SIRT1 is regulated by a PPARγ-SIRT1 negative feedback loop associated with senescence

Nucleic Acids Research

Volumn 38, Issue 21, 2010, Pages 7458-7471

  Han, Limin ^a,b   Zhou, Rui ^a,b   Niu, Jing ^a,b   McNutt, Michael A ^c   Wang, Pan ^a,b   Tong, Tanjun ^a,b  

^a PEKING UNIVERSITY   (China)

^b Department of Biochemistry and Molecular Biology ^*  (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P300; SIRTUIN 1;

ACETYLATION; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOREGULATION; CATALYSIS; CELL AGING; CONTROLLED STUDY; DEACETYLATION; EMBRYO; ENZYME ACTIVITY; HEART; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LONGEVITY; LUNG PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; CELL AGING; CELL LINE; DOWN-REGULATION; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, INBRED BALB C; P300-CBP TRANSCRIPTION FACTORS; PPAR GAMMA; PROMOTER REGIONS, GENETIC; PROTEIN INTERACTION DOMAINS AND MOTIFS; SIRTUIN 1; TRANSCRIPTION, GENETIC;

EID: 78649852533     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq609     Document Type: Article

References (36)

1. Finch, C. E. (1990) Longevity, Senescence, and the Genome. The University of Chicago, Chicago, IL.
2. Kaeberlein, M., McVey, M. and Guarente, L. (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomycescerevisiae by two different mechanisms. Genes Dev., 13, 2570-2580.
3. Guarente, L. (2000) Sir2 links chromatin silencing, metabolism, and aging. Genes Dev., 14, 1021-1026.
4. Guarente, L. and Kenyon, C. (2000) Genetic pathways that regulate ageing in model organisms. Nature, 408, 255-262.
5. Nemoto, S., Fergusson, M. M. and Finkel, T. (2004) Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science, 306, 2105-2108.
6. Masoro, E. J. (2000) Calorie restriction and aging: an update. Exp. Gerontol., 35, 299.
7. Picard, F., Kurtev, M., Chung, N., Topark-Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M., McBurney, M. W. and Guarente, L. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPARg. Nature, 429, 771-776.
8. Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M. and Puigserver, P. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature, 434, 113-118.
9. SIRT1 functions as an NAD-dependent p53 deacetylase. Cell, 107, 149-159.
10. Motta, M. C., Divecha, N., Lemieux, M., Kamel, C., Chen, D., Gu, W., Bultsma, Y., McBurney, M. and Guarente, L. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell, 116, 551-563.
11. Wong, S. and Weber, J. D. (2007) Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem. J., 407, 451-460.
12. Campisi, J. (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell, 120, 513-522.
13. Chang, T. H. and Szabo, E. (2000) Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer. Cancer. Res., 60, 1129-1138.
14. Tontonoz, P., Singer, S., Forman, B. M., Sarraf, P., Fletcher, J. A., Fletcher, C. D., Brun, R. P., Mueller, E., Altiok, S., Oppenheim, H. et al. (1997) Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator activated receptor gamma and the retinoid X receptor. Proc. Natl Acad. Sci. USA, 94, 237-241.
15. INK4a expression in human diploid fibroblasts. J. Cell. Sci., 121, 2235-2245.
16. Huang, J., Gan, Q. N., Han, L. M., Li, J., Zhang, H., Sun, Y., Zhang, Z. Y. and Tong, T. J. (2008) SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts. PLoS ONE, 3, e1710.
17. Tang, Z., Zhang, Z., Zheng, Y., Corbley, M. J. and Tong, T. (1994) Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in HER-2 expression. Mech. Ageing Dev., 73, 57-67.
18. Tontonoz, P., Hu, E. and Spiegelman, B. M. (1994) Stimulation of adipogenesis in fibroblasts by PPARg2, a lipid-activated transcription factor. Cell, 79, 1147-1156.
19. Kelly, D., Campbell, J. I., King, T. P., Grant, G., Jansson, E. A., Coutts, A. G., Pettersson, S. and Conway, S. (2004) Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat. Immunol., 5, 104-112.
20. SIRT1*. J. Biol. Chem., 279, 28873-28879.
21. Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I. and Pereira-Smith, O. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA, 92, 9363-9367.
22. Tissenbaum, H. A. and Guarente, L. (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature, 410, 227-230.
23. Ota, H., Tokunaga, E., Chang, K., Hikasa, M., Iijima, K., Eto, M., Kozaki, K., Akishita, M., Ouchi, Y. and Kaneki, M. (2006) Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene, 25, 176-85.
24. Motta, M. C., Divecha, N., Lemieux, M., Kamel, C., Chen, D., Gu, W., Bultsma, Y., McBurney, M. and Guarente, L. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell, 116, 551-563.
25. Sasaki, T., Maier, B., Bartke, A. and Scrable, H. (2006) Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell, 5, 413-422.
26. Fu, M., Wang, C., Reutens, A. T., Wang, J., Angeletti, R. H., Siconolfi-Baez, L., Ogryzko, V., Avantaggiati, M. L. and Pestell, R. G. (2000) p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. J. Biol. Chem., 275, 20853-20860.
27. Gaughan, L., Logan, I. R., Cook, S., Neal, D. E. and Robson, C. N. (2002) Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor. J. Biol. Chem., 277, 25904-25913.
28. Wang, C. (2001) Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity. J. Biol. Chem., 276, 18375-18383.
29. Gaughan, L., Logan, I. R., Neal, D. E. and Robson, C. N. (2005) Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation. Nucleic Acids Res., 33, 13-26.
30. Martinez-Balbas, M. A., Bauer, U. M., Nielsen, S. J., Brehm, A. and Kouzarides, T. (2000) Regulation of E2F1 activity by acetylation. EMBO J., 19, 662-671.
31. Bouras, T., Fu, M., Sauve, A. A., Wang, F., Quong, A. A., Perkins, N. D., Hay, R. T., Gu, W. and Pestell, R. G. (2005) SIRT1 deacetylation and repression of p300 involves lysine residues1020/ 1024 within the cell cycle regulatory domain 1. J. Biol. Chem., 80, 10264-10276.
32. Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L. and Gu, W. (2001) Negative control of p53 by Sir2 alpha promotes cell survival under stress. Cell, 107, 137-148.
33. Nemoto, S., Fergusson, M. M. and Finkel, T. (2004) Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science, 306, 2105-2108.
34. Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y. et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science, 26, 2011-2015.
35. Nemoto, S., Fergusson, M. M and Finkel, T. (2005) SIRT1 functionally interacts with the metabolic regulator and transcrip-tional coactivator PGC-1a. J. Biol . Chem., 280, 16456-16460.
36. Kahn, C. R., Chen, L. and Cohen, S. E. (2000) Unraveling the mechanism of action of thiazolidinediones. J. Clin. Invest., 106, 1305-1307.