9
-
-
0037291214
-
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
-
North, B. J., Marshall, B. L., Borra, M. T., Denu, J. M., Verdin, E. (2003) The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol. Cell. 11, 437-444.
-
(2003)
Mol. Cell.
, vol.11
, pp. 437-444
-
-
North, B.J.1
Marshall, B.L.2
Borra, M.T.3
Denu, J.M.4
Verdin, E.5
-
10
-
-
39149122568
-
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis
-
North, B. J. and Verdin, E. (2007) Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One 2, e784.
-
(2007)
PLoS One
, vol.2
-
-
North, B.J.1
Verdin, E.2
-
11
-
-
34250365395
-
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
-
Tanno, M., Sakamoto, J., Miura, T., Shimamoto, K., and Horio, Y. (2007) Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J. Biol. Chem. 282, 6823-6832.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 6823-6832
-
-
Tanno, M.1
Sakamoto, J.2
Miura, T.3
Shimamoto, K.4
Horio, Y.5
-
12
-
-
33744466971
-
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
-
Ford, E., Voit, R., Liszt, G., Magin, C., Grummt, I., et al. (2006) Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription, Genes. Dev. 20, 1075-1080.
-
(2006)
Genes. Dev.
, vol.20
, pp. 1075-1080
-
-
Ford, E.1
Voit, R.2
Liszt, G.3
Magin, C.4
Grummt, I.5
-
13
-
-
39049184073
-
Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene
-
Mahlknecht, U., Ho, A. D., and Voelter-Mahlknecht, S. (2006) Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene, Int. J. Oncol. 28, 447-456.
-
(2006)
Int. J. Oncol.
, vol.28
, pp. 447-456
-
-
Mahlknecht, U.1
Ho, A.D.2
Voelter-Mahlknecht, S.3
-
14
-
-
77956462423
-
Role of Sirtuin 1 in metabolic regulation
-
Silva, J. P. and Wahlestedt, C. (2010) Role of Sirtuin 1 in metabolic regulation. Drug Discov. Today 15, 781-791.
-
(2010)
Drug Discov. Today
, vol.15
, pp. 781-791
-
-
Silva, J.P.1
Wahlestedt, C.2
-
15
-
-
18144411313
-
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
-
Nemoto, S., Fergusson, M. M., and Finkel, T. (2005) SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J. Biol. Chem. 280, 16456-16460.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 16456-16460
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
16
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., et al. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434, 113-118.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
-
17
-
-
54049158932
-
Brain SIRT1: anatomical distribution and regulation by energy availability
-
Ramadori, G., Lee, C. E., Bookout, A. L., Lee, S., Williams, K. W., et al. (2008) Brain SIRT1: anatomical distribution and regulation by energy availability. J. Neurosci. 28, 9989-9996.
-
(2008)
J. Neurosci.
, vol.28
, pp. 9989-9996
-
-
Ramadori, G.1
Lee, C.E.2
Bookout, A.L.3
Lee, S.4
Williams, K.W.5
-
18
-
-
77956644726
-
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
-
Ramadori, G., Fujikawa, T., Fukuda, M., Anderson, J., Morgan, D. A., et al. (2010) SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab. 12, 78-87.
-
(2010)
Cell Metab.
, vol.12
, pp. 78-87
-
-
Ramadori, G.1
Fujikawa, T.2
Fukuda, M.3
Anderson, J.4
Morgan, D.A.5
-
19
-
-
84655167647
-
Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity
-
Clark, S. J., Falchi, M., Olsson, B., Jacobson, P., Cauchi, S., et al. (2012) Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity. Obesity (Silver Spring) 20, 178-185.
-
(2012)
Obesity (Silver Spring)
, vol.20
, pp. 178-185
-
-
Clark, S.J.1
Falchi, M.2
Olsson, B.3
Jacobson, P.4
Cauchi, S.5
-
20
-
-
29744463503
-
Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
-
Flachsbart, F., Croucher, P. J., Nikolaus, S., Hampe, J., Cordes, C., et al. (2006) Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity. Exp. Gerontol. 41, 98-102.
-
(2006)
Exp. Gerontol.
, vol.41
, pp. 98-102
-
-
Flachsbart, F.1
Croucher, P.J.2
Nikolaus, S.3
Hampe, J.4
Cordes, C.5
-
21
-
-
67650563916
-
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer
-
Kabra, N., Li, Z., Chen, L., Li, B., Zhang, X., et al. (2009) SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J. Biol. Chem. 284, 18210-18217.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 18210-18217
-
-
Kabra, N.1
Li, Z.2
Chen, L.3
Li, B.4
Zhang, X.5
-
23
-
-
79959866409
-
Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network
-
Audrito, V., Vaisitti, T., Rossi, D., Gottardi, D., D'Arena, G., et al. (2011) Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network. Cancer Res. 71, 4473-4483.
-
(2011)
Cancer Res.
, vol.71
, pp. 4473-4483
-
-
Audrito, V.1
Vaisitti, T.2
Rossi, D.3
Gottardi, D.4
D'Arena, G.5
-
24
-
-
53149137486
-
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
-
Wang, R. H., Sengupta, K., Li, C., Kim, H. S., Cao, L., et al. (2008) Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 14, 312-323.
-
(2008)
Cancer Cell.
, vol.14
, pp. 312-323
-
-
Wang, R.H.1
Sengupta, K.2
Li, C.3
Kim, H.S.4
Cao, L.5
-
25
-
-
33847793039
-
Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin
-
Li, W., Zhang, B., Tang, J., Cao, Q., Wu, Y., et al. (2007) Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin. J. Neurosci. 27, 2606-2616.
-
(2007)
J. Neurosci.
, vol.27
, pp. 2606-2616
-
-
Li, W.1
Zhang, B.2
Tang, J.3
Cao, Q.4
Wu, Y.5
-
26
-
-
0037405043
-
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
-
Dryden, S. C., Nahhas, F. A., Nowak, J. E., Goustin, A. S., and Tainsky, M. A. (2003) Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol. Cell. Biol. 23, 3173-3185.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 3173-3185
-
-
Dryden, S.C.1
Nahhas, F.A.2
Nowak, J.E.3
Goustin, A.S.4
Tainsky, M.A.5
-
27
-
-
0041829415
-
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene
-
Hiratsuka, M., Inoue, T., Toda, T., Kimura, N., Shirayoshi, Y., et al. (2003) Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem. Biophys. Res. Commun. 309, 558-566.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.309
, pp. 558-566
-
-
Hiratsuka, M.1
Inoue, T.2
Toda, T.3
Kimura, N.4
Shirayoshi, Y.5
-
28
-
-
80054769188
-
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
-
Kim, H. S., Vassilopoulos, A., Wang, R. H., Lahusen, T., Xiao, Z., et al. (2011) SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell 20, 487-499.
-
(2011)
Cancer Cell
, vol.20
, pp. 487-499
-
-
Kim, H.S.1
Vassilopoulos, A.2
Wang, R.H.3
Lahusen, T.4
Xiao, Z.5
-
29
-
-
78649328799
-
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
-
Verdin, E., Hirschey, M. D., Finley, L. W., and Haigis, M. C. (2010) Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem. Sci. 35, 669-675.
-
(2010)
Trends Biochem. Sci.
, vol.35
, pp. 669-675
-
-
Verdin, E.1
Hirschey, M.D.2
Finley, L.W.3
Haigis, M.C.4
-
30
-
-
19944433088
-
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
-
Bellizzi, D., Rose, G., Cavalcante, P., Covello, G., Dato, S., et al. (2005) A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 85, 258-263.
-
(2005)
Genomics
, vol.85
, pp. 258-263
-
-
Bellizzi, D.1
Rose, G.2
Cavalcante, P.3
Covello, G.4
Dato, S.5
-
31
-
-
79958041304
-
Fine tuning our cellular factories: sirtuins in mitochondrial biology
-
Zhong, L. and Mostoslavsky, R. (2011) Fine tuning our cellular factories: sirtuins in mitochondrial biology. Cell Metab. 13, 621-626.
-
(2011)
Cell Metab.
, vol.13
, pp. 621-626
-
-
Zhong, L.1
Mostoslavsky, R.2
-
32
-
-
77953285831
-
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia
-
Gertz, M. and Steegborn, C. (2010) Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia. Biochim. Biophys. Acta. 1804, 1658-1665.
-
(2010)
Biochim. Biophys. Acta.
, vol.1804
, pp. 1658-1665
-
-
Gertz, M.1
Steegborn, C.2
-
33
-
-
79959363092
-
SIRT6 promotes DNA repair under stress by activating PARP1
-
Mao, Z., Hine, C., Tian, X., Van Meter, M., Au, M., et al. (2011) SIRT6 promotes DNA repair under stress by activating PARP1. Science 332, 1443-1446.
-
(2011)
Science
, vol.332
, pp. 1443-1446
-
-
Mao, Z.1
Hine, C.2
Tian, X.3
Van Meter, M.4
Au, M.5
-
34
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., et al. (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315-329.
-
(2006)
Cell
, vol.124
, pp. 315-329
-
-
Mostoslavsky, R.1
Chua, K.F.2
Lombard, D.B.3
Pang, W.W.4
Fischer, M.R.5
-
35
-
-
80052908853
-
SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells
-
Van Meter, M., Mao, Z., Gorbunova, V., and Seluanov, A. (2011) SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle 10, 3153-3158.
-
(2011)
Cell Cycle
, vol.10
, pp. 3153-3158
-
-
Van Meter, M.1
Mao, Z.2
Gorbunova, V.3
Seluanov, A.4
-
36
-
-
64049090625
-
Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging
-
Vakhrusheva, O., Braeuer, D., Liu, Z., Braun, T., and Bober, E. (2008) Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging. J. Physiol. Pharmacol. 59, 201-212.
-
(2008)
J. Physiol. Pharmacol.
, vol.59
, pp. 201-212
-
-
Vakhrusheva, O.1
Braeuer, D.2
Liu, Z.3
Braun, T.4
Bober, E.5
-
37
-
-
41449083867
-
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
-
Vakhrusheva, O., Smolka, C., Gajawada, P., Kostin, S., Boettger, T., et al. (2008) Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ. Res. 102, 703-710.
-
(2008)
Circ. Res.
, vol.102
, pp. 703-710
-
-
Vakhrusheva, O.1
Smolka, C.2
Gajawada, P.3
Kostin, S.4
Boettger, T.5
-
38
-
-
84861140340
-
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription
-
Tsai, Y. C., Greco, T. M., Boonmee, A., Miteva, Y., and Cristea, I. M. (2012) Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol. Cell. Proteomics 11, M111 015156.
-
(2012)
Mol. Cell. Proteomics
, vol.11
-
-
Tsai, Y.C.1
Greco, T.M.2
Boonmee, A.3
Miteva, Y.4
Cristea, I.M.5
-
39
-
-
84867709427
-
-
(Fahy, G. M., West, M. D., Harris, S. B., eds.)., Springer, Heidelberg, London, New York.
-
Alcain, F. J., Minor, R. K., Villalba, J. M., and de Cabo, R. (2010) In The Future of Aging. Small Molecule Modulators of Sirtuin Activity. (Fahy, G. M., West, M. D., Harris, S. B., eds.). pp. 331-356, Springer, Heidelberg, London, New York.
-
(2010)
The Future of Aging. Small Molecule Modulators of Sirtuin Activity
, pp. 331-356
-
-
Alcain, F.J.1
Minor, R.K.2
Villalba, J.M.3
de Cabo, R.4
-
40
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin, S. J., Defossez, P. A., and Guarente, L. (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-2128.
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
41
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196.
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
-
42
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
-
Helfand, S. L.
-
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., and Helfand, S. L. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686-689.
-
(2004)
Nature
, vol.430
, pp. 686-689
-
-
Wood, J.G.1
Rogina, B.2
Lavu, S.3
Howitz, K.4
-
43
-
-
49649128314
-
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart
-
Barger, J. L., Kayo, T., Pugh, T. D., Prolla, T. A., and Weindruch, R. (2008) Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp. Gerontol. 43, 859-866.
-
(2008)
Exp. Gerontol.
, vol.43
, pp. 859-866
-
-
Barger, J.L.1
Kayo, T.2
Pugh, T.D.3
Prolla, T.A.4
Weindruch, R.5
-
44
-
-
48349144852
-
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
-
Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., et al. (2008) Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 8, 157-168.
-
(2008)
Cell Metab.
, vol.8
, pp. 157-168
-
-
Pearson, K.J.1
Baur, J.A.2
Lewis, K.N.3
Peshkin, L.4
Price, N.L.5
-
45
-
-
33746824192
-
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
-
Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., et al. (2006) Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J. Biol. Chem. 281, 21745-21754.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 21745-21754
-
-
Qin, W.1
Yang, T.2
Ho, L.3
Zhao, Z.4
Wang, J.5
-
46
-
-
34447308268
-
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
-
Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., et al. (2007) SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis, EMBO J. 26, 3169-3179.
-
(2007)
EMBO J.
, vol.26
, pp. 3169-3179
-
-
Kim, D.1
Nguyen, M.D.2
Dobbin, M.M.3
Fischer, A.4
Sananbenesi, F.5
-
48
-
-
79959261445
-
What is new for an old molecule? Systematic review and recommendations on the use of resveratrol
-
Vang, O., Ahmad, N., Baile, C. A., Baur, J. A., Brown, K., et al. (2011) What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS One 6, e19881.
-
(2011)
PLoS One
, vol.6
-
-
Vang, O.1
Ahmad, N.2
Baile, C.A.3
Baur, J.A.4
Brown, K.5
-
49
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342.
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
-
50
-
-
80455143206
-
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
-
Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., et al. (2011) Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 14, 612-622.
-
(2011)
Cell Metab.
, vol.14
, pp. 612-622
-
-
Timmers, S.1
Konings, E.2
Bilet, L.3
Houtkooper, R.H.4
van de Weijer, T.5
-
51
-
-
84950170835
-
Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure
-
Wong, R. H., Howe, P. R., Buckley, J. D., Coates, A. M., Kunz, I., et al. (2011) Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr. Metab. Cardiovasc. Dis. 21, 851-856.
-
(2011)
Nutr. Metab. Cardiovasc. Dis.
, vol.21
, pp. 851-856
-
-
Wong, R.H.1
Howe, P.R.2
Buckley, J.D.3
Coates, A.M.4
Kunz, I.5
-
52
-
-
82455220960
-
Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment
-
Fujitaka, K., Otani, H., Jo, F., Jo, H., Nomura, E., et al. (2011) Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment. Nutr. Res. 31, 842-847.
-
(2011)
Nutr. Res.
, vol.31
, pp. 842-847
-
-
Fujitaka, K.1
Otani, H.2
Jo, F.3
Jo, H.4
Nomura, E.5
-
53
-
-
63549094179
-
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
-
Smith, J. J., Kenney, R. D., Gagne, D. J., Frushour, B. P., Ladd, W., et al. (2009) Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst. Biol. 3, 31.
-
(2009)
BMC Syst. Biol.
, vol.3
, pp. 31
-
-
Smith, J.J.1
Kenney, R.D.2
Gagne, D.J.3
Frushour, B.P.4
Ladd, W.5
-
54
-
-
80052572943
-
Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases-safety, pharmacokinetics, and pharmacodynamics
-
Howells, L. M., Berry, D. P., Elliott, P. J., Jacobson, E. W., Hoffmann, E., et al. (2011) Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases-safety, pharmacokinetics, and pharmacodynamics. Cancer Prev. Res. (Phila) 4, 1419-1425.
-
(2011)
Cancer Prev. Res. (Phila)
, vol.4
, pp. 1419-1425
-
-
Howells, L.M.1
Berry, D.P.2
Elliott, P.J.3
Jacobson, E.W.4
Hoffmann, E.5
-
55
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne, J. C., Lambert, P. D., Schenk, S., Carney, D. P., Smith, J. J., et al. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450, 712-716.
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
Carney, D.P.4
Smith, J.J.5
-
56
-
-
54849425547
-
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
-
Feige, J. N., Lagouge, M., Canto, C., Strehle, A., Houten, S. M., et al. (2008) Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 8, 347-358.
-
(2008)
Cell Metab.
, vol.8
, pp. 347-358
-
-
Feige, J.N.1
Lagouge, M.2
Canto, C.3
Strehle, A.4
Houten, S.M.5
-
57
-
-
77951049870
-
SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells
-
Funk, J. A., Odejinmi, S., and Schnellmann, R. G. (2010) SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. J. Pharmacol. Exp. Ther. 333, 593-601.
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.333
, pp. 593-601
-
-
Funk, J.A.1
Odejinmi, S.2
Schnellmann, R.G.3
-
58
-
-
70350452395
-
Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
-
Yamazaki, Y., Usui, I., Kanatani, Y., Matsuya, Y., Tsuneyama, K., et al. (2009) Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. Am. J. Physiol. Endocrinol. Metab. 297, E 1179-1186.
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.297
-
-
Yamazaki, Y.1
Usui, I.2
Kanatani, Y.3
Matsuya, Y.4
Tsuneyama, K.5
-
59
-
-
84859909860
-
-
SRT1720 suppresses apoptosis and restores a more normal gene expression profile indicative of reduced inflammation in the livers of mice fed a high-fat diet. Scientific Reports 1, 10.1038/srep00070.
-
Minor, R. K., Baur, J. A., Gomes, A. P., Ward, T. M., Csiszar, A., et al. (2011) SRT1720 suppresses apoptosis and restores a more normal gene expression profile indicative of reduced inflammation in the livers of mice fed a high-fat diet. Scientific Reports 1, 10.1038/srep00070.
-
(2011)
-
-
Minor, R.K.1
Baur, J.A.2
Gomes, A.P.3
Ward, T.M.4
Csiszar, A.5
-
60
-
-
81155148158
-
Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
-
Chauhan, D., Bandi, M., Singh, A. V., Ray, A., Raje, N., et al. (2011) Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. Br. J. Haematol. 155, 588-598.
-
(2011)
Br. J. Haematol.
, vol.155
, pp. 588-598
-
-
Chauhan, D.1
Bandi, M.2
Singh, A.V.3
Ray, A.4
Raje, N.5
-
61
-
-
63149150180
-
Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators
-
Bemis, J. E., Vu, C. B., Xie, R., Nunes, J. J., Ng, P. Y., et al. (2009) Discovery of oxazolo[4, 5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators. Bioorg. Med. Chem. Lett. 19, 2350-2353.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 2350-2353
-
-
Bemis, J.E.1
Vu, C.B.2
Xie, R.3
Nunes, J.J.4
Ng, P.Y.5
-
62
-
-
64349118889
-
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators
-
Vu, C. B., Bemis, J. E., Disch, J. S., Ng, P. Y., Nunes, J. J., et al. (2009) Discovery of imidazo[1, 2-b]thiazole derivatives as novel SIRT1 activators. J. Med. Chem. 52, 1275-1283.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 1275-1283
-
-
Vu, C.B.1
Bemis, J.E.2
Disch, J.S.3
Ng, P.Y.4
Nunes, J.J.5
-
63
-
-
84867737204
-
-
SRT2104, a novel and selective small molecule SIRT1 activator, inhibits DSS-induced colitis in a SIRT1-dependent manner, 10th World Congress on Inflammation, Paris.
-
Ellis, D. J. G. J. L., Suri, V., Cermak, J. M., Lyng, G. D., Guarente, L. P., and Vlasuk, G. P. (2011) SRT2104, a novel and selective small molecule SIRT1 activator, inhibits DSS-induced colitis in a SIRT1-dependent manner, 10th World Congress on Inflammation, Paris.
-
(2011)
-
-
Ellis, D.J.G.J.L.1
Suri, V.2
Cermak, J.M.3
Lyng, G.D.4
Guarente, L.P.5
Vlasuk, G.P.6
-
64
-
-
84876203344
-
-
The first demonstration of clinical activity by a small molecule sirt1 activator: srt2104 reduces cytokine release and coagulation activation in a human endotoxemia model., 10th World Congress on Inflammation, Paris.
-
Van Der Meer, A., Scicluna, B., Lin, J., Jacobson, E., Vlasuk, G. P., et al. (2011) The first demonstration of clinical activity by a small molecule sirt1 activator: srt2104 reduces cytokine release and coagulation activation in a human endotoxemia model., 10th World Congress on Inflammation, Paris.
-
(2011)
-
-
Van Der Meer, A.1
Scicluna, B.2
Lin, J.3
Jacobson, E.4
Vlasuk, G.P.5
-
65
-
-
33751560439
-
SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents
-
Nayagam, V. M., Wang, X., Tan, Y. C., Poulsen, A., Goh, K. C., et al. (2006) SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J. Biomol. Screen. 11, 959-967.
-
(2006)
J. Biomol. Screen.
, vol.11
, pp. 959-967
-
-
Nayagam, V.M.1
Wang, X.2
Tan, Y.C.3
Poulsen, A.4
Goh, K.C.5
-
66
-
-
69949096844
-
Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors
-
Mai, A., Valente, S., Meade, S., Carafa, V., Tardugno, M., et al. (2009) Study of 1, 4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. J. Med. Chem. 52, 5496-5504.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 5496-5504
-
-
Mai, A.1
Valente, S.2
Meade, S.3
Carafa, V.4
Tardugno, M.5
-
67
-
-
70350524083
-
Resveratrol is not a direct activator of SIRT1 enzyme activity
-
Beher, D., Wu, J., Cumine, S., Kim, K. W., Lu, S. C., et al. (2009) Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem. Biol. Drug Des. 74, 619-624.
-
(2009)
Chem. Biol. Drug Des.
, vol.74
, pp. 619-624
-
-
Beher, D.1
Wu, J.2
Cumine, S.3
Kim, K.W.4
Lu, S.C.5
-
68
-
-
20444444649
-
Mechanism of human SIRT1 activation by resveratrol
-
Borra, M. T., Smith, B. C., and Denu, J. M. (2005) Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 280, 17187-17195.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17187-17195
-
-
Borra, M.T.1
Smith, B.C.2
Denu, J.M.3
-
69
-
-
78650184332
-
SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183
-
Huber, J. L., Mcburney, M. W., Distefano, P. S., and Mcdonagh, T. (2010) SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183. Future Med. Chem. 2, 1751-1759.
-
(2010)
Future Med. Chem.
, vol.2
, pp. 1751-1759
-
-
Huber, J.L.1
Mcburney, M.W.2
Distefano, P.S.3
and Mcdonagh, T.4
-
70
-
-
20444431507
-
Substrate-specific activation of sirtuins by resveratrol
-
Kaeberlein, M., Mcdonagh, T., Heltweg, B., Hixon, J., Westman, E. A., et al. (2005) Substrate-specific activation of sirtuins by resveratrol. J. Biol. Chem. 280, 17038-17045.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17038-17045
-
-
Kaeberlein, M.1
Mcdonagh, T.2
Heltweg, B.3
Hixon, J.4
Westman, E.A.5
-
71
-
-
77950246109
-
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
-
Pacholec, M., Bleasdale, J. E., Chrunyk, B., Cunningham, D., Flynn, D., et al. (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J. Biol. Chem. 285, 8340-8351.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 8340-8351
-
-
Pacholec, M.1
Bleasdale, J.E.2
Chrunyk, B.3
Cunningham, D.4
Flynn, D.5
-
72
-
-
40849135481
-
The Sirtuin family: therapeutic targets to treat diseases of aging
-
Milne, J. C. and Denu, J. M. (2008) The Sirtuin family: therapeutic targets to treat diseases of aging. Curr. Opin. Chem. Biol. 12, 11-17.
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 11-17
-
-
Milne, J.C.1
Denu, J.M.2
-
73
-
-
9444296057
-
High absorption but very low bioavailability of oral resveratrol in humans
-
Walle, U. K.
-
Walle, T., Hsieh, F., Delegge, M. H., Oatis, J. E., Jr, and Walle, U. K. (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab. Dispos. 32, 1377-1382.
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 1377-1382
-
-
Walle, T.1
Hsieh, F.2
Delegge, M.H.3
Oatis Jr, J.E.4
-
74
-
-
77958488312
-
SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator
-
Dai, H., Kustigian, L., Carney, D., Case, A., Considine, T., et al. (2010) SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator. J. Biol. Chem. 285, 32695-32703.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 32695-32703
-
-
Dai, H.1
Kustigian, L.2
Carney, D.3
Case, A.4
Considine, T.5
-
75
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
Canto, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., et al. (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458, 1056-1060.
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
-
76
-
-
77249156847
-
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
-
Canto, C., Jiang, L. Q., Deshmukh, A. S., Mataki, C., Coste, A., et al. (2010) Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 11, 213-219.
-
(2010)
Cell Metab.
, vol.11
, pp. 213-219
-
-
Canto, C.1
Jiang, L.Q.2
Deshmukh, A.S.3
Mataki, C.4
Coste, A.5
-
77
-
-
84863011114
-
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
-
Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., et al. (2012) Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148, 421-433.
-
(2012)
Cell
, vol.148
, pp. 421-433
-
-
Park, S.J.1
Ahmad, F.2
Philp, A.3
Baar, K.4
Williams, T.5
-
78
-
-
0041571570
-
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry
-
Sauve, A. A. and Schramm, V. L. (2003) Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Biochemistry 42, 9249-9256.
-
(2003)
Biochemistry
, vol.42
, pp. 9249-9256
-
-
Sauve, A.A.1
Schramm, V.L.2
-
79
-
-
70349810821
-
Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition
-
e1343.
-
Giammona, L. M., Panuganti, S., Kemper, J. M., Apostolidis, P. A., Lindsey, S., et al. (2009) Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition. Exp. Hematol. 37, 1340-1352 e1343.
-
(2009)
Exp. Hematol.
, vol.37
, pp. 1340-1352
-
-
Giammona, L.M.1
Panuganti, S.2
Kemper, J.M.3
Apostolidis, P.A.4
Lindsey, S.5
-
80
-
-
34547599329
-
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
-
Outeiro, T. F., Kontopoulos, E., Altmann, S. M., Kufareva, I., Strathearn, K. E., et al. (2007) Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 317, 516-519.
-
(2007)
Science
, vol.317
, pp. 516-519
-
-
Outeiro, T.F.1
Kontopoulos, E.2
Altmann, S.M.3
Kufareva, I.4
Strathearn, K.E.5
-
81
-
-
18844362632
-
Stage-specific antileishmanial activity of an inhibitor of SIR2 histone deacetylase
-
Vergnes, B., Vanhille, L., Ouaissi, A., and Sereno, D. (2005) Stage-specific antileishmanial activity of an inhibitor of SIR2 histone deacetylase. Acta Trop. 94, 107-115.
-
(2005)
Acta Trop.
, vol.94
, pp. 107-115
-
-
Vergnes, B.1
Vanhille, L.2
Ouaissi, A.3
Sereno, D.4
-
82
-
-
20144372893
-
SIRT1 regulates HIV transcription via Tat deacetylation
-
Pagans, S., Pedal, A., North, B. J., Kaehlcke, K., Marshall, B. L., et al. (2005) SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol. 3, e41.
-
(2005)
PLoS Biol.
, vol.3
-
-
Pagans, S.1
Pedal, A.2
North, B.J.3
Kaehlcke, K.4
Marshall, B.L.5
-
83
-
-
84856527254
-
Regulation and protection of mitochondrial physiology by sirtuins
-
Pereira, C. V., Lebiedzinska, M., Wieckowski, M. R., and Oliveira, P. J. (2012) Regulation and protection of mitochondrial physiology by sirtuins. Mitochondrion 12, 66-76.
-
(2012)
Mitochondrion
, vol.12
, pp. 66-76
-
-
Pereira, C.V.1
Lebiedzinska, M.2
Wieckowski, M.R.3
Oliveira, P.J.4
-
84
-
-
79957968813
-
Medicinal chemistry of sirtuin inhibitors
-
Chen, L. (2011) Medicinal chemistry of sirtuin inhibitors. Curr. Med. Chem. 18, 1936-1946.
-
(2011)
Curr. Med. Chem.
, vol.18
, pp. 1936-1946
-
-
Chen, L.1
-
85
-
-
80054767989
-
-
Yao, T.-P., and Seto, E. (eds.), Springer, Heidelberg, London, New York
-
Mahajan, S. S., Leko, V., Simon, J. A., and Bedalov, A. (2011) In Handbook of Experimental Pharmacology. Histone Deacetylases: The Biology and Clinical Implication (Yao, T.-P., and Seto, E. (eds.), Springer, Heidelberg, London, New York. pp. 241-255.
-
(2011)
In Handbook of Experimental Pharmacology. Histone Deacetylases: The Biology and Clinical Implication
, pp. 241-255
-
-
Mahajan, S.S.1
Leko, V.2
Simon, J.A.3
Bedalov, A.4
-
86
-
-
0035910031
-
Identification of a small molecule inhibitor of Sir2p
-
Simon, J. A.
-
Bedalov, A., Gatbonton, T., Irvine, W. P., Gottschling, D. E., and Simon, J. A. (2001) Identification of a small molecule inhibitor of Sir2p. Proc. Natl. Acad. Sci. USA 98, 15113-15118.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 15113-15118
-
-
Bedalov, A.1
Gatbonton, T.2
Irvine, W.P.3
Gottschling, D.E.4
-
87
-
-
41649103241
-
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode
-
Neugebauer, R. C., Uchiechowska, U., Meier, R., Hruby, H., Valkov, V., et al. (2008) Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J. Med. Chem. 51, 1203-1213.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 1203-1213
-
-
Neugebauer, R.C.1
Uchiechowska, U.2
Meier, R.3
Hruby, H.4
Valkov, V.5
-
88
-
-
41949125454
-
SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome
-
Biacsi, R., Kumari, D., and Usdin, K. (2008) SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. PLoS Genet. 4, e1000017.
-
(2008)
PLoS Genet.
, vol.4
-
-
Biacsi, R.1
Kumari, D.2
Usdin, K.3
-
89
-
-
0035914304
-
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
-
Grozinger, C. M., Chao, E. D., Blackwell, H. E., Moazed, D., and Schreiber, S. L. (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J. Biol. Chem. 276, 38837-38843.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38837-38843
-
-
Grozinger, C.M.1
Chao, E.D.2
Blackwell, H.E.3
Moazed, D.4
Schreiber, S.L.5
-
90
-
-
28144438533
-
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors
-
Mai, A., Massa, S., Lavu, S., Pezzi, R., Simeoni, S., et al. (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J. Med. Chem. 48, 7789-7795.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 7789-7795
-
-
Mai, A.1
Massa, S.2
Lavu, S.3
Pezzi, R.4
Simeoni, S.5
-
91
-
-
30544445468
-
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
-
Ota, H., Tokunaga, E., Chang, K., Hikasa, M., Iijima, K., et al. (2006) Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 25, 176-185.
-
(2006)
Oncogene
, vol.25
, pp. 176-185
-
-
Ota, H.1
Tokunaga, E.2
Chang, K.3
Hikasa, M.4
Iijima, K.5
-
92
-
-
79952398625
-
The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells
-
Jin, K. L., Park, J. Y., Noh, E. J., Hoe, K. L., Lee, J. H., et al. (2010) The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells. J. Gynecol. Oncol. 21, 262-268.
-
(2010)
J. Gynecol. Oncol.
, vol.21
, pp. 262-268
-
-
Jin, K.L.1
Park, J.Y.2
Noh, E.J.3
Hoe, K.L.4
Lee, J.H.5
-
93
-
-
47249154705
-
A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
-
Kojima, K., Ohhashi, R., Fujita, Y., Hamada, N., Akao, Y., et al. (2008) A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells. Biochem. Biophys. Res. Commun. 373, 423-428.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.373
, pp. 423-428
-
-
Kojima, K.1
Ohhashi, R.2
Fujita, Y.3
Hamada, N.4
Akao, Y.5
-
94
-
-
77950835404
-
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2
-
Peck, B., Chen, C. Y., Ho, K. K., Di Fruscia, P., Myatt, S. S., et al. (2010) SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol. Cancer Ther. 9, 844-855.
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 844-855
-
-
Peck, B.1
Chen, C.Y.2
Ho, K.K.3
Di Fruscia, P.4
Myatt, S.S.5
-
95
-
-
79953799195
-
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer
-
Alhazzazi, T. Y., Kamarajan, P., Joo, N., Huang, J. Y., Verdin, E., et al. (2011) Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer 117, 1670-1678.
-
(2011)
Cancer
, vol.117
, pp. 1670-1678
-
-
Alhazzazi, T.Y.1
Kamarajan, P.2
Joo, N.3
Huang, J.Y.4
Verdin, E.5
-
96
-
-
46249124837
-
Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1
-
Catoire, H., Pasco, M. Y., Abu-Baker, A., Holbert, S., Tourette, C., et al. (2008) Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1. Hum. Mol. Genet. 17, 2108-2117.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 2108-2117
-
-
Catoire, H.1
Pasco, M.Y.2
Abu-Baker, A.3
Holbert, S.4
Tourette, C.5
-
97
-
-
77249153712
-
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues
-
Pasco, M. Y., Rotili, D., Altucci, L., Farina, F., Rouleau, G. A., et al. (2010) Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues. J. Med. Chem. 53, 1407-1411.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 1407-1411
-
-
Pasco, M.Y.1
Rotili, D.2
Altucci, L.3
Farina, F.4
Rouleau, G.A.5
-
98
-
-
80052638751
-
Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells
-
Orecchia, A., Scarponi, C., Di Felice, F., Cesarini, E., Avitabile, S., et al. (2011) Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells. PLoS One 6, e24307.
-
(2011)
PLoS One
, vol.6
-
-
Orecchia, A.1
Scarponi, C.2
Di Felice, F.3
Cesarini, E.4
Avitabile, S.5
-
99
-
-
84855769254
-
SIRT2 activity is required for the survival of C6 glioma cells
-
He, X., Nie, H., Hong, Y., Sheng, C., Xia, W., et al. (2012) SIRT2 activity is required for the survival of C6 glioma cells. Biochem. Biophys. Res. Commun. 417, 468-472.
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.417
, pp. 468-472
-
-
He, X.1
Nie, H.2
Hong, Y.3
Sheng, C.4
Xia, W.5
-
100
-
-
79954527563
-
Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells
-
Nie, H., Chen, H., Han, J., Hong, Y., Ma, Y., et al. (2011) Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells. Int. J. Physiol. Pathophysiol. Pharmacol. 3, 65-70.
-
(2011)
Int. J. Physiol. Pathophysiol. Pharmacol.
, vol.3
, pp. 65-70
-
-
Nie, H.1
Chen, H.2
Han, J.3
Hong, Y.4
Ma, Y.5
-
101
-
-
77952413052
-
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
-
Luthi-Carter, R., Taylor, D. M., Pallos, J., Lambert, E., Amore, A., et al. (2010) SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc. Natl. Acad. Sci. USA 107, 7927-7932.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 7927-7932
-
-
Luthi-Carter, R.1
Taylor, D.M.2
Pallos, J.3
Lambert, E.4
Amore, A.5
-
102
-
-
33646254136
-
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
-
Heltweg, B., Gatbonton, T., Schuler, A. D., Posakony, J., Li, H., et al. (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 66, 4368-4377.
-
(2006)
Cancer Res.
, vol.66
, pp. 4368-4377
-
-
Heltweg, B.1
Gatbonton, T.2
Schuler, A.D.3
Posakony, J.4
Li, H.5
-
103
-
-
65649111534
-
Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity
-
Medda, F., Russell, R. J., Higgins, M., Mccarthy, A. R., Campbell, J., et al. (2009) Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity. J. Med. Chem. 52, 2673-2682.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 2673-2682
-
-
Medda, F.1
Russell, R.J.2
Higgins, M.3
Mccarthy, A.R.4
Campbell, J.5
-
104
-
-
33847635635
-
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
-
Schuetz, A., Min, J., Antoshenko, T., Wang, C. L., Allali-Hassani, A., et al. (2007) Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin. Structure 15, 377-389.
-
(2007)
Structure
, vol.15
, pp. 377-389
-
-
Schuetz, A.1
Min, J.2
Antoshenko, T.3
Wang, C.L.4
Allali-Hassani, A.5
-
105
-
-
35548936745
-
Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins)
-
Trapp, J., Meier, R., Hongwiset, D., Kassack, M. U., Sippl, W., et al. (2007) Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins). ChemMedChem 2, 1419-1431.
-
(2007)
ChemMedChem
, vol.2
, pp. 1419-1431
-
-
Trapp, J.1
Meier, R.2
Hongwiset, D.3
Kassack, M.U.4
Sippl, W.5
-
106
-
-
18244409076
-
New agents in intravesical chemotherapy of superficial bladder cancer
-
Perabo, F. G. and Muller, S. C. (2005) New agents in intravesical chemotherapy of superficial bladder cancer. Scand. J. Urol. Nephrol. 39, 108-116.
-
(2005)
Scand. J. Urol. Nephrol.
, vol.39
, pp. 108-116
-
-
Perabo, F.G.1
Muller, S.C.2
-
107
-
-
42949114938
-
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
-
Lain, S., Hollick, J. J., Campbell, J., Staples, O. D., Higgins, M., et al. (2008) Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13, 454-463.
-
(2008)
Cancer Cell
, vol.13
, pp. 454-463
-
-
Lain, S.1
Hollick, J.J.2
Campbell, J.3
Staples, O.D.4
Higgins, M.5
-
108
-
-
84863116364
-
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
-
Yuan, H., Wang, Z., Li, L., Zhang, H., Modi, H., et al. (2012) Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood 119, 1904-1914.
-
(2012)
Blood
, vol.119
, pp. 1904-1914
-
-
Yuan, H.1
Wang, Z.2
Li, L.3
Zhang, H.4
Modi, H.5
-
109
-
-
84857355902
-
Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins
-
McCarthy, A. R., Pirrie, L., Hollick, J. J., Ronseaux, S., Campbell, J., et al. (2012) Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins. Bioorg. Med. Chem. 20, 1779-1793.
-
(2012)
Bioorg. Med. Chem.
, vol.20
, pp. 1779-1793
-
-
McCarthy, A.R.1
Pirrie, L.2
Hollick, J.J.3
Ronseaux, S.4
Campbell, J.5
-
110
-
-
60149091562
-
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
-
Lara, E., Mai, A., Calvanese, V., Altucci, L., Lopez-Nieva, P., et al. (2009) Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene 28, 781-791.
-
(2009)
Oncogene
, vol.28
, pp. 781-791
-
-
Lara, E.1
Mai, A.2
Calvanese, V.3
Altucci, L.4
Lopez-Nieva, P.5
-
111
-
-
84863103122
-
Salermide upregulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells
-
doi: 10.1111/j.1582-4934.2011.01401.x
-
Liu, G., Su, L., Hao, X., Zhong, N., Zhong, D., et al. (2011) Salermide upregulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells. J. Cell. Mol. Med. doi: 10.1111/j.1582-4934.2011.01401.x
-
(2011)
J. Cell. Mol. Med.
-
-
Liu, G.1
Su, L.2
Hao, X.3
Zhong, N.4
Zhong, D.5
|